In vitro and in vivo studies on gelatin-siloxane nanoparticles conjugated with SynB peptide to increase drug delivery to the brain

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 1031-1041

  Tian, Xin hua ^a   Wei, Feng ^a   Wang, Tian xiao ^b   Wang, Peng ^a   Lin, Xiao ning ^a   Wang, Jun ^b   Wang, Dong ^b   Ren, Lei ^b,c  

^a ZHONGSHAN HOSPITAL OF XIAMEN UNIVERSITY   (China)

^b Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources   (China)

^c XIAMEN UNIVERSITY   (China)

Author keywords

Blood brain barrier; Brain targeting delivery; Nanoparticles; Peptide

Indexed keywords

GELATIN SILOXANE NANOPARTICLE; NANOPARTICLE; PEPTIDE; SYNB PEPTIDE; UNCLASSIFIED DRUG; DRUG CARRIER; GELATIN; MACROGOL DERIVATIVE; SILOXANE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BLOOD BRAIN BARRIER; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NONHUMAN; PARTICLE SIZE; RAT; TISSUE DISTRIBUTION; ZETA POTENTIAL; ANIMAL; ASTROCYTE; BRAIN; CAPILLARY PERMEABILITY; CELL CULTURE; CHEMISTRY; CYTOLOGY; ENDOTHELIUM CELL; FLUORESCENCE MICROSCOPY; METABOLISM; NUDE MOUSE; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CELLS, CULTURED; DRUG CARRIERS; ENDOTHELIAL CELLS; GELATIN; MALE; MICE; MICE, NUDE; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; PARTICLE SIZE; PEPTIDES; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SILOXANES;

EID: 84862322970     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S26541     Document Type: Article

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