-
1
-
-
77951216021
-
Activity-based proteomics of enzyme superfamilies: Serine hydrolases as a case study
-
Simon GM, Cravatt BF (2010) Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study. J Biol Chem 285: 11051-11055.
-
(2010)
J Biol Chem
, vol.285
, pp. 11051-11055
-
-
Simon, G.M.1
Cravatt, B.F.2
-
2
-
-
80054054097
-
The metabolic serine hydrolases and their functions in mammalian physiology and disease
-
Long JZ, Cravatt BF (2011) The metabolic serine hydrolases and their functions in mammalian physiology and disease. Chem Rev 11: 6022-6063.
-
(2011)
Chem Rev
, vol.11
, pp. 6022-6063
-
-
Long, J.Z.1
Cravatt, B.F.2
-
3
-
-
84873700102
-
Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism
-
Lord CC, Thomas G, Brown JM (2013) Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism. Biochim Biophys Acta 1831: 792-802.
-
(2013)
Biochim Biophys Acta
, vol.1831
, pp. 792-802
-
-
Lord, C.C.1
Thomas, G.2
Brown, J.M.3
-
4
-
-
55249111745
-
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling
-
Hoover HS, Blankman JL, Niessen S, Cravatt BF (2008) Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. Bioorg Med Chem Lett 18: 5838-5841.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 5838-5841
-
-
Hoover, H.S.1
Blankman, J.L.2
Niessen, S.3
Cravatt, B.F.4
-
5
-
-
78650495439
-
Superfamily-wide portrait of serine hydrolase inhibition achieved by libraryversus-library screening
-
Bachovchin DA, Ji T, Li W, Simon GM, Blankman JL, et al. (2010) Superfamily-wide portrait of serine hydrolase inhibition achieved by libraryversus-library screening. Proc Natl Acad Sci U S A 107: 20941-20946.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 20941-20946
-
-
Bachovchin, D.A.1
Ji, T.2
Li, W.3
Simon, G.M.4
Blankman, J.L.5
-
6
-
-
0024530930
-
A new cluster of genes within the human major histocompatibility complex
-
Spies T, Blanck G, Bresnahan M, Sands J, Strominger JL (1989) A new cluster of genes within the human major histocompatibility complex. Science 243: 214-217.
-
(1989)
Science
, vol.243
, pp. 214-217
-
-
Spies, T.1
Blanck, G.2
Bresnahan, M.3
Sands, J.4
Strominger, J.L.5
-
7
-
-
0024392729
-
Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B
-
Spies T, Bresnahan M, Strominger JL (1989) Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. Proc Natl Acad Sci U S A 86: 8955-8958.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 8955-8958
-
-
Spies, T.1
Bresnahan, M.2
Strominger, J.L.3
-
8
-
-
77955639059
-
Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm
-
Hsieh YY, Lin YJ, Chang CC, Chen DY, Hsu CM, et al. (2010) Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm. J Clin Lab Anal 24: 262-268.
-
(2010)
J Clin Lab Anal
, vol.24
, pp. 262-268
-
-
Hsieh, Y.Y.1
Lin, Y.J.2
Chang, C.C.3
Chen, D.Y.4
Hsu, C.M.5
-
9
-
-
84882622966
-
Identification and association analysis of several hundred single nucleotide polymorphisms within candidate genes for backfat thickness in Italian Large White pigs using a selective genotyping approach
-
Fontanesi L, Galimberti G, Calo DG, Fronza R, Martelli PL, et al. (2012) Identification and association analysis of several hundred single nucleotide polymorphisms within candidate genes for backfat thickness in Italian Large White pigs using a selective genotyping approach. J Anim Sci 90: 2450-2464.
-
(2012)
J Anim Sci
, vol.90
, pp. 2450-2464
-
-
Fontanesi, L.1
Galimberti, G.2
Calo, D.G.3
Fronza, R.4
Martelli, P.L.5
-
10
-
-
84867339289
-
Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)
-
Navia-Paldanius D, Savinainen JR, Laitinen JT (2012). Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). J Lipid Res 53: 2413-2424.
-
(2012)
J Lipid Res
, vol.53
, pp. 2413-2424
-
-
Navia-Paldanius, D.1
Savinainen, J.R.2
Laitinen, J.T.3
-
11
-
-
84894085407
-
Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency
-
Laitinen T, Navia-Paldanius D, Rytilahti R, Marjamaa JJ, Kařízková J, et al. (2014) Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. Mol Pharmacol 85: 510-519.
-
(2014)
Mol Pharmacol
, vol.85
, pp. 510-519
-
-
Laitinen, T.1
Navia-Paldanius, D.2
Rytilahti, R.3
Marjamaa, J.J.4
Kařízková, J.5
-
12
-
-
85047687143
-
Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber)
-
Liang S, Mele J, Wu Y, Buffenstein R, Hornsby PJ (2010) Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber). Aging Cell 9: 626-635.
-
(2010)
Aging Cell
, vol.9
, pp. 626-635
-
-
Liang, S.1
Mele, J.2
Wu, Y.3
Buffenstein, R.4
Hornsby, P.J.5
-
13
-
-
80054080661
-
Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: Cross-talk between the eicosanoid and endocannabinoid signaling pathways
-
Rouzer CA, Marnett LJ (2011) Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways. Chem Rev 111: 5899-5921.
-
(2011)
Chem Rev
, vol.111
, pp. 5899-5921
-
-
Rouzer, C.A.1
Marnett, L.J.2
-
14
-
-
84901791811
-
COX-2-derived endocannabinoid metabolites as novel inflammatory mediators
-
Alhouayek M, Muccioli GG (2014) COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. Trends Pharmacol Sci 35: 284-292.
-
(2014)
Trends Pharmacol Sci
, vol.35
, pp. 284-292
-
-
Alhouayek, M.1
Muccioli, G.G.2
-
15
-
-
78650452903
-
Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/ macrophages by activated organophosphorus insecticides: Role of carboxylesterases 1 and 2
-
Xie S, Borazjani A, Hatfield MJ, Edwards CC, Potter PM, et al. (2010). Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/ macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. Chem Res Toxicol 23: 1890-1904.
-
(2010)
Chem Res Toxicol
, vol.23
, pp. 1890-1904
-
-
Xie, S.1
Borazjani, A.2
Hatfield, M.J.3
Edwards, C.C.4
Potter, P.M.5
-
16
-
-
84887126250
-
Identification of palmitoyl protein thioesterase 1 in human THP-1 monocytes/ macrophages and characterization of unique biochemical activities for this enzyme
-
Wang R, Borazjani A, Matthews AT, Mangum LC, Edelmann MJ, et al. (2013) Identification of palmitoyl protein thioesterase 1 in human THP-1 monocytes/ macrophages and characterization of unique biochemical activities for this enzyme. Biochemistry 52: 7559-7574.
-
(2013)
Biochemistry
, vol.52
, pp. 7559-7574
-
-
Wang, R.1
Borazjani, A.2
Matthews, A.T.3
Mangum, L.C.4
Edelmann, M.J.5
-
17
-
-
84872867557
-
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC
-
Blankman JL, Long JZ, Trauger SA, Siuzdak G, Cravatt BF (2013) ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC. Proc Natl Acad Sci U S A 110: 1500-1505.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 1500-1505
-
-
Blankman, J.L.1
Long, J.Z.2
Trauger, S.A.3
Siuzdak, G.4
Cravatt, B.F.5
-
18
-
-
84902336189
-
Discovery of triterpenoids as reversible inhibitors of α/β hydrolase domain 12 (ABHD12)
-
Parkkari T, Haavikko R, Laitinen T, Navia-Paldanius D, Rytilahti R, et al. (2014) Discovery of triterpenoids as reversible inhibitors of α/β hydrolase domain 12 (ABHD12). PLoS ONE 9(5): e98286.
-
(2014)
PLoS ONE
, vol.9
, Issue.5
, pp. e98286
-
-
Parkkari, T.1
Haavikko, R.2
Laitinen, T.3
Navia-Paldanius, D.4
Rytilahti, R.5
-
19
-
-
77952541156
-
Smallmolecule inhibition of APT1 affects Ras localization and signaling
-
Dekker FJ, Rocks O, Vartak N, Menninger S, Hedberg C, et al. (2010) Smallmolecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol 6: 449-456.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 449-456
-
-
Dekker, F.J.1
Rocks, O.2
Vartak, N.3
Menninger, S.4
Hedberg, C.5
-
20
-
-
80053898528
-
Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M
-
Rusch M, Zimmermann TJ, Bürger M, Dekker FJ, Görmer K, et al. (2011) Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M. Angew Chem Int Ed Engl 50: 9838-9842.
-
(2011)
Angew Chem Int Ed Engl
, vol.50
, pp. 9838-9842
-
-
Rusch, M.1
Zimmermann, T.J.2
Bürger, M.3
Dekker, F.J.4
Görmer, K.5
-
21
-
-
73949109254
-
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
-
Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, et al. (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A 106: 20270-20275.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 20270-20275
-
-
Long, J.Z.1
Nomura, D.K.2
Vann, R.E.3
Walentiny, D.M.4
Booker, L.5
-
22
-
-
84875424144
-
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase
-
Aaltonen N, Savinainen JR, Ribas CR, Rönkkö J, Kuusisto A, et al. (2013) Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem Biol 20: 379-390.
-
(2013)
Chem Biol
, vol.20
, pp. 379-390
-
-
Aaltonen, N.1
Savinainen, J.R.2
Ribas, C.R.3
Rönkkö, J.4
Kuusisto, A.5
-
23
-
-
34547789923
-
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases
-
Li W, Blankman JL, Cravatt BF (2007) A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J Am Chem Soc 129: 9594-9595.
-
(2007)
J Am Chem Soc
, vol.129
, pp. 9594-9595
-
-
Li, W.1
Blankman, J.L.2
Cravatt, B.F.3
-
24
-
-
84887858786
-
Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors
-
Patel JZ, Parkkari T, Laitinen T, Kaczor AA, Saario SM, et al. (2013) Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors. J Med Chem 56: 8484-8496.
-
(2013)
J Med Chem
, vol.56
, pp. 8484-8496
-
-
Patel, J.Z.1
Parkkari, T.2
Laitinen, T.3
Kaczor, A.A.4
Saario, S.M.5
-
25
-
-
84863443024
-
Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes
-
Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, et al. (2012) Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. J Am Chem Soc 134: 10345-10348.
-
(2012)
J Am Chem Soc
, vol.134
, pp. 10345-10348
-
-
Adibekian, A.1
Martin, B.R.2
Chang, J.W.3
Hsu, K.L.4
Tsuboi, K.5
-
26
-
-
33751560057
-
Use of an inhibitor to identify members of the hormone-sensitive lipase family
-
Ben Ali Y, Chahinian H, Petry S, Muller G, Lebrun R, et al. (2006) Use of an inhibitor to identify members of the hormone-sensitive lipase family. Biochemistry 45: 14183-14191.
-
(2006)
Biochemistry
, vol.45
, pp. 14183-14191
-
-
Ben Ali, Y.1
Chahinian, H.2
Petry, S.3
Muller, G.4
Lebrun, R.5
-
27
-
-
84868704339
-
Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones
-
Point V, Pavan Kumar KV, Marc S, Delorme V, Parsiegla G, et al. (2012) Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones. Eur J Med Chem 58: 452-463.
-
(2012)
Eur J Med Chem
, vol.58
, pp. 452-463
-
-
Point, V.1
Pavan Kumar, K.V.2
Marc, S.3
Delorme, V.4
Parsiegla, G.5
-
28
-
-
68149170903
-
Screening of various hormone-sensitive lipase inhibitors as endocannabinoidhydrolyzing enzyme inhibitors
-
Minkkilä A, Savinainen JR, Käsnänen H, Xhaard H, Nevalainen T, et al. (2009) Screening of various hormone-sensitive lipase inhibitors as endocannabinoidhydrolyzing enzyme inhibitors. ChemMedChem 4: 1253-1259.
-
(2009)
ChemMedChem
, vol.4
, pp. 1253-1259
-
-
Minkkilä, A.1
Savinainen, J.R.2
Käsnänen, H.3
Xhaard, H.4
Nevalainen, T.5
-
29
-
-
77649184344
-
Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique
-
Savinainen JR, Yoshino M, Minkkilä A, Nevalainen T, Laitinen JT (2010) Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique. Anal Biochem 399: 132-134.
-
(2010)
Anal Biochem
, vol.399
, pp. 132-134
-
-
Savinainen, J.R.1
Yoshino, M.2
Minkkilä, A.3
Nevalainen, T.4
Laitinen, J.T.5
-
30
-
-
33746718652
-
Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system
-
Saario SM, Poso A, Juvonen RO, Järvinen T, Salo-Ahen OM (2006) Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. J Med Chem 49: 4650-4656.
-
(2006)
J Med Chem
, vol.49
, pp. 4650-4656
-
-
Saario, S.M.1
Poso, A.2
Juvonen, R.O.3
Järvinen, T.4
Salo-Ahen, O.M.5
|