Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway

Carcinogenesis

Volumn 32, Issue 12, 2011, Pages 1890-1896

  Wu, Chien Ting ^a   Lin, Tung Yi ^a   Hsu, Hsien Yeh ^a,b   Sheu, Fuu ^c   Ho, Chau Mei ^a   Chen, Edmund I T ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b GENOMICS RESEARCH CENTER   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; IMMUNOMODULATING AGENT; PROTEIN MDM2; PROTEIN P53; RECOMBINANT LING ZHI 8; RECOMBINANT PROTEIN; RIBOSOME PROTEIN; RIBOSOME PROTEIN S7; RIBOSOME RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRESS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DOSE COMPARISON; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEWIS CARCINOMA; LUNG CANCER; MALE; MOUSE; NONHUMAN; POLYSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; RNA SYNTHESIS;

ANIMALS; BASE SEQUENCE; CELL PROLIFERATION; DNA PRIMERS; FUNGAL PROTEINS; HUMANS; LUNG NEOPLASMS; MICE; NEOPLASM TRANSPLANTATION; PROTO-ONCOGENE PROTEINS C-MDM2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEINS; RNA INTERFERENCE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 81855206545     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr221     Document Type: Article

References (45)

1. Sliva,D. (2004) Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini Rev. Med. Chem., 4, 873-879.
2. Lin,Z.B. et al. (2004) Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta. Pharmacol. Sin., 25, 1387-1395.
3. Paterson,R.R. (2006) Ganoderma-a therapeutic fungal biofactory. Phytochemistry, 67, 1985-2001.
4. Hu,H. et al. (2002)Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int. J. Cancer, 102, 250-253.
5. Jiang,J. et al. (2004)Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. Int. J. Oncol., 24, 1093-1099.
6. Stanley,G. et al. (2005) Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells. Biochem. Biophys. Res. Commun., 330, 46-52.
7. Weng,C.J. et al. (2009) Inhibitory effects of Ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models. J. Agric. Food Chem., 57, 5049-5057.
8. Kino,K. et al. (1989) Isolation and characterization of a new immunomodulatory protein, Ling Zhi-8 (LZ-8), from Ganoderma lucidium. J. Biol. Chem., 264, 472-478.
9. Murasugi,A. et al. (1991) Molecular cloning of a cDNA and a gene encoding an immunomodulatory protein, Ling Zhi-8, from a fungus, Ganoderma lucidum. J. Biol.Chem., 266, 2486-2493.
10. Tong,M.H. et al. (2008) High processing tolerances of immunomodulatory proteins in Enoki and Reishi mushrooms. J. Agric. Food Chem., 56, 3160-3166.
11. Tanaka,S. et al. (1989) Complete amino acid sequence of an immunomodulatory protein, ling zhi-8 (LZ-8). An immunomodulator from a fungus, Ganoderma lucidium, having similarity to immunoglobulin variable regions. J. Biol. Chem., 264, 16372-16377.
12. Huang,L. et al. (2009) Crystal structure of LZ-8 from the medicinal fungus Ganoderma lucidum. Proteins, 75, 524-527.
13. van der Hem,L.G. et al. (1995) Ling Zhi-8: studies of a new immunomodulating agent. Transplantation, 60, 438-443.
14. Haak-Frendscho,M. et al. (1993) Ling Zhi-8: a novel T cell mitogen induces cytokine production and upregulation of ICAM-1 expression. Cell Immunol., 150, 101-113.
15. Hsu,H.Y. et al. (2008) Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells. J. Cell. Physiol., 215, 15-26.
16. Lin,Y.L. et al. (2009) An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and MAPK pathways. J. Leukoc. Biol., 86, 877-889.
17. Levine,A.J. (1997) p53, the cellular gatekeeper for growth and division. Cell, 88, 323-331.
18. Toledo,F. et al. (2006) Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer, 6, 909-923.
19. Brooks,C.L. et al. (2006) p53 ubiquitination: Mdm2 and beyond. Mol. Cell, 21, 307-315.
20. Rubbi,C.P. et al. (2003) Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses. EMBO J., 22, 6068-6077.
21. Yuan,X. et al. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol. Cell, 19, 77-87.
22. Lohrum,M.A. et al. (2003) Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell, 3, 577-587.
23. Zhang,Y. et al. (2003) Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol. Cell. Biol., 23, 8902-8912.
24. Dai,M.S. et al. (2004) Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol. Cell. Biol., 24, 7654-7668.
25. Dai,M.S. et al. (2004) Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J. Biol. Chem., 279, 44475-44482.
26. Chen,D. et al. (2007) Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene, 26, 5029-5037.
27. Zhu,Y. et al. (2009) Ribosomal protein S7 is both a regulator and a substrate of MDM2. Mol. Cell, 35, 316-326.
28. Ofir-Rosenfeld,Y. et al. (2008) Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol. Cell, 32, 180-189.
29. Zhang,Y. et al. (2009) Signaling to p53: ribosomal proteins find their way. Cancer Cell, 16, 369-377.
30. Deisenroth,C. et al. (2010) Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway. Oncogene, 29, 4253-4260.
31. Yeh,C.H. et al. (2010) Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes. J. Agric. Food Chem., 58, 8535-8544.
32. Kern,S.E. et al. (1992) Oncogenic forms of p53 inhibit p53-regulated gene expression. Science, 256, 827-830.
33. Chang,C.Y. et al. (2006) Involvement of Bcl-X(L) deamidation in E1A-mediated cisplatin sensitization of ovarian cancer cells. Oncogene, 25, 2656-2665.
34. Naldini,L. et al. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science, 272, 263-267.
35. Zufferey,R. et al. (1997) Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat. Biotechnol., 15, 871-875.
36. Rouquette,J. et al. (2005) Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells. EMBO J., 24, 2862-2872.
37. Sherr,C.J. et al. (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev., 13, 1501-1512.
38. Lafontaine,D.L. et al. (2001) The function and synthesis of ribosomes. Nat. Rev. Mol. Cell Biol., 2, 514-520.
39. Ruggero,D. et al. (2003) Does the ribosome translate cancer? Nat. Rev. Cancer, 3, 179-192.
40. Montanaro,L. et al. (2008) Nucleolus, ribosomes, and cancer. Am. J. Pathol., 173, 301-310.
41. Drygin,D. et al. (2010) The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer. Annu. Rev. Pharmacol. Toxicol., 50, 131-156.
42. White,R.J. (2005) RNA polymerases I and III, growth control and cancer. Nat. Rev. Mol. Cell Biol., 6, 69-78.
43. Prives,C. (1998) Signaling to p53: breaking the MDM2-p53 circuit. Cell, 95, 5-8.
44. Holz,M.K. et al. (2005) mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell, 123, 569-580.
45. Fumagalli,S. et al. (2009) Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction. Nat. Cell Biol., 11, 501-508.