Assessment of nuclear transfer techniques to prevent the transmission of heritable mitochondrial disorders without compromising embryonic development competence in mice

Mitochondrion

Volumn 18, Issue , 2014, Pages 27-33

  Neupane, Jitesh ^a   Vandewoestyne, Mado ^b   Ghimire, Sabitri ^a   Lu, Yuechao ^a   Qian, Chen ^a   Van Coster, Rudy ^a   Gerris, Jan ^a   Deroo, Tom ^a   Deforce, Dieter ^b   de Sutter, Petra ^a   Heindryckx, Björn ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Embryonic development potential; Mitochondrial DNA (mtDNA); MtDNA carry over; Nuclear transfer (NT)

Indexed keywords

MITOCHONDRIAL DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLASTOCYST; BLASTOMA; CELL NUCLEUS TRANSPLANTATION; CHROMOSOME; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; EMBRYO GROWTH; EMBRYONAL TISSUE; FEMALE; GERM LINE; GERM LINE GENE THERAPY; GERMINAL VESICLE; IN VITRO OOCYTE MATURATION; INTERMETHOD COMPARISON; INTRACYTOPLASMIC SPERM INJECTION; MALE; METAPHASE; MICROMANIPULATION; MOUSE; MOUSE MODEL; NONHUMAN; OOCYTE; SPINDLE APPARATUS; ADVERSE EFFECTS; ANIMAL; CHEMISTRY; EVALUATION STUDY; MITOCHONDRIAL DISEASES; PHYSIOLOGY; PREGNANCY;

ANIMALS; BLASTOCYST; BLASTOMERES; DNA, MITOCHONDRIAL; EMBRYONIC DEVELOPMENT; FEMALE; MALE; MICE; MITOCHONDRIAL DISEASES; NUCLEAR TRANSFER TECHNIQUES; PREGNANCY;

EID: 84907465169     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2014.09.003     Document Type: Article

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