Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses

Brain Research

Volumn 1581, Issue , 2014, Pages 1-11

  Daschil, Nina ^a   Humpel, Christian ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Alzheimer's disease; Calcium; L type calcium channel inhibitor; Neuroprotection; Neurotoxicity; Parkinson's disease

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; CALCIUM CHANNEL L TYPE; CASPASE 3; CATALASE; CHOLINE ACETYLTRANSFERASE; DEFEROXAMINE; DOPAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; ISRADIPINE; LACTATE DEHYDROGENASE; MACROPHAGE INFLAMMATORY PROTEIN 2; NERVE GROWTH FACTOR; NICARDIPINE; NIFEDIPINE; NIMODIPINE; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE; VERAPAMIL; CALCIUM CHANNEL BLOCKING AGENT; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN HOMOGENATE; BRAIN SLICE; CELL DEATH; CELL SURVIVAL; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; IRON OVERLOAD; NERVE FIBER TRANSECTION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; SUBSTANTIA NIGRA; TREATMENT DURATION; VENTRAL TEGMENTUM; ANIMAL; COMPARATIVE STUDY; DRUG EFFECTS; IMMUNOMODULATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TISSUE CULTURE TECHNIQUE;

RATTUS;

ANIMALS; AXOTOMY; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELL DEATH; CHOLINERGIC NEURONS; DOPAMINERGIC NEURONS; ISRADIPINE; NEUROIMMUNOMODULATION; NEUROPROTECTIVE AGENTS; NICARDIPINE; NIFEDIPINE; NIMODIPINE; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA; TISSUE CULTURE TECHNIQUES; VENTRAL TEGMENTAL AREA; VERAPAMIL;

EID: 84907694878     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.07.014     Document Type: Article

References (38)

1. T.S. Anekonda, and J.F. Quinn Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: the case for isradipine Biochim. Biophys. Acta 1812 12 2011 1584 1590
2. D.K. Arora, A.M. Mohammed, and A. Kowluru Nifedipine prevents etoposide-induced caspase-3 activation, prenyl transferase degradation and loss in cell viability in pancreatic β-cells Apoptosis 18 1 2013 1 8
3. D. Ben-Shachar, G. Eshel, J.P. Finberg, and M.B. Youdim The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons J. Neurochem. 56 4 1991 1441 1444
4. D.B. Ben-Shachar, N. Kahana, V. Kampel, A. Warshawsky, and M.B. Youdim Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats Neuropharmacology 46 2 2004 254 263
5. M.J. Berridge Calcium hypothesis of Alzheimer's disease Pflüg. Arch. - Eur. J. Physiol. 459 2010 441 449
6. P.A. Buchs, L. Stoppini, and D. Muller Structural modifications associated with synaptic development in area CA1 of rat hippocampal organotypic cultures Brain Res. Dev. 71 1993 81 91
7. C.S. Chan, T.S. Gertler, and D.J. Surmeier Calcium homeostasis, selective vulnerability and Parkinson's disease Trends Neurosci. 32 2009 249 256
8. P.F. Copenhaver, T.S. Anekonda, D. Musashe, K.M. Robinson, J.M. Ramaker, T.L. Swanson, T.L. Wadsworth, D. Kretzschmar, R.L. Woltjer, and J.F. Quinn A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug Dis. Model Mech. 4 5 2011 634 648
9. S.M. Crain, B. Crain, and E.R. Peterson Development of cross-tolerance to 5-hydroxytryptamine in organotypic cultures of mouse spinal cord-ganglia during chronic exposure to morphine Life Sci. 31 1982 241 247
10. D.T. Dexter, S.A. Statton, C. Whitmore, W. Freinbichler, P. Weinberger, K.F. Tipton, L. Della Corte, R.J. Ward, and R.R. Crichton Clinically available iron chelators induce neuroprotection in the 6-OHDA model of Parkinson's disease after peripheral administration J. Neural Transm. 118 2 2011 223 231
11. B.H. Gähwiler, M. Capogna, D. Debanne, R.A. McKinney, and S.M. Thompson Organotypic slice cultures: a technique has come of age Trends Neurosci. 20 1997 471 477
12. B.H. Gähwiler, and F. Hefti Guidance of acetylcholinesterase-containing fibers by target tissue in co-cultured brain slices Neuroscience 40 1984 235 243
13. B.H. Gähwiler, L. Tietschin, T. Knöpfel, and A. Enz Continuous presence of nerve growth factor is required for maintenance of cholinergic septal neurons in organotypic slice cultures Neuroscience 36 1990 27 31
14. T. Hochstrasser, C. Ullrich, B. Sperner-Unterweger, and C. Humpel Inflammatory stimuli reduce survival of serotonergic neurons and induce neuronal expression of indoleamine 2,3-dioxygenase in rat dorsal raphe nucleus organotypic brain slices Neuroscience 184 2011 128 138
15. C. Humpel, M. Johansson, J. Marksteiner, A. Saria, and I. Strömberg Mesencephalic grafts increase preprotachykinin-A mRNA expression in striatal grafts in an in oculo co-graft model Regul. Pept. 56 1995 9 17
16. C. Humpel, and C. Weis Nerve growth factor and cholinergic CNS neurons studied in organotypic brain slices J. Neural Transm. 62 2002 253 263
17. H. Katsuki, C. Takenaka, T. Kume, S. Kaneko, and A. Akaike Requirement of neural activity for the maintenance of dopaminergic neurons in rat midbrain slice cultures Neurosci. Lett. 300 2001 166 170
18. S. Lecht, E. Rotfeld, H. Arien-Zakay, R. Tabakman, H. Matzner, R. Yaka, P.I. Lelkes, and P. Lazarovici Neuroprotective effects of nimodipine and nifedipine in the NGF-differentiated PC12 cells exposed to oxygen-glucose deprivation or trophic withdrawal Int. J. Dev. Neurosci. 30 6 2012 465 469
19. Y. Li, X. Hu, Y. Liu, Y. Bao, and L. An Nimodipine protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation Neuropharmacology 56 3 2008 580 589
20. Y. Liu, Y.C. Lo, L. Qian, F.T. Crews, B. Wilson, H.L. Chen, H.M. Wu, S.H. Chen, K. Wei, R.B. Lu, S. Ali, and J.S. Hong Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation Neuropharmacology 60 2-3 2011 373 380
21. S. Ludwiczek, I. Theurl, M.U. Muckenthaler, M. Jakab, S.M. Mair, M. Theurl, J. Kiss, M. Paulmichl, M.W. Hentze, M. Ritter, and G. Weiss Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1 Nat. Med. 13 4 2007 448 454
22. Z. Ma, Y. Zhou, and J. Xie Nifedipine prevents iron accumulation and reverses iron-overload-induced dopamine neuron degeneration in the substantia nigra of rats Neurotox. Res. 22 4 2012 274 279
23. P.P. Michel, D. Toulorge, S. Guerreiro, and E.C. Hirsch Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease FASEB J. 27 9 2013 3414 3423
24. K. Ostergaard, J.P. Schou, and J. Zimmer Rat ventral mesencephalon grown as organotypic slice cultures and co-cultured, hippocampus, and cerebellum Exp. Brain Res. 82 1990 547 565
25. E. Rousseau, P.P. Michel, and E.C. Hirsch The iron-binding protein lactoferrin protects vulnerable dopamine neurons from degeneration by preserving mitochondrial calcium homeostasis Mol. Pharmacol. 84 6 2013 888 898
26. Y. Sai, J. Chen, F. Ye, Y. Zhao, Z. Zou, J. Cao, and Z. Dong Dopamine release suppression dependent on an increase of intracellular Ca(2+) contributed to rotenone-induced neurotoxicity in PC12 cells J. Toxicol. Pathol. 26 2 2013 149 157
27. D.S. Schatz, W.A. Kaufmann, A. Saria, and C. Humpel Dopamine neurons in a simple GDNF-treated meso-striatal organotypic co-culture model Exp. Brain Res. 127 1999 270 280
28. D.S. Schatz, W.A. Kaufmann, R. Schuligoi, C. Humpel, and A. Saria 3,4-methylen-edioxymetamphetamine (Ecstasy) induces c-fos-like protein and mRNA in rat organotypic dorsal striatal slices Synapse 36 2000 75 83
29. M.P. Smith, and W.A. Cass GDNF reduces oxidative stress in a 6-hydroxydopamine model of Parkinson's disease Neurosci. Lett. 412 3 2007 259 263
30. L. Stoppini, P.A. Buch, and D. Muller A simple method for organotypic cultures of nervous tissue J. Neurosci. Methods 37 1991 173 182
31. J. Striessnig, A. Koschak, M.J. Sinnegger-Brauns, A. Hetzenauer, N.K. Nguyen, P. Busquet, G. Pelster, and N. Singewald Role of voltage-gated L-type Ca2+ channel isoforms for brain function Biochem. Soc. Trans. 34 2006 903 909
32. D. Surmeier Calcium, ageing, and neuronal vulnerability in Parkinson's disease Lancet Neurol. 6 2007 933 938
33. K. Syeda, A.M. Mohammed, D.K. Arora, and A. Kowluru Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: protection by nifedipine Biochem. Pharmacol. 86 9 2013 1338 1346
34. C. Ullrich, N. Daschil, and C. Humpel Organotypic vibrosections: novel whole sagittal brain cultures J. Neurosci. Methods 201 1 2011 131 141
35. C. Ullrich, and C. Humpel Rotenone induces cell death of cholinergic neurons in an organotypic co-culture brain slice model Neurochem. Res. 34 2009 2147 2153
36. C. Ullrich, and C. Humpel The pro-apoptotic substance thapsigargin selectively stimulates re-growth of brain capillaries Curr. Neurovasc. Res. 6 2009 171 180
37. C. Weis, J. Marksteiner, and C. Humpel Nerve growth factor and glial cell line-derived neurotrophic factor restore the cholinergic phenotype in organotypic brain slices of the basal nucleus of Meynert Neuroscience 102 2001 129 138
38. K. Yao, Y. Ina, K. Nagashima, K. Ohmori, and T. Ohno Antioxidant effects of calcium antagonists in rat brain homogenates Biol. Pharm. Bull. 23 6 2000 766 769