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Volumn 8, Issue SEP, 2014, Pages

Synapses as therapeutic targets for autism spectrum disorders: An international symposium held in pavia on July 4th, 2014

Author keywords

Animal models; ASDs; GABAergic signaling; Synapse; Therapeutic target

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CHROMOSOME22; DOUBLECORTIN; FRAGILE X MENTAL RETARDATION PROTEIN; INITIATION FACTOR 4E; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; METABOTROPIC RECEPTOR 5; METHYL CPG BINDING PROTEIN 2; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLIGIN; PARVALBUMIN; PROTEIN HOMER; RAPAMYCIN; RNA BINDING PROTEIN; TUBERIN; UNCLASSIFIED DRUG;

EID: 84907521823     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00309     Document Type: Article
Times cited : (9)

References (31)
  • 1
    • 79251590532 scopus 로고    scopus 로고
    • Theta-burst transcranial magnetic stimulation alters cortical inhibition
    • Benali, A., Trippe, J., Weiler, E., Mix, A., Petrasch-Parwez, E., Girzalsky, W., et al. (2011). Theta-burst transcranial magnetic stimulation alters cortical inhibition. J. Neurosci. 31, 1193–1203. doi:10.1523/JNEUROSCI.1379-10.2011
    • (2011) J. Neurosci , vol.31 , pp. 1193-1203
    • Benali, A.1    Trippe, J.2    Weiler, E.3    Mix, A.4    Petrasch-Parwez, E.5    Girzalsky, W.6
  • 2
    • 56349132711 scopus 로고    scopus 로고
    • Neuro-archaeology:Pre-symptomatic architecture and signature of neurological disorders
    • Ben-Ari, Y.(2008). Neuro-archaeology:pre-symptomatic architecture and signature of neurological disorders. Trends Neurosci. 31, 626–636. doi:10.1016/j.tins.2008.09.002
    • (2008) Trends Neurosci , vol.31 , pp. 626-636
    • Ben-Ari, Y.1
  • 3
    • 84866681617 scopus 로고    scopus 로고
    • The GABA excitatory/inhibitory shift in brain maturation and neurological disorders
    • Ben-Ari, Y., Khalilov, I., Kahle, K. T., and Cherubini, E. (2012). The GABA excitatory/inhibitory shift in brain maturation and neurological disorders. Neurosci-entist. 18, 467–486. doi:10.1177/1073858412438697
    • (2012) Neurosci-entist , vol.18 , pp. 467-486
    • Ben-Ari, Y.1    Khalilov, I.2    Kahle, K.T.3    Cherubini, E.4
  • 4
    • 77958168574 scopus 로고    scopus 로고
    • Phenotypic checkpoints regulate neuronal development
    • Ben-Ari, Y., and Spitzer, N. C. (2010). Phenotypic checkpoints regulate neuronal development. Trends Neurosci. 33, 485–492. doi:10.1016/j.tins.2010.08.005
    • (2010) Trends Neurosci , vol.33 , pp. 485-492
    • Ben-Ari, Y.1    Spitzer, N.C.2
  • 6
    • 84864027269 scopus 로고    scopus 로고
    • Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice
    • Brielmaier, J., Matteson, P. G., Silverman, J. L., Senerth, J. M., Kelly, S., Genes-tine, M., et al. (2012). Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice. PLoS ONE 7:e40914. doi:10.1371/journal.pone.0040914
    • (2012) PLoS ONE , vol.7
    • Brielmaier, J.1    Matteson, P.G.2    Silverman, J.L.3    Senerth, J.M.4    Kelly, S.5    Genes-Tine, M.6
  • 7
    • 33748170724 scopus 로고    scopus 로고
    • Neuropathological and genetic findings in autism: The significance of a putative mini columnopathy
    • Casanova, M. F. (2006). Neuropathological and genetic findings in autism: the significance of a putative mini columnopathy. Neuroscientist. 12, 435–441. doi:10.1177/1073858406290375
    • (2006) Neuroscientist , vol.12 , pp. 435-441
    • Casanova, M.F.1
  • 8
    • 85002674056 scopus 로고    scopus 로고
    • Reduced inhibitory gate in the barrel cortex of neuroligin3 R451C knock-in mice, an animal model of autism spectrum disorders
    • Cellot, G., and Cherubini, E. (2014). Reduced inhibitory gate in the barrel cortex of neuroligin3 R451C knock-in mice, an animal model of autism spectrum disorders. Physiol. Rep. 2, e12070. doi:10.14814/phy2.12077
    • (2014) Physiol. Rep , vol.2
    • Cellot, G.1    Cherubini, E.2
  • 9
    • 78149431869 scopus 로고    scopus 로고
    • Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
    • Chao, H. T., Chen, H., Samaco, R. C., Xue, M., Chahrour, M., Yoo, J., et al. (2010). Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature 468, 263–269. doi:10.1038/nature09582
    • (2010) Nature , vol.468 , pp. 263-269
    • Chao, H.T.1    Chen, H.2    Samaco, R.C.3    Xue, M.4    Chahrour, M.5    Yoo, J.6
  • 10
    • 34748831111 scopus 로고    scopus 로고
    • MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number
    • Chao, H. T., Zoghbi, H. Y., and Rosenmund, C. (2007). MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number. Neuron 56, 58–65. doi:10.1016/j.neuron.2007.08.018
    • (2007) Neuron , vol.56 , pp. 58-65
    • Chao, H.T.1    Zoghbi, H.Y.2    Rosenmund, C.3
  • 11
    • 77954403744 scopus 로고    scopus 로고
    • Autism spectrum disorders in tuberous sclerosis: Pathogenic pathways and implications for treatment
    • Curatolo, P., Napolioni, V., and Moavero, R. (2010). Autism spectrum disorders in tuberous sclerosis: pathogenic pathways and implications for treatment. J. Child Neurol. 25, 873–880. doi:10.1177/0883073810361789
    • (2010) J. Child Neurol , vol.25 , pp. 873-880
    • Curatolo, P.1    Napolioni, V.2    Moavero, R.3
  • 12
    • 84909978372 scopus 로고    scopus 로고
    • Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with intellectual disability and autism
    • D’Antoni, S., Spatuzza, M., Bonaccorso, C. M., Musumeci, S. A., Ciranna, L., Nico-letti, F., et al. (2014). Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with intellectual disability and autism. Neurosci. Biobehav. Rev. doi:10.1016/j.neubiorev.2014.02.003
    • (2014) Neurosci. Biobehav. Rev
    • D’antoni, S.1    Spatuzza, M.2    Bonaccorso, C.M.3    Musumeci, S.A.4    Ciranna, L.5    Nico-Letti, F.6
  • 13
    • 84877336575 scopus 로고    scopus 로고
    • Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling
    • Földy, C., Malenka, R. C., and Südhof, T. C. (2013). Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron 78, 498–509. doi:10.1016/j.neuron.2013.02.036
    • (2013) Neuron , vol.78 , pp. 498-509
    • Földy, C.1    Malenka, R.C.2    Südhof, T.C.3
  • 14
    • 33846921789 scopus 로고    scopus 로고
    • Autism spectrum disorders: Developmental disconnection syndromes
    • Geschwind, D. H., and Levitt, P. (2007). Autism spectrum disorders: developmental disconnection syndromes. Curr. Opin. Neurobiol. 17, 103–111. doi:10.1016/j.conb.2007.01.009
    • (2007) Curr. Opin. Neurobiol , vol.17 , pp. 103-111
    • Geschwind, D.H.1    Levitt, P.2
  • 15
    • 25644434915 scopus 로고    scopus 로고
    • Areducednumberofmetabotropicglutamate subtype 5 receptors are associated with constitutive Homer proteins in a mouse model of fragile X syndrome
    • Giuffrida, R., Musumeci, S., D’Antoni, S., Bonaccorso, C. M., Giuffrida-Stella, A. M., Oostra, B.A., et al.(2005).Areducednumberofmetabotropicglutamate subtype 5 receptors are associated with constitutive Homer proteins in a mouse model of fragile X syndrome. J. Neurosci. 25, 8908–8916. doi:10.1523/JNEUROSCI.0932-05.2005
    • (2005) J. Neurosci , vol.25 , pp. 8908-8916
    • Giuffrida, R.1    Musumeci, S.2    D’antoni, S.3    Bonaccorso, C.M.4    Giuffrida-Stella, A.M.5    Oostra, B.A.6
  • 16
    • 78049510406 scopus 로고    scopus 로고
    • Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2
    • Giza, J., Urbanski, M. J., Prestori, F., Bandyopadhyay, B., Yam, A., Friedrich, V., et al. (2010). Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2. J. Neurosci. 30, 14805–14816. doi:10.1523/JNEUROSCI.1161-10.2010
    • (2010) J. Neurosci , vol.30 , pp. 14805-14816
    • Giza, J.1    Urbanski, M.J.2    Prestori, F.3    Bandyopadhyay, B.4    Yam, A.5    Friedrich, V.6
  • 17
    • 77956467119 scopus 로고    scopus 로고
    • Reversal of plasticity-like effects in the human motor cortex
    • Huang, Y. Z., Rothwell, J. C., Lu, C. S., Chuang, W. L., Lin, W. Y., and Chen, R. S. (2010). Reversal of plasticity-like effects in the human motor cortex. J. Physiol. 588, 3683–3693. doi:10.1113/jphysiol.2010.191361
    • (2010) J. Physiol , vol.588 , pp. 3683-3693
    • Huang, Y.Z.1    Rothwell, J.C.2    Lu, C.S.3    Chuang, W.L.4    Lin, W.Y.5    Chen, R.S.6
  • 18
    • 84871770774 scopus 로고    scopus 로고
    • A randomised controlled trial of bumetanide in the treatment of autism in children
    • Lemonnier, E., Degrez, C., Phelep, M., Tyzio, R., Josse, F., Grandgeorge, M., et al. (2012). A randomised controlled trial of bumetanide in the treatment of autism in children. Transl. Psychiatry 2, e202. doi:10.1038/tp.2012.124
    • (2012) Transl. Psychiatry , vol.2
    • Lemonnier, E.1    Degrez, C.2    Phelep, M.3    Tyzio, R.4    Josse, F.5    Grandgeorge, M.6
  • 19
    • 58549101513 scopus 로고    scopus 로고
    • Autistic phenotypes and genetic testing: State-of-the-art for the clinical geneticist
    • Lintas, C., and Persico, A. M. (2009). Autistic phenotypes and genetic testing: state-of-the-art for the clinical geneticist. J. Med. Genet. 46, 1–8. doi:10.1136/jmg.2008.060871
    • (2009) J. Med. Genet , vol.46 , pp. 1-8
    • Lintas, C.1    Persico, A.M.2
  • 20
    • 84866364334 scopus 로고    scopus 로고
    • Abnormal modulation of corticospinal excitability in adults with Asperger’s syndrome
    • Oberman, L., Eldaief, M., Fecteau, S., Ifert-Miller, F., Tormos, J. M., and Pascual-Leone, A. (2012). Abnormal modulation of corticospinal excitability in adults with Asperger’s syndrome. Eur. J. Neurosci. 36, 2782–2788. doi:10.1111/j.1460-9568.2012.08172.x
    • (2012) Eur. J. Neurosci , vol.36 , pp. 2782-2788
    • Oberman, L.1    Eldaief, M.2    Fecteau, S.3    Ifert-Miller, F.4    Tormos, J.M.5    Pascual-Leone, A.6
  • 21
    • 79951677784 scopus 로고    scopus 로고
    • Transcranial magnetic stimulation provides means to assess cortical plasticity and excitability in humans with fragile X syndrome and autism spectrum disorder. Front
    • Oberman, L., Ifert-Miller, F., Najib, U., Bashir, S., Woollacott, I., Gonzalez-Heydrich, J., et al. (2010). Transcranial magnetic stimulation provides means to assess cortical plasticity and excitability in humans with fragile X syndrome and autism spectrum disorder. Front. Synaptic Neurosci. 2:26. doi:10.3389/fnsyn.2010.00026
    • (2010) Synaptic Neurosci , vol.2 , pp. 26
    • Oberman, L.1    Ifert-Miller, F.2    Najib, U.3    Bashir, S.4    Woollacott, I.5    Gonzalez-Heydrich, J.6
  • 22
    • 84905561175 scopus 로고    scopus 로고
    • Use of transcranial magnetic stimulationinautism spectrum disorders
    • Epub ahead or print
    • Oberman, L. M., Rotenberg, A., and Pascual-Leone, A. (2013). Use of transcranial magnetic stimulationinautism spectrum disorders.J. AutismDev. Disord. [Epub ahead or print].
    • (2013) J. AutismDev. Disord
    • Oberman, L.M.1    Rotenberg, A.2    Pascual-Leone, A.3
  • 23
    • 84907493959 scopus 로고    scopus 로고
    • Hippocampal dysregulation of neurofibromin-dependent pathways is associated with impaired spatial learning in engrailed 2 knockout mice
    • in press
    • Provenzano, G., Pangrazzi, L., Poli, A., Sgadò, P., Genovesi, S., Zunino, G., et al. (2014). Hippocampal dysregulation of neurofibromin-dependent pathways is associated with impaired spatial learning in engrailed 2 knockout mice. J. Neu-rosci. (in press).
    • (2014) J. Neu-rosci
    • Provenzano, G.1    Pangrazzi, L.2    Poli, A.3    Sgadò, P.4    Genovesi, S.5    Zunino, G.6
  • 24
    • 84862777306 scopus 로고    scopus 로고
    • Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome
    • Ronesi, J. A., Collins, K. A., Hays, S. A., Tsai, N. P., Guo, W., Birnbaum, S. G., et al. (2012). Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nat. Neurosci. 15, 431–440. doi:10.1038/nn.3033
    • (2012) Nat. Neurosci , vol.15 , pp. 431-440
    • Ronesi, J.A.1    Collins, K.A.2    Hays, S.A.3    Tsai, N.P.4    Guo, W.5    Birnbaum, S.G.6
  • 25
    • 84871765155 scopus 로고    scopus 로고
    • Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex
    • Sato, A., Kasai, S., Kobayashi, T., Takamatsu, Y., Hino, O., Ikeda, K., et al. (2012). Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex. Nat. Commun. 3, 1292. doi:10.1038/ncomms2295
    • (2012) Nat. Commun , vol.3 , pp. 1292
    • Sato, A.1    Kasai, S.2    Kobayashi, T.3    Takamatsu, Y.4    Hino, O.5    Ikeda, K.6
  • 26
    • 84881378088 scopus 로고    scopus 로고
    • Loss of GABAergic neurons in the hippocampus and cerebral cortex of engrailed-2 null mutant mice: implications for autism spectrum disorders
    • Sgadò, P., Genovesi, S., Kalinovsky, A., Zunino, G., Macchi, F., Allegra, M., et al. (2013a). Loss of GABAergic neurons in the hippocampus and cerebral cortex of engrailed-2 null mutant mice: implications for autism spectrum disorders. Exp. Neurol. 247, 496–505. doi:10.1016/j.expneurol.2013.01.021
    • (2013) Exp. Neurol , vol.247 , pp. 496-505
    • Sgadò, P.1    Genovesi, S.2    Kalinovsky, A.3    Zunino, G.4    Macchi, F.5    Allegra, M.6
  • 27
    • 84890376069 scopus 로고    scopus 로고
    • Transcriptome profiling in engrailed2 knockout mice reveals common molecular pathways associated with ASD
    • Sgadò, P., Provenzano, G., Dassi, E., Adami, V., Zunino, G., Genovesi, S., et al. (2013b). Transcriptome profiling in engrailed2 knockout mice reveals common molecular pathways associated with ASD. Mol. Autism 4, 51. doi:10.1186/2040-2392-4-51
    • (2013) Mol. Autism , vol.4 , pp. 51
    • Sgadò, P.1    Provenzano, G.2    Dassi, E.3    Adami, V.4    Zunino, G.5    Genovesi, S.6
  • 28
    • 54049091941 scopus 로고    scopus 로고
    • Neuroligins and neurexins link synaptic function to cognitive disease
    • Südhof, T. C. (2008). Neuroligins and neurexins link synaptic function to cognitive disease. Nature 455, 903–911. doi:10.1038/nature07456
    • (2008) Nature , vol.455 , pp. 903-911
    • Südhof, T.C.1
  • 29
    • 35148858044 scopus 로고    scopus 로고
    • A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
    • Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M., et al. (2007). A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science 318, 71–76. doi:10.1126/science.1146221
    • (2007) Science , vol.318 , pp. 71-76
    • Tabuchi, K.1    Blundell, J.2    Etherton, M.R.3    Hammer, R.E.4    Liu, X.5    Powell, C.M.6
  • 30
    • 84865508373 scopus 로고    scopus 로고
    • Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice
    • Tsai, P. T., Hull, C., Chu, Y., Greene-Colozzi, E., Sadowski, A. R., Leech, J. M., et al. (2012). Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature 488, 647–651. doi:10.1038/nature11310
    • (2012) Nature , vol.488 , pp. 647-651
    • Tsai, P.T.1    Hull, C.2    Chu, Y.3    Greene-Colozzi, E.4    Sadowski, A.R.5    Leech, J.M.6
  • 31
    • 84893640636 scopus 로고    scopus 로고
    • Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring
    • Tyzio, R., Nardou, R., Ferrari, D. C., Tsintsadze, T., Shahrokhi, A., Eftekhari, S., et al. (2014). Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. Science 343, 675–679. doi:10.1126/science.1247190
    • (2014) Science , vol.343 , pp. 675-679
    • Tyzio, R.1    Nardou, R.2    Ferrari, D.C.3    Tsintsadze, T.4    Shahrokhi, A.5    Eftekhari, S.6


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