메뉴 건너뛰기




Volumn 28, Issue 10, 2014, Pages 4441-4456

Niche anchorage and signaling through membranebound Kit-ligand/c-kit receptor are kinase independent and imatinib insensitive

Author keywords

Adhesion and spreading; Fibronectin; Integrin; Mast cells; Stem cell factor

Indexed keywords

BLOCKING ANTIBODY; F ACTIN; FIBRONECTIN; IMATINIB; INTEGRIN; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; ACTIN; BENZAMIDE DERIVATIVE; PIPERAZINE DERIVATIVE; PROTEIN BINDING; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

EID: 84907707634     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-249425     Document Type: Article
Times cited : (15)

References (63)
  • 1
    • 84867718489 scopus 로고    scopus 로고
    • Stem cell factor receptor/c-Kit: From basic science to clinical implications
    • Lennartsson, J., and Ronnstrand, L. (2012) Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol. Rev. 92, 1619-1649
    • (2012) Physiol. Rev. , vol.92 , pp. 1619-1649
    • Lennartsson, J.1    Ronnstrand, L.2
  • 2
    • 77950617070 scopus 로고    scopus 로고
    • Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance
    • DiNitto, J. P., Deshmukh, G. D., Zhang, Y., Jacques, S. L., Coli, R., Worrall, J. W., Diehl, W., English, J. M., and Wu, J. C. (2010) Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance. J. Biochem. 147, 601-609
    • (2010) J. Biochem. , vol.147 , pp. 601-609
    • Dinitto, J.P.1    Deshmukh, G.D.2    Zhang, Y.3    Jacques, S.L.4    Coli, R.5    Worrall, J.W.6    Diehl, W.7    English, J.M.8    Wu, J.C.9
  • 5
    • 15944404601 scopus 로고    scopus 로고
    • The development of imatinib as a therapeutic agent for chronic myeloid leukemia
    • Deininger, M., Buchdunger, E., and Druker, B. J. (2005) The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 105, 2640-2653
    • (2005) Blood , vol.105 , pp. 2640-2653
    • Deininger, M.1    Buchdunger, E.2    Druker, B.J.3
  • 6
    • 0036493872 scopus 로고    scopus 로고
    • The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; Kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
    • Ma, Y., Zeng, S., Metcalfe, D. D., Akin, C., Dimitrijevic, S., Butterfield, J. H., McMahon, G., and Longley, B. J. (2002) The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations. Blood 99, 1741-1744
    • (2002) Blood , vol.99 , pp. 1741-1744
    • Ma, Y.1    Zeng, S.2    Metcalfe, D.D.3    Akin, C.4    Dimitrijevic, S.5    Butterfield, J.H.6    McMahon, G.7    Longley, B.J.8
  • 7
    • 78650949272 scopus 로고    scopus 로고
    • Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
    • Corbin, A. S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M. W., and Druker, B. J. (2011) Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J. Clin. Invest. 121, 396-409
    • (2011) J. Clin. Invest. , vol.121 , pp. 396-409
    • Corbin, A.S.1    Agarwal, A.2    Loriaux, M.3    Cortes, J.4    Deininger, M.W.5    Druker, B.J.6
  • 8
    • 0025979427 scopus 로고
    • Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant
    • Flanagan, J. G., Chan, D. C., and Leder, P. (1991) Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell 64, 1025-1035
    • (1991) Cell , vol.64 , pp. 1025-1035
    • Flanagan, J.G.1    Chan, D.C.2    Leder, P.3
  • 9
    • 0027089718 scopus 로고
    • Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2
    • Huang, E. J., Nocka, K. H., Buck, J., and Besmer, P. (1992) Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. Mol. Biol. Cell. 3, 349-362
    • (1992) Mol. Biol. Cell. , vol.3 , pp. 349-362
    • Huang, E.J.1    Nocka, K.H.2    Buck, J.3    Besmer, P.4
  • 11
    • 0028908201 scopus 로고
    • Soluble and cellbound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway
    • Wehrle-Haller, B., and Weston, J. A. (1995) Soluble and cellbound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway. Development 121, 731-742
    • (1995) Development , vol.121 , pp. 731-742
    • Wehrle-Haller, B.1    Weston, J.A.2
  • 12
    • 0026667401 scopus 로고
    • Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membranebound and secreted forms of the human homolog of the steel gene product, stem cell factor
    • Toksoz, D., Zsebo, K. M., Smith, K. A., Hu, S., Brankow, D., Suggs, S. V., Martin, F. H., and Williams, D. A. (1992) Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membranebound and secreted forms of the human homolog of the steel gene product, stem cell factor. Proc. Natl. Acad. Sci. U.S.A. 89, 7350-7354
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 7350-7354
    • Toksoz, D.1    Zsebo, K.M.2    Smith, K.A.3    Hu, S.4    Brankow, D.5    Suggs, S.V.6    Martin, F.H.7    Williams, D.A.8
  • 13
    • 0028917884 scopus 로고
    • Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form
    • Miyazawa, K., Williams, D. A., Gotoh, A., Nishimaki, J., Broxmeyer, H. E., and Toyama, K. (1995) Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. Blood 85, 641-649
    • (1995) Blood , vol.85 , pp. 641-649
    • Miyazawa, K.1    Williams, D.A.2    Gotoh, A.3    Nishimaki, J.4    Broxmeyer, H.E.5    Toyama, K.6
  • 14
    • 0028151430 scopus 로고
    • Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3=-kinase, and protein kinase C
    • Yee, N. S., Hsiau, C. W., Serve, H., Vosseller, K., and Besmer, P. (1994) Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3=-kinase, and protein kinase C. J. Biol. Chem. 269, 31991-31998
    • (1994) J. Biol. Chem. , vol.269 , pp. 31991-31998
    • Yee, N.S.1    Hsiau, C.W.2    Serve, H.3    Vosseller, K.4    Besmer, P.5
  • 16
    • 84865714828 scopus 로고    scopus 로고
    • Membrane-bound Kit ligand regulates melanocyte adhesion and survival, providing physical interaction with an intraepithelial niche
    • Tabone-Eglinger, S., Wehrle-Haller, M., Aebischer, N., Jacquier, M. C., and Wehrle-Haller, B. (2012) Membrane-bound Kit ligand regulates melanocyte adhesion and survival, providing physical interaction with an intraepithelial niche. FASEB J. 26, 3738-3753
    • (2012) FASEB J. , vol.26 , pp. 3738-3753
    • Tabone-Eglinger, S.1    Wehrle-Haller, M.2    Aebischer, N.3    Jacquier, M.C.4    Wehrle-Haller, B.5
  • 17
    • 84856147560 scopus 로고    scopus 로고
    • Endothelial and perivascular cells maintain haematopoietic stem cells
    • Ding, L., Saunders, T. L., Enikolopov, G., and Morrison, S. J. (2012) Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 481, 457-462
    • (2012) Nature , vol.481 , pp. 457-462
    • Ding, L.1    Saunders, T.L.2    Enikolopov, G.3    Morrison, S.J.4
  • 18
    • 0035889143 scopus 로고    scopus 로고
    • Molecular pathways in bone marrow homing: Dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins
    • Papayannopoulou, T., Priestley, G. V., Nakamoto, B., Zafiropoulos, V., and Scott, L. M. (2001) Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins. Blood 98, 2403-2411
    • (2001) Blood , vol.98 , pp. 2403-2411
    • Papayannopoulou, T.1    Priestley, G.V.2    Nakamoto, B.3    Zafiropoulos, V.4    Scott, L.M.5
  • 19
    • 0028174124 scopus 로고
    • Stem cell factor induces mast cell adhesion to fibronectin
    • Dastych, J., and Metcalfe, D. D. (1994) Stem cell factor induces mast cell adhesion to fibronectin. J. Immunol. 152, 213-219
    • (1994) J. Immunol. , vol.152 , pp. 213-219
    • Dastych, J.1    Metcalfe, D.D.2
  • 20
    • 0027957554 scopus 로고
    • Steel factor and c-kit regulate cell-matrix adhesion
    • Kinashi, T., and Springer, T. A. (1994) Steel factor and c-kit regulate cell-matrix adhesion. Blood 83, 1033-1038
    • (1994) Blood , vol.83 , pp. 1033-1038
    • Kinashi, T.1    Springer, T.A.2
  • 21
    • 0025772979 scopus 로고
    • In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: Two distinct waves of c-kit-dependency during melanocyte development
    • Nishikawa, S., Kusakabe, M., Yoshinaga, K., Ogawa, M., Hayashi, S., Kunisada, T., Era, T., and Sakakura, T. (1991) In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development. EMBO J. 10, 2111-2118
    • (1991) EMBO J. , vol.10 , pp. 2111-2118
    • Nishikawa, S.1    Kusakabe, M.2    Yoshinaga, K.3    Ogawa, M.4    Hayashi, S.5    Kunisada, T.6    Era, T.7    Sakakura, T.8
  • 22
    • 37249092533 scopus 로고    scopus 로고
    • Analysis of integrin dynamics by fluorescence recovery after photobleaching
    • Wehrle-Haller, B. (2007) Analysis of integrin dynamics by fluorescence recovery after photobleaching. Methods Mol. Biol. 370, 173-202
    • (2007) Methods Mol. Biol. , vol.370 , pp. 173-202
    • Wehrle-Haller, B.1
  • 23
    • 35148819692 scopus 로고    scopus 로고
    • Quantitative measurements of integrinmediated adhesion to extracellular matrix
    • Boettiger, D. (2007) Quantitative measurements of integrinmediated adhesion to extracellular matrix. Methods Enzymol. 426, 1-25
    • (2007) Methods Enzymol. , vol.426 , pp. 1-25
    • Boettiger, D.1
  • 24
    • 70349326733 scopus 로고    scopus 로고
    • Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domain
    • Paulhe, F., Wehrle-Haller, M., Jacquier, M. C., Imhof, B. A., Tabone-Eglinger, S., and Wehrle-Haller, B. (2009) Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domain. FASEB J. 23, 3037-3048
    • (2009) FASEB J. , vol.23 , pp. 3037-3048
    • Paulhe, F.1    Wehrle-Haller, M.2    Jacquier, M.C.3    Imhof, B.A.4    Tabone-Eglinger, S.5    Wehrle-Haller, B.6
  • 26
    • 0025334596 scopus 로고
    • Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W
    • Nocka, K., Tan, J. C., Chiu, E., Chu, T. Y., Ray, P., Traktman, P., and Besmer, P. (1990) Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J. 9, 1805-1813
    • (1990) EMBO J. , vol.9 , pp. 1805-1813
    • Nocka, K.1    Tan, J.C.2    Chiu, E.3    Chu, T.Y.4    Ray, P.5    Traktman, P.6    Besmer, P.7
  • 27
    • 0025192609 scopus 로고
    • The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase
    • Tan, J. C., Nocka, K., Ray, P., Traktman, P., and Besmer, P. (1990) The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase. Science 247, 209-212
    • (1990) Science , vol.247 , pp. 209-212
    • Tan, J.C.1    Nocka, K.2    Ray, P.3    Traktman, P.4    Besmer, P.5
  • 28
    • 0028895383 scopus 로고
    • Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells
    • Serve, H., Yee, N. S., Stella, G., Sepp-Lorenzino, L., Tan, J. C., and Besmer, P. (1995) Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J. 14, 473-483
    • (1995) EMBO J. , vol.14 , pp. 473-483
    • Serve, H.1    Yee, N.S.2    Stella, G.3    Sepp-Lorenzino, L.4    Tan, J.C.5    Besmer, P.6
  • 29
    • 0029820859 scopus 로고    scopus 로고
    • Differential utilization of VLA-4 (alpha 4 beta 1) and -5 (alpha 5 beta 1) integrins during the development of mouse bone marrow-derived mast cells
    • Fehlner-Gardiner, C. C., Uniyal, S., von Ballestrem, C. G., and Chan, B. M. (1996) Differential utilization of VLA-4 (alpha 4 beta 1) and -5 (alpha 5 beta 1) integrins during the development of mouse bone marrow-derived mast cells. Differentiation 60, 317-325
    • (1996) Differentiation , vol.60 , pp. 317-325
    • Fehlner-Gardiner, C.C.1    Uniyal, S.2    Von Ballestrem, C.G.3    Chan, B.M.4
  • 31
    • 0030786589 scopus 로고    scopus 로고
    • Early transplantation to a normal microenvironment prevents the development of Steel hematopoietic stem cell defects
    • Barker, J. E. (1997) Early transplantation to a normal microenvironment prevents the development of Steel hematopoietic stem cell defects. Exp. Hematol. 25, 542-547
    • (1997) Exp. Hematol. , vol.25 , pp. 542-547
    • Barker, J.E.1
  • 33
    • 34248359065 scopus 로고    scopus 로고
    • Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    • Parmar, K., Mauch, P., Vergilio, J. A., Sackstein, R., and Down, J. D. (2007) Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc. Natl. Acad. Sci. U.S.A. 104, 5431-5436
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 5431-5436
    • Parmar, K.1    Mauch, P.2    Vergilio, J.A.3    Sackstein, R.4    Down, J.D.5
  • 34
    • 84859023600 scopus 로고    scopus 로고
    • P85alpha SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation
    • Comb, W. C., Hutti, J. E., Cogswell, P., Cantley, L. C., and Baldwin, A. S. (2012) p85alpha SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation. Mol. Cell 45, 719-730
    • (2012) Mol. Cell , vol.45 , pp. 719-730
    • Comb, W.C.1    Hutti, J.E.2    Cogswell, P.3    Cantley, L.C.4    Baldwin, A.S.5
  • 36
    • 77649119006 scopus 로고    scopus 로고
    • Awakening dormant haematopoietic stem cells
    • Trumpp, A., Essers, M., and Wilson, A. (2010) Awakening dormant haematopoietic stem cells. Nat. Rev. Immunol. 10, 201-209
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 201-209
    • Trumpp, A.1    Essers, M.2    Wilson, A.3
  • 37
    • 0027970797 scopus 로고
    • A comparative study of the phenotype and proliferative capacity of peripheral blood (PB) CD34+ cells mobilized by four different protocols and those of steady-phase PB and bone marrow CD34+ cells
    • To, L. B., Haylock, D. N., Dowse, T., Simmons, P. J., Trimboli, S., Ashman, L. K., and Juttner, C. A. (1994) A comparative study of the phenotype and proliferative capacity of peripheral blood (PB) CD34+ cells mobilized by four different protocols and those of steady-phase PB and bone marrow CD34+ cells. Blood 84, 2930-2939
    • (1994) Blood , vol.84 , pp. 2930-2939
    • To, L.B.1    Haylock, D.N.2    Dowse, T.3    Simmons, P.J.4    Trimboli, S.5    Ashman, L.K.6    Juttner, C.A.7
  • 38
    • 0032055189 scopus 로고    scopus 로고
    • Anti-VLA4/VCAM-1-induced mobilization requires cooperative signaling through the kit/mkit ligand pathway
    • Papayannopoulou, T., Priestley, G. V., and Nakamoto, B. (1998) Anti-VLA4/VCAM-1-induced mobilization requires cooperative signaling through the kit/mkit ligand pathway. Blood 91, 2231-2239
    • (1998) Blood , vol.91 , pp. 2231-2239
    • Papayannopoulou, T.1    Priestley, G.V.2    Nakamoto, B.3
  • 39
    • 33749438538 scopus 로고    scopus 로고
    • A functional interaction between sprouty proteins and caveolin- 1
    • Cabrita, M. A., Jaggi, F., Widjaja, S. P., and Christofori, G. (2006) A functional interaction between sprouty proteins and caveolin- 1. J. Biol. Chem. 281, 29201-29212
    • (2006) J. Biol. Chem. , vol.281 , pp. 29201-29212
    • Cabrita, M.A.1    Jaggi, F.2    Widjaja, S.P.3    Christofori, G.4
  • 40
    • 0034730837 scopus 로고    scopus 로고
    • The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity
    • Mancini, A., Koch, A., Stefan, M., Niemann, H., and Tamura, T. (2000) The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. FEBS Lett. 482, 54-58
    • (2000) FEBS Lett. , vol.482 , pp. 54-58
    • Mancini, A.1    Koch, A.2    Stefan, M.3    Niemann, H.4    Tamura, T.5
  • 41
    • 0037459344 scopus 로고    scopus 로고
    • Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
    • Azam, M., Latek, R. R., and Daley, G. Q. (2003) Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell 112, 831-843
    • (2003) Cell , vol.112 , pp. 831-843
    • Azam, M.1    Latek, R.R.2    Daley, G.Q.3
  • 44
    • 84875248854 scopus 로고    scopus 로고
    • Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix
    • Martino, M. M., Briquez, P. S., Ranga, A., Lutolf, M. P., and Hubbell, J. A. (2013) Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix. Proc. Natl. Acad. Sci. U.S.A. 110, 4563-4568
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 4563-4568
    • Martino, M.M.1    Briquez, P.S.2    Ranga, A.3    Lutolf, M.P.4    Hubbell, J.A.5
  • 45
    • 77949412667 scopus 로고    scopus 로고
    • Restriction of receptor movement alters cellular response: Physical force sensing by EphA2
    • Salaita, K., Nair, P. M., Petit, R. S., Neve, R. M., Das, D., Gray, J. W., and Groves, J. T. (2010) Restriction of receptor movement alters cellular response: physical force sensing by EphA2. Science 327, 1380-1385
    • (2010) Science , vol.327 , pp. 1380-1385
    • Salaita, K.1    Nair, P.M.2    Petit, R.S.3    Neve, R.M.4    Das, D.5    Gray, J.W.6    Groves, J.T.7
  • 46
    • 74549222971 scopus 로고    scopus 로고
    • Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate
    • Paszek, M. J., Boettiger, D., Weaver, V. M., and Hammer, D. A. (2009) Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate. PLoS Comput. Biol. 5, e1000604
    • (2009) PLoS Comput. Biol. , vol.5 , pp. e1000604
    • Paszek, M.J.1    Boettiger, D.2    Weaver, V.M.3    Hammer, D.A.4
  • 47
    • 0035425217 scopus 로고    scopus 로고
    • Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa
    • Beghini, A., Tibiletti, M. G., Roversi, G., Chiaravalli, A. M., Serio, G., Capella, C., and Larizza, L. (2001) Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa. Cancer 92, 657-662
    • (2001) Cancer , vol.92 , pp. 657-662
    • Beghini, A.1    Tibiletti, M.G.2    Roversi, G.3    Chiaravalli, A.M.4    Serio, G.5    Capella, C.6    Larizza, L.7
  • 49
    • 12144286747 scopus 로고    scopus 로고
    • Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia
    • Robson, M. E., Glogowski, E., Sommer, G., Antonescu, C. R., Nafa, K., Maki, R. G., Ellis, N., Besmer, P., Brennan, M., and Offit, K. (2004) Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia. Clin. Cancer Res. 10, 1250-1254
    • (2004) Clin. Cancer Res. , vol.10 , pp. 1250-1254
    • Robson, M.E.1    Glogowski, E.2    Sommer, G.3    Antonescu, C.R.4    Nafa, K.5    Maki, R.G.6    Ellis, N.7    Besmer, P.8    Brennan, M.9    Offit, K.10
  • 52
    • 0037071418 scopus 로고    scopus 로고
    • Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease
    • Scheijen, B., and Griffin, J. D. (2002) Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease. Oncogene 21, 3314-3333
    • (2002) Oncogene , vol.21 , pp. 3314-3333
    • Scheijen, B.1    Griffin, J.D.2
  • 54
    • 58149177123 scopus 로고    scopus 로고
    • A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis
    • Agosti, V., Karur, V., Sathyanarayana, P., Besmer, P., and Wojchowski, D. M. (2009) A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis. Exp. Hematol. 37, 159-171
    • (2009) Exp. Hematol. , vol.37 , pp. 159-171
    • Agosti, V.1    Karur, V.2    Sathyanarayana, P.3    Besmer, P.4    Wojchowski, D.M.5
  • 55
    • 0031760305 scopus 로고    scopus 로고
    • Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis
    • Dastych, J., Taub, D., Hardison, M. C., and Metcalfe, D. D. (1998) Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis. Am. J. Physiol. 275, C1291-C1299
    • (1998) Am. J. Physiol. , vol.275 , pp. C1291-C1299
    • Dastych, J.1    Taub, D.2    Hardison, M.C.3    Metcalfe, D.D.4
  • 56
    • 34250007693 scopus 로고    scopus 로고
    • Kit is essential for PMA-inflammationinduced mast-cell accumulation in the skin
    • Waskow, C., Bartels, S., Schlenner, S. M., Costa, C., and Rodewald, H. R. (2007) Kit is essential for PMA-inflammationinduced mast-cell accumulation in the skin. Blood 109, 5363-5370
    • (2007) Blood , vol.109 , pp. 5363-5370
    • Waskow, C.1    Bartels, S.2    Schlenner, S.M.3    Costa, C.4    Rodewald, H.R.5
  • 57
    • 0026599524 scopus 로고
    • Necessity of extracellular domain of W (c-kit) receptors for attachment of murine cultured mast cells to fibroblasts
    • Adachi, S., Ebi, Y., Nishikawa, S., Hayashi, S., Yamazaki, M., Kasugai, T., Yamamura, T., Nomura, S., and Kitamura, Y. (1992) Necessity of extracellular domain of W (c-kit) receptors for attachment of murine cultured mast cells to fibroblasts. Blood 79, 650-656
    • (1992) Blood , vol.79 , pp. 650-656
    • Adachi, S.1    Ebi, Y.2    Nishikawa, S.3    Hayashi, S.4    Yamazaki, M.5    Kasugai, T.6    Yamamura, T.7    Nomura, S.8    Kitamura, Y.9
  • 58
    • 77953280340 scopus 로고    scopus 로고
    • Pharmacologic modulation of niche accessibility via tyrosine kinase inhibition enhances marrow and thymic engraftment after hematopoietic stem cell transplantation
    • Fewkes, N. M., Krauss, A. C., Guimond, M., Meadors, J. L., Dobre, S., and Mackall, C. L. (2010) Pharmacologic modulation of niche accessibility via tyrosine kinase inhibition enhances marrow and thymic engraftment after hematopoietic stem cell transplantation. Blood 115, 4120-4129
    • (2010) Blood , vol.115 , pp. 4120-4129
    • Fewkes, N.M.1    Krauss, A.C.2    Guimond, M.3    Meadors, J.L.4    Dobre, S.5    Mackall, C.L.6
  • 59
    • 84856501335 scopus 로고    scopus 로고
    • The developing cancer stem-cell model: Clinical challenges and opportunities
    • Vermeulen, L., de Sousa e Melo, F., Richel, D. J., and Medema, J. P. (2012) The developing cancer stem-cell model: clinical challenges and opportunities. Lancet Oncol. 13, e83-89
    • (2012) Lancet Oncol. , vol.13 , pp. e83-89
    • Vermeulen, L.1    De Sousa E Melo, F.2    Richel, D.J.3    Medema, J.P.4
  • 61
    • 33749524667 scopus 로고    scopus 로고
    • Dynamic modeling of imatinib-treated chronic myeloid leukemia: Functional insights and clinical implications
    • Roeder, I., Horn, M., Glauche, I., Hochhaus, A., Mueller, M. C., and Loeffler, M. (2006) Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications. Nat. Med. 12, 1181-1184
    • (2006) Nat. Med. , vol.12 , pp. 1181-1184
    • Roeder, I.1    Horn, M.2    Glauche, I.3    Hochhaus, A.4    Mueller, M.C.5    Loeffler, M.6
  • 63
    • 78049237405 scopus 로고    scopus 로고
    • Cancer stem cells versus phenotype-switching in melanoma
    • Hoek, K. S., and Goding, C. R. (2010) Cancer stem cells versus phenotype-switching in melanoma. Pigment Cell Melanoma Res. 23, 746-759
    • (2010) Pigment Cell Melanoma Res. , vol.23 , pp. 746-759
    • Hoek, K.S.1    Goding, C.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.