메뉴 건너뛰기




Volumn 111, Issue 39, 2014, Pages 14136-14140

Kinesin processivity is gated by phosphate release

Author keywords

Mechanochemistry; Molecular motors; Optical tweezers; Single molecule

Indexed keywords

ADENOSINE TRIPHOSPHATE; DROSOPHILA PROTEIN; HYBRID PROTEIN; KINESIN; KINESIN-1 PROTEIN, DROSOPHILA; MOLECULAR MOTOR; PHOSPHATE;

EID: 84907584481     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1410943111     Document Type: Article
Times cited : (105)

References (41)
  • 1
    • 0022385727 scopus 로고
    • Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
    • Vale RD, Reese TS, Sheetz MP (1985) Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell 42(1):39-50.
    • (1985) Cell , vol.42 , Issue.1 , pp. 39-50
    • Vale, R.D.1    Reese, T.S.2    Sheetz, M.P.3
  • 2
    • 34247571461 scopus 로고    scopus 로고
    • Kinesin motor mechanics: Binding, stepping, tracking, gating, and limping
    • Block SM (2007) Kinesin motor mechanics: Binding, stepping, tracking, gating, and limping. Biophys J 92(9):2986-2995.
    • (2007) Biophys J , vol.92 , Issue.9 , pp. 2986-2995
    • Block, S.M.1
  • 3
    • 60749121148 scopus 로고    scopus 로고
    • Walking the walk: How kinesin and dynein coordinate their steps
    • Gennerich A, Vale RD (2009) Walking the walk: How kinesin and dynein coordinate their steps. Curr Opin Cell Biol 21(1):59-67.
    • (2009) Curr Opin Cell Biol , vol.21 , Issue.1 , pp. 59-67
    • Gennerich, A.1    Vale, R.D.2
  • 4
    • 0347623370 scopus 로고    scopus 로고
    • Kinesin moves by an asymmetric hand-over-hand mechanism
    • Asbury CL, Fehr AN, Block SM (2003) Kinesin moves by an asymmetric hand-over-hand mechanism. Science 302(5653):2130-2134.
    • (2003) Science , vol.302 , Issue.5653 , pp. 2130-2134
    • Asbury, C.L.1    Fehr, A.N.2    Block, S.M.3
  • 6
    • 0025222347 scopus 로고
    • Bead movement by single kinesin molecules studied with optical tweezers
    • Block SM, Goldstein LS, Schnapp BJ (1990) Bead movement by single kinesin molecules studied with optical tweezers. Nature 348(6299):348-352.
    • (1990) Nature , vol.348 , Issue.6299 , pp. 348-352
    • Block, S.M.1    Goldstein, L.S.2    Schnapp, B.J.3
  • 7
    • 0030744142 scopus 로고    scopus 로고
    • Kinesin hydrolyses one ATP per 8-nm step
    • Schnitzer MJ, Block SM (1997) Kinesin hydrolyses one ATP per 8-nm step. Nature 388(6640):386-390.
    • (1997) Nature , vol.388 , Issue.6640 , pp. 386-390
    • Schnitzer, M.J.1    Block, S.M.2
  • 8
    • 0030844286 scopus 로고    scopus 로고
    • Coupling of kinesin steps to ATP hydrolysis
    • Hua W, Young EC, Fleming ML, Gelles J (1997) Coupling of kinesin steps to ATP hydrolysis. Nature 388(6640):390-393.
    • (1997) Nature , vol.388 , Issue.6640 , pp. 390-393
    • Hua, W.1    Young, E.C.2    Fleming, M.L.3    Gelles, J.4
  • 9
    • 0031471243 scopus 로고    scopus 로고
    • The crystal structure of dimeric kinesin and implications for microtubule-dependent motility
    • Kozielski F, et al. (1997) The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell 91(7):985-994.
    • (1997) Cell , vol.91 , Issue.7 , pp. 985-994
    • Kozielski, F.1
  • 10
    • 0033576727 scopus 로고    scopus 로고
    • A structural change in the kinesin motor protein that drives motility
    • Rice S, et al. (1999) A structural change in the kinesin motor protein that drives motility. Nature 402(6763):778-784.
    • (1999) Nature , vol.402 , Issue.6763 , pp. 778-784
    • Rice, S.1
  • 11
    • 0035955690 scopus 로고    scopus 로고
    • ATP reorients the neck linker of kinesin in two sequential steps
    • Rosenfeld SS, Jefferson GM, King PH (2001) ATP reorients the neck linker of kinesin in two sequential steps. J Biol Chem 276(43):40167-40174.
    • (2001) J Biol Chem , vol.276 , Issue.43 , pp. 40167-40174
    • Rosenfeld, S.S.1    Jefferson, G.M.2    King, P.H.3
  • 12
    • 33745839864 scopus 로고    scopus 로고
    • Nucleotide binding and hydrolysis induces a disorder-order transition in the kinesin neck-linker region
    • Asenjo AB, Weinberg Y, Sosa H (2006) Nucleotide binding and hydrolysis induces a disorder-order transition in the kinesin neck-linker region. Nat Struct Mol Biol 13(7): 648-654.
    • (2006) Nat Struct Mol Biol , vol.13 , Issue.7 , pp. 648-654
    • Asenjo, A.B.1    Weinberg, Y.2    Sosa, H.3
  • 13
    • 33749515974 scopus 로고    scopus 로고
    • Single-molecule observations of neck linker conformational changes in the kinesin motor protein
    • TomishigeM, Stuurman N, Vale RD (2006) Single-molecule observations of neck linker conformational changes in the kinesin motor protein. Nat Struct Mol Biol 13(10): 887-894.
    • (2006) Nat Struct Mol Biol , vol.13 , Issue.10 , pp. 887-894
    • Tomishige, M.1    Stuurman, N.2    Vale, R.D.3
  • 14
    • 51549097934 scopus 로고    scopus 로고
    • Intramolecular strain coordinates kinesin stepping behavior along microtubules
    • Yildiz A, Tomishige M, Gennerich A, Vale RD (2008) Intramolecular strain coordinates kinesin stepping behavior along microtubules. Cell 134(6):1030-1041.
    • (2008) Cell , vol.134 , Issue.6 , pp. 1030-1041
    • Yildiz, A.1    Tomishige, M.2    Gennerich, A.3    Vale, R.D.4
  • 15
    • 58049202168 scopus 로고    scopus 로고
    • Kinesin's cover-neck bundle folds forward to generate force
    • Khalil AS, et al. (2008) Kinesin's cover-neck bundle folds forward to generate force. Proc Natl Acad Sci USA 105(49):19247-19252.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.49 , pp. 19247-19252
    • Khalil, A.S.1
  • 16
    • 77749239756 scopus 로고    scopus 로고
    • An atomic-level mechanism for activation of the kinesin molecular motors
    • Sindelar CV, Downing KH (2010) An atomic-level mechanism for activation of the kinesin molecular motors. Proc Natl Acad Sci USA 107(9):4111-4116.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.9 , pp. 4111-4116
    • Sindelar, C.V.1    Downing, K.H.2
  • 18
    • 0027453868 scopus 로고
    • Direct observation of kinesin stepping by optical trapping interferometry
    • Svoboda K, Schmidt CF, Schnapp BJ, Block SM (1993) Direct observation of kinesin stepping by optical trapping interferometry. Nature 365(6448):721-727.
    • (1993) Nature , vol.365 , Issue.6448 , pp. 721-727
    • Svoboda, K.1    Schmidt, C.F.2    Schnapp, B.J.3    Block, S.M.4
  • 19
    • 0034306462 scopus 로고    scopus 로고
    • Force production by single kinesin motors
    • Schnitzer MJ, Visscher K, Block SM (2000) Force production by single kinesin motors. Nat Cell Biol 2(10):718-723.
    • (2000) Nat Cell Biol , vol.2 , Issue.10 , pp. 718-723
    • Schnitzer, M.J.1    Visscher, K.2    Block, S.M.3
  • 20
    • 0037418263 scopus 로고    scopus 로고
    • Probing the kinesin reaction cycle with a 2D optical force clamp
    • Block SM, Asbury CL, Shaevitz JW, Lang MJ (2003) Probing the kinesin reaction cycle with a 2D optical force clamp. Proc Natl Acad Sci USA 100(5):2351-2356.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.5 , pp. 2351-2356
    • Block, S.M.1    Asbury, C.L.2    Shaevitz, J.W.3    Lang, M.J.4
  • 21
    • 0842277818 scopus 로고    scopus 로고
    • Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism
    • Schief WR, Clark RH, Crevenna AH, Howard J (2004) Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism. Proc Natl Acad Sci USA 101(5):1183-1188.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.5 , pp. 1183-1188
    • Schief, W.R.1    Clark, R.H.2    Crevenna, A.H.3    Howard, J.4
  • 22
    • 28444447392 scopus 로고    scopus 로고
    • Cooperative cargo transport by several molecular motors
    • Klumpp S, Lipowsky R (2005) Cooperative cargo transport by several molecular motors. Proc Natl Acad Sci USA 102(48):17284-17289.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.48 , pp. 17284-17289
    • Klumpp, S.1    Lipowsky, R.2
  • 23
    • 42449124179 scopus 로고    scopus 로고
    • Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors
    • Müller MJ, Klumpp S, Lipowsky R (2008) Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors. Proc Natl Acad Sci USA 105(12): 4609-4614.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.12 , pp. 4609-4614
    • Müller, M.J.1    Klumpp, S.2    Lipowsky, R.3
  • 24
    • 0029159959 scopus 로고
    • X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4
    • Fisher AJ, et al. (1995) X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-. Biochemistry 34(28): 8960-8972.
    • (1995) Biochemistry , vol.34 , Issue.28 , pp. 8960-8972
    • Fisher, A.J.1
  • 25
    • 0029978938 scopus 로고    scopus 로고
    • Complexes of myosin subfragment-1 with adenosine diphosphate and phosphate analogs: Probes of active site and protein conformation
    • Phan BC, Cheung P, Stafford WF, Reisler E (1996) Complexes of myosin subfragment-1 with adenosine diphosphate and phosphate analogs: Probes of active site and protein conformation. Biophys Chem 59(3):341-349.
    • (1996) Biophys Chem , vol.59 , Issue.3 , pp. 341-349
    • Phan, B.C.1    Cheung, P.2    Stafford, W.F.3    Reisler, E.4
  • 26
    • 36749068925 scopus 로고    scopus 로고
    • How kinesin waits between steps
    • Mori T, Vale RD, Tomishige M (2007) How kinesin waits between steps. Nature 450(7170):750-754.
    • (2007) Nature , vol.450 , Issue.7170 , pp. 750-754
    • Mori, T.1    Vale, R.D.2    Tomishige, M.3
  • 27
    • 65249096643 scopus 로고    scopus 로고
    • A mobile kinesin-head intermediate during the ATP-waiting state
    • Asenjo AB, Sosa H (2009) A mobile kinesin-head intermediate during the ATP-waiting state. Proc Natl Acad Sci USA 106(14):5657-5662.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.14 , pp. 5657-5662
    • Asenjo, A.B.1    Sosa, H.2
  • 28
    • 69949092035 scopus 로고    scopus 로고
    • Direct observation of the binding state of the kinesin head to the microtubule
    • Guydosh NR, Block SM (2009) Direct observation of the binding state of the kinesin head to the microtubule. Nature 461(7260):125-128.
    • (2009) Nature , vol.461 , Issue.7260 , pp. 125-128
    • Guydosh, N.R.1    Block, S.M.2
  • 31
    • 0032548489 scopus 로고    scopus 로고
    • Alternating site mechanism of the kinesin ATPase
    • Gilbert SP, Moyer ML, Johnson KA (1998) Alternating site mechanism of the kinesin ATPase. Biochemistry 37(3):792-799.
    • (1998) Biochemistry , vol.37 , Issue.3 , pp. 792-799
    • Gilbert, S.P.1    Moyer, M.L.2    Johnson, K.A.3
  • 32
    • 0343415156 scopus 로고    scopus 로고
    • The way things move: Looking under the hood of molecular motor proteins
    • Vale RD, Milligan RA (2000) The way things move: Looking under the hood of molecular motor proteins. Science 288(5463):88-95.
    • (2000) Science , vol.288 , Issue.5463 , pp. 88-95
    • Vale, R.D.1    Milligan, R.A.2
  • 33
    • 0031021473 scopus 로고    scopus 로고
    • Interacting head mechanism of microtubule-kinesin ATPase
    • Ma YZ, Taylor EW (1997) Interacting head mechanism of microtubule-kinesin ATPase. J Biol Chem 272(2):724-730.
    • (1997) J Biol Chem , vol.272 , Issue.2 , pp. 724-730
    • Ma, Y.Z.1    Taylor, E.W.2
  • 34
    • 0037053362 scopus 로고    scopus 로고
    • The role of ATP hydrolysis for kinesin processivity
    • Farrell CM, Mackey AT, Klumpp LM, Gilbert SP (2002) The role of ATP hydrolysis for kinesin processivity. J Biol Chem 277(19):17079-17087.
    • (2002) J Biol Chem , vol.277 , Issue.19 , pp. 17079-17087
    • Farrell, C.M.1    Mackey, A.T.2    Klumpp, L.M.3    Gilbert, S.P.4
  • 35
    • 0141755126 scopus 로고    scopus 로고
    • A kinesin switch i arginine to lysine mutation rescues microtubule function
    • Klumpp LM, Mackey AT, Farrell CM, Rosenberg JM, Gilbert SP (2003) A kinesin switch I arginine to lysine mutation rescues microtubule function. J Biol Chem 278(40): 39059-39067.
    • (2003) J Biol Chem , vol.278 , Issue.40 , pp. 39059-39067
    • Klumpp, L.M.1    Mackey, A.T.2    Farrell, C.M.3    Rosenberg, J.M.4    Gilbert, S.P.5
  • 36
    • 84871744734 scopus 로고    scopus 로고
    • The structural basis of force generation by the mitotic motor kinesin-5
    • Goulet A, et al. (2012) The structural basis of force generation by the mitotic motor kinesin-5. J Biol Chem 287(53):44654-44666.
    • (2012) J Biol Chem , vol.287 , Issue.53 , pp. 44654-44666
    • Goulet, A.1
  • 37
    • 84893496828 scopus 로고    scopus 로고
    • Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family
    • Goulet A, et al. (2014) Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family. Proc Natl Acad Sci USA 111(5):1837-1842.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.5 , pp. 1837-1842
    • Goulet, A.1
  • 38
    • 70350011897 scopus 로고    scopus 로고
    • Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers
    • Valentine MT, Block SM (2009) Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers. Biophys J 97(6):1671-1677.
    • (2009) Biophys J , vol.97 , Issue.6 , pp. 1671-1677
    • Valentine, M.T.1    Block, S.M.2
  • 39
    • 77953135927 scopus 로고    scopus 로고
    • Neck linker length determines the degree of processivity in kinesin-1 and kinesin-2 motors
    • Shastry S, Hancock WO (2010) Neck linker length determines the degree of processivity in kinesin-1 and kinesin-2 motors. Curr Biol 20(10):939-943.
    • (2010) Curr Biol , vol.20 , Issue.10 , pp. 939-943
    • Shastry, S.1    Hancock, W.O.2
  • 41
    • 41549169619 scopus 로고    scopus 로고
    • Precision steering of an optical trap by electro-optic deflection
    • Valentine MT, et al. (2008) Precision steering of an optical trap by electro-optic deflection. Opt Lett 33(6):599-601.
    • (2008) Opt Lett , vol.33 , Issue.6 , pp. 599-601
    • Valentine, M.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.