A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin

Toxicon

Volumn 92, Issue , 2014, Pages 36-41

  Sully, Erin K ^a   Whaley, Kevin ^b   Bohorova, Natasha ^b   Bohorov, Ognian ^b   Goodman, Charles ^b   Kim, Do ^b   Pauly, Michael ^b   Velasco, Jesus ^b   Holtsberg, Frederick W ^c   Stavale, Eric ^c   Aman, M Javad ^c   Tangudu, Chandra ^d   Uzal, Francisco A ^e   Mantis, Nicholas J ^a,f   Zeitlin, Larry ^b  

^a WADSWORTH CENTER   (United States)

^b Mapp Biopharmaceutical Inc   (United States)

^c Integrated BioTherapeutics   (United States)

^d IOWA STATE UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Antibody; Biodefense; Therapeutic; Toxin

Indexed keywords

ANTITOXIN; BACTERIAL TOXIN; CHIMERIC ANTIBODY; CLOSTRIDIUM PERFRINGENS EPSILON TOXIN; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; RICIN; STAPHYLOCOCCUS ENTEROTOXIN B; UNCLASSIFIED DRUG; CLOSTRIDIUM PERFRINGENS EPSILON-TOXIN; ENTEROTOXIN; ENTEROTOXIN B, STAPHYLOCOCCAL; HYBRID PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; BINDING AFFINITY; CELL VIABILITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IC50; IMMUNOREACTIVITY; LD 50; LETHAL DOSE; LETHALITY; MOUSE; NONHUMAN; TOXIN ANALYSIS; ANIMAL; BAGG ALBINO MOUSE; BIOTERRORISM; FEMALE; INTOXICATION; PREVENTION AND CONTROL; SERODIAGNOSIS;

CLOSTRIDIUM PERFRINGENS; MUS;

ANIMALS; ANTIBODIES, MONOCLONAL; BACTERIAL TOXINS; BIOTERRORISM; ENTEROTOXINS; FEMALE; MICE; MICE, INBRED BALB C; NEUTRALIZATION TESTS; POISONING; RECOMBINANT FUSION PROTEINS; RICIN;

EID: 84907529187     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2014.09.006     Document Type: Article

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