-
1
-
-
84855396777
-
American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive summary: Heart disease and stroke statistics
-
V.L. Roger American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive summary: heart disease and stroke statistics Circulation 125 2012 188 197
-
(2012)
Circulation
, vol.125
, pp. 188-197
-
-
Roger, V.L.1
-
2
-
-
1842678190
-
Remodeling the blood coagulation cascade
-
M. Hoffman Remodeling the blood coagulation cascade J. Thromb. Thrombolysis 16 2003 17 20
-
(2003)
J. Thromb. Thrombolysis
, vol.16
, pp. 17-20
-
-
Hoffman, M.1
-
3
-
-
0025772165
-
Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation
-
J.H. Lawson, and K.G. Mann Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation J. Biol. Chem. 266 1991 11317 11327
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 11317-11327
-
-
Lawson, J.H.1
Mann, K.G.2
-
4
-
-
0027327680
-
Thrombin production, inactivation and expression during open heart surgery measured by assays for activation fragments including a new ELISA for prothrombin fragment F1 + 2
-
M.D. Boisclair Thrombin production, inactivation and expression during open heart surgery measured by assays for activation fragments including a new ELISA for prothrombin fragment F1 + 2 Thromb. Haemost. 70 1993 253 258
-
(1993)
Thromb. Haemost.
, vol.70
, pp. 253-258
-
-
Boisclair, M.D.1
-
5
-
-
0024997547
-
Factor IX is activated in vivo by the tissue factor mechanism
-
K.A. Bauer Factor IX is activated in vivo by the tissue factor mechanism Blood 76 1990 731 736
-
(1990)
Blood
, vol.76
, pp. 731-736
-
-
Bauer, K.A.1
-
6
-
-
1842840779
-
Roles of factor XI, platelets and tissue factor-initiated blood coagulation
-
P.N. Walsh Roles of factor XI, platelets and tissue factor-initiated blood coagulation J. Thromb. Haemost. 10 2003 2081 2086
-
(2003)
J. Thromb. Haemost.
, vol.10
, pp. 2081-2086
-
-
Walsh, P.N.1
-
7
-
-
0038101450
-
Haemophilias A and B
-
P.H. Bolton-Maggs, and K.J. Pasi Haemophilias A and B Lancet 9371 2003 1801 1809
-
(2003)
Lancet
, vol.9371
, pp. 1801-1809
-
-
Bolton-Maggs, P.H.1
Pasi, K.J.2
-
9
-
-
0037176941
-
Direct thrombin inhibitors in acute coronary syndromes: Present and future
-
J.I. Weitz, and H.R. Buller Direct thrombin inhibitors in acute coronary syndromes: present and future Circulation 105 2002 1004 1011
-
(2002)
Circulation
, vol.105
, pp. 1004-1011
-
-
Weitz, J.I.1
Buller, H.R.2
-
10
-
-
0030768937
-
Interaction of factor IXa with factor VIIIa. Effects of protease domain Ca2+ binding site, proteolysis in the autolysis loop, phospholipid, and factor X
-
A. Mathur Interaction of factor IXa with factor VIIIa. Effects of protease domain Ca2+ binding site, proteolysis in the autolysis loop, phospholipid, and factor X J. Biol. Chem. 272 1997 23418 23426
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 23418-23426
-
-
Mathur, A.1
-
11
-
-
0030817391
-
A coagulation factor IX-knockout mouse model for human hemophilia B
-
H.F. Lin A coagulation factor IX-knockout mouse model for human hemophilia B Blood 90 1997 3962 3966
-
(1997)
Blood
, vol.90
, pp. 3962-3966
-
-
Lin, H.F.1
-
12
-
-
0034842912
-
Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors
-
H. Chao Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors Mol. Ther. 4 2001 217 222
-
(2001)
Mol. Ther.
, vol.4
, pp. 217-222
-
-
Chao, H.1
-
13
-
-
23044453832
-
Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice
-
X. Wang Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice J. Thromb. Haemost. 3 2005 695 702
-
(2005)
J. Thromb. Haemost.
, vol.3
, pp. 695-702
-
-
Wang, X.1
-
14
-
-
0030056114
-
Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IX
-
S.J. Freedman Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IX J. Biol. Chem. 271 1996 16227 16236
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 16227-16236
-
-
Freedman, S.J.1
-
15
-
-
0028801352
-
X-ray structure of clotting factor IXa: Active site and module structure related to Xase activity and hemophilia B
-
H. Brandstetter X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B Proc. Natl. Acad. Sci. U. S. A. 92 1995 9796 9800
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 9796-9800
-
-
Brandstetter, H.1
-
16
-
-
0029661981
-
2+ binding to the first epidermal growth factor-like domain of human blood coagulation factor IX promotes enzyme activity and factor VIII light chain binding
-
2+ binding to the first epidermal growth factor-like domain of human blood coagulation factor IX promotes enzyme activity and factor VIII light chain binding J. Biol. Chem. 271 1996 25332 25337
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 25332-25337
-
-
Lenting, P.J.1
-
17
-
-
0034670013
-
Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor-related protein
-
J.G. Neels Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor-related protein Blood 96 2000 3459 3465
-
(2000)
Blood
, vol.96
, pp. 3459-3465
-
-
Neels, J.G.1
-
18
-
-
50449141336
-
Recent history of coronary disease
-
J.N. Morris Recent history of coronary disease Lancet 1 1951 69 73
-
(1951)
Lancet
, vol.1
, pp. 69-73
-
-
Morris, J.N.1
-
19
-
-
0029807088
-
Macrophages and atherosclerotic plaque stability
-
P. Libby Macrophages and atherosclerotic plaque stability Curr. Opin. Lipidol. 7 1996 330 335
-
(1996)
Curr. Opin. Lipidol.
, vol.7
, pp. 330-335
-
-
Libby, P.1
-
20
-
-
33646470969
-
An overview of the structure and function of thrombin
-
E.W. Davie, and J.D. Kulman An overview of the structure and function of thrombin Semin. Thromb. Haemost. 32 2006 3 15
-
(2006)
Semin. Thromb. Haemost.
, vol.32
, pp. 3-15
-
-
Davie, E.W.1
Kulman, J.D.2
-
21
-
-
0029817853
-
Identification of active tissue factor in human coronary atheroma
-
J.D. Marmur Identification of active tissue factor in human coronary atheroma Circulation 94 1996 1226 1232
-
(1996)
Circulation
, vol.94
, pp. 1226-1232
-
-
Marmur, J.D.1
-
22
-
-
0032977708
-
Tissue factor in atherosclerosis
-
E. Tremoli Tissue factor in atherosclerosis Atherosclerosis 144 1999 273 283
-
(1999)
Atherosclerosis
, vol.144
, pp. 273-283
-
-
Tremoli, E.1
-
23
-
-
33748373993
-
Elevated factor XI activity levels are associated with an increased odds ratio for cerebrovascular events
-
D.T. Yang Elevated factor XI activity levels are associated with an increased odds ratio for cerebrovascular events Am. J. Clin. Pathol. 126 2006 411 415
-
(2006)
Am. J. Clin. Pathol.
, vol.126
, pp. 411-415
-
-
Yang, D.T.1
-
24
-
-
33845497457
-
Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: Opposite and synergistic effects of factors XI and XII
-
C.J. Doggen Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: opposite and synergistic effects of factors XI and XII Blood 108 2006 4045 4051
-
(2006)
Blood
, vol.108
, pp. 4045-4051
-
-
Doggen, C.J.1
-
25
-
-
0033764837
-
Activation of clotting factors XI and IX in patients with acute myocardial infarction
-
M.C. Minnema Activation of clotting factors XI and IX in patients with acute myocardial infarction Arterioscler. Thromb. Vasc. Biol. 20 2000 2489 2493
-
(2000)
Arterioscler. Thromb. Vasc. Biol.
, vol.20
, pp. 2489-2493
-
-
Minnema, M.C.1
-
26
-
-
0024346843
-
Platelet receptor occupancy with factor IXa promotes factor X activation
-
S.S. Ahmad Platelet receptor occupancy with factor IXa promotes factor X activation J. Biol. Chem. 264 1989 20012 20016
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 20012-20016
-
-
Ahmad, S.S.1
-
27
-
-
0034648757
-
Thrombin signaling and protease-activated receptors
-
S.R. Coughlin Thrombin signaling and protease-activated receptors Nature 407 2000 258 264
-
(2000)
Nature
, vol.407
, pp. 258-264
-
-
Coughlin, S.R.1
-
28
-
-
77953201509
-
Anticoagulant therapy for percutaneous coronary intervention
-
S.V. Rao, and E.M. Ohman Anticoagulant therapy for percutaneous coronary intervention Circ. Cardiovasc. Interv. 3 2010 80 88
-
(2010)
Circ. Cardiovasc. Interv.
, vol.3
, pp. 80-88
-
-
Rao, S.V.1
Ohman, E.M.2
-
29
-
-
0028812558
-
Effects on coagulation and fibrinolysis with reduced versus full systemic heparinization and heparin-coated cardiopulmonary bypass
-
E. Ovrum Effects on coagulation and fibrinolysis with reduced versus full systemic heparinization and heparin-coated cardiopulmonary bypass Circulation 92 1995 2579 2584
-
(1995)
Circulation
, vol.92
, pp. 2579-2584
-
-
Ovrum, E.1
-
30
-
-
0027159961
-
Blood-surface interactions during cardiopulmonary bypass
-
L.H. Edmunds Jr. Blood-surface interactions during cardiopulmonary bypass J. Card. Surg. 8 1993 404 410
-
(1993)
J. Card. Surg.
, vol.8
, pp. 404-410
-
-
Edmunds, L.H.1
-
31
-
-
0024598672
-
Alterations in coagulation and fibrinolysis associated with cardiopulmonary bypass during open heart surgery
-
K. Tanaka Alterations in coagulation and fibrinolysis associated with cardiopulmonary bypass during open heart surgery J. Cardiothorac. Anesth. 3 1989 181 188
-
(1989)
J. Cardiothorac. Anesth.
, vol.3
, pp. 181-188
-
-
Tanaka, K.1
-
32
-
-
0028933865
-
Hemostatic complications of cardiopulmonary bypass
-
R.W. Colman Hemostatic complications of cardiopulmonary bypass Am. J. Hematol. 48 1995 267 272
-
(1995)
Am. J. Hematol.
, vol.48
, pp. 267-272
-
-
Colman, R.W.1
-
33
-
-
0032033608
-
Activation of coagulation and fibrinolysis during cardiothoracic operations
-
B.J. Hunt Activation of coagulation and fibrinolysis during cardiothoracic operations Ann. Thorac. Surg. 65 1998 712 718
-
(1998)
Ann. Thorac. Surg.
, vol.65
, pp. 712-718
-
-
Hunt, B.J.1
-
34
-
-
0029078950
-
An ELISA for factor X activation peptide: Application to the investigation of thrombogenesis in cardiopulmonary bypass
-
H. Philippou An ELISA for factor X activation peptide: application to the investigation of thrombogenesis in cardiopulmonary bypass Br. J. Haematol. 90 1995 432 437
-
(1995)
Br. J. Haematol.
, vol.90
, pp. 432-437
-
-
Philippou, H.1
-
35
-
-
0037392121
-
Management of heparin resistance during cardiopulmonary bypass: The effect of five different anticoagulation strategies on hemostatic activation
-
A. Koster Management of heparin resistance during cardiopulmonary bypass: the effect of five different anticoagulation strategies on hemostatic activation J. Cardiothorac. Vasc. Anesth. 17 2003 171 175
-
(2003)
J. Cardiothorac. Vasc. Anesth.
, vol.17
, pp. 171-175
-
-
Koster, A.1
-
36
-
-
0027249775
-
Thrombin generation during cardiac surgery: Is heparin the ideal anticoagulant?
-
S.J. Brister Thrombin generation during cardiac surgery: is heparin the ideal anticoagulant? Thromb. Haemost. 70 1993 259 262
-
(1993)
Thromb. Haemost.
, vol.70
, pp. 259-262
-
-
Brister, S.J.1
-
37
-
-
0028809946
-
Heparin causes platelet dysfunction and induces fibrinolysis before cardiopulmonary bypass
-
S. Khuri Heparin causes platelet dysfunction and induces fibrinolysis before cardiopulmonary bypass Ann. Thorac. Surg. 60 1995 1008 1014
-
(1995)
Ann. Thorac. Surg.
, vol.60
, pp. 1008-1014
-
-
Khuri, S.1
-
38
-
-
0031965512
-
Heparinless cardiopulmonary bypass with active-site blocked factor IXa: A preliminary study on the dog
-
T.B. Spanier Heparinless cardiopulmonary bypass with active-site blocked factor IXa: a preliminary study on the dog J. Thorac. Cardiovasc. Surg. 115 1998 1179 1188
-
(1998)
J. Thorac. Cardiovasc. Surg.
, vol.115
, pp. 1179-1188
-
-
Spanier, T.B.1
-
39
-
-
33746867177
-
A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery
-
S.M. Nimjee A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery Mol. Ther. 14 2006 408 415
-
(2006)
Mol. Ther.
, vol.14
, pp. 408-415
-
-
Nimjee, S.M.1
-
40
-
-
0036720340
-
Off-pump coronary artery bypass surgery
-
P.P. de Jaegere, and W.J. Suyker Off-pump coronary artery bypass surgery Heart 88 2002 313 318
-
(2002)
Heart
, vol.88
, pp. 313-318
-
-
De Jaegere, P.P.1
Suyker, W.J.2
-
41
-
-
0031739665
-
Selective anticoagulation with active site-blocked factor IXA suggests separate roles for intrinsic and extrinsic coagulation pathways in cardiopulmonary bypass
-
T.B. Spanier Selective anticoagulation with active site-blocked factor IXA suggests separate roles for intrinsic and extrinsic coagulation pathways in cardiopulmonary bypass J. Thorac. Cardiovasc. Surg. 116 1998 860 869
-
(1998)
J. Thorac. Cardiovasc. Surg.
, vol.116
, pp. 860-869
-
-
Spanier, T.B.1
-
42
-
-
34147192480
-
Epidemiology and risk factors for venous thrombosis
-
M. Cushman Epidemiology and risk factors for venous thrombosis Semin. Hematol. 44 2007 62 69
-
(2007)
Semin. Hematol.
, vol.44
, pp. 62-69
-
-
Cushman, M.1
-
43
-
-
0029144243
-
Factors IXa and Xa play distinct roles in tissue factor-dependent initiation of coagulation
-
M. Hoffman Factors IXa and Xa play distinct roles in tissue factor-dependent initiation of coagulation Blood 86 1995 1794 1801
-
(1995)
Blood
, vol.86
, pp. 1794-1801
-
-
Hoffman, M.1
-
44
-
-
2542427449
-
The significance of circulating factor IXa in blood
-
S. Butenas The significance of circulating factor IXa in blood J. Biol. Chem. 279 2004 22875 22882
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 22875-22882
-
-
Butenas, S.1
-
45
-
-
34247606502
-
Microparticle-associated tissue factor activity: A link between cancer and thrombosis?
-
M.E. Tesselaar Microparticle-associated tissue factor activity: a link between cancer and thrombosis? J. Thromb. Haemost. 5 2007 520 527
-
(2007)
J. Thromb. Haemost.
, vol.5
, pp. 520-527
-
-
Tesselaar, M.E.1
-
46
-
-
28344441333
-
The P-selectin, tissue factor, coagulation triad
-
J. Polgar The P-selectin, tissue factor, coagulation triad J. Thromb. Haemost. 3 2005 1590 1596
-
(2005)
J. Thromb. Haemost.
, vol.3
, pp. 1590-1596
-
-
Polgar, J.1
-
47
-
-
0034099043
-
High levels of coagulation factor XI as a risk factor for venous thrombosis
-
J.C. Meijers High levels of coagulation factor XI as a risk factor for venous thrombosis N. Engl. J. Med. 342 2000 696 701
-
(2000)
N. Engl. J. Med.
, vol.342
, pp. 696-701
-
-
Meijers, J.C.1
-
48
-
-
0032701594
-
An inhibitory anti-factor IX antibody effectively reduces thrombus formation in a rat model of venous thrombosis
-
G.Z. Feuerstein An inhibitory anti-factor IX antibody effectively reduces thrombus formation in a rat model of venous thrombosis Thromb. Haemost. 82 1999 1443 1445
-
(1999)
Thromb. Haemost.
, vol.82
, pp. 1443-1445
-
-
Feuerstein, G.Z.1
-
49
-
-
70449461639
-
Genetic fusion to albumin improves the pharmacokinetic properties of factor IX
-
H.J. Metzner Genetic fusion to albumin improves the pharmacokinetic properties of factor IX Thromb. Haemost. 102 2009 634 644
-
(2009)
Thromb. Haemost.
, vol.102
, pp. 634-644
-
-
Metzner, H.J.1
-
50
-
-
84889632409
-
Evidence of clinically significant extravascular stores of factor IX
-
D. Feng Evidence of clinically significant extravascular stores of factor IX J. Thromb. Haemost. 11 2013 2176 2178
-
(2013)
J. Thromb. Haemost.
, vol.11
, pp. 2176-2178
-
-
Feng, D.1
-
51
-
-
0025789568
-
Active site-blocked factor IXa prevents intravascular thrombus formation in the coronary vasculature without inhibiting extravascular coagulation in a canine thrombosis model
-
C.R. Benedict Active site-blocked factor IXa prevents intravascular thrombus formation in the coronary vasculature without inhibiting extravascular coagulation in a canine thrombosis model J. Clin. Invest. 88 1991 1760 1765
-
(1991)
J. Clin. Invest.
, vol.88
, pp. 1760-1765
-
-
Benedict, C.R.1
-
52
-
-
0024386731
-
Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis
-
T.A. Drake Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis Am. J. Pathol. 134 1989 1087 1097
-
(1989)
Am. J. Pathol.
, vol.134
, pp. 1087-1097
-
-
Drake, T.A.1
-
53
-
-
0017660808
-
Kinetics of the activation of bovine coagulation factor X by components of the extrinsic pathway. Kinetic behavior of two-chain factor VII in the presence and absence of tissue factor
-
S.A. Silverberg Kinetics of the activation of bovine coagulation factor X by components of the extrinsic pathway. Kinetic behavior of two-chain factor VII in the presence and absence of tissue factor J. Biol. Chem. 252 1977 8481 8488
-
(1977)
J. Biol. Chem.
, vol.252
, pp. 8481-8488
-
-
Silverberg, S.A.1
-
54
-
-
0020456713
-
An alternative extrinsic pathway of human blood coagulation
-
R.A. Marlar An alternative extrinsic pathway of human blood coagulation Blood 60 1982 1353 1358
-
(1982)
Blood
, vol.60
, pp. 1353-1358
-
-
Marlar, R.A.1
-
55
-
-
0023270387
-
In vivo evidence of intravascular binding sites for coagulation factor IX
-
D.M. Stern In vivo evidence of intravascular binding sites for coagulation factor IX Br. J. Haematol. 66 1987 227 232
-
(1987)
Br. J. Haematol.
, vol.66
, pp. 227-232
-
-
Stern, D.M.1
-
56
-
-
0026660188
-
The binding of human factor IX to endothelial cells is mediated by residues 3-11
-
W.F. Cheung The binding of human factor IX to endothelial cells is mediated by residues 3-11 J. Biol. Chem. 267 1992 20529 20531
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 20529-20531
-
-
Cheung, W.F.1
-
57
-
-
34347358644
-
The heparin-binding exosite is critical to allosteric activation of factor IXa in the intrinsic tenase complex: The role of arginine 165 and factor X
-
T.M. Misenheimer The heparin-binding exosite is critical to allosteric activation of factor IXa in the intrinsic tenase complex: the role of arginine 165 and factor X Biochemistry 46 2007 7886 7895
-
(2007)
Biochemistry
, vol.46
, pp. 7886-7895
-
-
Misenheimer, T.M.1
-
58
-
-
0037032426
-
Calcium-binding analysis and molecular modeling reveal echis coagulation factor IX/factor X-binding protein has the Ca-binding properties and Ca ion-independent folding of other C-type lectin-like proteins
-
H. Atoda Calcium-binding analysis and molecular modeling reveal echis coagulation factor IX/factor X-binding protein has the Ca-binding properties and Ca ion-independent folding of other C-type lectin-like proteins FEBS Lett. 531 2002 229 234
-
(2002)
FEBS Lett.
, vol.531
, pp. 229-234
-
-
Atoda, H.1
-
59
-
-
19744372224
-
A C-type lectin-like protein from Agkistrodon acutus venom binds to both platelet glycoprotein Ib and coagulation factor IX/factor X
-
W.F. Li A C-type lectin-like protein from Agkistrodon acutus venom binds to both platelet glycoprotein Ib and coagulation factor IX/factor X Biochem. Biophys. Res. Commun. 332 2005 904 912
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.332
, pp. 904-912
-
-
Li, W.F.1
-
60
-
-
0033526817
-
Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage
-
T.F. Choudhri Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage J. Exp. Med. 190 1999 91 99
-
(1999)
J. Exp. Med.
, vol.190
, pp. 91-99
-
-
Choudhri, T.F.1
-
61
-
-
0033950343
-
Use of phage display for the generation of human antibodies that neutralize factor IXa function
-
S. Suggett Use of phage display for the generation of human antibodies that neutralize factor IXa function Blood Coagul. Fibrinolysis 11 2000 27 42
-
(2000)
Blood Coagul. Fibrinolysis
, vol.11
, pp. 27-42
-
-
Suggett, S.1
-
62
-
-
0036122624
-
A human antibody that inhibits factor IX/IXa function potently inhibits arterial thrombosis without increasing bleeding
-
C.J. Refino A human antibody that inhibits factor IX/IXa function potently inhibits arterial thrombosis without increasing bleeding Arterioscler. Thromb. Vasc. Biol. 22 2002 517 522
-
(2002)
Arterioscler. Thromb. Vasc. Biol.
, vol.22
, pp. 517-522
-
-
Refino, C.J.1
-
63
-
-
34247201717
-
Factor IXa inhibitors as novel anticoagulants
-
E.L. Howard Factor IXa inhibitors as novel anticoagulants Arterioscler. Thromb. Vasc. Biol. 27 2007 722 727
-
(2007)
Arterioscler. Thromb. Vasc. Biol.
, vol.27
, pp. 722-727
-
-
Howard, E.L.1
-
64
-
-
0034306757
-
Comparing the antithrombotic efficacy of a humanized anti-factor IX(a) monoclonal antibody (SB 249417) to the low molecular weight heparin enoxaparin in a rat model of arterial thrombosis
-
J.R. Toomey Comparing the antithrombotic efficacy of a humanized anti-factor IX(a) monoclonal antibody (SB 249417) to the low molecular weight heparin enoxaparin in a rat model of arterial thrombosis Thromb. Res. 100 2000 73 79
-
(2000)
Thromb. Res.
, vol.100
, pp. 73-79
-
-
Toomey, J.R.1
-
65
-
-
0036158760
-
Inhibition of factor IX(a) is protective in a rat model of thromboembolic stroke
-
J.R. Toomey Inhibition of factor IX(a) is protective in a rat model of thromboembolic stroke Stroke 33 2002 578 585
-
(2002)
Stroke
, vol.33
, pp. 578-585
-
-
Toomey, J.R.1
-
66
-
-
0033968587
-
Pharmacokinetics and pharmacodynamics of a humanized monoclonal antibody to factor IX in cynomolgus monkeys
-
L.J. Benincosa Pharmacokinetics and pharmacodynamics of a humanized monoclonal antibody to factor IX in cynomolgus monkeys J. Pharmaco. Exp. Ther. 292 2000 810 816
-
(2000)
J. Pharmaco. Exp. Ther.
, vol.292
, pp. 810-816
-
-
Benincosa, L.J.1
-
67
-
-
39549104685
-
Fixit Study Group. Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: An exploratory study
-
B.I. Eriksson Fixit Study Group. Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: an exploratory study J. Thromb. Haemost. 6 2008 457 463
-
(2008)
J. Thromb. Haemost.
, vol.6
, pp. 457-463
-
-
Eriksson, B.I.1
-
68
-
-
84856776395
-
New antithrombotic drugs: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
-
J.I. Weitz New antithrombotic drugs: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest 141 2012 120S 151S
-
(2012)
Chest
, vol.141
, pp. 120S-151S
-
-
Weitz, J.I.1
-
69
-
-
33845388596
-
First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: A Phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity
-
C.K. Dyke First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a Phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity Circulation 114 2006 2490 2497
-
(2006)
Circulation
, vol.114
, pp. 2490-2497
-
-
Dyke, C.K.1
-
70
-
-
44649163943
-
Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease
-
M.Y. Chan Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease Circulation 117 2008 2865 2874
-
(2008)
Circulation
, vol.117
, pp. 2865-2874
-
-
Chan, M.Y.1
-
71
-
-
84861736559
-
The REG1 anticoagulation system: A novel actively controlled factor IX inhibitor using RNA aptamer technology for treatment of acute coronary syndrome
-
J.P. Vavalle, and M.G. Cohen The REG1 anticoagulation system: a novel actively controlled factor IX inhibitor using RNA aptamer technology for treatment of acute coronary syndrome Future Cardiol. 8 2012 371 382
-
(2012)
Future Cardiol.
, vol.8
, pp. 371-382
-
-
Vavalle, J.P.1
Cohen, M.G.2
-
72
-
-
0037026484
-
RNA aptamers as reversible antagonists of coagulation factor IXa
-
C.P. Rusconi RNA aptamers as reversible antagonists of coagulation factor IXa Nature 419 2002 90 94
-
(2002)
Nature
, vol.419
, pp. 90-94
-
-
Rusconi, C.P.1
-
73
-
-
80054052562
-
RADAR Investigators. Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy
-
T.J. Povsic RADAR Investigators. Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy Eur. Heart J. 32 2011 2412 2419
-
(2011)
Eur. Heart J.
, vol.32
, pp. 2412-2419
-
-
Povsic, T.J.1
-
75
-
-
44249122195
-
HORIZONS-AMI Trial Investigators. Bivalirudin during primary PCI in acute myocardial infarction
-
G.W. Stone HORIZONS-AMI Trial Investigators. Bivalirudin during primary PCI in acute myocardial infarction N. Engl. J. Med. 358 2008 2218 2230
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 2218-2230
-
-
Stone, G.W.1
-
76
-
-
33751221316
-
ACUITY Investigators. Bivalirudin for patients with acute coronary syndromes
-
G.W. Stone ACUITY Investigators. Bivalirudin for patients with acute coronary syndromes N. Engl. J. Med. 355 2006 2203 2216
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 2203-2216
-
-
Stone, G.W.1
-
77
-
-
84907814899
-
-
Laval, Quebec.sanofi-aventis Canada Inc. July 2013
-
Lovenox [package insert]. Laval, Quebec.sanofi-aventis Canada Inc. July 2013
-
Lovenox [Package Insert]
-
-
-
78
-
-
85028098507
-
-
New York, NY. Pfizer Inc. October 2010
-
Fragmin [package insert]. New York, NY. Pfizer Inc. October 2010
-
Fragmin [Package Insert]
-
-
-
79
-
-
8844255607
-
-
Princeton, NJ: Bristol-Myers Squibb. October 2011
-
Coumadin [package insert]. Princeton, NJ: Bristol-Myers Squibb. October 2011
-
Coumadin [Package Insert]
-
-
-
80
-
-
10044274724
-
-
Parsipanny, NJ; The Medicines Company. May 2013
-
Angiomax [package insert]. Parsipanny, NJ; The Medicines Company. May 2013
-
Angiomax [Package Insert]
-
-
-
81
-
-
84899503362
-
-
Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals Inc. January 2013
-
Pradaxa [package insert]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals Inc. January 2013
-
Pradaxa [Package Insert]
-
-
-
82
-
-
85028114303
-
-
Research Triangle Park, NC: GlaxoSmithKline Inc. April 2012
-
Acova [package insert]. Research Triangle Park, NC: GlaxoSmithKline Inc. April 2012
-
Acova [Package Insert]
-
-
-
83
-
-
85028102456
-
-
Research Triangle Park, NC: GlaxoSmithKline Inc. September 2013
-
Arixtra [package insert]. Research Triangle Park, NC: GlaxoSmithKline Inc. September 2013
-
Arixtra [Package Insert]
-
-
-
84
-
-
84899497042
-
-
Titusville, NJ: Janssen Pharmaceuticals Inc. November 2012
-
Xarelto [package insert]. Titusville, NJ: Janssen Pharmaceuticals Inc. November 2012
-
Xarelto [Package Insert]
-
-
-
85
-
-
84905246424
-
-
Princeton, New Jersey: Bristol-Myers Squibb Inc; December 2012
-
Eliquis [package insert]. Princeton, New Jersey: Bristol-Myers Squibb Inc; December 2012
-
Eliquis [Package Insert]
-
-
|