The improved blood-brain barrier permeability of endomorphin-1 using the cell-penetrating peptide synB3 with three different linkages

International Journal of Pharmaceutics

Volumn 476, Issue 1, 2014, Pages 1-8

  Liu, Hui ^a   Zhang, Wei ^a   Ma, Linnan ^a   Fan, Linlan ^a   Gao, Feiyun ^a   Ni, Jingman ^a   Wang, Rui ^a,b  

^a LANZHOU UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Brain delivery; Cell penetrating peptides; Covalent linkage; Endomorphin 1; SynB3

Indexed keywords

AMIDE; CELL PENETRATING PEPTIDE; CELL PENETRATING PEPTIDE SYNB3; DISULFIDE; ENDOMORPHIN 1; MALEIMIDE; NALOXONE; UNCLASSIFIED DRUG; OLIGOPEPTIDE; SYNB3 PEPTIDE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN TISSUE; CONTROLLED STUDY; COVALENT BOND; DISULFIDE BOND; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG PENETRATION; DRUG STABILITY; DRUG UPTAKE; FLUORESCENCE MICROSCOPY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROSCOPY; MOUSE; NEAR INFRARED FLUORESCENT MICROSCOPY; NOCICEPTION; NONHUMAN; PHARMACODYNAMICS; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; ANIMAL; CELL MEMBRANE PERMEABILITY; CHEMISTRY; METABOLISM; PERMEABILITY; TISSUE DISTRIBUTION; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CELL MEMBRANE PERMEABILITY; CELL-PENETRATING PEPTIDES; DRUG DELIVERY SYSTEMS; MICE; MICROSCOPY, FLUORESCENCE; OLIGOPEPTIDES; PERMEABILITY; TISSUE DISTRIBUTION;

EID: 84907812473     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.08.045     Document Type: Article

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