Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice

Developmental Biology

Volumn 395, Issue 1, 2014, Pages 167-181

  Hou, Congzhe ^a   Ding, Lingcui ^a   Zhang, Jian ^a   Jin, Yecheng ^a   Sun, Chen ^a   Li, Zhenzu ^a   Sun, Xiaoyang ^a   Zhang, Tingting ^a   Zhang, Aizhen ^a   Li, Huashun ^b,c,d   Gao, Jiangang ^a  

^a SHANDONG UNIVERSITY   (China)

^b Tongji University   (China)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^d SHANGHAI ADVANCED RESEARCH INSTITUTE   (China)

Author keywords

Cerebellar development; Granule cell; Lgl1; Purkinje cells

Indexed keywords

CELL PROTEIN; LETHAL GIANT LARVA 1 PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR PAX2; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; LLGL1 PROTEIN, MOUSE; PAX2 PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREBELLUM DISEASE; CONTROLLED STUDY; DENDRITIC CELL; DYSPLASIA; EMBRYO; FEMALE; GENE; GENE DELETION; GENE INACTIVATION; LETHAL GIANT LARVA 1 GENE; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; NICK END LABELING; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PURKINJE CELL; 129 MOUSE; ANIMAL; ANIMAL EMBRYO; C57BL MOUSE; CEREBELLUM; CYTOLOGY; EMBRYOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; GROWTH, DEVELOPMENT AND AGING; KNOCKOUT MOUSE; MALE; METABOLISM; MOTOR ACTIVITY; NEURAL STEM CELL; NEWBORN; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREBELLUM; EMBRYO, MAMMALIAN; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOTYPE; HOMEODOMAIN PROTEINS; MALE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NEURAL STEM CELLS; PAX2 TRANSCRIPTION FACTOR; PURKINJE CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84907529238     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2014.07.007     Document Type: Article

References (47)

1. Albertson R., Doe C.Q. Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat. Cell Biol. 2003, 5:166-170.
2. Altman J., Bayer S.A. Development of the Cerebellar System 1997, CRC, New York.
3. Anderson D.J. Stem cell sand pattern for mationin the nevous system: the possible versus the actual. Neuron 2001, 30:19-35.
4. Aruga J., Minowa O., Yaginuma H., Kuno J., Nagai T., Noda T., Mikoshiba K. Mouse Zic1 is involved in cerebellar development. J. Neurosci. 1998, 18:284-293.
5. Aruga J., Inoue T., Hoshino J., Mikoshiba K. Zic2 controls cerebellar development in cooperation with Zic1. J. Neurosci. 2002, 22:218-225.
6. Barres B.A. A new role for glia: generation of neurons!. Cell 1999, 97:667-670.
7. Bertrand N., Castro D.S., Guillemot F. Proneural genes and the specification of neural cell types. Nat. Rev. Neurosci. 2002, 3:517-530.
8. Betschinger J., Mechtler K., Knoblich J.A. The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature 2003, 422:326-330.
9. Bilder D., Li M., Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumour suppressors. Science 2000, 289:113-116.
10. Chenn A., Walsh C.A. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 2002, 297:365-369.
11. Chizhikov V., Millen K.J. Development and malformations of the cerebellum in mice. Mol. Genet. Metab. 2003, 80:54-65.
12. Christakos S., Malkowitz L., Sori A., Sperduto A., Feldman S.C. Calcium binding protein in squid brain: biochemical similarity to the 28,000-Mr vitamin D-dependent calcium binding protein (calbindin-D28k). J. Neurochem. 1987, 49:1427-1437.
13. Dahmane N., Ruiz-i-Altaba A. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 1999, 126:3089-3100.
14. Dollar G.L., Weber U., Mlodzik M., Sokol SY. Regulation of lethal giant larvae by dishevelled. Nature 2005, 437:1376-1380.
15. Doughty M.L., Lohof A., Campana A., Delhaye-Bouchaud N., Mariani J. Neurotrophin-3 promotes cerebellar granule cell exit from the EGL. Eur. J. Neurosci. 1998, 10:3007-3011.
16. Dussault I., Fawcett D., Matthyssen A., Bader J.A., Giguère V. Orphan nuclear receptor ROR alpha-deficient mice display the cerebellar defects of staggerer. Mech. Dev. 1998, 70:147-153.
17. Engelkamp D., Rashbass P., Seawright A., van Heyningen V. Role of Pax6 in development of the cerebellar system. Development 1999, 126:3585-3596.
18. Fink A.J., Englund C., Daza R.A., Pham D., Lau C., Nivison M., Kowalczyk T., Hevner R.F. Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip. J. Neurosci. 2006, 26:3066-3076.
19. Fujita H., Suqihara I. FoxP2 expression in the cerebellum and inferior olive: development of the transverse stripe-shaped expression pattern in the mouse cerebellar cortex. J. Comp. Neurol. 2012, 520:656-677.
20. Gänzler-Odenthal S.I.I., Redies C. Blocking N-cadherin function disrupts the epithelial structure of differentiating neural tissue in the embryonic chicken brain. J. Neurosci. 1998, 18:5415-5425.
21. Gateff E. Malignant neoplasms of genetic origin in Drosophila melanogaster. Science 1978, 200:1448-1459.
22. Guillemot F., Joyner A.L. Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system. Mech. Dev. 1993, 42:171-185.
23. Hatten M.E. Riding the glial monorail: a common mechanism for glial-guided neuronal migration in different regions of the developing mammalian brain. Trends Neurosci. 1990, 13:179-184.
24. He Y., Zu T., Benzow K.A., Orr H.T., Clark H.B., Koob M.D. Targeted deletion of a single Sca8 ataxia locus allele in mice causes abnormal gait, progressive loss of motor coordination, and PCs dendritic deficits. J. Neurosci. 2006, 26:9975-9982.
25. Hutterer A., Betschinger J., Petronczki M., Knoblich J.A. Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Dev. Cell 2004, 6:845-854.
26. Klezovitch O., Fernandez T.E., Tapscott S.J., Vasioukhin V. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev. 2004, 18:559-571.
27. Lee C.Y., Robinson K.J., Doe C.Q. Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature 2006, 439:594-598.
28. Lein P.J., Beck H.N., Chandrasekaran V., Gallagher P.J., Chen H.L., Lin Y., Guo X., Kaplan P.L., Tiedge H., Higgins D. Glia induce dendritic growth in cultured sympathetic neurons by modulating the balance between bone morphogenetic proteins (BMPs) and BMP antagonists. J. Neurosci. 2002, 22:10377-10387.
29. Levitt, Rakic Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain. J. Comp. Neurol. 1980, 193:815-840.
30. Lordkipanidze T., Dunaevsky A. PCs dendrites grow in alignment with Bergmann glia. Glia 2005, 51:229-234.
31. Mares V., Lodin Z. The cellular kinetics of the developing mouse cerebellum. II. The function of the external granular layer in the process of gyrification. Brain Res. 1970, 23:343-352.
32. Nishihara E., Yoshida-Komiya H., Chan C.S., Liao L., Davis R.L., O'Malley B.W., Xu J. SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar PCs. J. Neurosci. 2003, 23:213-222.
33. Ohtsuka T., Ishibashi M., Gradwohl G., Nakanishi S., Guillemot F., Kageyama R. Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation. EMBO J. 1999, 18:2196-2207.
34. Ohshiro T., Yagami T., Zhang C., Matsuzaki F. Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 2000, 408:593-596.
35. Ohyama T., Groves A.K. Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome. Genesis 2004, 38:195-199.
36. Peng C.Y., Manning L., Albertson R., Doe C.Q. The tumour suppressor genes Lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 2000, 408:596-600.
37. Pfrieger F.W., Barres B.A. New views on synapse-glia interactions. Curr. Opin. Neurobiol. 1996, 6:615-621.
38. Qian X., Goderie S.K., Shen Q., Stern J.H., Temple S. Intrinsic programs of patterned cell lineages in isolated vertebrate CNS ventricular zone cells. Development 1998, 125:3143-3152.
39. Qian X., Shen Q., Goderie S.K., He W., Capela A., Davis A.A., Temple S. Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron 2000, 28:69-80.
40. Shen Q., Zhong W., Jan Y.N., Temple S. Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development 2002, 129:4843-4853.
41. Sudarov A., Joyner A.L. Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers. Neural Dev. 2007, 3:2-26.
42. Takahashi T., Goto T., Miyama S., Nowakowski R.S., Caviness V.S. Sequence of neuron origin and neocortical laminar fate: relation to cell cycle of origin in the developing murine cerebral wall. J. Neurosci. 1999, 19:10357-10371.
43. Tallquist M.D., Soriano P. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 2000, 26:113-115.
44. Tanentzapf G., Tepass U. Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization. Nat. Cell Biol. 2003, 5:46-52.
45. Temple Sally The development of neural stem cells. Nature 2001, 414:112-117.
46. Yang H., Xie X., Deng M., Chen X., Gan L. Generation and characterization of Atoh1-Cre knock-in mouse line. Genesis 2010, 48:407-413.
47. Wechsler-Reya R.J., Scott M.P. Control of neuronal precursor proliferation in the cerebellum by Sonic hedgehog. Neuron 1999, 22:103-114.