Regulation of the AbrA1/A2 two-component system in streptomyces coelicolor and the potential of its deletion strain as a heterologous host for antibiotic production

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Rico, Sergio ^a   Yepes, Ana ^b   Rodriguez, Héctor ^a   Santamaría, Jorge ^a   Antoraz, Sergio ^a   Krause, Eva M ^c   Díaz, Margarita ^a   Santamaría, Ramón I ^a  

^a Instituto de Biología Funcional y Genómica and Departamento de Microbiología y Genética   (Spain)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; PROTEIN HISTIDINE KINASE; BACTERIAL PROTEIN;

ARTICLE; BACTERIAL STRAIN; BIOTECHNOLOGY; CONTROLLED STUDY; DRUG MANUFACTURE; NONHUMAN; OPERON; PHENOTYPE; PROMOTER REGION; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; STREPTOMYCES COELICOLOR; WILD TYPE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; REGULATOR GENE;

STREPTOMYCES COELICOLOR;

BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REGULATOR; OPERON; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; STREPTOMYCES COELICOLOR;

EID: 84907855766     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109844     Document Type: Article

References (42)

1. Chen Y, Smanski MJ, Shen B (2010) Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Appl Microbiol Biotechnol 86: 19-25.
2. Bibb MJ (2005) Regulation of secondary metabolism in streptomycetes. Curr Opin Microbiol 8: 208-215.
3. Martin J, Sola-Landa A, Rodríguez-García A (2012) Two-component systems in Streptomyces. In: Gross R, Beier D, editors. Two-component systems in bacteria. Wurzburg: Caister Academic Press, pp. 315-331.
4. Rodríguez H, Rico S, Díaz M, Santamaría RI (2013) Two-component systems in Streptomyces'. key regulators of antibiotic complex pathways. Microbial cell factories 12: 127.
5. Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, et al. (2005) Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.J Biol Chem 280: 1448-1456.
6. Pawelczyk S, Scott KA, Hamer R, Blades G, Deane CM, et al. (2012) Predicting inter-species cross-talk in two-component signalling systems. PLOS ONE 7: e37737.
7. Hoskisson PA, Hutchings MI (2006) MtrAB-LpqB: a conserved threecomponent system in actinobacteria? Trends Microbiol 14: 444-449.
8. Lukat GS, McCleary WR, Stock AM, Stock JB (1992) Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors. Proc Natl Acad Sci U S A 89: 718-722.
9. Mitrophanov AY, Hadley TJ, Groisman EA (2010) Positive auto regulation shapes response timing and intensity in two-component signal transduction systems. Journal of molecular biology 401: 671 -680.
10. Yepes A, Rico S, Rodríguez-García A, Santamaría RI, Díaz M (2011) Novel two-component systems implied in antibiotic production in Streptomyces coelicolor. PLOS ONE 6: e19980.
11. Lombo F, Abdelfattah MS, Braña AF, Salas JA, Rohr J, et al. (2009) Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity. Chembiochem: a European journal of chemical biology 10: 296-303.
12. Lombo F, Braña AF, Salas JA, Méndez C (2004) Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891. Chembiochem: a European journal of chemical biology 5: 1181-1187.
13. Méndez C. , Kunzel E., Lipata F., Lombo F., Gotham W., et al. (2002) Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC 11891. Journal of natural products779-782.
14. Studier FW, Moffatt BA (1986) Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. Journal of Molecular Biology 189: 113-130.
15. Datsenko K.A. , Wanner B.E. (2000) One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Nad Acad Sci USA 97:6640-6645.
16. MacNeil DJ, Gewain KM, Ruby CL, Dezeny G, Gibbons PH, et al. (1992) Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. Gene 111: 61-68.
17. Kieser T, Hopwood DA, Bibb JM, Chater KF, Büttner MJ (2000) Practical Streptomyces genetics. Norwich, UK: John Innes Foundation.
18. Hopwood DA, Bibb JM, Chater KF, Kieser T, Bruton CJ, et al. (1985) Genetic manipulation of Streptomyces'. A laboratory manual. Norwich, UK: John Innes Foundation.
19. Gust B. , Challis G.L., Fowler K., Kieser T., Chater K.F. (2003) PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin.Proc Natl Acad Sci USA 1541-1546.
20. Adham S.A. , Honrubia P., Díaz M., Fernández-Ábalos J.M.,Santamaría R.I.,et al.(2014) Expression of the genes coding for the xylanase Xysl and the cellulase Cell from the straw-decomposing Streptomyces halstedii JM8 cloned into the amino-acid producer Brevibacterium lactofermentum ATCC 13869. Arch Microbiol 177: 91-97.
21. Rodríguez S, Santamaría RI, Fernández-Ábalos JM, Díaz M (2005) Identification of the sequences involved in the glucose-repressed transcription of the Streptomyces halstedii JM8 xysA promoter. Gene 351: 1-9.
22. Katz E, Thompson CJ, Hopwood DA (1983) Cloning and expression of the tyrosinase gene from Streptomyces antibioticus in Streptomyces lividans. Journal of General Microbiology 129: 2703-2714.
23. Sambrook J, Fritsch E, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor, N. Y: Cold Spring Harbor Laboratory.
24. Robinson VL, Wu T, Stock AM (2003) Structural analysis of the domain interface in DrrB, a response regulator of the OmpR/PhoB subfamily. J Bacteriol 185: 4186-4194.
25. Sheridan R, McCullough J, Wakefield Z (1971) Phosphoramidic acid and is salts. Inorganic Synthesis 13: 23-26.
26. Hesketh A, Kock H, Mootien S, Bibb M (2009) The role of absC, a novel regulatory gene for secondary metabolism, in zinc-dependent antibiotic production in Streptomyces coelicolor A3(2). Molecular microbiology 74: 14271444.
27. Sprusansky O, Stirrett K, Skinner D, Denoya C, Westpheling J (2005) The bkdR gene of Streptomyces coelicolor is required for morphogenesis and antibiotic production and encodes a transcriptional regulator of a branched-chain amino acid dehydrogenase complex. J Bacteriol 187: 664-671.
28. Rico S, Santamaría RI, Yepes A, Rodríguez H, Laing E, et al. (2014) Deciphering the Regulon of Streptomyces coelicolor AbrC3, a Positive Response Regulator of Antibiotic Production. Applied and Environmental Microbiology 80: 2417-2428.
29. Cho HS, Pelton JG, Yan D, Kustu S, Wemmer DE (2001) Phosphoaspartates in bacterial signal transduction. Curr Opin Struct Biol 11: 679-684.
30. Neumuller AM, Konz D, Marahiel MA (2001) The two-component regulatory system BacRS is associated with bacitracin 'self-resistance' of Bacillus licheniformis ATCC 10716. Eur J Bioochem 268: 3180-3189.
31. Gebhard S (2012) ABC transporters of antimicrobial peptides in Firmicutes bacteria - phylogeny, function and regulation. Molecular microbiology 86: 1295-1317.
32. Bendey S.D. , Chater K.F., Cerdeño-Tárraga A.M., Challis G.L., Thomson N.R.,et al. Complete genome sequence of the model actinomycète Streptomyces coelicolor A3(2). Nature 417: 141-147.
33. Caballero JL, Martinez E, Malpartida F, Hopwood DA (1991) Organisation and functions of the actVA region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor. Molecular & general genetics: MGG 230: 401-412.
34. Fernández-Moreno MA, Caballero JL, Hopwood DA, Malparada F (1991) The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces. Cell 66: 769-780.
35. Lee LF, Chen YJ, Kirby R, Chen C, Chen CW (2007) A multidrug efflux system is involved in colony growth in Streptomyces lividans. Microbiology 153: 924 -934.
36. Coisne S, Bechet M, Blondeau R (1999) Actinorhodin production by Streptomyces coelicolor A3 (2) in iron-restricted media. Lett Appl Microbiol 28: 199-202.
37. Liu R, Hu J (2011) HemeBIND: a novel method for heme binding residue prediction by combining structural and sequence information. BMC bioinformatics 12: 207.
38. Ortiz de Orue Lucana D, Groves MR (2009) The three-component signalling system HbpS-SenS-SenR as an example of a redox sensing pathway in bacteria. Amino acids 37: 479-486.
39. Groisman EA (2001) The pleiotropic two-component regulatory system PhoPPhoQ. Journal of bacteriology 183: 1835-1842.
40. Mitrophanov AY, Groisman EA (2008) Signal integration in bacterial twocomponent regulatory systems. Genes Dev 22: 2601-2611.
41. Medema MH, Breitling R, Bovenberg R, Takano E (2011) Exploiting plug-andplay synthetic biology for drug discovery and production in microorganisms. Nature reviews Microbiology 9: 131-137.
42. Zerikly M. , Challis G.L. (2009) Strategies for the discovery of new natural products by genome mining. Chembiochem: a European journal of chemical biology 10:625-633.