메뉴 건너뛰기




Volumn 15, Issue 10, 2014, Pages 17751-17764

Recombinant expression of a novel fungal immunomodulatory protein with human tumor cell antiproliferative activity from Nectria haematococca

Author keywords

Antitumor; Fungal immunomodulatory protein (FIP); Hemagglutination; Interleukin 2 (IL 2); Nectria haematococca; Proliferation

Indexed keywords

DEXTRANOMER; FUNGAL PROTEIN; INTERLEUKIN 2; RECOMBINANT PROTEIN;

EID: 84907833334     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms151017751     Document Type: Article
Times cited : (23)

References (46)
  • 1
    • 0031962229 scopus 로고    scopus 로고
    • Cancer patients' use of nonproven therapy: A 5-year follow-up study
    • Risberg, T.; Lund, E.; Wist, E.; Kaasa, S.; Wilsgaard, T. Cancer patients' use of nonproven therapy: A 5-year follow-up study. J. Clin. Oncol. 1998, 16, 6-12.
    • (1998) J. Clin. Oncol , vol.16 , pp. 6-12
    • Risberg, T.1    Lund, E.2    Wist, E.3    Kaasa, S.4    Wilsgaard, T.5
  • 2
    • 0030935175 scopus 로고    scopus 로고
    • The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T-lymphocytes
    • Wang, S. Y.; Hsu, M. L.; Hsu, H. C.; Tzeng, C. H.; Lee, S. S.; Shiao, M. S.; Ho C. K. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T-lymphocytes. Int. J. Cancer 1997, 70, 699-705.
    • (1997) Int. J. Cancer , vol.70 , pp. 699-705
    • Wang, S.Y.1    Hsu, M.L.2    Hsu, H.C.3    Tzeng, C.H.4    Lee, S.S.5    Shiao, M.S.6    Ho, C.K.7
  • 4
    • 0028956911 scopus 로고
    • A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence
    • Ko, J. L.; Hsu, C. I.; Lin, R. H.; Kao, C. L.; Lin, J. Y. A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence. Eur. J. Biochem. 1995, 228, 244-249.
    • (1995) Eur. J. Biochem , vol.228 , pp. 244-249
    • Ko, J.L.1    Hsu, C.I.2    Lin, R.H.3    Kao, C.L.4    Lin, J.Y.5
  • 5
    • 0024570087 scopus 로고
    • Isolation and characterization of a new immunomodulatory protein, Ling Zhi-8 (LZ-8) from Ganoderrna zucidiurn
    • Kino, K.; Yamashita, A.; Yamaoka, K.; Watanabe, J.; Tanaka, S.; Ko, K.; Shimizu, K.; Tsunoo, H. Isolation and characterization of a new immunomodulatory protein, Ling Zhi-8 (LZ-8) from Ganoderrna zucidiurn. J. Biol. Chem. 1989, 264, 472-478.
    • (1989) J. Biol. Chem , vol.264 , pp. 472-478
    • Kino, K.1    Yamashita, A.2    Yamaoka, K.3    Watanabe, J.4    Tanaka, S.5    Ko, K.6    Shimizu, K.7    Tsunoo, H.8
  • 6
    • 0030945379 scopus 로고    scopus 로고
    • Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea
    • Hsu, H. C.; Hsu, C. I.; Lin, R. H.; Kao, C. L.; Lin, J. Y. Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea. Biochem. J. 1997, 323, 557-565.
    • (1997) Biochem. J , vol.323 , pp. 557-565
    • Hsu, H.C.1    Hsu, C.I.2    Lin, R.H.3    Kao, C.L.4    Lin, J.Y.5
  • 8
    • 66149139421 scopus 로고    scopus 로고
    • Crystal structure of LZ-8 from the medicinal fungus Ganoderma lucidium
    • Huang, L.; Sun, F.; Liang, C. Y.; He, Y. X.; Bao, R.; Liu, L. X.; Zhou, C. Z. Crystal structure of LZ-8 from the medicinal fungus Ganoderma lucidium. Proteins 2008, 75, 524-527.
    • (2008) Proteins , vol.75 , pp. 524-527
    • Huang, L.1    Sun, F.2    Liang, C.Y.3    He, Y.X.4    Bao, R.5    Liu, L.X.6    Zhou, C.Z.7
  • 10
    • 0025769940 scopus 로고
    • Molecular cloning of a cDNA and a gene encoding an immunomodulatory protein, Ling Zhi-8, from a fungus, Ganoderma lucidium
    • Murasugi, A.; Tanaka, S.; Komiyama, N.; Iwata, N.; Kino, K.; Tsunoo, H.; Sakuma, S. Molecular cloning of a cDNA and a gene encoding an immunomodulatory protein, Ling Zhi-8, from a fungus, Ganoderma lucidium. J. Biol. Chem. 1991, 266, 2486-2493.
    • (1991) J. Biol. Chem , vol.266 , pp. 2486-2493
    • Murasugi, A.1    Tanaka, S.2    Komiyama, N.3    Iwata, N.4    Kino, K.5    Tsunoo, H.6    Sakuma, S.7
  • 11
    • 0027220910 scopus 로고
    • Ling Zhi-8: A novel T cell mitogen induces cytokine production and upregulation of ICAM-1 expression
    • Haak-Frendscho, M.; Kino, K.; Sone, T.; Jardieu, P. Ling Zhi-8: A novel T cell mitogen induces cytokine production and upregulation of ICAM-1 expression. Cell Immunol. 1993, 150, 101-113.
    • (1993) Cell Immunol , vol.150 , pp. 101-113
    • Haak-Frendscho, M.1    Kino, K.2    Sone, T.3    Jardieu, P.4
  • 12
    • 2342640288 scopus 로고    scopus 로고
    • Fungal immunomodulatory protein from Flammulina velutipes induces interferon-gamma production through p38 mitogen-activated protein kinase signaling pathway
    • Wang, P. H.; Hsu, C. I.; Tang, S. C.; Huang, Y. L.; Lin, J. Y.; Ko, J. L. Fungal immunomodulatory protein from Flammulina velutipes induces interferon-gamma production through p38 mitogen-activated protein kinase signaling pathway. J. Agric. Food Chem. 2004, 52, 2721-2725.
    • (2004) J. Agric. Food Chem , vol.52 , pp. 2721-2725
    • Wang, P.H.1    Hsu, C.I.2    Tang, S.C.3    Huang, Y.L.4    Lin, J.Y.5    Ko, J.L.6
  • 13
    • 33645457460 scopus 로고    scopus 로고
    • Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line
    • Liao, C. H.; Hsiao, Y. M.; Hsu, C. P.; Lin, M. Y.; Wang, J. C.; Huang, Y. L.; Ko, J. L. Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line. Mol. Carcinog. 2006, 45, 220-229.
    • (2006) Mol. Carcinog , vol.45 , pp. 220-229
    • Liao, C.H.1    Hsiao, Y.M.2    Hsu, C.P.3    Lin, M.Y.4    Wang, J.C.5    Huang, Y.L.6    Ko, J.L.7
  • 14
    • 35348877300 scopus 로고    scopus 로고
    • Nuclear translocation of telomerase reverse transcriptase and calcium signaling in repression of telomerase activity in human lung cancer cells by fungal immunomodulatory protein from Ganoderma tsugae
    • Liao, C. H.; Hsiao, Y. M.; Sheu, G. T.; Chang, J. T.; Wang, P. H.; Wu, M. F.; Shieh, G. J.; Ko, J. L. Nuclear translocation of telomerase reverse transcriptase and calcium signaling in repression of telomerase activity in human lung cancer cells by fungal immunomodulatory protein from Ganoderma tsugae. Biochem. Pharmacol. 2007, 74, 1541-1554.
    • (2007) Biochem. Pharmacol , vol.74 , pp. 1541-1554
    • Liao, C.H.1    Hsiao, Y.M.2    Sheu, G.T.3    Chang, J.T.4    Wang, P.H.5    Wu, M.F.6    Shieh, G.J.7    Ko, J.L.8
  • 15
    • 74749088450 scopus 로고    scopus 로고
    • Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma
    • Chang, H. H.; Hsieh, K. Y.; Yeh, C. H.; Tu, Y. P.; Sheu, F. Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma. Int. Immunopharm. 2010, 10, 239-246.
    • (2010) Int. Immunopharm , vol.10 , pp. 239-246
    • Chang, H.H.1    Hsieh, K.Y.2    Yeh, C.H.3    Tu, Y.P.4    Sheu, F.5
  • 16
    • 0030839875 scopus 로고    scopus 로고
    • Dimerization of the N-terminal amphipathic α-helix domain of the fungal immunomodulatory protein from Ganoderma tsugae (Fip-gts) defined by a yeast two-hybrid system and site-directed mutagenesis
    • Lin, W. H.; Huang, C. H.; Hsu, C. I.; Lin, J. Y. Dimerization of the N-terminal amphipathic α-helix domain of the fungal immunomodulatory protein from Ganoderma tsugae (Fip-gts) defined by a yeast two-hybrid system and site-directed mutagenesis. J. Biol. Chem. 1997, 272, 20044-20048.
    • (1997) J. Biol. Chem , vol.272 , pp. 20044-20048
    • Lin, W.H.1    Huang, C.H.2    Hsu, C.I.3    Lin, J.Y.4
  • 17
    • 77955053878 scopus 로고    scopus 로고
    • A new immunomodulatory protein from Ganoderma microsporum inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells
    • Lin, Y. W.; Yeh, C. H.; Huang, Y. H.; Lai, Y. C.; Chang, J. G.; Ko, J. L. A new immunomodulatory protein from Ganoderma microsporum inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells. Process Biochem. 2010, 45, 1537-1542.
    • (2010) Process Biochem , vol.45 , pp. 1537-1542
    • Lin, Y.W.1    Yeh, C.H.2    Huang, Y.H.3    Lai, Y.C.4    Chang, J.G.5    Ko, J.L.6
  • 18
    • 67650931265 scopus 로고    scopus 로고
    • A novel immunomodulatory protein from Poria cocos induces Toll-like receptor 4-dependent activation within mouse peritoneal macrophages
    • Chang, H. H.; Yeh, C. H.; Sheu, F. A novel immunomodulatory protein from Poria cocos induces Toll-like receptor 4-dependent activation within mouse peritoneal macrophages. J. Agric. Food Chem. 2009, 57, 6129-6139.
    • (2009) J. Agric. Food Chem , vol.57 , pp. 6129-6139
    • Chang, H.H.1    Yeh, C.H.2    Sheu, F.3
  • 19
    • 84862777865 scopus 로고    scopus 로고
    • Gene cloning and recombinant expression of a novel fungal immunomodulatory protein from Trametes versicolor
    • Li, F.; Wen, H.; Liu, X.; Zhou, F.; Chen, G. Gene cloning and recombinant expression of a novel fungal immunomodulatory protein from Trametes versicolor. Protein Expr. Purif. 2012, 82, 339-344.
    • (2012) Protein Expr. Purif , vol.82 , pp. 339-344
    • Li, F.1    Wen, H.2    Liu, X.3    Zhou, F.4    Chen, G.5
  • 20
    • 81055144464 scopus 로고    scopus 로고
    • Recent status and prospects of the fungal immunomodulatory protein family
    • Li, Q. Z.; Wang, X. F.; Zhou, X. W. Recent status and prospects of the fungal immunomodulatory protein family. Crit. Rev. Biotechnol. 2011, 31, 365-375.
    • (2011) Crit. Rev. Biotechnol , vol.31 , pp. 365-375
    • Li, Q.Z.1    Wang, X.F.2    Zhou, X.W.3
  • 22
    • 84871369304 scopus 로고    scopus 로고
    • Biochemical and functional characterization of recombinant fungal immunomodulatory proteins (rFIPs)
    • Bastiaan-Net, S.; Chanput, W.; Hertz, A.; Zwittink. R. D.; Mes, J. J.; Wichers, H. J. Biochemical and functional characterization of recombinant fungal immunomodulatory proteins (rFIPs). Int. Immunopharmacol. 2013, 15, 167-175.
    • (2013) Int. Immunopharmacol , vol.15 , pp. 167-175
    • Bastiaan-Net, S.1    Chanput, W.2    Hertz, A.3    Zwittink, R.D.4    Mes, J.J.5    Wichers, H.J.6
  • 23
    • 84861810645 scopus 로고    scopus 로고
    • Optimization of an extracellular zinc-metalloprotease (SVP2) expression in Escherichia coli BL21 (DE3) using response surface methodology
    • Beigia, L.; Karbalaei-Heidaria, H. R.; Kharrati-Kopaeib, M. Optimization of an extracellular zinc-metalloprotease (SVP2) expression in Escherichia coli BL21 (DE3) using response surface methodology. Protein Expr. Purif. 2012, 84, 161-166.
    • (2012) Protein Expr. Purif , vol.84 , pp. 161-166
    • Beigia, L.1    Karbalaei-Heidaria, H.R.2    Kharrati-Kopaeib, M.3
  • 24
    • 60749105811 scopus 로고    scopus 로고
    • Functional expression of LZ8, a fungal immunomodulatory protein from Ganoderma lucidium in Pichia pastoris
    • Qin, X.; Ding, Y. X.; Shang, C. H.; Jiang, C.; Zhao, M. W. Functional expression of LZ8, a fungal immunomodulatory protein from Ganoderma lucidium in Pichia pastoris. J. Gen. Appl. Microbiol. 2008, 54, 393-398.
    • (2008) J. Gen. Appl. Microbiol , vol.54 , pp. 393-398
    • Qin, X.1    Ding, Y.X.2    Shang, C.H.3    Jiang, C.4    Zhao, M.W.5
  • 25
    • 60249101844 scopus 로고    scopus 로고
    • Characterization and antitumor activity of alkali-extracted polysaccharide from Enteromorpha intestinalis
    • Jiao, L.; Li, X.; Li, T.; Jiang, P.; Zhang, L.; Wu, M. Characterization and antitumor activity of alkali-extracted polysaccharide from Enteromorpha intestinalis. Int. Immunopharmacol. 2009, 9, 324-329.
    • (2009) Int. Immunopharmacol , vol.9 , pp. 324-329
    • Jiao, L.1    Li, X.2    Li, T.3    Jiang, P.4    Zhang, L.5    Wu, M.6
  • 26
    • 0034703508 scopus 로고    scopus 로고
    • Adrenocorticotropic hormone controls Concanavalin A activation of rat lymphocytes by modulating IL-2 production
    • Wermerskirchen, A. S.; LaTocha, D. H.; Clarke, B. L. Adrenocorticotropic hormone controls Concanavalin A activation of rat lymphocytes by modulating IL-2 production. Life Sci. 2000, 67, 2177-2187.
    • (2000) Life Sci , vol.67 , pp. 2177-2187
    • Wermerskirchen, A.S.1    LaTocha, D.H.2    Clarke, B.L.3
  • 27
    • 42149093297 scopus 로고    scopus 로고
    • Expression and purification of a recombinant Fip-fve protein from Flammulina velutipes in baculovirus-infected insect cells
    • Wu, C. M.; Wu, T. Y.; Kao, S. S.; Ko, J. L.; Jinn, T. R. Expression and purification of a recombinant Fip-fve protein from Flammulina velutipes in baculovirus-infected insect cells. J. Appl. Microbiol. 2008, 104, 1354-1362.
    • (2008) J. Appl. Microbiol , vol.104 , pp. 1354-1362
    • Wu, C.M.1    Wu, T.Y.2    Kao, S.S.3    Ko, J.L.4    Jinn, T.R.5
  • 28
    • 33751401824 scopus 로고    scopus 로고
    • Functional expression of FIP-gts, a fungal immunomodulatory protein from Ganoderma tsugae in Sf21 insect cells
    • Jinn, T. R.; Wu, C. M.; Tu, W. C.; Ko, J. L.; Tzen, J. T. Functional expression of FIP-gts, a fungal immunomodulatory protein from Ganoderma tsugae in Sf21 insect cells. Biosci. Biotechnol. Biochem. 2006, 70, 2627-2634.
    • (2006) Biosci. Biotechnol. Biochem , vol.70 , pp. 2627-2634
    • Jinn, T.R.1    Wu, C.M.2    Tu, W.C.3    Ko, J.L.4    Tzen, J.T.5
  • 29
    • 72449167453 scopus 로고    scopus 로고
    • FIP-fve stimulates interferongamma production via modulation of calcium release and PKC-alpha activation
    • Ou, C. C.; Hsiao, Y. M.; Wu, W. J.; Tasy, G. J.; Ko, J. L.; Lin, M. Y. FIP-fve stimulates interferongamma production via modulation of calcium release and PKC-alpha activation. J. Agric. Food Chem. 2009, 57, 11008-11013.
    • (2009) J. Agric. Food Chem , vol.57 , pp. 11008-11013
    • Ou, C.C.1    Hsiao, Y.M.2    Wu, W.J.3    Tasy, G.J.4    Ko, J.L.5    Lin, M.Y.6
  • 30
    • 70450253186 scopus 로고    scopus 로고
    • Stability of fungal immunomodulatory protein, FIP-gts and FIP-fve, in IFN-γ production
    • Ou, C. C.; Hsiao, Y. M.; Wang, W. H.; Ko, J. L.; Lin, M. Y. Stability of fungal immunomodulatory protein, FIP-gts and FIP-fve, in IFN-γ production. Food Agric. Immunol. 2009, 20, 319-332.
    • (2009) Food Agric. Immunol , vol.20 , pp. 319-332
    • Ou, C.C.1    Hsiao, Y.M.2    Wang, W.H.3    Ko, J.L.4    Lin, M.Y.5
  • 31
    • 77955921738 scopus 로고    scopus 로고
    • Cytokines expression induced by Ganoderma sinensis Fungal Immunomodulatory Proteins (FIP-gsi) in Mouse Spleen Cells
    • Li, Q. Z.; Wang, X. F.; Chen, Y. Y.; Lin, J.; Zhou, X. W. Cytokines expression induced by Ganoderma sinensis Fungal Immunomodulatory Proteins (FIP-gsi) in Mouse Spleen Cells. Appl. Biochem. Biotechnol. 2010, 162, 1403-1413.
    • (2010) Appl. Biochem. Biotechnol , vol.162 , pp. 1403-1413
    • Li, Q.Z.1    Wang, X.F.2    Chen, Y.Y.3    Lin, J.4    Zhou, X.W.5
  • 32
    • 84856368379 scopus 로고    scopus 로고
    • Flammulina velutipes induces cytokine gene expression in mouse spleen cells
    • Li, Q. Z.; Huang, L.; Wang, X. F.; Li, X. S.; Wu, S. Q.; Zhou, X. W. Flammulina velutipes induces cytokine gene expression in mouse spleen cells. Curr. Top. Nutraceut. Res. 2011, 9, 111-118.
    • (2011) Curr. Top. Nutraceut. Res , vol.9 , pp. 111-118
    • Li, Q.Z.1    Huang, L.2    Wang, X.F.3    Li, X.S.4    Wu, S.Q.5    Zhou, X.W.6
  • 33
    • 77949429613 scopus 로고    scopus 로고
    • Ganoderma lucidum immunomodulatory protein (Lz-8) expressed in Pichia pastoris and the identification of immunocompetence
    • Liang, C. Y.; Zhang, S. Q.; Liu, Z. Y.; Sun F. Ganoderma lucidum immunomodulatory protein (Lz-8) expressed in Pichia pastoris and the identification of immunocompetence. Chin. J. Biotech. 2009, 25, 441-447.
    • (2009) Chin. J. Biotech , vol.25 , pp. 441-447
    • Liang, C.Y.1    Zhang, S.Q.2    Liu, Z.Y.3    Sun, F.4
  • 34
    • 59449109408 scopus 로고    scopus 로고
    • Molecular cloning and recombinant expression of a gene encoding a fungal immunomodulatory protein from Ganoderma lucidum in Pichia pastoris
    • Lin, J. W.; Hao, L. X.; Xu G. X.; Sun, F.; Gao, F.; Zhang, R.; Liu L. X. Molecular cloning and recombinant expression of a gene encoding a fungal immunomodulatory protein from Ganoderma lucidum in Pichia pastoris. World J. Microbiol. Biotechnol. 2009, 25, 383-390.
    • (2009) World J. Microbiol. Biotechnol , vol.25 , pp. 383-390
    • Lin, J.W.1    Hao, L.X.2    Xu, G.X.3    Sun, F.4    Gao, F.5    Zhang, R.6    Liu, L.X.7
  • 35
    • 81855206545 scopus 로고    scopus 로고
    • Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway
    • Wu, C. T.; Lin, T. Y.; Hsu, H. Y.; Sheu, F.; Ho, C. M.; Chen, E. I. Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway. Carcinogenesis 2011, 32, 1890-1896.
    • (2011) Carcinogenesis , vol.32 , pp. 1890-1896
    • Wu, C.T.1    Lin, T.Y.2    Hsu, H.Y.3    Sheu, F.4    Ho, C.M.5    Chen, E.I.6
  • 36
    • 85027957698 scopus 로고    scopus 로고
    • A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendriticcells
    • Lin, C. C.; Yu, Y. L.; Shih, C. C.; Liu, K. J.; Ou, K. L.; Hong, L. Z.; Chen, J. D.; Chu, C. L. A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendriticcells. Cancer Immunol. Immunother. 2011, 60, 1019−1027.
    • (2011) Cancer Immunol. Immunother , vol.60 , pp. 1019-1027
    • Lin, C.C.1    Yu, Y.L.2    Shih, C.C.3    Liu, K.J.4    Ou, K.L.5    Hong, L.Z.6    Chen, J.D.7    Chu, C.L.8
  • 37
    • 40849125461 scopus 로고    scopus 로고
    • Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae
    • Liao, C. H.; Hsiao, Y. M.; Lin, C. H.; Yeh, C. S.; Wang, J. C.; Ni, C. H.; Hsu, C. P.; Ko, J. L. Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae. Food Chem. Toxicol. 2008, 46, 1851−1859.
    • (2008) Food Chem. Toxicol , vol.46 , pp. 1851-1859
    • Liao, C.H.1    Hsiao, Y.M.2    Lin, C.H.3    Yeh, C.S.4    Wang, J.C.5    Ni, C.H.6    Hsu, C.P.7    Ko, J.L.8
  • 38
    • 79952278584 scopus 로고    scopus 로고
    • GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor alpha-induced expression of matrix metal loproteinase 9 via NF-kappaB pathway in human alveolar epithelial A549 cells
    • Lin, C. H.; Hsiao, Y. M.; Ou, C. C.; Lin, Y. W.; Chiu, Y. L.; Lue, K. H.; Chang, J. G.; Ko, J. L. GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor alpha-induced expression of matrix metal loproteinase 9 via NF-kappaB pathway in human alveolar epithelial A549 cells. J. Agric. Food Chem. 2010, 58, 12014-12021.
    • (2010) J. Agric. Food Chem , vol.58 , pp. 12014-12021
    • Lin, C.H.1    Hsiao, Y.M.2    Ou, C.C.3    Lin, Y.W.4    Chiu, Y.L.5    Lue, K.H.6    Chang, J.G.7    Ko, J.L.8
  • 39
    • 84890489969 scopus 로고    scopus 로고
    • Interruption of lung cancer cell migration and proliferation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes
    • Chang, Y. C.; Hsiao, Y. M.; Wu, M. F.; Ou, C. C.; Lin, Y. W.; Lue, K. H.; Ko, J. L. Interruption of lung cancer cell migration and proliferation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes. J. Agric. Food Chem. 2013, 61, 12044-12052.
    • (2013) J. Agric. Food Chem , vol.61 , pp. 12044-12052
    • Chang, Y.C.1    Hsiao, Y.M.2    Wu, M.F.3    Ou, C.C.4    Lin, Y.W.5    Lue, K.H.6    Ko, J.L.7
  • 40
    • 84856558003 scopus 로고    scopus 로고
    • Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-gamma+IL-17+ polyfunctional T cells that mediate rejection of murine tumors
    • Marshall, N. A.; Galvin, K. C.; Corcoran, A. M.; Boon, L.; Higgs, R.; Mills, K. H. Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-gamma+IL-17+ polyfunctional T cells that mediate rejection of murine tumors. Cancer Res. 2012, 72, 581-591.
    • (2012) Cancer Res , vol.72 , pp. 581-591
    • Marshall, N.A.1    Galvin, K.C.2    Corcoran, A.M.3    Boon, L.4    Higgs, R.5    Mills, K.H.6
  • 41
    • 79955472378 scopus 로고    scopus 로고
    • Purification and characterization of a novel immunomodulatory protein from the medicinal mushroom Trametes versicolor
    • Li, F.; Wen, H.; Zhang, Y.; Aa, M.; Liu, X. Purification and characterization of a novel immunomodulatory protein from the medicinal mushroom Trametes versicolor. Sci. China Life Sci. 2011, 54, 379-385.
    • (2011) Sci. China Life Sci , vol.54 , pp. 379-385
    • Li, F.1    Wen, H.2    Zhang, Y.3    Aa, M.4    Liu, X.5
  • 42
    • 84882945135 scopus 로고    scopus 로고
    • High-level expression, purification and production of the fungal immunomodulatory protein-gts in baculovirus-infected insect larva
    • Wu, T. Y.; Chen, H. A.; Li, F. Y.; Lin, C. T.; Wu, C. M.; Hsieh, F. C.; Tzen, J. T.; Hsieh, S. K.; Ko, J. L.; Jinn, T. R. High-level expression, purification and production of the fungal immunomodulatory protein-gts in baculovirus-infected insect larva. Appl. Biochem. Biotechnol. 2013, 169, 976-989.
    • (2013) Appl. Biochem. Biotechnol , vol.169 , pp. 976-989
    • Wu, T.Y.1    Chen, H.A.2    Li, F.Y.3    Lin, C.T.4    Wu, C.M.5    Hsieh, F.C.6    Tzen, J.T.7    Hsieh, S.K.8    Ko, J.L.9    Jinn, T.R.10
  • 43
    • 84875120613 scopus 로고    scopus 로고
    • High-yield production in Escherichia coli of fungal immunomodulatory protein isolated from Flammulina velutipes and its bioactivity assay in vivo
    • Kong, X.; Zhang, J.; Han, X.; Zhang, P.; Dai, X.; Liu, J.; Zhang, X.; Lee, I.; Liu, S. High-yield production in Escherichia coli of fungal immunomodulatory protein isolated from Flammulina velutipes and its bioactivity assay in vivo. Int. J. Mol. Sci. 2013, 14, 2230-2241.
    • (2013) Int. J. Mol. Sci , vol.14 , pp. 2230-2241
    • Kong, X.1    Zhang, J.2    Han, X.3    Zhang, P.4    Dai, X.5    Liu, J.6    Zhang, X.7    Lee, I.8    Liu, S.9
  • 44
    • 0030797511 scopus 로고    scopus 로고
    • Molecular cloning and expression of a fungal immunomodulatory protein, FIP-fve, from Flammulina velutipes
    • Ko, J. L.; Lin, S. J.; Hsu, C. I.; Kao, C. L.; Lin, J. Y. Molecular cloning and expression of a fungal immunomodulatory protein, FIP-fve, from Flammulina velutipes. J. Formos Med. Assoc. 1997, 96, 517-524.
    • (1997) J. Formos Med. Assoc , vol.96 , pp. 517-524
    • Ko, J.L.1    Lin, S.J.2    Hsu, C.I.3    Kao, C.L.4    Lin, J.Y.5
  • 45
    • 0015609711 scopus 로고
    • In vitro stimulation of murine spleen cells using a micro culture system and a multiple automated sample harvester
    • Strong, D. M.; Ahmed, A. A.; Thurman, G. B.; Sell, K. W. In vitro stimulation of murine spleen cells using a micro culture system and a multiple automated sample harvester. J. Immunol. Methods 1973, 2, 279-291.
    • (1973) J. Immunol. Methods , vol.2 , pp. 279-291
    • Strong, D.M.1    Ahmed, A.A.2    Thurman, G.B.3    Sell, K.W.4
  • 46
    • 53849127840 scopus 로고    scopus 로고
    • Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight
    • Peng, Y. R.; Li, Y. B.; Liu, X. D.; Zhang, J. F.; Duan, J. A. Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight. Phytomedicine 2008, 15, 1016-1020.
    • (2008) Phytomedicine , vol.15 , pp. 1016-1020
    • Peng, Y.R.1    Li, Y.B.2    Liu, X.D.3    Zhang, J.F.4    Duan, J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.