A systematic analysis of the suitability of preimplantation genetic diagnosis for mitochondrial diseases in a heteroplasmic mitochondrial mouse model

Human Reproduction

Volumn 29, Issue 4, 2014, Pages 852-859

  Neupane, Jitesh ^a   Vandewoestyne, Mado ^b   Heindryckx, Björn ^a   Ghimire, Sabitri ^a   Lu, Yuechao ^a   Qian, Chen ^a   Lierman, Sylvie ^a   Van Coster, Rudy ^a   Gerris, Jan ^a   Deroo, Tom ^a   Deforce, Dieter ^b   De Sutter, Petra ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Mitochondrial DNA; MtDNA disorders; MtDNA heteroplasmy; Preimplantation embryos; Preimplantation genetic diagnosis

Indexed keywords

MITOCHONDRIAL DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLASTOCYST; BLASTOMA; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; FEMALE; GENETIC SCREENING; HETEROPLASMIC MITOCHONDRIA; HETEROPLASMY; INTRACYTOPLASMIC SPERM INJECTION; MALE; METAPHASE; MOUSE; NONHUMAN; OOCYTE; POLAR BODY; POLYMERASE CHAIN REACTION; PREIMPLANTATION EMBRYO; PREIMPLANTATION GENETIC DIAGNOSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TROPHECTODERM; TROPHOBLAST; VALIDATION STUDY; ZYGOTE; ANIMAL; BAGG ALBINO MOUSE; CYTOLOGY; EVALUATION STUDY; GENETICS; MICROMANIPULATION; MITOCHONDRIAL DISEASES; PHYSIOLOGY; PRENATAL DIAGNOSIS; PROCEDURES;

ANIMALS; BLASTOMERES; MICE; MICE, INBRED BALB C; MICROMANIPULATION; MITOCHONDRIAL DISEASES; OOCYTES; PREIMPLANTATION DIAGNOSIS; ZYGOTE;

EID: 84899016624     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/deu016     Document Type: Article

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