Selective anticoagulation with active site-blocked factor IXa suggests separate roles for intrinsic and extrinsic coagulation pathways in cardiopulmonary bypass

Journal of Thoracic and Cardiovascular Surgery

Volumn 116, Issue 5, 1998, Pages 860-869

  Spanier, T B ^a   Chen, J M ^a   Oz, M C ^a   Edwards, N M ^a   Kisiel, W ^a   Stern, D M ^a   Rose, E A ^a,a   Schmidt, A M ^a   Copeland III, J G ^a   Chen, J C ^a   Khorasan, A R ^a  

^a College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A INHIBITOR; HEPARIN; PROCOAGULANT; PROTAMINE; THROMBIN; THROMBIN ANTITHROMBIN COMPLEX; THROMBOPLASTIN;

ANTICOAGULATION; ARTICLE; BLEEDING; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; HEMOSTASIS; IMMUNOHISTOCHEMISTRY; INTRAVENOUS DRUG ADMINISTRATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0031739665     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5223(98)00437-1     Document Type: Article

References (30)

1. E Ovrum AM Brossstad Holen G Tangen M. Abdelnoor Effects on coagulation and cardiopulmonary bypass Circulation 92 1995 2579 2584
2. LH Edmunds Jr. Blood-surface interactions during cardiopulmonary bypass J Card Surg 8 1993 404 410
3. K Tanaka M Takao I Yada H Yuasa M Kusagawa K. Deguchi Alterations in coagulation and fibrinolysis associated with cardiopulmonary bypass during open heart surgery J Cardiothoracic Anaesth 3 1989 181 188
4. RW. Colman Hemostatic complications of cardiopulmonary bypass Am J Hematol 48 1995 267 272
5. JF Burman HI Chung DA Lan H Philippou A Adami JCR. Lincoln Role of factor XII in thrombin generation and fibrinolysis during cardiopulmonary bypass Lancet 344 1994 1192 1193
6. MD Bosclaire DA Lane H Philippou S Scheikh B. Hunt Thrombin production, inactivation and expression during open heart surgery measured by assays for activation fragments including a new ELISA for prothrombin fragment F1+2 Thromb Hemost 70 1993 253 258
7. J Kappelmayer A Bernabei LH Edmunds Jr TS Edgington RW. Colman Tissue factor is expressed on monocytes during stimulated extracorporeal circulation Circ Res 72 1993 1075 1081
8. JH Chung N Gikakis AK Rao TA Drake RW Colman LH. Edmunds Pericardial blood activates the extrinsic coagulation pathway during clinical cardiopulmonary bypass Circulation 93 1996 2014 2018
9. SJ Brister FA Ofosu MR. Buchanan Thrombin generation during cardiacsurgery: heparin the ideal anticoagulant Thromb Hemost 70 1993 259 262
10. SD Khuri CR Valeri J Loscalzo MJ Weinstein V Birjiniuk NA Healey Heparin causes platelet dysfunction and induces fibrinolysis before cardiopulmonary bypass Ann Thorac Surg 60 1995 1008 1014
11. KW Vander Kamp W. van Deveren Contact, coagulation and platelet interaction with heparin treated equipment during heart surgery Int J Artif Organs 16 1993 836 842
12. RA Pixley A Cssello RA DeLa Cadena N Kaufman RW. Colman Effect of heparin on the activation of factor XII and the contact system in plasma Thromb Haemost 66 1991 540 547
13. D Stern P Nawroth W Kisiel G Vehar C. Esmon The binding of factor IXa to cultured bovine endothelial cells: induction of a specific site in the presence of factors VIII and X J Biol Chem 260 1985 6717 6722
14. A. Thompson Structure, function and molecular defects of factor IX Blood 67 1986 565 572
15. B Osterud SI. Rapaport Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation Proc Natl Acad Sci U S A 74 1977 5260 5264
16. J Toomey K Smith D. Stafford Localization of human tissue factor recognition determinants of human factor VIIa J Biol Chem 266 1991 19198 19202
17. B. Osterud Cellular interactions in tissue factor expression by blood monocytes Blood Coagul Fibrinolysis 6 suppl 1995 S20 S25
18. T Spanier M Oz O Minanov R Simantov W Kisiel D Stern Heparinless cardiopulmonay bypass using active site blocked factor IXa: a preliminary study in the dog J Thorac Cardiovasc Surg 115 1998 1179 1188
19. KM Braunstein CM Noyes MJ Griffith RL Lundblad HR. Roberts Characterization of the defect in activation of factor IX Chapel Hill by human factor XIa J Clin Invest 68 1981 1420 1426
20. JC. Powers Haloketone inhibitors of proteolytic enzymes B Weinstein Chemistry and biochemistry of amino acids, peptides and proteins. vol. 4 1977 Marcel Dekker New York 65 178
21. P Lollar D. Fass Inhibition of activated porcine factor IX by dansyl-glutamyl-glycyl-arginyl-chloromethylketone Arch Biochem Biophys 233 1984 673 682
22. CR Benedict J Ryan B Wolitzky R Ramos M Gerlach P Tijburg Active site-blocked factor IXa prevents intravascular thrombus formation in the coronary vasculature without inhibiting extravascular coagulation in a canine thrombosis model J Clin Invest 88 1991 1760 1765
23. P. Echin The scanning electron microscope and its application to research Microscopica Acta 73 1973 189 204
24. A. Boyum Isolation of mononuclear cells and granulocytes from human blood Scan J Clin Lab Invest 21 1968 77 89
25. RM Barstad E Ovrum MA Ringdal R Oystese MJA Hamers OP Veiby Induction of monocyte tissue factor procoagulant activity during cardiopulmonary bypass surgery is reduced with heparin coated extracorporeal circuits Br J Haematol 94 1996 517 525
26. SA Greogory TS. Edgington Tissue factor induction in human monocytes: two distinct mechanisms displayed by different alloantigen responsive T cell clones J Clin Invest 76 1985 2440 2445
27. O Shigemitsu T Hadama H Takasaki Y Mori T Kimura S Miyamoto Biocompatibility of a heparin-bonded membrane oxygenator (Carmeda MAXIMA) during the first 90 minutes of cardiopulmonary bypass: clinical comparison with the conventional system Artif Organs 18 1994 936 941
28. S Sundaram JM Courtney DP Taggart AC Tweddel W Martin AM McQuiston Biocompatibility of cardiopulmonary bypass: influence on blood compatibility of device type, mode of blood flow and duration of application Int J Artif Organs 17 1994 118 128
29. M Ernofsson S Thelin A. Siegbahn Monocyte tissue factor expression, cell activation, and thrombin formation during cardiopulmonary bypass: a clinical study J Thorac Cardiovasc Surg 113 1997 576 584
30. HJ Weiss VT Turitto HR Baumgartner Y Nemerson T. Hoffman Evidence for the presence of tissue factor activity on subendothelium Blood 73 1989 968 975