3,4-methylenedioxymetamphetamine (ecstasy) induces c-fos-like protein and mRNA in rat organotypic dorsal striatal slices

Synapse

Volumn 36, Issue 1, 2000, Pages 75-83

  Schatz, Dieter S ^a   Kaufmann, Walter A ^a   Schuligoi, Rufina ^a   Humpel, Christian ^a   Saria, Alois ^b  

^a Dept of Exp and Clin Pharmacology ^*

^b Neurochemistry Unit   (Austria)

Author keywords

Dopamine receptor; Ecstasy; Immediate early gene; MDMA; NMDA receptor

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DIZOCILPINE; DOPAMINE; DOPAMINE 2 RECEPTOR; GLUTAMATE RECEPTOR; MESSENGER RNA; METOCLOPRAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN C FOS; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; CORPUS STRIATUM; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; BRAIN CHEMISTRY; DOPAMINE; DOPAMINE ANTAGONISTS; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; HALLUCINOGENS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MESENCEPHALON; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; N-METHYLASPARTATE; NEOSTRIATUM; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER;

EID: 0034050461     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(200004)36:1<75::AID-SYN8>3.0.CO;2-I     Document Type: Article

References (43)

1. 3H]paroxetine-labeled serotonin uptake sites. J Pharmacol Exp Ther 242:911-916.
2. Battaglia G, Brooks BP, Kulsakdinun C, DeSouza EB. 1988. Pharmacological profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites. Eur J Pharmacol 149:59-163.
3. 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum. Life Sci 35:1885-1893.
4. Cole RL, Konradi C, Douglass J, Hyman SE. 1995. Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14:813-823.
5. Commins DL, Vosmer G, Virus RM, Wollverton WL, Schuster CR, Seiden LS. 1987. Biochemical and histological evidence that methylenedioxymethamphetamine (MDMA) is toxic to neurons in the rat brain. J Pharmacol Exp Ther 24:338-345.
6. Criswell HE, Mueller RA, Breese GR. 1990. Long-term D1-dopamine receptor sensitization in neonatal 6-OHDA-lesioned rats is blocked by an NMDA antagonist. Brain Res 512:284-290.
7. Dingledine R, McBain CJ. 1994. Excitatory amino acid transmitters. In: Siegel GJ, Agranoff BW, Albers RW, Molinoff PB, editors. Raven Press, New York. Basic neurochemistry. p 367-387.
8. Dragunow M, Logan B, Laverty R. 1991. 3,4-Methylenedioxymethamphetamine induces Fos-like proteins in rat basal ganglia: reversal with MK 801. Eur J Pharmacol 206:255-258.
9. Gazzara RA, Takeda H, Cho AK, Howard SG. 1989. Inhibition of dopamine release by methylenedioxymethamphetamine is mediated by serotonin. Eur J Pharmacol 168:209-217.
10. Graybiel AM, Moratalla R, Robertson HA. 1990. Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosomematrix compartments and limbic subdivisions of the striatum. Proc Natl Acad Sci USA 87:6912-6916.
11. Groves PM, Ryan LJ, Linder JC. 1987. Amphetamine changes neostriatal morphology. NIDA Res Monogr 78:132-142.
12. Humpel C, Marksteiner J, Saria A. 1996. Glial-cell-line-derived neurotrophic factor enhances biosynthesis of substance P in striatal neurons in vitro. Cell Tissue Res 286:249-255.
13. Hutter P, Johansson M, Saria A, Humpel C. 1996. Acute and chronic noradrenergic regulation of neurotrophin messenger RNA expression in rat hippocampus: evidence from lesions and organotypic cultures. Neuroscience 70:15-29.
14. Jenner P, Clow A, Reavill C, Theodorou A, Marsden CD. 1978. A behavioural and biochemical comparison of dopamine receptor blockade produced by haloperidol with that produced by substituted benzamide drugs. Life Sci 23:545-550.
15. Johnson M, Letter AA, Merchant K, Hanson GR, Gibb JW. 1988. Effects of 3,4-methylenedioxyamphetmamine and 3,4-methylenedioxymethamphetamine isomers on central serotonergic, dopaminergic and nigral neurotensin systems of the rat. J Pharmacol Exp Ther 244:977-982.
16. Kelland MD, Freeman AS, Chiodo LA. 1989. (±)-3,4-Methylenedioxymethamphetamine-induced changes in the basal activity and pharmacological responsiveness of nigrostriatal dopamine neurons. Eur J Pharmacol 169:11-21.
17. Konradi C, Cole RL, Heckers S, Hyman SE. 1994. Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J Neurosci 14:5623-5634.
18. Konradi C, Leveque J-C, Hyman S. 1996. Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium. J Neurosci 16:4231-4239.
19. Koob GF, Bloom FE. 1988. Cellular and molecular mechanisms of drug dependence. Science 242:715-723.
20. Kosofsky BE, Genova LM, Hyman SE. 1995. Substance P phenotype defines specificity of c-fos induction by cocaine in developing rat striatum. J Comp Neurol 351:41-50.
21. Liu FCh, Takahashi H, McKay RDG, Graybiel AM. 1995. Dopaminergic regulation of transcription factor expression in organotypic cultures of developing striatum. J Neurosci 15:2367-2384.
22. A receptor α 1 subunit-like immunoreactivity. Synapse 23:107-114.
23. McKenna DJ, Peroutka SJ. 1990. Neurochemistry and neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). J Neurochem 54:14-22.
24. Moratalla R, Robertson HA, Graybiel AM. 1992. Dynamic regulation of NGFI-A(zif268, egr1) gene expression in the striatum. J Neurosci 12:2609-2622.
25. Moratalla R, Vickers EA, Robertson HA, Cochran BH, Graybiel AM. 1993. Coordinate expression of c-fos and junB is induced in the rat striatum by cocaine. J Neurosci 13:423-433.
26. Morgan JI, Curran T. 1989. Stimulus-transcription coupling in neurons: role of cellular immediate-early genes. TINS 12:459-462.
27. Nguyen TV, Kosofsky BE, Birnbaum R, Cohen BM, Hyman SE. 1992. Differential expression of c-Fos and Zif268 in rat striatum after haloperidol, clozapine, and amphetamine. Proc Natl Acad Sci USA 89:4270-4274.
28. Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ. 1987. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237:1219-1223.
29. Schatz DS, Kaufmann WA, Sana A, Humpel C. 1999. Dopamine neurons in a simple GDNF-treated meso-striatal organotypic co-culture model. Exp Brain Res 127:270-278.
30. Schmidt CJ. 1987. Neurotoxicity of the psychedelic amphetamine, methylenedioxv-methamphetamine. J Pharmacol Exp Ther 240: 1-7.
31. Schmidt CJ, Taylor VL. 1987. Depression of rat brain tryptophan hydroxylase activity following the acute administration of MDMA. Biochem Pharmacol 36:4095-4102.
32. Schmidt CJ, Wu L, Lovenberg W. 1986. Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue. Eu J Pharmacol 124:175-178.
33. Schmidt CJ, Levin JA, Lovenberg W. 1987. In vitro and in vivo neurochemical effects of MDMA on striatal monoaminergic systems in the rat brain. Biochem Pharmacol 36:747-755.
34. Self DW, Nestler EJ. 1995. Molecular mechanisms of drug reinforcement and addiction. Annu Rev Neurosci 18:463-495.
35. Sirinathsinghji DJS, Dunnett SB. 1994. Imaging gene expression in neural grafts. Molecular imaging in neuroscience: a practical approach. Oxford: Oxford University Press. p 43-73.
36. Stone DM, Stahl DC, Hanson GR, Gibb JW. 1986. The effects of 3,4-methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine on monoaminergic systems in the rat brain. Eur J Pharmacol 128:41-48.
37. Stoppini L, Buchs PA, Muller D. 1991. A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 37:173-182.
38. Wise RW. 1984. Neural mechanisms of the reinforcing action of cocaine. NIDA Res Monogr 50:15-33.
39. Wong EHF, Kemp JA, Priestley T, Knight AR, Woodruff GN, Iverson LL. 1986. The anticonvulsant MK-801 is a potent NMDA antagonist. Proc Natl Acad Sci USA 83:7104-7109.
40. Yamamoto BK, Spanos JL. 1988. The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat. Eur J Pharmacol 148:195-203.
41. Young ST, Porrino LJ, Iadarola MJ. 1991. Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors. Proc Natl Acad Sci USA 88:1291-1295.
42. Zamboni I, DeMartino C. 1967. Buffered picric acid formaldehyde: a new rapid fixative for electron microscopy. J Cell Biol 25:148A.
43. Zhang P, Hirsch EC, Damier P, Duyckaerts C, Javoy-Agid F. 1992. c-fos protein-like immunoreactivity: distribution in the human brain and over-expression in the hippocampus of patients with Alzheimer's disease. Neuroscience 46:9-21.