Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton

Biochemical Journal

Volumn 365, Issue 1, 2002, Pages 79-87

  Kiss, Eniko ^a   Murányi, Andrea ^a   Csortos, Csilla ^a   Gergely, Pál ^a   Ito, Masaaki ^a   Hartshorne, David J ^a   Erdodi, Ferenc ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Human platelet; Inhibitory phosphorylation; Protein phosphatase 1; Zipper interacting protein kinase (ZIP kinase)

Indexed keywords

ANTIBODIES; ENZYME INHIBITION; MUSCLE; PROTEINS;

PLATLET CYTOSKELETONS;

BIOCHEMISTRY;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; INTEGRIN; MYOSIN; PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOTRANSFERASE;

ARTICLE; CELL ISOLATION; CHROMATOGRAPHY; CYTOSKELETON; ELECTROPHORESIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THROMBOCYTE; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ADULT; BINDING SITES; BLOOD PLATELETS; CYTOSKELETON; HUMANS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS;

EID: 0036646489     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20011295     Document Type: Article

References (43)

1. Platelet activation
2. The platelet cytoskeleton
3. Effects of the protein phosphatase inhibitors, tautomycin and calyculin-A, on protein phosphorylation and cytoskeleton of human platelets
4. Purification and characterization of three distinct types of protein phosphatase catalytic subunits in bovine platelets
5. Differential association of protein Ser/Thr phosphatase types 1 and 2A with the cytoskeleton upon platelet activation
6. Identification and localization of myosin phosphatase in human platelets
7. Myosin light chain phosphatase: Subunit composition, interactions and regulation
8. Regulation of myosin phosphatase through phosphorylation of the myosin-binding subunit in platelet activation
9. A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping
10. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
11. Dichofomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets
12. Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape change
13. Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase
14. Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase
15. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
16. 2+-sensitization of myosin phosphorylation and force in guinea-pig ileum
17. Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts
18. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton
19. Identification of the endogenous smooth muscle myosin phosphatase-associated kinase
20. Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity
21. Phosphorylation of MYPT1 by protein kinase C attenuates interaction with PP1 catalytic subunit and the 20 kDa light chain of myosin
22. Activation of myosin phosphatase targeting subunit by mitosis-specific phosphorylation
23. Rho-associated kinase of chicken gizzard smooth muscle
24. Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle
25. Endothall thioanhydride inhibits protein phosphatases-1 and -2A in vivo
26. Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase
27. Interactions of the subunits of smooth muscle myosin phosphatase
28. Study of the subunit interactions in myosin phosphatase by surface plasmon resonance
29. A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel
30. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
31. Identification of trimeric myosin phosphatase (PP1M) as a target for a novel PKC-potentiated protein phosphatase-1 inhibitory protein (CPI17) in porcine aorta smooth muscle
32. Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility
33. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase
34. Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N
35. Protein kinase C-catalyzed phosphorylation of an inhibitory phosphoprotein of myosin phosphatase is involved in human platelet secretion
36. Specificity and mechanism of action of some commonly used protein kinase inhibitors
37. Integrin-dependent translocation of p160ROCK to cytoskeletal complex in thrombin-stimulated human platelets
38. 2+-free smooth muscle contraction via myosin light chain phosphorylation
39. ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells
40. 2+-independent smooth muscle contraction. A novel function for integrin-linked kinase
41. Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity
42. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis
43. Integrin-linked kinase (ILK): A "hot" therapeutic target