Prevention and treatment of Clostridium perfringens epsilon toxin intoxication in mice with a neutralizing monoclonal antibody (c4D7) produced in Nicotiana benthamiana

Toxicon

Volumn 88, Issue , 2014, Pages 93-98

  Garcia, J P ^a   Beingesser, J ^a   Bohorov, O ^b   Bohorova, N ^b   Goodman, C ^b   Kim, D ^b   Pauly, M ^b   Velasco, J ^b   Whaley, K ^b   Zeitlin, L ^b   Roy, C J ^c   Uzal, F A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Mapp Biopharmaceutical Inc   (United States)

^c TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

Epsilon toxin; Monoclonal antibody; Nicotiana benthamiana; Preventive; Therapeutic

Indexed keywords

BACTERIAL TOXIN; EPSILON TOXIN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C4D7; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CLOSTRIDIUM PERFRINGENS EPSILON-TOXIN; CYTOKINE; NEUTRALIZING ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; INTOXICATION; LD 50; LETHALITY; MALE; MOUSE; NICOTIANA BENTHAMIANA; NONHUMAN; PASSIVE IMMUNIZATION; PILOT STUDY; POST EXPOSURE PROPHYLAXIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SINGLE DRUG DOSE; TREATMENT OUTCOME; TREATMENT RESPONSE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; GENETICS; IMMUNOLOGY; LD50; TOBACCO;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; BACTERIAL TOXINS; CYTOKINES; FEMALE; LETHAL DOSE 50; MALE; MICE; MICE, INBRED BALB C; TOBACCO;

EID: 84903950099     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2014.06.012     Document Type: Article

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