-
1
-
-
0023219950
-
RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes
-
Endo Y, Tsurugi K. 1987. RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes. J. Biol. Chem. 262:8128-8130. (Pubitemid 17104265)
-
(1987)
Journal of Biological Chemistry
, vol.262
, Issue.17
, pp. 8128-8130
-
-
Endo, Y.1
Tsurugi, K.2
-
2
-
-
0023091105
-
Structure and evolution of ricin B chain
-
DOI 10.1038/326624a0
-
Rutenber E, Ready M, Robertus JD. 1987. Structure and evolution of ricin B chain. Nature 326:624-626. (Pubitemid 17051336)
-
(1987)
Nature
, vol.326
, Issue.6113
, pp. 624-626
-
-
Rutenber, E.1
Ready, M.2
Robertus, J.D.3
-
3
-
-
0002954612
-
Ricin toxin
-
Zajtchuk R (ed), Borden Institute, Washington, DC
-
Franz D, Jaax N. 1997. Ricin toxin, p 631-642. In Zajtchuk R (ed), Textbook of military medicine. Borden Institute, Washington, DC.
-
(1997)
Textbook of Military Medicine
, pp. 631-642
-
-
Franz, D.1
Jaax, N.2
-
5
-
-
84873527715
-
The need for continued development of ricin countermeasures
-
doi:10.1155/2012/149737
-
Reisler RB, Smith LA. 2012. The need for continued development of ricin countermeasures. Adv. Prev. Med. 2012:149737. doi:10.1155/2012/149737.
-
(2012)
Adv. Prev. Med.
, vol.2012
, pp. 149737
-
-
Reisler, R.B.1
Smith, L.A.2
-
6
-
-
2442626550
-
Immunological Characteristics Associated with the Protective Efficacy of Antibodies to Ricin
-
Maddaloni M, Cooke C, Wilkinson R, Stout AV, Eng L, Pincus SH. 2004. Immunological characteristics associated with the protective efficacy of antibodies to ricin. J. Immunol. 172:6221-6228. (Pubitemid 38621228)
-
(2004)
Journal of Immunology
, vol.172
, Issue.10
, pp. 6221-6228
-
-
Maddaloni, M.1
Cooke, C.2
Wilkinson, R.3
Stout, A.V.4
Eng, L.5
Pincus, S.H.6
-
7
-
-
80053636763
-
Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB)
-
Yermakova A, Mantis NJ. 2011. Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB). Vaccine 29:7925-7935.
-
(2011)
Vaccine
, vol.29
, pp. 7925-7935
-
-
Yermakova, A.1
Mantis, N.J.2
-
9
-
-
0037056037
-
A novel recombinant vaccine which protects mice against ricin intoxication
-
DOI 10.1016/S0264-410X(02)00312-2, PII S0264410X02003122
-
Smallshaw JE, Firan A, Fulmer JR, Ruback SL, Ghetie V, Vitetta ES. 2002. A novel recombinant vaccine which protects mice against ricin intoxication. Vaccine 20:3422-3427. (Pubitemid 35245826)
-
(2002)
Vaccine
, vol.20
, Issue.27-28
, pp. 3422-3427
-
-
Smallshaw, J.E.1
Firan, A.2
Fulmer, J.R.3
Ruback, S.L.4
Ghetie, V.5
Vitetta, E.S.6
-
10
-
-
0037382907
-
Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice
-
DOI 10.1038/nbt800
-
Smallshaw JE, Ghetie V, Rizo J, Fulmer JR, Trahan LL, Ghetie MA, Vitetta ES. 2003. Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice. Nat. Biotechnol. 21:387-391. (Pubitemid 36397658)
-
(2003)
Nature Biotechnology
, vol.21
, Issue.4
, pp. 387-391
-
-
Smallshaw, J.E.1
Ghetie, V.2
Rizo, J.3
Fulmer, J.R.4
Trahan, L.L.5
Ghetie, M.-A.6
Vitetta, E.S.7
-
11
-
-
34247326598
-
Improved formulation of a recombinant ricin A-chain vaccine increases its stability and effective antigenicity
-
DOI 10.1016/j.vaccine.2007.03.011, PII S0264410X07003040
-
Carra JH, Wannemacher RW, Tammariello RF, Lindsey CY, Dinterman RE, Schokman RD, Smith LA. 2007. Improved formulation of a recombinant ricin A-chain vaccine increases its stability and effective antigenicity. Vaccine 25:4149-4158. (Pubitemid 46635951)
-
(2007)
Vaccine
, vol.25
, Issue.21
, pp. 4149-4158
-
-
Carra, J.H.1
Wannemacher, R.W.2
Tammariello, R.F.3
Lindsey, C.Y.4
Dinterman, R.E.5
Schokman, R.D.6
Smith, L.A.7
-
12
-
-
4143060688
-
Improved stability of a protein vaccine through elimination of a partially unfolded state
-
DOI 10.1110/ps.04897904
-
McHugh CA, Tammariello RF, Millard CB, Carra JH. 2004. Improved stability of a protein vaccine through elimination of a partially unfolded state. Protein Sci. 13:2736-2743. (Pubitemid 39274641)
-
(2004)
Protein Science
, vol.13
, Issue.10
, pp. 2736-2743
-
-
McHugh, C.A.1
Tammariello, R.F.2
Millard, C.B.3
Carra, J.H.4
-
13
-
-
4143103548
-
Finding a new vaccine in the ricin protein fold
-
DOI 10.1093/protein/gzh043
-
Olson MA, Carra JH, Roxas-Duncan V, Wannemacher RW, Smith LA, Millard CB. 2004. Finding a new vaccine in the ricin protein fold. Protein Eng. Des. Sel. 17:391-397. (Pubitemid 39093520)
-
(2004)
Protein Engineering, Design and Selection
, vol.17
, Issue.4
, pp. 391-397
-
-
Olson, M.A.1
Carra, J.H.2
Roxas-Duncan, V.3
Wannemacher, R.W.4
Smith, L.A.5
Millard, C.B.6
-
14
-
-
77957601374
-
Folding domains within the ricin toxin A subunit as targets of protective antibodies
-
O'Hara JM, Neal LM, McCarthy EA, Kasten-Jolly JA, Brey RN, III, Mantis NJ. 2010. Folding domains within the ricin toxin A subunit as targets of protective antibodies. Vaccine 28:7035-7046.
-
(2010)
Vaccine
, vol.28
, pp. 7035-7046
-
-
O'Hara, J.M.1
Neal, L.M.2
McCarthy, E.A.3
Kasten-Jolly, J.A.4
Brey III, R.N.5
Mantis, N.J.6
-
15
-
-
77954958642
-
Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication
-
Marconescu PS, Smallshaw JE, Pop LM, Ruback SL, Vitetta ES. 2010. Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication. Vaccine 28:5315-5322.
-
(2010)
Vaccine
, vol.28
, pp. 5315-5322
-
-
Marconescu, P.S.1
Smallshaw, J.E.2
Pop, L.M.3
Ruback, S.L.4
Vitetta, E.S.5
-
16
-
-
25144493280
-
Preclinical toxicity and efficacy testing of RiVax, a recombinant protein vaccine against ricin
-
DOI 10.1016/j.vaccine.2005.04.037
-
Smallshaw JE, Richardson JA, Pincus S, Schindler J, Vitetta ES. 2005. Preclinical toxicity and efficacy testing of RiVax, a recombinant protein vaccine against ricin. Vaccine 23:4775-4784. (Pubitemid 41557328)
-
(2005)
Vaccine
, vol.23
, Issue.39
, pp. 4775-4784
-
-
Smallshaw, J.E.1
Richardson, J.A.2
Pincus, S.3
Schindler, J.4
Vitetta, E.S.5
-
17
-
-
34748918488
-
RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol
-
DOI 10.1016/j.vaccine.2007.08.018, PII S0264410X07009139
-
Smallshaw JE, Richardson JA, Vitetta ES. 2007. RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol. Vaccine 25:7459-7469. (Pubitemid 47484003)
-
(2007)
Vaccine
, vol.25
, Issue.42
, pp. 7459-7469
-
-
Smallshaw, J.E.1
Richardson, J.A.2
Vitetta, E.S.3
-
18
-
-
33144473223
-
A pilot clinical trial of a recombinant ricin vaccine in normal humans
-
DOI 10.1073/pnas.0510893103
-
Vitetta ES, Smallshaw JE, Coleman E, Jafri H, Foster C, Munford R, Schindler J. 2006. A pilot clinical trial of a recombinant ricin vaccine in normal humans. Proc. Natl. Acad. Sci. U. S. A. 103:2268-2273. (Pubitemid 43271659)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.7
, pp. 2268-2273
-
-
Vitetta, E.S.1
Smallshaw, J.E.2
Coleman, E.3
Jafri, H.4
Foster, C.5
Munford, R.6
Schindler, J.7
-
19
-
-
84867241458
-
Pilot phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine
-
Vitetta ES, Smallshaw JE, Schindler J. 2012. Pilot phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine. Clin. Vaccine Immunol. 19:1697-1699.
-
(2012)
Clin. Vaccine Immunol.
, vol.19
, pp. 1697-1699
-
-
Vitetta, E.S.1
Smallshaw, J.E.2
Schindler, J.3
-
20
-
-
79955635252
-
Progress in biological threat agent vaccine development: A repeat-dose toxicity study of a recombinant ricin toxin A-chain (rRTA) 1-33/44-198 vaccine (RVEc) in male and female New Zealand white rabbits
-
McLain DE, Horn TL, Detrisac CJ, Lindsey CY, Smith LA. 2011. Progress in biological threat agent vaccine development: a repeat-dose toxicity study of a recombinant ricin toxin A-chain (rRTA) 1-33/44-198 vaccine (RVEc) in male and female New Zealand white rabbits. Int. J. Toxicol. 30:143-152.
-
(2011)
Int. J. Toxicol.
, vol.30
, pp. 143-152
-
-
McLain, D.E.1
Horn, T.L.2
Detrisac, C.J.3
Lindsey, C.Y.4
Smith, L.A.5
-
21
-
-
84863393032
-
Protective effect of two recombinant ricin subunit vaccines in the New Zealand White rabbit subjected to a lethal aerosolized ricin challenge: Survival, immunological response and histopathological findings
-
McLain DE, Lewis BS, Chapman JL, Wannemacher RW, Lindsey CY, Smith LA. 2012. Protective effect of two recombinant ricin subunit vaccines in the New Zealand White rabbit subjected to a lethal aerosolized ricin challenge: survival, immunological response and histopathological findings. Toxicol. Sci. 126:72-83.
-
(2012)
Toxicol. Sci.
, vol.126
, pp. 72-83
-
-
McLain, D.E.1
Lewis, B.S.2
Chapman, J.L.3
Wannemacher, R.W.4
Lindsey, C.Y.5
Smith, L.A.6
-
22
-
-
79961128084
-
Process development and cGMP manufacturing of a recombinant ricin vaccine: An effective and stable recombinant ricin A-chain vaccine-RVEc
-
Meagher MM, Seravalli JG, Swanson ST, Ladd RG, Khasa YP, Inan M, Harner JC, Johnson SK, Van Cott K, Lindsey C, Wannemacher R, Smith LA. 2011. Process development and cGMP manufacturing of a recombinant ricin vaccine: an effective and stable recombinant ricin A-chain vaccine-RVEc. Biotechnol. Prog. 27:1036-1047.
-
(2011)
Biotechnol. Prog.
, vol.27
, pp. 1036-1047
-
-
Meagher, M.M.1
Seravalli, J.G.2
Swanson, S.T.3
Ladd, R.G.4
Khasa, Y.P.5
Inan, M.6
Harner, J.C.7
Johnson, S.K.8
Van Cott, K.9
Lindsey, C.10
Wannemacher, R.11
Smith, L.A.12
-
23
-
-
79959374624
-
Evaluation of a ricin vaccine candidate (RVEc) for human toxicity using an in vitro vascular leak assay
-
Porter A, Phillips G, Smith L, Erwin-Cohen R, Tammariello R, Hale M, Dasilva L. 2011. Evaluation of a ricin vaccine candidate (RVEc) for human toxicity using an in vitro vascular leak assay. Toxicon 58:68-75.
-
(2011)
Toxicon
, vol.58
, pp. 68-75
-
-
Porter, A.1
Phillips, G.2
Smith, L.3
Erwin-Cohen, R.4
Tammariello, R.5
Hale, M.6
Dasilva, L.7
-
24
-
-
33846131223
-
A rapid, three-step process for the preformulation of a recombinant ricin toxin A-chain vaccine
-
DOI 10.1002/jps.20675
-
Peek LJ, Brey RN, Middaugh CR. 2007. A rapid, three-step process for the preformulation of a recombinant ricin toxin A-chain vaccine. J. Pharm. Sci. 96:44-60. (Pubitemid 46087338)
-
(2007)
Journal of Pharmaceutical Sciences
, vol.96
, Issue.1
, pp. 44-60
-
-
Peek, L.J.1
Brey, R.N.2
Middaugh, C.R.3
-
25
-
-
0036956623
-
Identification of hypoglycemia in mice as a surrogate marker of ricin toxicosis
-
Pincus SH, Eng L, Cooke CL, Maddaloni M. 2002. Identification of hypoglycemia in mice as a surrogate marker of ricin toxicosis. Comp. Med. 52:530-533. (Pubitemid 36091703)
-
(2002)
Comparative Medicine
, vol.52
, Issue.6
, pp. 530-533
-
-
Pincus, S.H.1
Eng, L.2
Cooke, C.L.3
Maddaloni, M.4
-
26
-
-
73449123743
-
A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin
-
Neal LM, O'Hara J, Brey RN, III, Mantis NJ. 2010. A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin. Infect. Immun. 78:552-561.
-
(2010)
Infect. Immun.
, vol.78
, pp. 552-561
-
-
Neal, L.M.1
O'Hara, J.2
Brey III, R.N.3
Mantis, N.J.4
-
27
-
-
84877146713
-
Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen
-
Thomas JC, O'Hara JM, Hu L, Gao FP, Joshi SB, Volkin DB, Brey RN, Fang J, Karanicolas J, Mantis NJ, Middaugh CR. 2013. Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen. Hum. Vaccin. Immunother. 9:740-748.
-
(2013)
Hum. Vaccin. Immunother.
, vol.9
, pp. 740-748
-
-
Thomas, J.C.1
O'Hara, J.M.2
Hu, L.3
Gao, F.P.4
Joshi, S.B.5
Volkin, D.B.6
Brey, R.N.7
Fang, J.8
Karanicolas, J.9
Mantis, N.J.10
Middaugh, C.R.11
-
28
-
-
35348968868
-
Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation
-
DOI 10.1586/14760584.6.5.685
-
Hem SL, Hogenesch H. 2007. Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. Expert Rev. Vaccines 6:685-698. (Pubitemid 47607846)
-
(2007)
Expert Review of Vaccines
, vol.6
, Issue.5
, pp. 685-698
-
-
Hem, S.L.1
Hogenesch, H.2
-
29
-
-
77954762107
-
Preformulation studies: The next advance in aluminum adjuvant-containing vaccines
-
Hem SL, HogenEsch H, Middaugh CR, Volkin DB. 2010. Preformulation studies: the next advance in aluminum adjuvant-containing vaccines. Vaccine 28:4868-4870.
-
(2010)
Vaccine
, vol.28
, pp. 4868-4870
-
-
Hem, S.L.1
HogenEsch, H.2
Middaugh, C.R.3
Volkin, D.B.4
-
30
-
-
84865988677
-
Structural and immunological analysis of anthrax recombinant protective antigen adsorbed to aluminum hydroxide adjuvant
-
Wagner L, Verma A, Meade BD, Reiter K, Narum DL, Brady RA, Little SF, Burns DL. 2012. Structural and immunological analysis of anthrax recombinant protective antigen adsorbed to aluminum hydroxide adjuvant. Clin. Vaccine Immunol. 19:1465-1473.
-
(2012)
Clin. Vaccine Immunol.
, vol.19
, pp. 1465-1473
-
-
Wagner, L.1
Verma, A.2
Meade, B.D.3
Reiter, K.4
Narum, D.L.5
Brady, R.A.6
Little, S.F.7
Burns, D.L.8
-
31
-
-
0028102678
-
Identification and characterization of a monoclonal antibody that neutralizes ricin toxicity in vitro and in vivo
-
Lemley PV, Amanatides P, Wright DC. 1994. Identification and characterization of a monoclonal antibody that neutralizes ricin toxicity in vitro and in vivo. Hybridoma 13:417-421. (Pubitemid 24351544)
-
(1994)
Hybridoma
, vol.13
, Issue.5
, pp. 417-421
-
-
Lemley, P.V.1
Amanatides, P.2
Wright, D.C.3
-
32
-
-
84864055517
-
Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant alpha-helix in ricin toxin's enzymatic subunit
-
Vance DJ, Mantis NJ. 2012. Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant alpha-helix in ricin toxin's enzymatic subunit. Toxicon 60:874-877.
-
(2012)
Toxicon
, vol.60
, pp. 874-877
-
-
Vance, D.J.1
Mantis, N.J.2
-
33
-
-
79952467216
-
Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen
-
Compton JR, Legler PM, Clingan BV, Olson MA, Millard CB. 2011. Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen. Proteins 79:1048-1060.
-
(2011)
Proteins
, vol.79
, pp. 1048-1060
-
-
Compton, J.R.1
Legler, P.M.2
Clingan, B.V.3
Olson, M.A.4
Millard, C.B.5
-
34
-
-
80052625909
-
Structure of RiVax: A recombinant ricin vaccine
-
Legler PM, Brey RN, Smallshaw JE, Vitetta ES, Millard CB. 2011. Structure of RiVax: a recombinant ricin vaccine. Acta Crystallogr. D Biol. Crystallogr. 67:826-830.
-
(2011)
Acta Crystallogr. D Biol. Crystallogr.
, vol.67
, pp. 826-830
-
-
Legler, P.M.1
Brey, R.N.2
Smallshaw, J.E.3
Vitetta, E.S.4
Millard, C.B.5
|