Positive autoregulation shapes response timing and intensity in two-component signal transduction systems

Journal of Molecular Biology

Volumn 401, Issue 4, 2010, Pages 671-680

  Mitrophanov, Alexander Y ^a   Hadley, Tricia J ^a   Groisman, Eduardo A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dynamics; Promoter strength; Stimulus intensity; Two component system

Indexed keywords

ARTICLE; AUTOREGULATION; GENETIC REGULATION; MATHEMATICAL MODEL; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROMOTER REGION; RESPONSE TIME; SALMONELLA ENTERICA; SIGNAL TRANSDUCTION; STEADY STATE; STIMULUS RESPONSE;

SALMONELLA ENTERICA;

EID: 77955313189     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.06.051     Document Type: Article

References (41)

1. Alon U. Network motifs: theory and experimental approaches. Nat. Rev. Genet. 2007, 8:450-461.
2. Brandman O., Meyer T. Feedback loops shape cellular signals in space and time. Science 2008, 322:390-395.
3. Ferrell J.E. Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr. Opin. Cell Biol. 2002, 14:140-148.
4. Mitrophanov A.Y., Groisman E.A. Positive feedback in cellular control processes. BioEssays 2008, 30:542-555.
5. Thomas R., D'Ari R. Biological Feedback 1990, CRC Press, Boca Raton, FL.
6. Miyashiro T., Goulian M. High stimulus unmasks positive feedback in an autoregulated bacterial signaling circuit. Proc. Natl Acad. Sci. USA 2008, 105:17457-17462.
7. Shin D., Lee J., Huang H., Groisman E.A. A positive feedback loop promotes transcription surge that jump-starts Salmonella virulence circuit. Science 2006, 314:1607-1609.
8. Mitrophanov A.Y., Churchward G., Borodovsky M. Control of Streptococcus pyogenes virulence: modeling of the CovR/S signal transduction system. J. Theor. Biol. 2007, 246:113-128.
9. Semsey S., Krishna S., Erdossy J., Horvath P., Orosz L., Sneppen K., Adhya S. Dominant negative autoregulation limits steady-state repression levels in gene networks. J. Bacteriol. 2009, 191:4487-4491.
10. Savageau M.A. Comparison of classical and autogenous systems in inducible operons. Nature 1974, 252:546-549.
11. Savageau M.A. Significance of autogenously regulated and constitutive synthesis of regulatory proteins in repressible biosynthetic systems. Nature 1975, 258:208-214.
12. Chang D.E., Leung S., Atkinson M.R., Reifler A., Forger D., Ninfa A.J. Building biological memory by linking positive feedback loops. Proc. Natl Acad. Sci. USA 2009, 107:175-180.
13. Thattai M., van Oudenaarden A. Intrinsic noise in gene regulatory networks. Proc. Natl Acad. Sci. USA 2001, 98:8614-8619.
14. Archaea: Molecular and Cellular Biology 2007, ASM Press, Washington, DC. R. Cavicchioli (Ed.).
15. Williams C.L., Cotter P.A. Autoregulation is essential for precise temporal and steady-state regulation by the Bordetella BvgAS phosphorelay. J. Bacteriol. 2007, 189:1974-1982.
16. Goulian M. Two-component signaling circuit structure and properties. Curr. Opin. Microbiol. 2010, 13:184-189.
17. Stock A.M., Robinson V.L., Goudreau P.N. Two-component signal transduction. Annu. Rev. Biochem. 2000, 69:183-215.
18. Hoch J.A. Two-component and phosphorelay signal transduction. Curr. Opin. Microbiol. 2000, 3:165-170.
19. Mitrophanov A.Y., Groisman E.A. Signal integration in bacterial two-component regulatory systems. Genes Dev. 2008, 22:2601-2611.
20. Buelow D.R., Raivio T.L. Three (and more) component regulatory systems - auxiliary regulators of bacterial histidine kinases. Mol. Microbiol. 2009, 75:547-566.
21. Mitrophanov A.Y., Groisman E.A. Response acceleration in post-translationally regulated genetic circuits. J. Mol. Biol 2010, 396:1398-1409.
22. Mitrophanov A.Y., Jewett M.W., Hadley T.J., Groisman E.A. Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria. PLoS Genet. 2008, 4:e1000233.
23. Groisman E.A. The pleiotropic two-component regulatory system PhoP-PhoQ. J. Bacteriol. 2001, 183:1835-1842.
24. Kato A., Groisman E.A. The PhoP/PhoQ regulatory network of Salmonella enterica. Bacterial Signal Transduction: Networks and Drug Targets 2008, 7-21. Landes Bioscience and Springer Science, New York, NY. R. Utsumi (Ed.).
25. Batchelor E., Goulian M. Robustness and the cycle of phosphorylation and dephosphorylation in a two-component regulatory system. Proc. Natl Acad. Sci. USA 2003, 100:691-696.
26. Perez J.C., Groisman E.A. Evolution of transcriptional regulatory circuits in bacteria. Cell 2009, 138:233-244.
27. 2+ as an extracellular signal: Environmental regulation of Salmonella virulence. Cell 1996, 84:165-174.
28. Isaacs F.J., Hasty J., Cantor C.C., Collins J.J. Prediction and measurement of an autoregulatory genetic module. Proc. Natl Acad. Sci. USA 2003, 100:7714-7719.
29. McDaniel R., Weiss R. Advances in synthetic biology: on the path from prototypes to applications. Curr. Opin. Biotech. 2005, 16:476-483.
30. Purnick P.E.M., Weiss R. The second wave of synthetic biology: from modules to systems. Nat. Rev. Mol. Cell. Biol. 2009, 10:410-422.
31. Stricker J., Cookson S., Bennett M.R., Mather W.H., Tsimring L.S., Hasty J. A fast, robust and tunable synthetic gene oscillator. Nature 2008, 456:516-519.
32. 2+-responsive promoters. J. Bacteriol. 1999, 181:5516-5520.
33. Soncini F.C., Vescovi E.G., Groisman E.A. Transcriptional autoregulation of the Salmonella typhimurium phoPQ operon. J. Bacteriol. 1995, 177:4364-4371.
34. Perez J.C., Groisman E.A. Transcription factor function and promoter architecture govern the evolution of bacterial regulons. Proc. Natl Acad. Sci. USA 2009, 106:4319-4324.
35. 2+ homeostasis. PLoS Genet. 2009, 5:e1000428.
36. Lejona S., Castelli M.E., Cabeza M.L., Kenney L.J., Vescovi E.G., Soncini F.C. PhoP can activate its target genes in a PhoQ-independent manner. J. Bacteriol. 2004, 186:2476-2480.
37. BlancPotard A.B., Groisman E.A. The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival. EMBO J. 1997, 16:5376-5385.
38. Shi Y.X., Cromie M.J., Hsu F.F., Turk J., Groisman E.A. PhoP-regulated Salmonella resistance to the antimicrobial peptides magainin 2 and polymyxin B. Mol. Microbiol. 2004, 53:229-241.
39. Dubnau D., Losick R. Bistability in bacteria. Mol. Microbiol. 2006, 61:564-572.
40. Lu T.K., Khalil A.S., Collins J.J. Next-generation synthetic gene networks. Nat. Biotechnol. 2009, 27:1139-1150.
41. Kaznessis Y.N. Models for synthetic biology. BMC Systems Biol. 2007, 1:47.