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Volumn 16, Issue 5, 2014, Pages 580-593

Double Transgenesis of Humanized fat1 and fat2 Genes Promotes Omega-3 Polyunsaturated Fatty Acids Synthesis in a Zebrafish Model

Author keywords

Desaturase; Omega 3 fatty acids; Omega 6 fatty acids; Transcriptional regulation; Transgenic fish

Indexed keywords

AQUACULTURE; FATTY ACIDS; FISH; POLYUNSATURATED FATTY ACIDS;

EID: 84907595897     PISSN: 14362228     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10126-014-9577-9     Document Type: Article
Times cited : (39)

References (54)
  • 1
    • 79955858161 scopus 로고    scopus 로고
    • Activation of GH signaling and GH-independent stimulation of growth in zebrafish by introduction of a constitutively activated GHR construct
    • doi:10.1007/s11248-010-9439-9
    • Ahmed AS, Xiong F, Pang SC, He MD, Waters MJ, Zhu ZY, Sun YH (2011) Activation of GH signaling and GH-independent stimulation of growth in zebrafish by introduction of a constitutively activated GHR construct. Transgenic Res 20(3): 557-567. doi: 10. 1007/s11248-010-9439-9.
    • (2011) Transgenic Res , vol.20 , Issue.3 , pp. 557-567
    • Ahmed, A.S.1    Xiong, F.2    Pang, S.C.3    He, M.D.4    Waters, M.J.5    Zhu, Z.Y.6    Sun, Y.H.7
  • 2
    • 19944423821 scopus 로고    scopus 로고
    • Enhancement of EPA and DHA biosynthesis by over-expression of masu salmon delta6-desaturase-like gene in zebrafish
    • Alimuddin, Yoshizaki G, Kiron V, Satoh S, Takeuchi T (2005) Enhancement of EPA and DHA biosynthesis by over-expression of masu salmon delta6-desaturase-like gene in zebrafish. Transgenic Res 14(2): 159-165.
    • (2005) Transgenic Res , vol.14 , Issue.2 , pp. 159-165
    • Alimuddin1    Yoshizaki, G.2    Kiron, V.3    Satoh, S.4    Takeuchi, T.5
  • 3
    • 33847377046 scopus 로고    scopus 로고
    • Expression of masu salmon delta5-desaturase-like gene elevated EPA and DHA biosynthesis in zebrafish
    • doi:10.1007/s10126-006-6003-y (NY)
    • Alimuddin, Yoshizaki G, Kiron V, Satoh S, Takeuchi T (2007) Expression of masu salmon delta5-desaturase-like gene elevated EPA and DHA biosynthesis in zebrafish. Mar Biotechnol (NY) 9(1): 92-100. doi: 10. 1007/s10126-006-6003-y.
    • (2007) Mar Biotechnol , vol.9 , Issue.1 , pp. 92-100
    • Alimuddin1    Yoshizaki, G.2    Kiron, V.3    Satoh, S.4    Takeuchi, T.5
  • 4
    • 50649119257 scopus 로고    scopus 로고
    • Cloning and over-expression of a masu salmon (Oncorhynchus masou) fatty acid elongase-like gene in zebrafish
    • doi:10.1016/j.aquaculture.2008.06.033
    • Alimuddin, Kiron V, Satoh S, Takeuchi T, Yoshizaki G (2008) Cloning and over-expression of a masu salmon (Oncorhynchus masou) fatty acid elongase-like gene in zebrafish. Aquaculture 282(1-4): 13-18. doi: 10. 1016/j. aquaculture. 2008. 06. 033.
    • (2008) Aquaculture , vol.282 , Issue.1-4 , pp. 13-18
    • Alimuddin1    Kiron, V.2    Satoh, S.3    Takeuchi, T.4    Yoshizaki, G.5
  • 5
    • 78751492630 scopus 로고    scopus 로고
    • Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease
    • doi:10.1194/jlr.M011692
    • Bousquet M, Gue K, Emond V, Julien P, Kang JX, Cicchetti F, Calon F (2011) Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease. J Lipid Res 52(2): 263-271. doi: 10. 1194/jlr. M011692.
    • (2011) J Lipid Res , vol.52 , Issue.2 , pp. 263-271
    • Bousquet, M.1    Gue, K.2    Emond, V.3    Julien, P.4    Kang, J.X.5    Cicchetti, F.6    Calon, F.7
  • 6
    • 0030034975 scopus 로고    scopus 로고
    • The desaturation and elongation of linolenic acid and eicosapentaenoic acid by hepatocytes and liver microsomes from rainbow trout (Oncorhynchus mykiss) fed diets containing fish oil or olive oil
    • Buzzi M, Henderson RJ, Sargent JR (1996) The desaturation and elongation of linolenic acid and eicosapentaenoic acid by hepatocytes and liver microsomes from rainbow trout (Oncorhynchus mykiss) fed diets containing fish oil or olive oil. Biochim Biophys Acta 1299(2): 235-244.
    • (1996) Biochim Biophys Acta , vol.1299 , Issue.2 , pp. 235-244
    • Buzzi, M.1    Henderson, R.J.2    Sargent, J.R.3
  • 7
    • 73249128478 scopus 로고    scopus 로고
    • Generation of fad2 transgenic mice that produce omega-6 fatty acids
    • doi:10.1007/s11427-009-0143-z
    • Chen Q, Liu Q, Wu Z, Wang Z, Gou K (2009) Generation of fad2 transgenic mice that produce omega-6 fatty acids. Sci China Ser C Life Sci Chin Acad Sci 52(11): 1048-1054. doi: 10. 1007/s11427-009-0143-z.
    • (2009) Sci China Ser C Life Sci Chin Acad Sci , vol.52 , Issue.11 , pp. 1048-1054
    • Chen, Q.1    Liu, Q.2    Wu, Z.3    Wang, Z.4    Gou, K.5
  • 8
    • 84885010238 scopus 로고    scopus 로고
    • The generation of transgenic mice with fat1 and fad2 genes that have their own polyunsaturated fatty acid biosynthetic pathway
    • doi:10.1159/000354456
    • Chen Y, Mei M, Zhang P, Ma K, Song G, Ma X, Zhao T, Tang B, Ouyang H, Li G, Li Z (2013) The generation of transgenic mice with fat1 and fad2 genes that have their own polyunsaturated fatty acid biosynthetic pathway. Cell Physiol Biochem 32(3): 523-532. doi: 10. 1159/000354456.
    • (2013) Cell Physiol Biochem , vol.32 , Issue.3 , pp. 523-532
    • Chen, Y.1    Mei, M.2    Zhang, P.3    Ma, K.4    Song, G.5    Ma, X.6    Zhao, T.7    Tang, B.8    Ouyang, H.9    Li, G.10    Li, Z.11
  • 9
    • 78650411172 scopus 로고    scopus 로고
    • n-6 and n-3 fatty acids and atherosclerosis: ratios or amounts?
    • doi:10.1161/atvbaha.110.214353
    • Deckelbaum RJ (2010) n-6 and n-3 fatty acids and atherosclerosis: ratios or amounts? Arterioscler Thromb Vasc Biol 30(12): 2325-2326. doi: 10. 1161/atvbaha. 110. 214353.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , Issue.12 , pp. 2325-2326
    • Deckelbaum, R.J.1
  • 10
    • 69449096142 scopus 로고    scopus 로고
    • Optimized Gal4 genetics for permanent gene expression mapping in zebrafish
    • doi:10.1073/pnas.0903060106
    • Distel M, Wullimann MF, Koster RW (2009) Optimized Gal4 genetics for permanent gene expression mapping in zebrafish. Proc Natl Acad Sci U S A 106(32): 13365-13370. doi: 10. 1073/pnas. 0903060106.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.32 , pp. 13365-13370
    • Distel, M.1    Wullimann, M.F.2    Koster, R.W.3
  • 12
    • 33750110432 scopus 로고    scopus 로고
    • Fatty acids as modulators of the immune response
    • doi:10.1146/annurev.nutr.25.050304.092610
    • Fritsche K (2006) Fatty acids as modulators of the immune response. Annu Rev Nutr 26(1): 45-73. doi: 10. 1146/annurev. nutr. 25. 050304. 092610.
    • (2006) Annu Rev Nutr , vol.26 , Issue.1 , pp. 45-73
    • Fritsche, K.1
  • 14
    • 34248559599 scopus 로고    scopus 로고
    • Gene splicing and mutagenesis by PCR-driven overlap extension
    • doi:10.1038/nprot.2007.132
    • Heckman KL, Pease LR (2007) Gene splicing and mutagenesis by PCR-driven overlap extension. Nat Protoc 2(4): 924-932. doi: 10. 1038/nprot. 2007. 132.
    • (2007) Nat Protoc , vol.2 , Issue.4 , pp. 924-932
    • Heckman, K.L.1    Pease, L.R.2
  • 15
    • 43249114663 scopus 로고    scopus 로고
    • n-3 polyunsaturated fatty acid regulation of hepatic gene transcription
    • doi:10.1097/MOL.0b013e3282ffaf6a
    • Jump DB (2008) n-3 polyunsaturated fatty acid regulation of hepatic gene transcription. Curr Opin Lipidol 19(3): 242-247. doi: 10. 1097/MOL. 0b013e3282ffaf6a.
    • (2008) Curr Opin Lipidol , vol.19 , Issue.3 , pp. 242-247
    • Jump, D.B.1
  • 16
    • 84892469068 scopus 로고    scopus 로고
    • Modification of the n-3 HUFA biosynthetic pathway by transgenesis in a marine teleost, nibe croaker
    • doi:10.1016/j.jbiotec.2013.12.004
    • Kabeya N, Takeuchi Y, Yamamoto Y, Yazawa R, Haga Y, Satoh S, Yoshizaki G (2014) Modification of the n-3 HUFA biosynthetic pathway by transgenesis in a marine teleost, nibe croaker. J Biotechnol 172: 46-54. doi: 10. 1016/j. jbiotec. 2013. 12. 004.
    • (2014) J Biotechnol , vol.172 , pp. 46-54
    • Kabeya, N.1    Takeuchi, Y.2    Yamamoto, Y.3    Yazawa, R.4    Haga, Y.5    Satoh, S.6    Yoshizaki, G.7
  • 17
    • 36649010249 scopus 로고    scopus 로고
    • Fat-1 transgenic mice: a new model for omega-3 research
    • doi:10.1016/j.plefa.2007.10.010
    • Kang JX (2007) Fat-1 transgenic mice: a new model for omega-3 research. Prostaglandins Leukot Essent Fat Acids 77(5-6): 263-267. doi: 10. 1016/j. plefa. 2007. 10. 010.
    • (2007) Prostaglandins Leukot Essent Fat Acids , vol.77 , Issue.5-6 , pp. 263-267
    • Kang, J.X.1
  • 18
    • 0035957344 scopus 로고    scopus 로고
    • Adenoviral gene transfer of Caenorhabditis elegans n-3 fatty acid desaturase optimizes fatty acid composition in mammalian cells
    • doi:10.1073/pnas.061040198
    • Kang ZB, Ge Y, Chen Z, Cluette-Brown J, Laposata M, Leaf A, Kang JX (2001) Adenoviral gene transfer of Caenorhabditis elegans n-3 fatty acid desaturase optimizes fatty acid composition in mammalian cells. Proc Natl Acad Sci U S A 98(7): 4050-4054. doi: 10. 1073/pnas. 061040198.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.7 , pp. 4050-4054
    • Kang, Z.B.1    Ge, Y.2    Chen, Z.3    Cluette-Brown, J.4    Laposata, M.5    Leaf, A.6    Kang, J.X.7
  • 19
    • 1142310943 scopus 로고    scopus 로고
    • Transgenic mice: Fat-1 mice convert n-6 to n-3 fatty acids
    • Kang JX, Wang J, Wu L, Kang ZB (2004) Transgenic mice: Fat-1 mice convert n-6 to n-3 fatty acids. Nature 427(6974): 504-504.
    • (2004) Nature , vol.427 , Issue.6974 , pp. 504
    • Kang, J.X.1    Wang, J.2    Wu, L.3    Kang, Z.B.4
  • 20
    • 4344636300 scopus 로고    scopus 로고
    • A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish
    • Kawakami K, Takeda H, Kawakami N, Kobayashi M, Matsuda N, Mishina M (2004) A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish. Dev Cell 7(1): 133-144.
    • (2004) Dev Cell , vol.7 , Issue.1 , pp. 133-144
    • Kawakami, K.1    Takeda, H.2    Kawakami, N.3    Kobayashi, M.4    Matsuda, N.5    Mishina, M.6
  • 21
    • 0029045033 scopus 로고
    • Stages of embryonic development of the zebrafish
    • doi:10.1002/aja.1002030302
    • Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF (1995) Stages of embryonic development of the zebrafish. Dev Dyn 203(3): 253-310. doi: 10. 1002/aja. 1002030302.
    • (1995) Dev Dyn , vol.203 , Issue.3 , pp. 253-310
    • Kimmel, C.B.1    Ballard, W.W.2    Kimmel, S.R.3    Ullmann, B.4    Schilling, T.F.5
  • 22
    • 0037317469 scopus 로고    scopus 로고
    • Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    • Committee ftN, doi:10.1161/01.atv.0000038493.65177.94
    • Kris-Etherton PM, Harris WS, Appel LJ, Committee ftN (2003) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arterioscler Thromb Vasc Biol 23(2): e20-e30. doi: 10. 1161/01. atv. 0000038493. 65177. 94.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , Issue.2
    • Kris-Etherton, P.M.1    Harris, W.S.2    Appel, L.J.3
  • 24
    • 34247186766 scopus 로고    scopus 로고
    • Animal models of human disease: zebrafish swim into view
    • Lieschke GJ, Currie PD (2007) Animal models of human disease: zebrafish swim into view. Nat Rev Genet 8(5): 353-367.
    • (2007) Nat Rev Genet , vol.8 , Issue.5 , pp. 353-367
    • Lieschke, G.J.1    Currie, P.D.2
  • 25
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2 - ΔΔCT method
    • doi:10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 - ΔΔCT method. Methods 25(4): 402-408. doi: 10. 1006/meth. 2001. 1262.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 26
    • 28444434796 scopus 로고    scopus 로고
    • Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you
    • doi:10.1146/annurev.cellbio.21.122303.120624
    • Marszalek JR, Lodish HF (2005) Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. Annu Rev Cell Dev Biol 21: 633-657. doi: 10. 1146/annurev. cellbio. 21. 122303. 120624.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 633-657
    • Marszalek, J.R.1    Lodish, H.F.2
  • 27
    • 61549121432 scopus 로고    scopus 로고
    • n-3 oil sources for use in aquaculture-alternatives to the unsustainable harvest of wild fish
    • doi:10.1017/S0954422408102414
    • Miller MR, Nichols PD, Carter CG (2008) n-3 oil sources for use in aquaculture-alternatives to the unsustainable harvest of wild fish. Nutr Res Rev 21(2): 85-96. doi: 10. 1017/S0954422408102414.
    • (2008) Nutr Res Rev , vol.21 , Issue.2 , pp. 85-96
    • Miller, M.R.1    Nichols, P.D.2    Carter, C.G.3
  • 28
    • 70349287548 scopus 로고    scopus 로고
    • Expression of long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis genes during zebrafish Danio rerio early embryogenesis
    • doi:10.1016/j.bbalip.2009.07.002
    • Monroig O, Rotllant J, Sanchez E, Cerda-Reverter JM, Tocher DR (2009) Expression of long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis genes during zebrafish Danio rerio early embryogenesis. Biochim Biophys Acta 1791(11): 1093-1101. doi: 10. 1016/j. bbalip. 2009. 07. 002.
    • (2009) Biochim Biophys Acta , vol.1791 , Issue.11 , pp. 1093-1101
    • Monroig, O.1    Rotllant, J.2    Sanchez, E.3    Cerda-Reverter, J.M.4    Tocher, D.R.5
  • 29
    • 77954659194 scopus 로고    scopus 로고
    • Multiple genes for functional {increment}6 fatty acyl desaturases (Fad) in Atlantic salmon (Salmo salar L.): gene and cDNA characterization, functional expression, tissue distribution and nutritional regulation
    • doi:10.1016/j.bbalip.2010.04.007
    • Monroig Ó, Zheng X, Morais S, Leaver MJ, Taggart JB, Tocher DR (2010) Multiple genes for functional {increment}6 fatty acyl desaturases (Fad) in Atlantic salmon (Salmo salar L.): gene and cDNA characterization, functional expression, tissue distribution and nutritional regulation. Biochim Biophys Acta (BBA) - Mol Cell Biol Lipids 1801(9): 1072-1081. doi: 10. 1016/j. bbalip. 2010. 04. 007.
    • (2010) Biochim Biophys Acta (BBA) - Mol Cell Biol Lipids , vol.1801 , Issue.9 , pp. 1072-1081
    • Monroig, Ó.1    Zheng, X.2    Morais, S.3    Leaver, M.J.4    Taggart, J.B.5    Tocher, D.R.6
  • 30
    • 84865387122 scopus 로고    scopus 로고
    • Long-chain polyunsaturated fatty acids in fish: recent advances on desaturases and elongases involved in their byosinthesis
    • Monroig Ó, Navarro JC, Tocher DR (2011) Long-chain polyunsaturated fatty acids in fish: recent advances on desaturases and elongases involved in their byosinthesis. Avances Nutr Acuícola 11: 257-283.
    • (2011) Avances Nutr Acuícola , vol.11 , pp. 257-283
    • Monroig, Ó.1    Navarro, J.C.2    Tocher, D.R.3
  • 31
    • 79956198111 scopus 로고    scopus 로고
    • Genotype-specific responses in Atlantic salmon (Salmo salar) subject to dietary fish oil replacement by vegetable oil: a liver transcriptomic analysis
    • doi:10.1186/1471-2164-12-255
    • Morais S, Pratoomyot J, Taggart JB, Bron JE, Guy DR, Bell JG, Tocher DR (2011) Genotype-specific responses in Atlantic salmon (Salmo salar) subject to dietary fish oil replacement by vegetable oil: a liver transcriptomic analysis. BMC Genomics 12: 255. doi: 10. 1186/1471-2164-12-255.
    • (2011) BMC Genomics , vol.12 , pp. 255
    • Morais, S.1    Pratoomyot, J.2    Taggart, J.B.3    Bron, J.E.4    Guy, D.R.5    Bell, J.G.6    Tocher, D.R.7
  • 32
    • 22144495462 scopus 로고    scopus 로고
    • Endogenous production of n-3 and n-6 fatty acids in mammalian cells
    • Morimoto KC, van Eenennaam AL, DePeters EJ, Medrano JF (2005) Endogenous production of n-3 and n-6 fatty acids in mammalian cells. J Dairy Sci 88(3): 1142-1146.
    • (2005) J Dairy Sci , vol.88 , Issue.3 , pp. 1142-1146
    • Morimoto, K.C.1    van Eenennaam, A.L.2    DePeters, E.J.3    Medrano, J.F.4
  • 33
    • 3142753961 scopus 로고    scopus 로고
    • Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases
    • doi:10.1146/annurev.nutr.24.121803.063211
    • Nakamura MT, Nara TY (2004) Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 24: 345-376. doi: 10. 1146/annurev. nutr. 24. 121803. 063211.
    • (2004) Annu Rev Nutr , vol.24 , pp. 345-376
    • Nakamura, M.T.1    Nara, T.Y.2
  • 34
    • 0028115514 scopus 로고
    • Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis
    • doi:10.1105/tpc.6.1.147
    • Okuley J, Lightner J, Feldmann K, Yadav N, Lark E, Browse J (1994) Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. Plant Cell Online 6(1): 147-158. doi: 10. 1105/tpc. 6. 1. 147.
    • (1994) Plant Cell Online , vol.6 , Issue.1 , pp. 147-158
    • Okuley, J.1    Lightner, J.2    Feldmann, K.3    Yadav, N.4    Lark, E.5    Browse, J.6
  • 35
    • 33847021150 scopus 로고    scopus 로고
    • Fatty acid profiles and fat contents of commercially important seawater and freshwater fish species of Turkey: a comparative study
    • doi:10.1016/j.foodchem.2006.08.009
    • Özogul Y, Özogul F, Alagoz S (2007) Fatty acid profiles and fat contents of commercially important seawater and freshwater fish species of Turkey: a comparative study. Food Chem 103(1): 217-223. doi: 10. 1016/j. foodchem. 2006. 08. 009.
    • (2007) Food Chem , vol.103 , Issue.1 , pp. 217-223
    • Özogul, Y.1    Özogul, F.2    Alagoz, S.3
  • 36
    • 41549147240 scopus 로고    scopus 로고
    • Identification and characterization of a novel gene differentially expressed in zebrafish cross-subfamily cloned embryos
    • doi:10.1186/1471-213X-8-29
    • Pei DS, Sun YH, Chen CH, Chen SP, Wang YP, Hu W, Zhu ZY (2008) Identification and characterization of a novel gene differentially expressed in zebrafish cross-subfamily cloned embryos. BMC Dev Biol 8: 29. doi: 10. 1186/1471-213X-8-29.
    • (2008) BMC Dev Biol , vol.8 , pp. 29
    • Pei, D.S.1    Sun, Y.H.2    Chen, C.H.3    Chen, S.P.4    Wang, Y.P.5    Hu, W.6    Zhu, Z.Y.7
  • 37
    • 0034655983 scopus 로고    scopus 로고
    • Identification and characterization of an animal delta(12) fatty acid desaturase gene by heterologous expression in Saccharomyces cerevisiae
    • doi:10.1006/abbi.2000.1733
    • Peyou-Ndi MM, Watts JL, Browse J (2000) Identification and characterization of an animal delta(12) fatty acid desaturase gene by heterologous expression in Saccharomyces cerevisiae. Arch Biochem Biophys 376(2): 399-408. doi: 10. 1006/abbi. 2000. 1733.
    • (2000) Arch Biochem Biophys , vol.376 , Issue.2 , pp. 399-408
    • Peyou-Ndi, M.M.1    Watts, J.L.2    Browse, J.3
  • 38
    • 84878868204 scopus 로고    scopus 로고
    • Two Δ6-desaturase-like genes in common carp (Cyprinus carpio var. Jian): Structure characterization, mRNA expression, temperature and nutritional regulation
    • doi:10.1016/j.gene.2013.04.073
    • Ren H-t, Zhang G-q, Li J-l, Tang Y-k, Li H-x, Yu J-h, Xu P (2013) Two Δ6-desaturase-like genes in common carp (Cyprinus carpio var. Jian): Structure characterization, mRNA expression, temperature and nutritional regulation. Gene 525(1): 11-17. doi: 10. 1016/j. gene. 2013. 04. 073.
    • (2013) Gene , vol.525 , Issue.1 , pp. 11-17
    • Ren, H.-T.1    Zhang, G.-Q.2    Li, J.-I.3    Tang, Y.-K.4    Li, H.-X.5    Yu, J.-H.6    Xu, P.7
  • 39
    • 0034214246 scopus 로고    scopus 로고
    • Transcriptional regulation of adipogenesis
    • doi: 10. 1101/gad. 14. 11. 1293
    • Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM (2000) Transcriptional regulation of adipogenesis. Genes Dev 14(11): 1293-1307. doi: 10. 1101/gad. 14. 11. 1293.
    • (2000) Genes Dev , vol.14 , Issue.11 , pp. 1293-1307
    • Rosen, E.D.1    Walkey, C.J.2    Puigserver, P.3    Spiegelman, B.M.4
  • 41
    • 79851503709 scopus 로고    scopus 로고
    • Effects of dietary alpha-linolenic acid (18:3n-3)/linoleic acid (18:2n-6) ratio on fatty acid metabolism in Murray cod (Maccullochella peelii peelii)
    • doi:10.1021/jf104242y
    • Senadheera SD, Turchini GM, Thanuthong T, Francis DS (2011) Effects of dietary alpha-linolenic acid (18: 3n-3)/linoleic acid (18: 2n-6) ratio on fatty acid metabolism in Murray cod (Maccullochella peelii peelii). J Agric Food Chem 59(3): 1020-1030. doi: 10. 1021/jf104242y.
    • (2011) J Agric Food Chem , vol.59 , Issue.3 , pp. 1020-1030
    • Senadheera, S.D.1    Turchini, G.M.2    Thanuthong, T.3    Francis, D.S.4
  • 42
    • 0031037689 scopus 로고    scopus 로고
    • Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis
    • Spychalla JP, Kinney AJ, Browse J (1997) Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis. Proc Natl Acad Sci U S A 94(4): 1142-1147.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.4 , pp. 1142-1147
    • Spychalla, J.P.1    Kinney, A.J.2    Browse, J.3
  • 44
    • 83855165768 scopus 로고    scopus 로고
    • LC-PUFA biosynthesis in rainbow trout is substrate limited: use of the whole body fatty acid balance method and different 18:3n-3/18:2n-6 ratios
    • doi:10.1007/s11745-011-3607-4
    • Thanuthong T, Francis DS, Senadheera SP, Jones PL, Turchini GM (2011) LC-PUFA biosynthesis in rainbow trout is substrate limited: use of the whole body fatty acid balance method and different 18: 3n-3/18: 2n-6 ratios. Lipids 46(12): 1111-1127. doi: 10. 1007/s11745-011-3607-4.
    • (2011) Lipids , vol.46 , Issue.12 , pp. 1111-1127
    • Thanuthong, T.1    Francis, D.S.2    Senadheera, S.P.3    Jones, P.L.4    Turchini, G.M.5
  • 45
    • 78650420062 scopus 로고    scopus 로고
    • Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation
    • doi:10.1161/ATVBAHA.110.210054
    • Wan JB, Huang LL, Rong R, Tan R, Wang J, Kang JX (2010) Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation. Arterioscler Thromb Vasc Biol 30(12): 2487-2494. doi: 10. 1161/ATVBAHA. 110. 210054.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , Issue.12 , pp. 2487-2494
    • Wan, J.B.1    Huang, L.L.2    Rong, R.3    Tan, R.4    Wang, J.5    Kang, J.X.6
  • 46
    • 84896765469 scopus 로고    scopus 로고
    • Transcriptional factors Smad1 and Smad9 act redundantly to mediate zebrafish ventral specification downstream of Smad5
    • doi:10.1074/jbc.M114.549758
    • Wei C-Y, Wang H-P, Zhu Z-Y, Sun Y-H (2014) Transcriptional factors Smad1 and Smad9 act redundantly to mediate zebrafish ventral specification downstream of Smad5. J Biol Chem. doi: 10. 1074/jbc. M114. 549758.
    • (2014) J Biol Chem
    • Wei, C.-Y.1    Wang, H.-P.2    Zhu, Z.-Y.3    Sun, Y.-H.4
  • 47
    • 33750139770 scopus 로고    scopus 로고
    • Innovative dietary sources of n-3 fatty acids
    • doi:10.1146/annurev.nutr.25.050304.092605
    • Whelan J, Rust C (2006) Innovative dietary sources of n-3 fatty acids. Annu Rev Nutr 26(1): 75-103. doi: 10. 1146/annurev. nutr. 25. 050304. 092605.
    • (2006) Annu Rev Nutr , vol.26 , Issue.1 , pp. 75-103
    • Whelan, J.1    Rust, C.2
  • 49
    • 84881549619 scopus 로고    scopus 로고
    • Targeted expression in zebrafish primordial germ cells by Cre/loxP and Gal4/UAS systems
    • doi:10.1007/s10126-013-9505-4 (NY)
    • Xiong F, Wei ZQ, Zhu ZY, Sun YH (2013) Targeted expression in zebrafish primordial germ cells by Cre/loxP and Gal4/UAS systems. Mar Biotechnol (NY) 15(5): 526-539. doi: 10. 1007/s10126-013-9505-4.
    • (2013) Mar Biotechnol , vol.15 , Issue.5 , pp. 526-539
    • Xiong, F.1    Wei, Z.Q.2    Zhu, Z.Y.3    Sun, Y.H.4
  • 51
  • 53
    • 2442490876 scopus 로고    scopus 로고
    • Effects of diets containing vegetable oil on expression of genes involved in highly unsaturated fatty acid biosynthesis in liver of Atlantic salmon (Salmo salar)
    • doi:10.1016/j.aquaculture.2004.02.003
    • Zheng X, Tocher DR, Dickson CA, Bell JG, Teale AJ (2004) Effects of diets containing vegetable oil on expression of genes involved in highly unsaturated fatty acid biosynthesis in liver of Atlantic salmon (Salmo salar). Aquaculture 236(1-4): 467-483. doi: 10. 1016/j. aquaculture. 2004. 02. 003.
    • (2004) Aquaculture , vol.236 , Issue.1-4 , pp. 467-483
    • Zheng, X.1    Tocher, D.R.2    Dickson, C.A.3    Bell, J.G.4    Teale, A.J.5
  • 54
    • 0034151019 scopus 로고    scopus 로고
    • Embryonic and genetic manipulation in fish
    • Zhu ZY, Sun YH (2000) Embryonic and genetic manipulation in fish. Cell Res 10(1): 17-27.
    • (2000) Cell Res , vol.10 , Issue.1 , pp. 17-27
    • Zhu, Z.Y.1    Sun, Y.H.2


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