Study of distribution and biological effects of fullerene C60 after Single and Multiple Intragastrical Administrations to Rats

Fullerenes Nanotubes and Carbon Nanostructures

Volumn 23, Issue 7, 2015, Pages 658-668

  Hendrickson, Olga D ^a   Morozova, Olga V ^a   Zherdev, Anatoly V ^a   Yaropolov, Alexander I ^a   Klochkov, Sergey G ^b   Bachurin, Sergey O ^b   Dzantiev, Boris B ^a  

^a BACH INSTITUTE OF BIOCHEMISTRY   (Russian Federation)

^b INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

Author keywords

biodistribution; biological effects; fullerene C60; in vivo; intragastrical administration

Indexed keywords

BLOOD; RATS;

BIOCHEMICAL PARAMETERS; BIODISTRIBUTIONS; BIOLOGICAL EFFECTS; EXPERIMENTAL CONDITIONS; FULLERENE C60; FULLERENE NANOPARTICLES; IN-VIVO; STATISTICALLY SIGNIFICANT DIFFERENCE;

FULLERENES;

EID: 84907483805     PISSN: 1536383X     EISSN: 15364046     Source Type: Journal    
DOI: 10.1080/1536383X.2014.949695     Document Type: Article

References (43)

1. Schulte, P. A. and Salamanca-Buentello, F. (2007) Ethical and scientific issues of nanotechnology in the workplace. Environ. Health Perspect., 115: 5-12
2. Siegrist, M., Stampfli, N., Kastenholz, H., and Keller, C. (2008) Perceived risks and perceived benefits of different nanotechnology foods and nanotechnology food packaging. Appetite, 51: 283-290
3. Ray, P. C., Yu, H., and Fu, P. P. (2009) Toxicity and environmental risks of nanomaterials: Challenges and future needs. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev., 27: 1-35
4. Gajewicz, A., Rasulev, B., Dinadayalane, T. C., Urbaszek, P., Puzyn, T., Leszczynska, D., and Leszczynski, J. (2012) Advancing risk assessment of engineered nanomaterials: Application of computational approaches. Adv. Drug Deliv. Rev., 64: 1663-1693
5. Davis, J. M. (2013) A comprehensive environmental assessment approach to engineered nanomaterials. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 5: 139-149
6. Bouwmeester, H., Lynch, I., Marvin, H. J., Dawson, K. A., Berges, M., Braguer, D., Byrne, H. J., Casey, A., Chambers, G., Clift, M. J., Elia, G., Fernandes, T. F., Fjellsbo, L. B., Hatto, P., Juillerat, L., Klein, C., Kreyling, W. G., Nickel, C., Riediker, M., and Stone, V. (2011) Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices. Nanotoxicology, 5: 1-11
7. Peralta-Videa, J. R., Zhao, L., Lopez-Moreno, M. L., de la Rosa, G., Hong, J., and Gardea-Torresdey, J. L. (2011) Nanomaterials and the environment: A review for the biennium 2008-2010. J. Hazard Mater., 186: 1-15
8. Mashino, T., Nishikawa, D., Takahashi, K., Usui, N., Yamori, T., Seki, M., Endo, T., and Mochizuki, M. (2003) Antibacterial and antiproliferative activity of cationic fullerene derivatives. Bioorg. Med. Chem. Lett., 13: 4395-4397
9. Anilkumar, P., Lu, F., Cao, L., Luo, P. G., Liu, J. H., Sahu, S., Tackett, K. N., Wang, Y., and Sun YP. (2011) Fullerenes for applications in biology and medicine. Curr. Med. Chem., 18: 2045-2059
10. Meng, J., Liang, X., Chen, X., and Zhao, Y. (2013) Biological characterizations of [Gd@C82(OH)22]n nanoparticles as fullerene derivatives for cancer therapy. Integr. Biol. (Camb), 5: 43-47
11. Nielsen, G. D., Roursgaard, M., Jensen, K. A., Poulsen, S. S., and Larsen, S. T. (2008) In vivo biology and toxicology of fullerenes and their derivatives. Basic Clin. Pharmacol. Toxicol., 103: 197-208
12. Aschberger, K., Johnston, H. J., Stone, V., Aitken, R. J., Tran, C. L., Hankin, S. M., Peters, S. A., Christensen, F. M. (2010) Review of fullerene toxicity and exposure-appraisal of a human health risk assessment, based on open literature. Regul. Toxicol. Pharmacol., 58: 455-473
13. Johnston, H. J., Hutchison, G. R., Christensen, F. M., Aschberger, K., and Stone, V. (2010) The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicity. Toxicol. Sci., 114: 162-182
14. Trpkovic, A., Todorovic-Markovic, B., and Trajkovic, V. (2012) Toxicity of pristine versus functionalized fullerenes: Mechanisms of cell damage and the role of oxidative stress. Arch. Toxicol. 86: 1809-1827
15. Tsuchiya, T., Oguri, I., Yamakoshi, Y. N., and Miyata, N. (1996) Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo. FEBS Lett., 393: 139-145
16. Chen, H. H., Yu, C., Ueng, T. H., Chen, S., Chen, B. J., Huang, K. J., and Chiang, L. Y. (1998) Acute and subacute toxicity study of water-soluble polyalkylsulfonated C60 in rats. Toxicol. Pathol., 26: 143-151
17. Xu, J. Y., Han, K., Li, S. X., Cheng, J. S., Xu, G. T., Li, W. X., and Li, Q. N. (2009) Pulmonary responses to polyhydroxylated fullerenols, C(60)(OH)(x). J. Appl. Toxicol., 29: 578-584
18. Ogami, A., Yamamoto, K., Morimoto, Y., Fujita, K., Hirohashi, M., Oyabu, T., Myojo, T., Nishi, K., Kadoya, C., Todoroki, M., Yamamoto, M., Murakami, M., Shimada, M., Wang, W. N., Shinohara, N., Endoh, S., Uchida, K., Nakanishi, J., and Tanaka, I. (2011) Pathological features of rat lung following inhalation and intratracheal instillation of C(60) fullerene. Inhal. Toxicol., 23: 407-416
19. Ema, M., Tanaka, J., Kobayashi, N., Naya, M., Endoh, S., Maru, J., Hosoi, M., Nagai, M., Nakajima, M., Hayashi, M., and Nakanishi, J. (2012) Genotoxicity evaluation of fullerene C60 nanoparticles in a comet assay using lung cells of intratracheally instilled rats. Regul. Toxicol. Pharmacol., 62: 419-424
20. Aoshima, H., Saitoh, Y., Ito, S., Yamana, S., and Miwa N. (2009) Safety evaluation of highly purified fullerenes (HPFs): Based on screening of eye and skin damage. J. Toxicol. Sci., 34: 555-562
21. Yah, C. S., Simate, G. S., and Iyuke, S. E. (2012) Nanoparticles toxicity and their routes of exposures. Pak. J. Pharm. Sci., 25: 477-491
22. Krusic, P. J., Wasserman, E., Keizer, P. N., Morton, J. R., and Preston K. F. (1991) Radical Reactions of C60. Science, 254: 1183-1185
23. Baati, T., Bourasset, F., Gharbi, N., Njim, L., Abderrabba, M., Kerkeni, A., Szwarc, H., and Moussa, F. (2012) The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene. Biomaterials, 19: 4936-4946
24. Andrievsky, G. V., Bruskov, V. I., Tykhomyrov, A. A., and Gudkov, S. V. (2009) Peculiarities of the antioxidant and radioprotective effects of hydrated C60 fullerene nanostuctures in vitro and in vivo. Free Radic Biol Med., 47: 786-793
25. Mori, T., Takada, H., Ito, S., Matsubayashi, K., Miwa, N., and Sawaguchi, T. (2006) Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis. Toxicology, 225: 48-54
26. Folkmann, J. K., Risom, L., Jacobsen, N. R., Wallin, H., Loft, S., and Moller, P. (2009) Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes. Environ. Health Perspect., 117: 703-708
27. Takahashi, M., Kato, H., Doi, Y., Hagiwara, A., Hirata-Koizumi, M., Ono, A., Kubota, R., Nishimura, T., and Hirose, A. (2012) Sub-acute oral toxicity study with fullerene C60 in rats. J. Toxicol. Sci., 37: 353-361
28. Shipelin, V. A., Avreneva, L. I., Guseva, G. V., Trushina, E. N., Mustafina, O. K., Selifanov, A. V., Soto, S. Kh., Maltsev, G. U., Gmoshinskii, I. V., and Khotimchenko, S. A. (2012) [Characterization of fullerene C60 peroral toxicity to rats in the 92-day experiment]. Vopr. Pitan., 81: 20-27
29. Yamashita, K., Yoshioka, Y., Pan, H., Taira, M., Ogura, T., Nagano, T., Aoyama, M., Nagano, K., Abe, Y., Kamada, H., Tsunoda, S. I., Aoshima, H., Nabeshi, H., Yoshikawa, T., and Tsutsumi, Y. (2013) Biochemical and hematologic effects of polyvinylpyrrolidone- wrapped fullerene C60 after oral administration. Pharmazie, 68: 54-57
30. Moussa, F., Pressac, M., Genin, E., Roux, S., Trivin, F., Rassat, A., Ceolin, R., and Szwarc, H. (1997) Quantitative analysis of C60 fullerene in blood and tissues by high-performance liquid chromatography with photodiode-array and mass spectrometric detection. J. Chromatogr. B Biomed. Sci. Appl., 696: 153-159
31. Petterino, C. and Argentino-Storino, A. (2006) Clinical chemistry and haematology historical data in control Sprague-Dawley rats from pre-clinical toxicity studies. Exp. Toxicol. Pathol., 57: 213-219
32. Nelson, M. A., Domann, F. E., Bowden, G. T., Hooser, S. B., Fernando, Q., and Carter, D. E. (1993) Effects of acute and subchronic exposure of topically applied fullerene extracts on the mouse skin. Toxicol. Ind. Health., 9: 623-630
33. Yamago, S., Tokuyama, H., Nakamura, E., Kikuchi, K., Kananishi, S., Sueki, K., Nakahara, H., Enomoto, S., and Ambe, F. (1995) In vivo biological behavior of a water-miscible fullerene: 14C labeling, absorption, distribution, excretion and acute toxicity. Chem. Biol. 2(6): 385-389
34. Baker, G. L., Gupta, A., Clark, M. L., Valenzuela, B. R., Staska, L. M., Harbo, S. J., Pierce, J. T., and Dill, J. A. (2008) Inhalation toxicity and lung toxicokinetics of C60 fullerene nanoparticles and microparticles. Toxicol. Sci., 101: 122-131
35. Gharbi, N., Pressac, M., Hadchouel, M., Szwarc, H., Wilson, S. R., and Moussa, F. (2005) [60]fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity. Nano Lett., 5: 2578-2585
36. Monteiro-Riviere, N. A., Linder, K. E., Inman, A. O., Saathoff, J. G., Xia, X. R., and Riviere, J. E. (2012) Lack of hydroxylated fullerene toxicity after intravenous administration to female Sprague- Dawley rats. J. Toxicol. Environ. Health A., 75: 367-373
37. Cataldo, F. and Da Ros, T. (2008) Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes, Springer: New York
38. Cataldo, F. and Braun, T. (2007) The solubility of C60 fullerene in long chain fatty acids esters. Fullerenes Nanotubes Carbon Nanostruct., 15: 331-339
39. Cataldo, F. (2009) On the solubility parameter of C60 and higher fullerenes. Fullerenes Nanotubes Carbon Nanostruct., 17: 79-84
40. Cataldo, F. (2010) Interaction of C(60) fullerene with lipids. Chem. Phys. Lipids, 163: 524-529
41. Bruce, R. D. An up-and-down procedure for acute toxicity testing. (1985) Fundam. Appl. Toxicol., 5: 151-157
42. OECD Guidelines for the Testing of Chemicals, Section 4, Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure. OECD Publishing: Paris
43. Carboni, A., Emke, E., Parsons, J. R., Kalbitz, K., and de Voogt. P. (2014) An analytical method for determination of fullerenes and functionalized fullerenes in soils with high performance liquid chromatography and UV detection. Anal. Chim. Acta., 807: 159-165