Revealing Molecular Mechanisms by Integrating High-Dimensional Functional Screens with Protein Interaction Data

PLoS Computational Biology

Volumn 10, Issue 9, 2014, Pages

  Simeone, Angela ^a   Marsico, Giovanni ^b   Collinet, Claudio ^b   Galvez, Thierry ^b   Kalaidzidis, Yannis ^b,c   Zerial, Marino ^b   Beyer, Andreas ^a,d,e  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^c MOSCOW STATE UNIVERSITY   (Russian Federation)

^d CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^e UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR BIOLOGY;

CELLULAR PROCESS; CELLULARS; FUNCTIONAL GENOMICS; HIGH-DIMENSIONAL; HIGHER-DIMENSIONAL; INTERACTING GENES; MOLECULAR MECHANISM; PROFILE ANALYSIS; PROTEIN INTERACTION; SYSTEMATIC INTEGRATION;

GENES;

EPIDERMAL GROWTH FACTOR; NOTCH1 RECEPTOR; SMAD3 PROTEIN; TRANSFERRIN; PROTEIN;

ANALYTIC METHOD; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; ENDOCYTOSIS; ENRICHMENT CULTURE; FUNCTIONAL GENOMICS; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; INTEGRATIVE MULTI PROFILE ANALYSIS OF CELLULAR TRAITS; INTERNALIZATION; MOLECULAR DYNAMICS; PHENOTYPE; PLEIOTROPY; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DATABASE; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; BIOLOGICAL MODEL; BIOLOGY; CHEMICAL STRUCTURE; GENETICS; HEK293 CELL LINE; METABOLISM; NEOPLASM; PHYSIOLOGY; PROCEDURES; PROTEIN ANALYSIS;

COMPUTATIONAL BIOLOGY; ENDOCYTOSIS; HEK293 CELLS; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NEOPLASMS; PROTEIN INTERACTION MAPPING; PROTEINS; SIGNAL TRANSDUCTION;

EID: 84907573465     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003801     Document Type: Article

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