Negative regulation of Grb10 interacting GYF protein 2 on insulin-like growth factor-1 receptor signaling pathway caused diabetic mice cognitive impairment

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Xie, Jing ^a   Wei, Qianping ^a   Deng, Huacong ^a   Li, Gang ^b   Ma, Lingli ^a   Zeng, Hui ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b SHANDONG MENTAL HEALTH CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 10; GYF PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; CARRIER PROTEIN; GIGYF2 PROTEIN, MOUSE; GRB10 PROTEIN, MOUSE; PROTEIN KINASE B; SMALL INTERFERING RNA; SOMATOMEDIN RECEPTOR; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DOWN REGULATION; DOWNSTREAM PROCESSING; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MORRIS WATER MAZE TEST; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; STEREOTAXIC SURGERY; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; COGNITION; COGNITION DISORDERS; COMPLICATION; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENE THERAPY; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; CARRIER PROTEINS; COGNITION; COGNITION DISORDERS; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION; GENETIC THERAPY; GRB10 ADAPTOR PROTEIN; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, SOMATOMEDIN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STREPTOZOCIN;

EID: 84907485584     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108559     Document Type: Article

References (54)

1. Northam EA, Rankins D, Cameron FJ (2006) Therapy insight: the impact of type 1 diabetes on brain development and function. Nat Clin Pract Neurol 2:78-86.
2. Brismar T, Maurex L, Cooray G, Juntti BL, Lindstrom P, et al. (2007) Predictors of cognitive impairment in type 1 diabetes. Psychoneuroendocrino 32: 041-051.
3. Åberg ND, Brywe KG, Isgaard J (2006) Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. Sci World J 6: 53-80.
4. D'Ercole AJ, Ye P (2008) Expanding the mind: insulin-like growth factor I and brain development. Endocrinology 149: 5958-5962.
5. Aleman A, Torres AI (2009) Circulating insulin-like growth factor I and cognitive function: neuromodulation throughout the lifespan. Prog Neurobiol 89: 256-265.
6. Lupien SB, Bluhm EJ, Ishii DN (2003) Systemic Insulin-Like Growth Factor-I Administration Prevents Cognitive Impairment in Diabetic Rats, and Brain IGF Regulates Learning/Memory in Normal Adult Rats. J Neurosci Res 74: 512-523.
7. Kooijman R (2006) Regulation of apoptosis by insulin-like growth factor (IGF)-I. Cytokine Growth F R 17: 305-323.
8. Efstratiadis A (1998) Genetics of mouse growth. Int J Dev Biol 42: 955-976.
9. Dufresne AM, Smith BJ (2005) The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling. Endocrinology 146:4399-4409.
10. Langlais P, Dong LQ, Ramos FJ, Flu D, Li Y, et al. (2004) Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10. Mol Endocrinol 18: 350-358.
11. Stein EG, Gustafson TA, Hubbard SR (2001) The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors. FEBS Letters 493: 106-111.
12. Mori K, Giovannone B, Smith BJ (2005) Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling. Mol Cell Endocrinol 230: 39-50.
13. Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland KA, et al. (2003) Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem 278: 31564-31573.
14. Giovannone B, Tsiaras WG, Monte S, Klysik J, Lautier C, et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet 18: 4629-4639.
15. Higashi S, Iseki E, Minegishi M, Togo T, Kabuta T, et al. (2010) GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF1-induced ERK1/2 activation. J Neurochem 115: 423-437.
16. Lautier C, Goldwurm S, Durr A, Giovannone B, Tsiaras WG, et al. (2008) Mutations in the GIGYF2(TNRC15) Gene at the PARK11 Locus in Familial Parkinson Disease. Hum Gene 82: 822 -833.
17. Guella I, Pistocchi A, Asselta R, Rimoldi V, Ghilardi A, et al. (2011) Mutational screening and zebrafish functional analysis of GIGYF2 as a Parkinson-disease gene. Neurobiol Aging 32: 1994-2005.
18. Wang L, Guo JF, Zhang WW, Xu Q, Zuo X, et al. (2011) Follow-up study of variants of the GIGYF2 gene in Chinese patients with Parkinson's disease. J Clin Neurosci 18: 1699-1701.
19. Ma L, Wei Q, Deng H, Zhang Q, Li G, et al. (2013) Growth Factor Receptor-Bound Protein 10-Mediated Negative Regulation of the Insulin-Like Growth Factor-1 Receptor-Activated Signalling Pathway Results in Cognitive Disorder in Diabetic Rats. J Neuroendocrinol 25: 626-634.
20. Saenger S, Goeldner C, Frey JR, Ozmen L, Ostrowitzki S, et al. (2011) PEGylation enhances the therapeutic potential for insulin-like growth factor I in central nervous system disorders. Growth Horm IGF Res 21: 292-303.
21. Guo J, Yu CY, Li HZ,Liu FF, Feng R, et al. (2010) Impaired neural stem/ progenitor cell proliferation in streptozotocin-induced and spontaneous diabetic mice. Neurosci Res 68: 329-336.
22. Heiser WC (2004) Gene delivery to mammalian cells. Methods in Molecular Biology 246.
23. Jessberger S, Clark RE, Broadbent NJ, Clemenson GD Jr, Consiglio A, et al. (2009) Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem 16: 147-154.
24. Ansaloni S, Lelkes N, Snyder J, Epstein C, Dubey A, et al. (2010) A streamlined sub-cloning procedure to transfer shRNA from a pSM2 vector to a pGIPZ lentiviral vector. J RNAi Gene Silencing 6: 411- 415.
25. Paxinos G, Franklin KBJ (2001) The Mouse Brain in stereotaxic Coordinates. Second edn. San Diego, CA: Academic Press.
26. Luikart BW, Schnell E, Washburn EK, Bensen AL, Tovar ICR, et al. (2011) Pten Knockdown In Vivo Increases Excitatory Drive onto Dentate Granule Cells. J Neurosci 31: 4345-4354.
27. Barron AM, Verdile G, Taddei K, Bates KA, Martins RN (2010) Effect of chronic hCG administration on Alzheimer's-related cognition and A beta accumulation in PS1KI mice. Endocrinology 151: 5380-5388.
28. Gupta R, Gupta LK, Mediratta PK, Bhattacharya SK (2012) Effect of resveratrol on scopolamine-induced cognitive impairment in mice. Pharmacol Rep 64: 438-444.
29. Maurice T, Lockhart BP, Privat A (1996) Amnesia induced in mice by centrally administered-amyloid peptides involves cholinergic dysfunction. Brain Res 706: 181-193.
30. Vorhees CV, Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2: 848-858.
31. Pleil KE, Glenn MJ, Williams CL (2011) Estradiol alters Fos-immunoreactivity in the hippocampus and dorsal striatum during place and response learning in middle-aged but not young adult female rats. Endocrinology 152: 946-956.
32. Zhou L, Fester L, Blittersdorff B, Hassu B, Nogens H, et al. (2010) Aromatase inhibitors induce spine synapse loss in the hippocampus of ovariectomized mice. Endocrinology 151: 1153-1160.
33. Shen L, Zhang L, Huang H, Liu H, Nan Y, et al. (2000) A computeraided analysis system for counting the synaptic numerical density based on disector technique. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 17: 167-169.
34. Colley BS, Cavallin MA, Biju K, Marks DR, Fadool DA (2009) Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc. BMC Neurosci 10: 8.
35. Mu Y, Gage FH (2011) Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener 6: 85.
36. Alvarez EO, Beauquis J, Revsin Y, Banzan MA, Roig P, et al. (2009) Cognitive dysfunction and hippocampal changes in experimental type 1 diabetes. Behav Brain Res 198: 224-230.
37. Orduna V, Hong E, Bouzas A (2011) Timing behavior in streptozotocin-induced diabetic rats. Behav Brain Res 224: 189-194.
38. Baserga R, Sell C, Porcu P, Rubini M (1994) The role of the IGF-I receptor in the growth and transformation of mammalian cells. Cell Prolif 27: 63-71.
39. Huang Y, Harrison MR, Osorio A, Kim J, Baugh A, et al. (2013) Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration. PLoS One 8: e67266.
40. Guaico E, Wang JY, Valle LD, Urbanska K, Peruzzi F, et al. (2009) IGF-IR in neuroprotection and brain tumors. Front Biosci 14: 352-375.
41. Lupien SB, Bluhm EJ, Ishii DN (2003) Systemic insulin-like growth factor-I administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats. J Neurosci Res 74: 512-523.
42. Hashizume K (2013) Endocrinological aspects of diabetes mellitus in the elderly. Nihon Rinsho 71(11): 1941-7.
43. Werner H, Leroith D (2014) Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects. Eur Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2014.01.020.
44. Freude S, Hettich MM, Schumann C, Stöhr O, Koch L, et al. (2009) Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. FASEB J 23: 3315-3324.
45. Moloney AM, Griffin RJ, Timmons S, O'Connor R, Ravid R, et al. (2010) Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol Aging 31: 224-243.
46. Zemva J, Schubert M (2011) Central insulin and insulin-like growth factor-1 signaling: implications for diabetes associated dementia. Curr Diabetes Rev 7:356-366.
47. Huang MH, Lai WP, Wong MS, Yang MS (2001) Effect of receptor phosphorylation on the binding between IRS-1 and IGF1R as revealed by surface Plasmon resonance biosensor. FEBS Lett 505: 31-36.
48. Landau D, Eshet R, Troib A, Gurman Y, Chen Y, et al. (2009) Increased renal Akt/mTOR and MAPK signaling in type I diabetes in the absence of IGF type 1 receptor activation. Endocrine 36(1): 126-134.
49. Yang SJ, Chen CY, Chang GD, Wen HC, Chen CY, et al. (2013) Activation of Akt by advanced glycation end products (AGEs): involvement of IGF-1 receptor and caveolin-1. PLoS One 8: e58100. doi: 10.1371/journal.pone.0058100.
50. Carson JP, Kulik G, Weber MJ (1999) Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3-kinase and Akt/protein kinase B. Cancer Res 59: 1449-1453.
51. Vecchione A, Marchese A, Henry P, Rotin D, Morrione A (2003) The Grb10/ Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol Cell Biol 23: 3363-3372.
52. Tsukuda S, Kusayanagi T, Umeda E, Watanabe C, Tosaki YT, et al. (2013) Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2. Bioorganic Med Chem 21: 311-320.
53. Duarte JM, Agostinho PM, Carvalho RA, Cunha RA (2012) Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcZNO10/LTJ mice. PLoS One 7: e21899. doi: 10.1371/journal.pone.0021899.
54. Popovic M, Biessels GJ, Isaacson RL, Gispen WH (2001) Learning and memory in streptozotocin-induced diabetic rats in a novel spatial/object discrimination task. Behav Brain Res 122: 201-207.