Structural evidence of N6-isopentenyladenosine as a new ligand of farnesyl pyrophosphate synthase

Journal of Medicinal Chemistry

Volumn 57, Issue 18, 2014, Pages 7798-7803

  Scrima, Mario ^a   Lauro, Gianluigi ^a   Grimaldi, Manuela ^a   Di Marino, Sara ^b   Tosco, Alessandra ^a   Picardi, Paola ^a   Gazzerro, Patrizia ^a   Riccio, Raffaele ^a   Novellino, Ettore ^b   Bifulco, Maurizio ^a,c   Bifulco, Giuseppe ^a   D'Ursi, Anna Maria ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 N (3,3 DIMETHYLALLYL)ADENOSINE; FARNESYL PYROPHOSPHATE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; GERANYLTRANSFERASE; LIGAND;

ARTICLE; CHEMICAL ANALYSIS; DRUG PROTEIN BINDING; ENZYME STRUCTURE; INVERSE VIRTUAL SCREENING; NUCLEAR MAGNETIC RESONANCE; SATURATION TRANSFER DIFFERENCE; CHEMISTRY; DRUG SCREENING; HUMAN; METABOLISM; MOLECULAR DOCKING; PROTEIN CONFORMATION;

ANTINEOPLASTIC AGENTS; DRUG EVALUATION, PRECLINICAL; GERANYLTRANSTRANSFERASE; HUMANS; ISOPENTENYLADENOSINE; LIGANDS; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION;

EID: 84907457173     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500869x     Document Type: Article

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