Examining Variable Domain Orientations in Antigen Receptors Gives Insight into TCR-Like Antibody Design

PLoS Computational Biology

Volumn 10, Issue 9, 2014, Pages

  Dunbar, James ^a   Knapp, Bernhard ^a   Fuchs, Angelika ^b   Shi, Jiye ^c   Deane, Charlotte M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ROCHE INNOVATION CENTER MUNICH   (Germany)

^c UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CELL MEMBRANES; T-CELLS;

ANTIBODY ORIENTATIONS; ANTIGEN RECEPTORS; ANTIGENICS; BINDING-SITES; COMPLEMENTARITY-DETERMINING REGIONS; DOMAIN ORIENTATION; LINEAR PEPTIDES; MAJOR HISTOCOMPATIBILITY COMPLEX; T CELLS RECEPTORS; VARIABLE DOMAIN;

ANTIBODIES;

LYMPHOCYTE ANTIGEN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; ANTIBODY; IMMUNOGLOBULIN VARIABLE REGION;

ANTIBODY STRUCTURE; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ANTIGEN STRUCTURE; ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; COMPLEX FORMATION; CONTROLLED STUDY; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR DOCKING; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CLUSTER ANALYSIS; HUMAN; MOUSE;

ANIMALS; ANTIBODIES; BINDING SITES; CLUSTER ANALYSIS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MODELS, MOLECULAR; RECEPTORS, ANTIGEN, T-CELL;

EID: 84907584667     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003852     Document Type: Article

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