Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1

Journal of Biological Chemistry

Volumn 278, Issue 27, 2003, Pages 24791-24799

  Ordentlich, Peter ^a   Yan, Yingzhuo ^a   Zhou, Sihong ^a   Heyman, Richard A ^a  

^a EXELIXIS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; DRUG PRODUCTS; HORMONES; METABOLITES; NUCLEIC ACIDS; PROTEINS; TUMORS;

ANTIPROLIFERATIVE EFFECTS;

BIOCHEMISTRY;

ANTIMETABOLITE; ANTINEOPLASTIC AGENT; CELL NUCLEUS RECEPTOR; HORMONE RECEPTOR; MERCAPTOPURINE; NUCLEAR RECEPTOR RELATED FACTOR 1; ANTINEOPLASTIC ANTIMETABOLITE; DNA BINDING PROTEIN; NURR1 NUCLEAR RECEPTOR; TRANSCRIPTION FACTOR;

ACUTE LEUKEMIA; ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; CANCER CELL; CHRONIC MYELOID LEUKEMIA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NONHUMAN; NUCLEIC ACID METABOLISM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PURINE SYNTHESIS; T LYMPHOCYTE ACTIVATION; TARGET CELL; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; ANIMAL; CELL DIVISION; CELL LINE; DRUG EFFECT; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALIA;

6-MERCAPTOPURINE; AMINO ACID SEQUENCE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL DIVISION; CELL LINE; DNA-BINDING PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0042591275     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302167200     Document Type: Article

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