Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor-related protein

Blood

Volumn 96, Issue 10, 2000, Pages 3459-3465

  Neels, J G ^a   Van den Berg, B M M ^a   Mertens, K ^a   Ter Maat, H ^a   Pannekoek, H ^a   Van Zonneveld, A J ^a   Lenting, P J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING FACTOR 9A; ENZYME PRECURSOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; PROTEOGLYCAN; RECOMBINANT RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; EQUILIBRIUM CONSTANT; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

EID: 0034670013     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.10.3459.h8003459_3459_3465     Document Type: Article

References (47)

1. The coagulation cascade: Initiation, maintenance, and regulation
2. Hemophilia A, hemophilia B, and von Willebrand's disease
3. A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S
4. Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecedent) and a protease from Russell's viper venom
5. The mechanism of activation of bovine factor IX (Christmas factor) by bovine factor XIa (activated plasma thromboplastin antecedent)
6. Surface-dependent reactions of the vitamin K-dependent enzyme complexes
7. Binding of coagulation factors IX and X to the endothelial cell surface
8. Binding of factors iX and IXa to cultured vascular endothelial cells
9. Identification of the endothelial cell binding site for factor IX
10. Regulation of factor IXa in vitro in human and mouse plasma and in vivo in the mouse: Role of the endothelium and the plasma proteinase inhibitors
11. Cellular internalization and degradation of antithrombin III-thrombin, heparin cofactor II-thrombin, and alpha 1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein
12. Receptors of the low density lipoprotein (LDL) receptor family in man: Multiple functions of the large family members via interaction with complex ligands
13. Ligand-receptor interactions of the low density lipoprotein receptor-related protein, a multi-ligand endocytic receptor
14. Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues
15. Insulin stimulates receptor-mediated uptake of apoE-enriched lipoproteins and activated alpha 2-macroglobulin in adipocytes
16. Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor
17. Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein
18. The light chain of factor Viii comprises a binding site for low density lipoprotein receptor-related protein
19. The second and fourth cluster of class A cysteine-rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties
20. Purification of the human placental alpha 2-macroglobulin receptor
21. The human alpha 2-macroglobulin receptor: Identification of a 420-kD cell surface glycoprotein specific for the activated conformation of alpha 2-macroglobulin
22. Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase
23. Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex: Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes
24. Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein: Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor
25. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation
26. Lipoprotein lipase induces catabolism of normal triglyceride-rich lipoproteins via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor in vitro. A process facilitated by cell-surface proteoglycans
27. The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor
28. Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates the cellular internalization and degradation of thrombospondin: A process facilitated by cell-surface proteoglycans
29. Cleavage at arginine 145 in human blood coagulation factor IX converts the zymogen into a factor VIII binding enzyme
30. The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX
31. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
32. Molecular analysis of ligand binding to the second cluster of complement-type repeats of the low density lipoprotein receptor-related protein: Evidence for an allosteric component in receptor-associated protein-mediated inhibition of ligand binding
33. Kinetic analysis of biosensor data: Elementary tests for self-consistency
34. Animal cell mutants defective in glycosarninoglycan biosynthesis
35. Analysis of ligand recognition by the purified alpha 2-macroglobulin receptor (low density lipoprotein receptor-related protein): Evidence that high affinity of alpha 2-macroglobulin-proteinase complex is achieved by binding to adjacent receptors
36. The active site of anti-thrombin: Release of the same proteolytically cleaved form of the inhibitor from complexes with factor IXa, factor Xa, and thrombin
37. Protease nexin-2/amyloid beta protein precursor: A tight-binding inhibitor of coagulation factor IXa
38. The low-density lipoprotein receptor-related protein (LRP) mediates clearance of coagulation factor Xa in vivo
39. Low density lipoprotein receptor-related protein/ alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator
40. Role of the low density lipoprotein-related protein receptor in mediation of factor VIII catabolism
41. The activation of human blood coagulation factor X on the surface of endothelial cells: A comparison with various vascular cells, platelets and monocytes
42. Determinants of binding and internalization of tissue-type plasminogen activator by human vascular smooth muscle and endothelial cells
43. Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans
44. The cellular internalization and degradation of hepatic lipase is mediated by low density lipoprotein receptor-related protein and requires cell surface proteoglycans
45. Remnant lipoprotein metabolism: Key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
46. The syndecan family of proteoglycans: Novel receptors mediating internalization of atherogenic lipoproteins in vitro