The HIV-1 Envelope Transmembrane Domain Binds TLR2 through a Distinct Dimerization Motif and Inhibits TLR2-Mediated Responses

PLoS Pathogens

Volumn 10, Issue 8, 2014, Pages

  Reuven, Eliran Moshe ^a   Ali, Mohammad ^a   Rotem, Etai ^a   Schwarzter, Roland ^b   Gramatica, Andrea ^b   Futerman, Anthony H ^a   Shai, Yechiel ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENVELOPE PROTEIN; GLYCOPROTEIN GP 41; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; MEMBRANE PROTEIN; TLR2 PROTEIN, MOUSE; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DIMERIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOMODULATION; MACROPHAGE ACTIVATION; MORTALITY; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION; SPLEEN INJURY; TISSUE INJURY; ANIMAL; C57BL MOUSE; CELL LINE; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE EVASION; IMMUNOLOGY; INNATE IMMUNITY; MACROPHAGE; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; DIMERIZATION; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIV INFECTIONS; HIV-1; IMMUNE EVASION; IMMUNITY, INNATE; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 2; VIRAL ENVELOPE PROTEINS;

EID: 84907576605     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004248     Document Type: Article

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