Correlation between EGFR Y1068 tyrosine phosphorylation and AP-1 activation by tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin

Environmental Toxicology and Pharmacology

Volumn 33, Issue 1, 2012, Pages 92-97

  Cichocki, Michał ^a   Szamałek, Mateusz ^a   Dałek, Miłosz ^a   Baer Dubowska, Wanda ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

AP 1; Carcinogenesis; EGFR; JNK; Mouse skin; TPA

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EPIDERMIS; FEMALE; IMMUNOPRECIPITATION; KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR PROMOTION; WESTERN BLOTTING;

ANIMALS; CARCINOGENS; CATALYTIC DOMAIN; ENZYME ACTIVATION; FEMALE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SKIN; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1; TYROSINE;

EID: 84455161016     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2011.09.005     Document Type: Article

References (23)

1. Abe M., Kuroda Y., Hirose M., Watanabe Y., Nakano M., Handa T. Inhibition of autophosphorylation of epidermal growth factor receptor by small peptides in vitro. Br. J. Pharmacol. 2006, 147:402-411.
2. Baer-Dubowska W. Mouse skin model as a reliable short-term carcinogenesis assay. Acta Pol. Toxicol. 1997, 5:9-23.
3. Chen N., Ma W.-Y., She Q.-B., Wu E., Liu G., Bode A.M., Dong Z. Transactivation of the Epidermal Growth Factor Receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction. J. Biol. Chem. 2001, 276:46722-46728.
4. DiGiovanni J. Multistage carcinogenesis in mouse skin. Pharmacol. Ther. 1992, 54:19-29.
5. Kiguchi K., Beltran L., Rupp T., DiGiovanni J. Altered expression of epidermal growth factor receptor ligands in tumor promoter-treated mouse epidermis and in primary mouse skin tumors induced by an initiation-promotion protocol. Mol. Carcinog. 1998, 22:73-83.
6. Laurent-Puig P., Lievre A., Blons H. Mutations and response to epidermal growth factor receptor inhibitors. Clin. Cancer Res. 2009, 15:1133-1139.
7. Lee J.C., Kundu J.K., Hwang D.M., Na H.K., Surh Y.-J. Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-κB and AP-1: IκB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. Carcinogenesis 2007, 28:1491-1498.
8. Cichocki M., Paluszczak J., Szaefer H., Piechowiak A., Rimando A.M., Baer-Dubowska W. Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NF-κB, AP-1, COX-2, and iNOS in mouse epidermis. Mol. Nutr. Food Res. 2008, 52:S62-S70.
9. 2 -terminal kinase 2 plays a dominant role in human epidermal neoplasia. Cancer Res. 2010, 70:3080-3088.
10. Oehler T., Pintzas A., Stumm S., Darling A., Gillespie D., Angel P. Mutation of a phosphorylation site in the DNA-binding domain is required for redox-independent transactivation of AP-1-dependent genes by v-Jun. Oncogene 1993, 8:1141-1147.
11. Pulverer B.J., Kyriakis J.M., Avruch J., Nikolakaki E., Woodgett J.R. Phosphorylation of c-jun mediated by MAP kinases. Nature 1991, 353:670-674.
12. Renard P., Ernest I., Houbion A., Art M., Le Calvez H., Raes M., Remacle J. Development of a sensitive multi-well colorimetric assay for active NFkappaB. Nucleic Acids Res. 2001, 29:E21.
13. Rho O., Beltran L.M., Giminez-Conti I.B., DiGiovanni J. Altered expression of the epidermal growth factor receptor and transforming growth factor-α during multistage skin carcinogenesis in SENCAR mice. Mol. Carcinog. 1994, 11:19-28.
14. Saez E., Rutberg S.E., Mueller E., Oppenheim H., Smoluk J., Yuspa S.H., Spiegelman B.M. c-fos is required for malignant progression of skin tumors. Cell 1995, 82:721-732.
15. Segrelles C., Ruiz S., Perez P., Murga C., Santos M., Budunova I.V., Martinez J., Larcher F., Slaga T.J., Gutkind J.S., Jorcano J.L., Paramio J.M. Functional roles of Akt signaling in mouse skin tumorigenesis. Oncogene 2002, 21:53-64.
16. Sharma A., Luke C.T., Dower N.A., Stone J.C., Lorenzo P.S. RasGRP1 is essential for ras activation by tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes. J. Biol. Chem. 2010, 285:15724-15730.
17. Szaefer H., Kaczmarek J., Rybczyska M., Baer-Dubowska W. The effect of plant phenols on the expression and activity of phorbol ester induced PKC in mouse epidermis. Toxicology 2007, 230:1-10.
18. Szamałek M., Baer-Dubowska W. RasGRP proteins - Ras activating factors. Adv. Biochem. 2007, 53:112-121.
19. Tang M.-S., Vulimiri S.V., Viaje A., Chen J.X., Bilolikar D.S., Morris R.J., Harvey R.G., Slaga T.J., DiGiovanni J. Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at codon 61 of c-H-ras. Cancer Res. 2000, 60:5688-5695.
20. Xian W., Kiguchi K., Imamoto A., Rrupp T., Zilberstein A., DiGiovanni J. Activation of Epidermal Growth Factor Receptor by skin tumor promoters and in skin tumors from SENCAR mice. Cell Growth Differ. 1995, 6:1447-1455.
21. Weyergang A., Selbo P.K., Berg K. Y1068 phosphorylation is the most sensitive target of disulfonated tetraphenylporphyrin-based photodynamic therapy on epidermal growth factor receptor. Biochem. Pharmacol. 2007, 74:226-235.
22. Whitmarsh A.J., Davis R.J. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J. Mol. Med. 1996, 74:589-607.
23. Yuspa S.H. The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis. 33rd G.H.A. Clowes Memorial Award Lecture. Cancer Res. 1994, 54:1178-1189.