Reducible cationic PAA-g-PEI polymeric micelle/DNA complexes for enhanced gene delivery

Journal of Bioactive and Compatible Polymers

Volumn 29, Issue 5, 2014, Pages 458-473

  Yuan, Taiming ^a   Wang, Yaning ^a   Cao, Wanxu ^a   Sun, Yong ^a   Liang, Jie ^a   Fan, Yujiang ^a   Zhang, Xingdong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

cationic polymeric micelles; gene delivery; gene transfection; hydrophobic modification; micelle DNA complexes; polyethylenimine; Reduction sensitive

Indexed keywords

COVALENT BONDS; CYSTINES; DNA; DYNAMIC LIGHT SCATTERING; EFFICIENCY; GENE TRANSFER; GENES; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; POLYMERS; SULFUR COMPOUNDS;

GENE DELIVERY; GENE TRANSFECTION; HYDROPHOBIC MODIFICATION; POLYETHYLENIMINES; POLYMERIC MICELLE;

MICELLES;

COPOLYMER; NANOPARTICLE; NUCLEASE; PLASMID DNA; POLYETHYLENEIMINE; POLY[PHENETHYLAMIDO N,N BIS(ACRYLOYL)CYSTINE]; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; EMBRYO; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; LIGHT SCATTERING; MICELLE; MOUSE; NONHUMAN; POLYMERIZATION; SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84907537276     PISSN: 08839115     EISSN: 15308030     Source Type: Journal    
DOI: 10.1177/0883911514545912     Document Type: Article

References (45)

1. Nabel GJ. Genetic, cellular and immune approaches to disease therapy: past and future. Nat Med. 2004 ; 10 (2). 135-141
2. Lin P, Ya NX, Shi WH, et al. The effectiveness, cytotoxicity, and intracellular trafficking of nonviral vectors for gene delivery to bone mesenchymal stem cells. J Bioact Compat Pol. 2013 ; 28: 204-217
3. Blomberg P, Smith CIE. Gene therapy of monogenic and cardiovascular disorders. Expert Opin Biol Ther. 2003 ; 3 (6). 941-949
4. Wattiaux R, Laurent N, Jadot M. Endosomes, lysosomes: their implication in gene transfer. Adv Drug Deliv Rev. 2000 ; 41 (2). 201-208
5. Posadas I, Javier GF, Cena V. Nonviral vectors for the delivery of small interfering RNAs to the CNS. Nanomedicine. 2010 ; 5 (8). 1219-1236
6. Morille M, Passirani C, Vonarbourg A, et al. Progress in developing cationic vectors for non-viral systemic gene therapy against cancer. Biomaterials. 2008 ; 29 (24-25). 3477-3496
7. Wang HH, Sun YQ, Qiu LP, et al. A pH-sensitive gene delivery system based on folic acid-PEG-chitosan - PAMAM-plasmid DNA complexes for cancer cell targeting. Biomaterials. 2013 ; 34 (38). 10120-10132
8. Mariska SL, Sandra B, Katrin B, et al. SPECT/CT imaging of temperature-sensitive liposomes for MR-image guided drug delivery with high intensity focused ultrasound. J Control Release. 2013 ; 169: 82-90
9. Shim MS, Kwon YJ. Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications. Adv Drug Deliv Rev. 2012 ; 64 (11). 1046-1059
10. Sonawane ND, Szoka FC, Verkman AS. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem. 2003 ; 278 (45). 44826-44831
11. Cho YW, Kim JD, Park K. Polycation gene delivery systems: escape from endosomes to cytosol. J Pharm Pharmacol. 2003 ; 55 (6). 721-734
12. Zhang ZL, Li WL, Li FC, et al. Nuclear location signal peptide-modified poly(ethyleneimine)/DNA complexes: an efficient gene delivery vector in vitro and in vivo. J Bioact Compat Pol. 2013 ; 28: 218-232
13. Lechardeur D, Verkman AS, Lukacs GL. Intracellular routing of plasmid DNA during non-viral gene transfer. Adv Drug Deliv Rev. 2005 ; 57 (5). 755-767
14. Lv H, Zhang S, Wang B, et al. Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release. 2006 ; 114 (1). 100-109
15. Shah N, Zhang H, Smith SC, et al. Reducible disulfide-based non-viral gene delivery systems. Mini Rev Med Chem. 2009 ; 9 (10). 1242-1250
16. Zeng X, Sun YX, Zhang XZ, et al. Biotinylated disulfide containing PEI/avidin bioconjugate shows specific enhanced transfection efficiency in HepG2 cells. Org Biomol Chem. 2009 ; 7 (20). 4201-4210
17. Michael A, Gosselin WG, Lee RJ. Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. Bioconjug Chem. 2001 ; 12: 989-994
18. Lee HM, Heebeom K, Park JS, et al. Visualization of the degradation of a disulfide polymer, linear poly(ethylenimine sulfide), for gene delivery. Bioconjug Chem. 2007 ; 18 (1). 13-18
19. Tian HY, Xiong W, Wei JZ, et al. Gene transfection of hyperbranched PEI grafted by hydrophobic amino acid segment PBLG. Biomaterials. 2007 ; 28 (18). 2899-2907
20. Bae YM, Choi H, Lee S, et al. Dexamethasone-conjugated low molecular weight polyethylenimine as a nucleus-targeting lipopolymer gene carrier. Bioconjug Chem. 2007 ; 18 (6). 2029-2036
21. Masotti A, Moretti F, Mancini F, et al. Physicochemical and biological study of selected hydrophobic polyethylenimine-based polycationic liposomes and their complexes with DNA. Bioorg Med Chem. 2007 ; 15: 1504-1515
22. Kang HC, Kang HJ, Bae YH. A reducible polycationic gene vector derived from thiolated low molecular weight branched polyethyleneimine linked by 2-iminothiolane. Biomaterials. 2011 ; 32 (4). 1193-1203
23. Christensen LV, Chang CW, Yockman JW, et al. Reducible poly(amido ethylenediamine) for hypoxia-inducible VEGF delivery. J Control Release. 2007 ; 118 (2). 254-261
24. Forrest ML, Meister GE, Koerber JT, et al. Partial acetylation of polyethylenimine enhances in vitro gene delivery. Pharm Res. 2004 ; 21 (2). 365-371
25. Liu Z, Zhang Z, Zhou C, et al. Hydrophobic modifications of cationic polymers for gene delivery. Prog Polym Sci. 2010 ; 35 (9). 1144-1162
26. Davaran S, Omidi Y, Rashidi MR, et al. Preparation and in vitro evaluation of linear and star-branched PLGA nanoparticles for insulin delivery. J Bioact Compat Pol. 2008 ; 23: 115-131
27. Emilitri E, Ranucci E, Ferruti P. New poly(amidoamine)s containing disulfide linkages in their main chain. J Polym Sci Pol Chem. 2005 ; 43 (7). 1404-1416
28. Wang DA, Narang AS, Kotb M, et al. Novel branched poly(ethylenimine)-cholesterol water-soluble lipopolymers for gene delivery. Biomacromolecules. 2002 ; 3 (6). 1197-1207
29. Li F, Ma M, Yuan ZF, et al. Novel poly (glycidyl methacrylate-b-propylene oxide-b-glycidyl methacrylate) derivatives with low cytotoxicity and efficient gene delivery. J Bioact Compat Pol. 2011 ; 26 (4). 389-403
30. Son S, Singha K, Kim WJ. Bioreducible BPEI-SS-PEG-cNGR polymer as a tumor targeted nonviral gene carrier. Biomaterials. 2010 ; 31 (24). 6344-6354
31. Dai J, Zou S, Pei Y, et al. Polyethylenimine-grafted copolymer of poly(L-lysine) and poly(ethylene glycol) for gene delivery. Biomaterials. 2011 ; 32 (6). 1694-1705
32. Tang GP, Guo HY, Alexis F, et al. Low molecular weight polyethylenimines linked by beta-cyclodextrin for gene transfer into the nervous system. J Gene Med. 2006 ; 8 (6). 736-744
33. Ou M, Xu R, Kim SH, et al. A family of bioreducible poly(disulfide amine)s for gene delivery. Biomaterials. 2009 ; 30 (29). 5804-5814
34. Park MR, Han KO, Han IK, et al. Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers. J Control Release. 2005 ; 105 (3). 367-380
35. Tian HY, Deng C, Lin H, et al. Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization. Biomaterials. 2005 ; 26 (20). 4209-4217
36. Forrest ML, Gabrielson N, Pack DW. Reduction of polyethylenimine buffering capacity enhances in-vitro gene delivery activity. Mol Ther. 2004 ; 9: S138
37. Suk JS, Suh J, Choy K, et al. Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles. Biomaterials. 2006 ; 27 (29). 5143-5150
38. Arote R, Kim TH, Kim YK, et al. A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier. Biomaterials. 2007 ; 28: 735-744
39. Pack DW, Hoffman AS, Pun S, et al. Design and development of polymers for gene delivery. Nat Rev Drug Discov. 2005 ; 4 (7). 581-593
40. Kunath K, von Harpe A, Fischer D, et al. Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. J Control Release. 2003 ; 89 (1). 113-125
41. Wang YQ, Su J, Wu F, et al. Biscarbamate cross-linked polyethylenimine derivative with low molecular weight, low cytotoxicity, and high efficiency for gene delivery. Int J Nanomedicine. 2012 ; 7: 693-704
42. Deng JZ, Sun YX, Wang HY, et al. Poly(beta-amino amine) cross-linked PEIs as highly efficient gene vectors. Acta Biomater. 2007 ; 7 (5). 2200-2208
43. Nguyen DH, Choi JH, Joung YK, et al. Disulfide-crosslinked heparin-pluronic nanogels as a redox-sensitive nanocarrier for intracellular protein delivery. J Bioact Compat Pol. 2011 ; 26: 287-299
44. Bauhuber S, Hozsa C, Breunig M, et al. Delivery of nucleic acids via disulfide-based carrier systems. Adv Mater. 2009 ; 21 (32-33). 3286-3306
45. Xuan Z, Yun XS, Wei Q, et al. Biotinylated transferrin/avidin/biotinylated disulfide containing PEI bioconjugates mediated p53 gene delivery system for tumor targeted transfection. Biomaterials. 2010 ; 31 (17). 4771-4780