N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation

FASEB Journal

Volumn 20, Issue 3, 2006, Pages 412-418

  Laezza, Chiara ^a,e   Notarnicola, Maria ^b   Caruso, Maria Gabriella ^b   Messa, Caterina ^b   Macchia, Marco ^c   Bertini, Simone ^c   Minutolo, Filippo ^c   Portella, Giuseppe ^d   Fiorentino, Laura ^e   Stingo, Stefania ^e   Bifulco, Maurizio ^e  

^a CNR   (Italy)

^b NATIONAL INSTITUTE FOR DIGESTIVE DISEASES   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF SALERNO   (Italy)

Author keywords

Cell growth; Isoprenoid pathway

Indexed keywords

6 N (3,3 DIMETHYLALLYL)ADENOSINE; ADENOSINE; ADENOSINE RECEPTOR; FARNESOL; FARNESYL DIPHOSPHATE; GERANYLTRANSFERASE; ISOPRENOID; LAMIN B; MEVALONIC ACID; ANTINEOPLASTIC AGENT; MEVINOLIN; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THYROID CELL; TUMOR CELL; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; CELL DIVISION; CELL LINE; CYTOLOGY; DRUG SCREENING; METABOLISM; PROTEIN PROCESSING; THYROID GLAND;

MUS MUSCULUS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE; CELL LINE, TRANSFORMED; DRUG SCREENING ASSAYS, ANTITUMOR; GERANYLTRANSTRANSFERASE; ISOPENTENYLADENOSINE; LOVASTATIN; MALE; MEVALONIC ACID; MICE; NEOPLASM PROTEINS; PROTEIN ISOPRENYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; THYROID GLAND;

EID: 33645831753     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-4044lsf     Document Type: Article

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