Preventing the transmission of pathogenic mitochondrial DNA mutations: Can we achieve long-term benefits from germ-line gene transfer?

Human Reproduction

Volumn 28, Issue 3, 2013, Pages 554-559

  Samuels, David C ^a   Wonnapinij, Passorn ^a,b,c   Chinnery, Patrick F ^d  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c KASETSART UNIVERSITY   (Thailand)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

gene therapy; germ line; mitochondria; mtDNA; prenatal diagnosis

Indexed keywords

MITOCHONDRIAL DNA;

ARTICLE; GENE MUTATION; GENE TRANSFER; GENETIC DRIFT; GERM LINE; HETEROPLASMY; HUMAN; MITOCHONDRIAL DNA DISORDER; MITOCHONDRIAL GENOME; NONHUMAN; RECURRENT DISEASE;

EID: 84874301669     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/des439     Document Type: Article

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