Molecular pathways in bone marrow homing: Dominant role of α4β1 over β2-integrins and selectins

Blood

Volumn 98, Issue 8, 2001, Pages 2403-2411

  Papayannopoulou, Thalia ^a   Priestley, Gregory V ^a   Nakamoto, Betty ^a   Zafiropoulos, Vivian ^a   Scott, Linda M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 INTEGRIN; CD18 ANTIGEN; INTEGRIN; SELECTIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL POPULATION; COLONY FORMING UNIT; CONTROLLED STUDY; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SPLEEN; STEM CELL;

EID: 0035889143     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.8.2403     Document Type: Article

References (73)

1. Tavassoli M, Hardy CL. Molecular basis of homing of intravenously transplanted stem cells to the marrow. Blood. 1990;76:1059-1070.
2. Williams DA, Rios M, Stephens C, Patel VP. Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature. 1991;352:438-441.
3. 4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen. Proc Natl Acad Sci U S A. 1995;92:9647-9651.
4. Mazo IB, Gutierrez-Ramos J-C, Frenette PS, Hynes RO, Wagner DD, von Andrian UH. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. J Exp Med. 1998;188:465-474.
5. Frenette PS, Subbarao S, Mazo IB, etal. Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc Natl Acad Sci U S A. 1998;88:75-81.
6. Peled A, Petit 1, Kollet O, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science. 1999;283:845-848.
7. Imai K, Kobayashi M, Wang J, et al. Selective transendothelial migration of hematopoietic progenitor cells: a role in homing of progenitor cells. Blood. 1999;93:149-156.
8. Honczarenko M, Douglas RS, Mathia C, Lee B, Ratajczak MZ, Silberstein LE. SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells. Blood. 1999;94:2990-2998.
9. Jo DY, Rafii S, Hamada T, Moore MAS. Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1. J Clin Invest. 2000;105;101-111.
10. + cells (long-term culture-initiating cells) through endothelial cells is mediated by E-selectin. Blood. 1999;94:4011-4019.
11. Bradstock KF, Makrynikola V, Bianchi A, Shen W, Hewson J, Gottlieb DJ. Effects of the chemokine stromal cell-derived factor-1 on the migration and localization of precursor-B acute lymphoblastic leukemia cells within bone marrow stromal layers. Leukemia. 2000;14:882-888.
12. Sanz- Rodriguez F, Hidalgo A, Teixidó J. Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1. Blood. 2001;97:346-351.
13. Kawabata K, Ujikawa M, Egawa T, et al. A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution. Proc Natl Acad Sci U S A. 1999;96:5663-5667.
14. Ma Q, Jones D, Springer TA. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity. 1999; 10:463-471.
15. Wiesmann A, Spangrude GJ, Marrow engraftment of hematopoietic stem and progenitor cells is independent Gα-coupled chemokine receptors. Exp Hematol. 1999;27:946-955.
16. Khaldoyanidi S, Denzel A, Zöller M. Requirement for CD44 in proliferation and homing of hematopoietic precursors. J Leuk Biol. 1996;60:579-592.
17. Vermeulen M, Le Pesteur F, Gagnerault M-C, Mary J-Y, Sainteny F, Lepault F Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells. Blood. 1998;92:894-900.
18. Pilarski LM, Pruski E, Wizniak J, et al. Potential role for hyaluronan and the hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells. Blood, 1999;93:2918-2927.
19. Oostendorp RAJ, Ghaffari S, Eaves CJ. Kinetics of in vivo homing and recruitment into cycle of hematopoietic cells are organ-specific but CD44-independent. Bone Marrow Transplant. 2000;26:559-566.
20. Hirsch E, Iglesias A, Potocnik AJ, Hartmann U, F̈assler R. Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins. Nature, 1996;380:171-175.
21. Potocnik AJ, Brakelbusch C, Fässler R. Fetal and adult hematopoietic stem cells require β1 integrin function for colonizing fetal liver, spleen, and bone marrow. Immunity. 2000;12:653-663.
22. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;2:301-314.
23. Etzioni A, Doerschuk CM, Harlan JM. Of man and mouse: leukocyte and endothelial adhesion molecule deficiencies. Blood. 1999;94:3281-3288.
24. Wilson RW, Ballantyne CM, Smith CW, et al. Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol. 1993;151:1571-1578.
25. Scharffetter-Kochanek K, Lu H, Norman K, et al. Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med. 1998;188:119-131.
26. Sweeney EA, Priestley GV, Nakamoto B, Collins RG, Beaudet AL, Papayannopoulou T. Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence. Blood. 2000:97:6544-6549.
27. Papayannopoulou T, Priestley GV, Nakamoto B, Zafiropoulos V, Scott LM, Harlan JM. Synergistic mobilization of hemopoietic progenitor cells using concurrent β1 and β2 integrin blockade or β2 deficient mice. Blood. 2001;97:1282-1287.
28. Friedrich C, Cybulsky MI, Gutierrez-Ramos JC. Vascular cell adhesion molecule-1 expression by hematopoiesis -supporting stromal cells is not essential for lymphoid or myeloid differentiation in vivo or in vitro.Eur J Immunol. 1996;26:2773-2780.
29. Boggs DR. The total marrow mass of the mouse: a simplified method of measurement. Am J Hematol. 1984;16:277-286.
30. Forlow SB, White EJ, Barlow SC, et at. Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice. J Clin Invest. 2000;106:1457-1466.
31. Horwitz BH, Mizgerd JP, Scott ML, Doerschuk CM. Mechanisms of granulocytosis in the absence of CD18. Blood. 2001;97:1578-1583.
32. Cui J, Wahl RL, Shen T, et al. Bone marrow cell trafficking following intravenous administration. Br J Haematol. 1999;107:895-902.
33. Lahiri SK, van Putten LM. Distribution and multiplication of colony-forming units from bone marrow and spleen after injection in irradiated mice. Cell Tissue Kinet. 1969;2:21-28.
34. Kretchmer AL, Conover WR. Colony-forming cells in the spleen: determination of the fraction transplanted. Transplantation. 1969;8:576-581.
35. Testa NG, Lord BI, Shore NA. The in vivo seeding of hemopoietic colony-forming cells in irradiated mice. Blood. 1972;40:654-661.
36. van Hennik PB, de Koning AE, Ploemacher RE. Seeding efficiency of primitive human hematopoietic cells in nonobese diabetic/severe combined immune deficiency mice: implications for stem cell frequency assessment. Blood. 1999;94:3055-3061.
37. Hendrikx PJ, Martens ACM, Hagenbeek A, et al. Homing of fluorescently labeled murine hematopoietic stem cells. Exp Hematol. 1996;24:129-140.
38. Szilvassy SJ, Bass MJ, Van Zant G, Grimes B. Organ-selective homing defines engraftment kinetics of murine hematopoietic stem cells and is compromised by ex vivo expansion. Blood. 1999;93:1557-1566.
39. Lanzkron SM, Collector MI, Sharkis SJ. Hematopoietic stem cell tracking in vivo: a comparison of short-term and long-term repopulating cells. Blood. 1999;93:1916-1921.
40. Van der Loo JCM, Ploemacher RE. Marrow- and spleen-seeding efficiencies of all murine hematopoietic stem cell subsets are decreased by preincubation with hematopoietic growth factors. Blood, 1999;85:2598-2606.
41. Kubes P, Jutila M, Payne D. Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. J Clin Invest, 1995;95:2510-2519.
42. Arroyo AG, Yang JT, Rayburn H, Hynes RO. α4 Integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity. 1999;11:555-566.
43. 4 integrins. J Immunol. 2000;165:4667-4675.
44. Kilger G, Needham LA, Nielsen PJ, Clements J, Vestweber D, Holzmann B. Differential regulation of α4 integrin-dependent binding to domains 1 and 4 of vascular cell adhesion molecule-1. J Biol Chem. 1995;270:5979-5984.
45. Terry RW, Kwee L, Levine JF, Labow MA. Cytokine induction of an alternatively spliced murine adhesion molecule (VCAM) mRNA encoding a glycosylphosphatidylinositol-anchored VCAM protein. Proc Natl Acad Sci U S A. 1993;90:5919-5923.
46. 4 integrin-dependent adhesion under static and flow conditions are differentially regulated. J Immunol. 1996; 157:5061-5069.
47. Berlin C, Bargatze RF, Campbell JJ, et al. α4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell. 1995;80:413-422.
48. Issekutz AC, Issekutz TB. Monocyte migration to arthritis in the rat utilizes both CD11/CD18 and very late activation antigen 4 integrin mechanisms. J Exp Med. 1995; 181:1197-1203.
49. Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol. 1995;128:1243-1253.
50. Issekutz TB, Miyasaka M, Issekutz AC. Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation. J Exp Med. 1996; 183:2175-2184.
51. 4 and LFA-1 integrins in selectin-independent monocyte and neutrophil migration to joints of rats with adjuvant arthritis. Int Immunol. 2000;12:141-150.
52. Johnston B, Issekutz TB, Kubes P. The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. J Exp Med. 1996;183:1995-2006.
53. Forlow SB, Ley K. Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1. Am J Physiol Heart Circ Physiol. 2001;280:H636-H641.
54. Ibbotson GC, Doig C, Kaur J, et al. Functional alpha-4-integrin: a newly identified pathway of neutrophil recruitment in critically ill septic patients. Nat Med. 2001;7:465-470.
55. Berlin-Rufenach C, Otto F, Mathies M, etal. Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1 -deficient mice. J Exp Med. 1999;189:1467-1478.
56. Papayannopoulou T, Brice M. Integrin expression profiles during erythroid differentiation. Blood. 1992;79:1686-1694.
57. Ogawa M, Kizumoto M, Nishikawa S, Fujimoto T, Kodama H, Nishikawa S-I. Expression of α4-integrin defines the earliest precursor of hematopoietic cell lineage diverged from endothelial cells. Blood. 1999;93:1168-1177.
58. Voura EB, Billia F, Iscove NN, Hawley RG. Expression mapping of adhesion receptor genes during differentiation of individual hematopoietic precursors. Exp Hematol. 1997;25:1172-1179.
59. Oostendorp RAJ, D6rmer P. VLA-4-mediated interactions between normal human hematopoietic progenitors and stromal cells. Leuk Lymphoma. 1997;24:423-435.
60. , Wang MWJ, Consoli U, Lane CM, et al. Rescue from apoptosis in early (CD34-selected) versus late (non-CD34-selected) human hematopoietic cells by very late antigen 4- and vascular cell adhesion molecule (VCAM) 1-dependent adhesion to bone marrow stromal cells. Cell Growth Differ. 1998;9:105-112.
61. Schweitzer KM, Drager AM, van der Valk P, et al. Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoletic tissues. Am J Pathol. 1996;148:165-175.
62. Jacobsen K, Kravitz J, Kincade PW, Osmond DG. Adhesion receptors on bone marrow stromal cells: in vivo expression of vascular cell adhesion molecule-1 by reticular cells and sinusoidal endothelium in normal and γ-irradiated mice. Blood. 1996;87:73-82.
63. Johnston B, Chee A, Issekutz TB, et al. α4 integrin-dependent leukocyte recruitment does not require VCAM-1 in a chronic model of inflammation. J Immunol. 2000;164:3337-3344.
64. Catalina MD, Estess P, Siegelman MH. Selective requirements for leukocyte adhesion molecules in models of acute and chronic cutaneous inflammation: participation of E- and P- but not L-selectin. Blood. 1999;93:580-589.
65. Koni PA, Joshi SK, Temann U-A, Olson D, Burkly L, Flavell RA. Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med. 2001;193:741-753.
66. Leuker CE, Labow M, Müller W, Wagner N. Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localizetion and T cell-dependent humoral immune response. J Exp Med. 2001;193:755-767.
67. 2 is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1). J Exp Med. 1998;188:2187-2191.
68. 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1. J Immunol. 1999;163:1984-1990.
69. Nagasawa T, Hirota S, Tachibana K, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996;382:635-638.
70. Nielsen PJ, Lorenz B, Muller AM, et al. Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. Blood. 1997;89:1058-1067.
71. Burger JA, Zvaifler NJ, Tsukada N, Firestein GS, Kipps TJ. FibroblasNike synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism. J Clin Invest. 2001;107:305-315.
72. Hidalgo A, Sanz-Rodriguez F, Rodriguez-Fernández JL, et al. Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells. Exp Hematol. 2001;29:345-355.
73. Peled A, Grabovsky V, Habler L, et al. The chemokine SDF-1 stimulates integrin-mediated arrest of CD34+ cells on vascular endothelium under shear flow. J Clin Invest. 1999;104:1199- 1210.