Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 52, 2014, Pages 18757-18762

  Johnson, Brian P ^a   Walisser, Jacqueline A ^a   Liu, Yan ^a   Shen, Anna L ^a   McDearmon, Erin L ^b   Moran, Susan M ^a   McIntosh, Brian E ^a   Vollrath, Aaron L ^a   Schook, Andrew C ^b   Takahashi, Joseph S ^c,d   Bradfield, Christopher A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Acetaminophen toxicity; Bmal1; Chronotoxicity; Circadian clock; NADPH cytochrome P450 oxidoreductase

Indexed keywords

GLUTATHIONE; NADPH CYTOCHROME P450; PARACETAMOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG; ANALGESIC AGENT; CIRCADIAN RHYTHM SIGNALING PROTEIN; CYTOCHROME P450;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONOTOXICITY; CIRCADIAN RHYTHM; DRUG METABOLISM; ENZYME ACTIVITY; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN SITU HYBRIDIZATION; LIVER CELL; LIVER FUNCTION; LIVER HISTOLOGY; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CIRCADIAN RHYTHM; CIRCADIAN RHYTHM SIGNALING PEPTIDES AND PROTEINS; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEPATOCYTES; MICE; MICE, TRANSGENIC;

EID: 84907585930     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1421708111     Document Type: Article

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