Inhibition of JNK phosphorylation by a novel curcumin analog prevents high glucose-induced inflammation and apoptosis in cardiomyocytes and the development of diabetic cardiomyopathy

Diabetes

Volumn 63, Issue 10, 2014, Pages 3497-3511

  Pan, Yong ^a   Wang, Yi ^a   Zhao, Yunjie ^a   Peng, Kesong ^a   Li, Weixin ^a   Wang, Yonggang ^b,c   Zhang, Jingjing ^d   Zhou, Shanshan ^b,c   Liu, Quan ^b,c   Li, Xiaokun ^a   Cai, Lu ^a,c   Liang, Guang ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^c University of Louisville School of Medicine   (United States)

^d the People's Hospital of Liaoning Province   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 BIS[2 (TRIFLUOROMETHYL)BENZYLIDENE]CYCLOHEXANONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; DRUG DERIVATIVE; GLUCOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDITIS; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; ENZYME INHIBITION; GENE OVEREXPRESSION; GENE REPRESSION; HEART; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART PROTECTION; HISTOPATHOLOGY; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOLECULAR DOCKING; MOUSE; NEWBORN; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; INFLAMMATION; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; APOPTOSIS; CURCUMIN; DIABETIC CARDIOMYOPATHIES; GLUCOSE; INFLAMMATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; NF-KAPPA B; PHOSPHORYLATION;

EID: 84907546206     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1577     Document Type: Article

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