Deep sequencing reveals low incidence of endogenous LINE-1 retrotransposition in human induced pluripotent stem cells

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Arokium, Hubert ^a   Kamata, Masakazu ^a   Kim, Sanggu ^a   Kim, Namshin ^b   Liang, Min ^a   Presson, Angela P ^c   Chen, Irvin S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; KRUPPEL LIKE FACTOR 4; LONG INTERSPERSED ELEMENT 1; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TRANSPOSASE; UNCLASSIFIED DRUG; RETROPOSON;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA TRANSPOSITION; FETUS; FIBROBLAST; GENE INSERTION; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; INTRON; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PYROSEQUENCING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RETROTRANSPOSITION; RNA EXTRACTION; SEQUENCE ALIGNMENT; UPREGULATION; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GERM CELL; INDUCED PLURIPOTENT STEM CELL; LONG INTERSPERSED REPEAT; METABOLISM; RETROPOSON;

CELL LINE; CELLULAR REPROGRAMMING; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; GERM CELLS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MUTAGENESIS, INSERTIONAL; RETROELEMENTS;

EID: 84907814464     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108682     Document Type: Article

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