메뉴 건너뛰기




Volumn 51, Issue 5, 2014, Pages 291-304

Predictive markers in bladder cancer: Do we have molecular markers ready for clinical use?

Author keywords

Immunohistochemistry; Pathology; Statistical analysis; Urinary malignancy

Indexed keywords

ALPHA CATENIN; ANGIOGENIC FACTOR; BETA CATENIN; BIOLOGICAL MARKER; CASPASE 3; CYCLIN D1; CYCLIN E; CYCLIN E1; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EZRIN; FAS ANTIGEN; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; KI 67 ANTIGEN; MOLECULAR MARKER; NERVE CELL ADHESION MOLECULE; P CADHERIN; PLAKOGLOBIN; PROTEIN BCL 2; PROTEIN P21; PROTEIN P27; PROTEIN P53; RETINOBLASTOMA PROTEIN; SURVIVIN; THROMBOSPONDIN 1; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG; UVOMORULIN; VASCULOTROPIN C; VASCULOTROPIN D; TUMOR MARKER;

EID: 84907443662     PISSN: 10408363     EISSN: 1549781X     Source Type: Journal    
DOI: 10.3109/10408363.2014.930412     Document Type: Review
Times cited : (40)

References (247)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127: 2893-917.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 2
    • 36849068956 scopus 로고    scopus 로고
    • Declining mortality from bladder cancer in Europe
    • Ferlay J, Randi G, Bosetti C, et al. Declining mortality from bladder cancer in Europe. BJU Int 2008;101:11-9.
    • (2008) BJU Int , vol.101 , pp. 11-19
    • Ferlay, J.1    Randi, G.2    Bosetti, C.3
  • 3
    • 84876305104 scopus 로고    scopus 로고
    • Incidence, survival and mortality rates of stage-specific bladder cancer in United States: A trend analysis
    • Abdollah F, Gandaglia G, Thuret R, et al. Incidence, survival and mortality rates of stage-specific bladder cancer in United States: a trend analysis. Cancer Epidemiol 2013;37:219-25.
    • (2013) Cancer Epidemiol , vol.37 , pp. 219-225
    • Abdollah, F.1    Gandaglia, G.2    Thuret, R.3
  • 4
    • 0002054216 scopus 로고    scopus 로고
    • Urothelial tumors of the urinary tract
    • In: Walsh PC, Retik AB, Vaughan ED, Wein AJ, eds., 8th ed. Philadelphia: Saunders
    • Messing EM. Urothelial tumors of the urinary tract. In: Walsh PC, Retik AB, Vaughan ED, Wein AJ, eds. Cambell's Urology, 8th ed. Philadelphia: Saunders, 2004:2737.
    • (2004) Cambell's Urology , pp. 2737
    • Messing, E.M.1
  • 6
    • 63149176522 scopus 로고    scopus 로고
    • Cancer of the bladder, ureter, and renal pelvis
    • In: DeVita VT, Hellman S, Rosenberg SA, eds., 8th ed. Philadelphia: Lippincott Williams and Wilkins
    • McDougal WS, Shipley WU, Kaufman DS, et al. Cancer of the bladder, ureter, and renal pelvis. In: DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology, 8th ed. Philadelphia: Lippincott Williams and Wilkins, 2008:1358-84.
    • (2008) Cancer: Principles and Practice of Oncology , pp. 1358-1384
    • McDougal, W.S.1    Shipley, W.U.2    Kaufman, D.S.3
  • 7
    • 77953819013 scopus 로고    scopus 로고
    • Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium
    • Goebell PJ, Knowles MA. Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium. Urol Oncol 2010; 28: 409-28.
    • (2010) Urol Oncol , vol.28 , pp. 409-428
    • Goebell, P.J.1    Knowles, M.A.2
  • 9
    • 33748925553 scopus 로고    scopus 로고
    • Clinical model of lifetime cost of treating bladder cancer and associated complications
    • Avritscher EB, Cooksley CD, Grossman HB, et al. Clinical model of lifetime cost of treating bladder cancer and associated complications. Urology 2006; 68: 549-53.
    • (2006) Urology , vol.68 , pp. 549-553
    • Avritscher, E.B.1    Cooksley, C.D.2    Grossman, H.B.3
  • 10
    • 33750708944 scopus 로고    scopus 로고
    • Guidelines on Non-muscle Invasive Bladder Cancer (TaT1 and CIS)
    • last accessed 4 May 2014
    • Babjuk M, Burger M, Zigeuner R, et al. Guidelines on Non-muscle Invasive Bladder Cancer (TaT1 and CIS). European Association of Urology. 2013. Available from http://www.uroweb.org/gls/pdf/05-TaT1-Bladder-Cancer-LR.pdf [last accessed 4 May 2014].
    • (2013) European Association of Urology.
    • Babjuk, M.1    Burger, M.2    Zigeuner, R.3
  • 11
    • 84887291216 scopus 로고    scopus 로고
    • Guidelines on muscle-invasive and metastatic bladder Cancer
    • last accessed 4 May 2014
    • Witjes JA, Comperat E, Cowan NC, et al. Guidelines on Muscle- Invasive and Metastatic Bladder Cancer. European Association of Urology. 2013. Available from http://www.uroweb.org/gls/pdf/05-TaT1-Bladder-Cancer-LR.pdf [last accessed 4 May 2014].
    • (2013) European Association of Urology
    • Witjes, J.A.1    Comperat, E.2    Cowan, N.C.3
  • 12
    • 32944465832 scopus 로고    scopus 로고
    • Predicting recurrence and progression in individual patients with stage TaT1 bladder cancer using EORTC risk tables: A combined analysis of 2596 patients from seven EORTC trials
    • Sylvester RJ, van der Meijden AP, Oosterlinck W, et al. Predicting recurrence and progression in individual patients with stage TaT1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. Eur Urol 2006; 49: 466-77.
    • (2006) Eur Urol , vol.49 , pp. 466-477
    • Sylvester, R.J.1    Van Der Meijden, A.P.2    Oosterlinck, W.3
  • 13
    • 70350462404 scopus 로고    scopus 로고
    • Predicting nonmuscle invasive bladder cancer recurrence and progression in patients treated with Bacillus Calmette-Guerin: The CUETO scoring model
    • Fernandez-Gomez J, Madero R, Solsona E, et al. Predicting nonmuscle invasive bladder cancer recurrence and progression in patients treated with Bacillus Calmette-Guerin: the CUETO scoring model. J Urol 2009;182:2195-203.
    • (2009) J Urol , vol.182 , pp. 2195-2203
    • Fernandez-Gomez, J.1    Madero, R.2    Solsona, E.3
  • 14
    • 77955508884 scopus 로고    scopus 로고
    • Molecular grade (FGFR3/MIB1) and EORTC risk scores are predictive in primary non-muscle-invasive bladder cancer
    • Van Rhijn BW, Zuiverloon TC, Vis AN, et al. Molecular grade (FGFR3/MIB1) and EORTC risk scores are predictive in primary non-muscle-invasive bladder cancer. Eur Urol 2010;58: 433-41.
    • (2010) Eur Urol , vol.58 , pp. 433-441
    • Van Rhijn, B.W.1    Zuiverloon, T.C.2    Vis, A.N.3
  • 15
    • 79961012135 scopus 로고    scopus 로고
    • The EORTC tables overestimate the risk of recurrence and progression in patients with nonmuscle- invasive bladder cancer treated with Bacillus Calmette- Guérin: External validation of the EORTC risk tables
    • Fernandez-Gomez J, Madero R, Solsona E, et al; Club Urológico Espan?ol de Tratamiento Oncológico. The EORTC tables overestimate the risk of recurrence and progression in patients with nonmuscle- invasive bladder cancer treated with Bacillus Calmette- Guérin: external validation of the EORTC risk tables. Eur Urol 2011;60:423-30.
    • (2011) Eur Urol , vol.60 , pp. 423-430
    • Fernandez-Gomez, J.1    Madero, R.2    Solsona, E.3
  • 16
    • 84884587306 scopus 로고    scopus 로고
    • Accuracy of the EORTC risk tables and of the CUETO scoring model to predict outcomes in non-muscle-invasive urothelial carcinoma of the bladder
    • Xylinas E, Kent M, Kluth L, et al. Accuracy of the EORTC risk tables and of the CUETO scoring model to predict outcomes in non-muscle-invasive urothelial carcinoma of the bladder. Br J Cancer 2013;109:1460-6.
    • (2013) Br J Cancer , vol.109 , pp. 1460-1466
    • Xylinas, E.1    Kent, M.2    Kluth, L.3
  • 17
    • 84861637633 scopus 로고    scopus 로고
    • Female gender and carcinoma in situ in the prostatic urethra are prognostic factors for recurrence, progression, and disease-specific mortality in T1G3 bladder cancer patients treated with Bacillus Calmette-Guérin
    • Palou J, Sylvester RJ, Faba OR, et al. Female gender and carcinoma in situ in the prostatic urethra are prognostic factors for recurrence, progression, and disease-specific mortality in T1G3 bladder cancer patients treated with Bacillus Calmette-Guérin. Eur Urol 2012;62:118-25.
    • (2012) Eur Urol , vol.62 , pp. 118-125
    • Palou, J.1    Sylvester, R.J.2    Faba, O.R.3
  • 18
    • 80053077763 scopus 로고    scopus 로고
    • Long-term prognostic value of the combination of EORTC risk group calculator and molecular markers in non-muscle-invasive bladder cancer patients treated with intravesical Bacille Calmette-Guérin
    • Alkhateeb SS, Neill M, Bar-Moshe S, et al. Long-term prognostic value of the combination of EORTC risk group calculator and molecular markers in non-muscle-invasive bladder cancer patients treated with intravesical Bacille Calmette-Guérin. Urol Ann 2011; 3:119-26.
    • (2011) Urol Ann , vol.3 , pp. 119-126
    • Alkhateeb, S.S.1    Neill, M.2    Bar-Moshe, S.3
  • 19
    • 79955485574 scopus 로고    scopus 로고
    • New strategies in muscleinvasive bladder cancer: On the road to personalized medicine
    • Shah JB, McConkey DJ, Dinney PN. New strategies in muscleinvasive bladder cancer: on the road to personalized medicine. Clin Cancer Res 2011;17:2608-12.
    • (2011) Clin Cancer Res , vol.17 , pp. 2608-2612
    • Shah, J.B.1    McConkey, D.J.2    Dinney, P.N.3
  • 21
    • 0025017058 scopus 로고
    • Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer
    • Tsai YC, Nichols PW, Hiti AL, et al. Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer. Cancer Res 1990; 50:44-7.
    • (1990) Cancer Res , vol.50 , pp. 44-47
    • Tsai, Y.C.1    Nichols, P.W.2    Hiti, A.L.3
  • 22
    • 33646359953 scopus 로고    scopus 로고
    • Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q
    • Lindgren D, Liedberg F, Andersson A, et al. Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q. Oncogene 2006;25:2685-96.
    • (2006) Oncogene , vol.25 , pp. 2685-2696
    • Lindgren, D.1    Liedberg, F.2    Andersson, A.3
  • 23
    • 0035876969 scopus 로고    scopus 로고
    • Characterization of chromosomal abnormalities in uroepithelial carcinomas by G-banding, spectral karyotyping and FISH analysis
    • Fadl-Elmula I, Kytola S, Pan Y, et al. Characterization of chromosomal abnormalities in uroepithelial carcinomas by G-banding, spectral karyotyping and FISH analysis. Int J Cancer 2001;92:824-31.
    • (2001) Int J Cancer , vol.92 , pp. 824-831
    • Fadl-Elmula, I.1    Kytola, S.2    Pan, Y.3
  • 24
    • 38949183789 scopus 로고    scopus 로고
    • Molecular cytogenetic characterization and diagnostics of bladder cancer
    • Houskova L, Zemanova Z, Babjuk M, et al. Molecular cytogenetic characterization and diagnostics of bladder cancer. Neoplasma 2007;54:511-6.
    • (2007) Neoplasma , vol.54 , pp. 511-516
    • Houskova, L.1    Zemanova, Z.2    Babjuk, M.3
  • 25
    • 0034902711 scopus 로고    scopus 로고
    • What we could do now: Molecular pathology of bladder cancer
    • Knowles MA. What we could do now: molecular pathology of bladder cancer. Mol Pathol 2000;54:215-21.
    • (2000) Mol Pathol , vol.54 , pp. 215-221
    • Knowles, M.A.1
  • 26
    • 70449093749 scopus 로고    scopus 로고
    • 9P21 index as estimated by dual-color fluorescence in situ hybridization is useful to predict urothelial carcinoma recurrence in bladder washing cytology
    • Kawauchi S, Sakai H, Ikemoto K, et al. 9P21 index as estimated by dual-color fluorescence in situ hybridization is useful to predict urothelial carcinoma recurrence in bladder washing cytology. Hum Pathol 2009;40:1783-9.
    • (2009) Hum Pathol , vol.40 , pp. 1783-1789
    • Kawauchi, S.1    Sakai, H.2    Ikemoto, K.3
  • 27
    • 1542540900 scopus 로고    scopus 로고
    • Numerical aberrations of chromosome 17 and the 9P21 locus are independent predictors of tumor recurrence in non-invasive transitional cell carcinoma of the urinary bladder
    • Kruger S, Mess F, Bohle A, Feller AC. Numerical aberrations of chromosome 17 and the 9P21 locus are independent predictors of tumor recurrence in non-invasive transitional cell carcinoma of the urinary bladder. Int J Oncol 2003;23:41-8.
    • (2003) Int J Oncol , vol.23 , pp. 41-48
    • Kruger, S.1    Mess, F.2    Bohle, A.3    Feller, A.C.4
  • 28
    • 33644841931 scopus 로고    scopus 로고
    • Genetic alterations in urothelial bladder carcinoma: An updated review
    • Mhawech-Faucelia P, Cheney RT, Schwaller J. Genetic alterations in urothelial bladder carcinoma: an updated review. Cancer 2006; 106:1205-16.
    • (2006) Cancer , vol.106 , pp. 1205-1216
    • Mhawech-Faucelia, P.1    Cheney, R.T.2    Schwaller, J.3
  • 29
    • 0025047287 scopus 로고
    • Allelic loss of chromosome 17p distinguishes high grade from low grade transitional cell carcinomas of the bladder
    • Olumi AF, Tsai YC, Nichols PW, et al. Allelic loss of chromosome 17p distinguishes high grade from low grade transitional cell carcinomas of the bladder. Cancer Res 1990;50:7081-3.
    • (1990) Cancer Res , vol.50 , pp. 7081-7083
    • Olumi, A.F.1    Tsai, Y.C.2    Nichols, P.W.3
  • 30
    • 0026051617 scopus 로고
    • Molecular genetic alterations in superficial and locally advanced human bladder cancer
    • Presti Jr JC, Reuter VE, Galan T, et al. Molecular genetic alterations in superficial and locally advanced human bladder cancer. Cancer Res 1991;51:5405-9.
    • (1991) Cancer Res , vol.51 , pp. 5405-5409
    • Presti, J.C.1    Reuter, V.E.2    Galan, T.3
  • 31
    • 0032969011 scopus 로고    scopus 로고
    • Numerical chromosomal aberrations in muscle invasive squamous cell and transitional cell cancer of the urinary bladder: An alternative to classic prognostic indicators
    • Pycha A, Mian C, Posch B, et al. Numerical chromosomal aberrations in muscle invasive squamous cell and transitional cell cancer of the urinary bladder: an alternative to classic prognostic indicators? Urology 1999;53:1005-10.
    • (1999) Urology , vol.53 , pp. 1005-1010
    • Pycha, A.1    Mian, C.2    Posch, B.3
  • 32
    • 0033163314 scopus 로고    scopus 로고
    • Microsatellite alterations in superficial and locally advanced transitional cell carcinoma of the bladder
    • Sardi I, Bartoletti R, Occhini I, et al. Microsatellite alterations in superficial and locally advanced transitional cell carcinoma of the bladder. Oncol Report 1999;6:901-5.
    • (1999) Oncol Report , vol.6 , pp. 901-905
    • Sardi, I.1    Bartoletti, R.2    Occhini, I.3
  • 33
    • 41349097718 scopus 로고    scopus 로고
    • Molecular biomarkers in urothelial bladder cancer
    • Kim W-J, Bae S-C. Molecular biomarkers in urothelial bladder cancer. Cancer Sci 2008;99:646-52.
    • (2008) Cancer Sci , vol.99 , pp. 646-652
    • Kim, W.-J.1    Bae, S.-C.2
  • 34
    • 14544299623 scopus 로고    scopus 로고
    • Microsatellite instability as prognostic marker in bladder tumors: A clinical significance
    • Vaish M, Mandhani A, Mittal RD, Mittal B. Microsatellite instability as prognostic marker in bladder tumors: a clinical significance. BMC Urol 2005;5:2.doi:10.1186/1471-2490-5-2.
    • (2005) BMC Urol , vol.5 , pp. 2
    • Vaish, M.1    Mandhani, A.2    Mittal, R.D.3    Mittal, B.4
  • 35
    • 33744825700 scopus 로고    scopus 로고
    • Use of a multitarget fluorescence in situ hybridization assay to diagnose bladder cancer in patients with hematuria
    • Sarosdy MF, Kahn PR, Ziffer MD, et al. Use of a multitarget fluorescence in situ hybridization assay to diagnose bladder cancer in patients with hematuria. J Urol 2006;176:44-7.
    • (2006) J Urol , vol.176 , pp. 44-47
    • Sarosdy, M.F.1    Kahn, P.R.2    Ziffer, M.D.3
  • 36
    • 78650239452 scopus 로고    scopus 로고
    • Prognostic significance of fluorescent in situ hybridisation in the follow-up of non-muscle-invasive bladder cancer
    • Maffezzini M, Campodonico F, Capponi G, et al. Prognostic significance of fluorescent in situ hybridisation in the follow-up of non-muscle-invasive bladder cancer. Anticancer Res 2010;30: 4761-5.
    • (2010) Anticancer Res , vol.30 , pp. 4761-4765
    • Maffezzini, M.1    Campodonico, F.2    Capponi, G.3
  • 37
    • 42949128661 scopus 로고    scopus 로고
    • The predictive value of multi-targeted fluorescent in-situ hybridization in patients with history of bladder cancer
    • Gofrit ON, Zorn KC, Silvestre J, et al. The predictive value of multi-targeted fluorescent in-situ hybridization in patients with history of bladder cancer. Urol Oncol 2008;26:246-9.
    • (2008) Urol Oncol , vol.26 , pp. 246-249
    • Gofrit, O.N.1    Zorn, K.C.2    Silvestre, J.3
  • 38
    • 65649113931 scopus 로고    scopus 로고
    • The prognostic value of cytology and fluorescence in situ hybridization in the follow-up of nonmuscle-invasive bladder cancer after intravesical Bacillus Calmette-Guerin therapy
    • Savic S, Zlobec I, Thalmann GN, et al. The prognostic value of cytology and fluorescence in situ hybridization in the follow-up of nonmuscle-invasive bladder cancer after intravesical Bacillus Calmette-Guerin therapy. Int J Cancer 2009;124:2899-904.
    • (2009) Int J Cancer , vol.124 , pp. 2899-2904
    • Savic, S.1    Zlobec, I.2    Thalmann, G.N.3
  • 39
    • 68049112265 scopus 로고    scopus 로고
    • A multicolour fluorescence in situ hybridization test predicts recurrence in patients with high-risk superficial bladder tumours undergoing intravesical therapy
    • Whitson J, Berry A, Carroll P, Konety B. A multicolour fluorescence in situ hybridization test predicts recurrence in patients with high-risk superficial bladder tumours undergoing intravesical therapy. BJU Int 2009;104:336-9.
    • (2009) BJU Int , vol.104 , pp. 336-339
    • Whitson, J.1    Berry, A.2    Carroll, P.3    Konety, B.4
  • 40
    • 33748879225 scopus 로고    scopus 로고
    • Multiprobe fluorescence in situ hybridisation: Prognostic perspectives in superficial bladder cancer
    • Mian C, Lodde M, Comploj E, et al. Multiprobe fluorescence in situ hybridisation: prognostic perspectives in superficial bladder cancer. J Clin Pathol 2006;59:984-7.
    • (2006) J Clin Pathol , vol.59 , pp. 984-987
    • Mian, C.1    Lodde, M.2    Comploj, E.3
  • 41
    • 79952993121 scopus 로고    scopus 로고
    • Bladder cancer: Translating molecular genetic insights into clinical practice
    • Cheng L, Zhang S, MacLennan GT, et al. Bladder cancer: translating molecular genetic insights into clinical practice. Hum Pathol 2011;42:455-81.
    • (2011) Hum Pathol , vol.42 , pp. 455-481
    • Cheng, L.1    Zhang, S.2    Maclennan, G.T.3
  • 42
    • 25444467767 scopus 로고    scopus 로고
    • Urothelial tumorigenesis: A tale of divergent pathways
    • Wu XR. Urothelial tumorigenesis: a tale of divergent pathways. Nat Rev Cancer 2005;5:713-25.
    • (2005) Nat Rev Cancer , vol.5 , pp. 713-725
    • Wu, X.R.1
  • 43
    • 20444417470 scopus 로고    scopus 로고
    • Expression of the epidermal growth factor receptor family in normal and malignant urothelium
    • Rotterud R, Nesland JM, Berner A, Fossa SD. Expression of the epidermal growth factor receptor family in normal and malignant urothelium. BJU Int 2005;95:1344-50.
    • (2005) BJU Int , vol.95 , pp. 1344-1350
    • Rotterud, R.1    Nesland, J.M.2    Berner, A.3    Fossa, S.D.4
  • 44
    • 0034969685 scopus 로고    scopus 로고
    • Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumors
    • Billerey C, Chopin D, Aubriot-Lorton MH, et al. Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumors. Am J Pathol 2001;158:1955-9.
    • (2001) Am J Pathol , vol.158 , pp. 1955-1959
    • Billerey, C.1    Chopin, D.2    Aubriot-Lorton, M.H.3
  • 45
    • 77957135510 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 expression status provides independent prognostic information in patients with urothelial carcinoma of the urinary bladder
    • Bolenz C, Shariat SF, Karakiewicz PI, et al. Human epidermal growth factor receptor 2 expression status provides independent prognostic information in patients with urothelial carcinoma of the urinary bladder. BJU Int 2010;106:1216-22.
    • (2010) BJU Int , vol.106 , pp. 1216-1222
    • Bolenz, C.1    Shariat, S.F.2    Karakiewicz, P.I.3
  • 46
    • 11844263352 scopus 로고    scopus 로고
    • HER2/neu expression in bladder cancer: Relationship to cell cycle kinetics
    • Eissa S, Ali HS, Al Tonsi AH, et al. HER2/neu expression in bladder cancer: relationship to cell cycle kinetics. Clin Biochem 2005;38:142-8.
    • (2005) Clin Biochem , vol.38 , pp. 142-148
    • Eissa, S.1    Ali, H.S.2    Al Tonsi, A.H.3
  • 47
    • 0036721561 scopus 로고    scopus 로고
    • Does HER2/neu expression provide prognostic information in patients with advanced urothelial carcinoma
    • Gandour-Edwards R, Lara Jr PN, Folkins AK, et al. Does HER2/neu expression provide prognostic information in patients with advanced urothelial carcinoma? Cancer 2002;95:1009-15.
    • (2002) Cancer , vol.95 , pp. 1009-1015
    • Gandour-Edwards, R.1    Lara, P.N.2    Folkins, A.K.3
  • 48
    • 0347627279 scopus 로고    scopus 로고
    • HER2/neu gene amplification and protein overexpression in G3 pT2 transitional cell carcinoma of the bladder: A role for anti-HER2 therapy
    • Latif Z, Watters AD, Dunn I, et al. HER2/neu gene amplification and protein overexpression in G3 pT2 transitional cell carcinoma of the bladder: a role for anti-HER2 therapy? Eur J Cancer 2004; 40:56-63.
    • (2004) Eur J Cancer , vol.40 , pp. 56-63
    • Latif, Z.1    Watters, A.D.2    Dunn, I.3
  • 49
    • 38849110197 scopus 로고    scopus 로고
    • EGFR expression in urothelial carcinoma of the upper urinary tract is associated with disease progression and metaplastic morphology
    • Leibl S, Zigeuner R, Hutterer G, Chromecki T, et al. EGFR expression in urothelial carcinoma of the upper urinary tract is associated with disease progression and metaplastic morphology. APMIS 2008;116:27-32.
    • (2008) APMIS , vol.116 , pp. 27-32
    • Leibl, S.1    Zigeuner, R.2    Hutterer, G.3    Chromecki, T.4
  • 50
    • 67650447331 scopus 로고    scopus 로고
    • EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis
    • Mason RA, Morlock EV, Karagas MR, et al. EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis. Carcinogenesis 2009;30:1155-60.
    • (2009) Carcinogenesis , vol.30 , pp. 1155-1160
    • Mason, R.A.1    Morlock, E.V.2    Karagas, M.R.3
  • 51
    • 65849287224 scopus 로고    scopus 로고
    • Role of polysomy 17 in transitional cell carcinoma of the bladder: Immunohistochemical study of HER2/neu expression and fish analysis of c-erbB-2 gene and chromosome 17
    • Simonetti S, Russo R, Ciancia G, et al. Role of polysomy 17 in transitional cell carcinoma of the bladder: immunohistochemical study of HER2/neu expression and fish analysis of c-erbB-2 gene and chromosome 17. Int J Surg Pathol 2009;17:198-205.
    • (2009) Int J Surg Pathol , vol.17 , pp. 198-205
    • Simonetti, S.1    Russo, R.2    Ciancia, G.3
  • 52
    • 36248943079 scopus 로고    scopus 로고
    • Role of FGFR3 in urothelial cell carcinoma: Biomarker and potential therapeutic target
    • Knowles MA. Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target. World J Urol 2007;25: 581-93.
    • (2007) World J Urol , vol.25 , pp. 581-593
    • Knowles, M.A.1
  • 53
    • 77953089991 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 mutation analysis on voided urine for surveillance of patients with low-grade non-muscle-invasive bladder cancer
    • Zuiverloon TC, van der Aa MN, van der Kwast TH, et al. Fibroblast growth factor receptor 3 mutation analysis on voided urine for surveillance of patients with low-grade non-muscle-invasive bladder cancer. Clin Cancer Res 2010;16: 3011-8.
    • (2010) Clin Cancer Res , vol.16 , pp. 3011-3018
    • Zuiverloon, T.C.1    Van Der Aa, M.N.2    Van Der Kwast, T.H.3
  • 54
    • 71849086230 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 mutation in voided urine is a useful diagnostic marker and significant indicator of tumor recurrence in non-muscle invasive bladder cancer
    • Miyake M, Sugano K, Sugino H, et al. Fibroblast growth factor receptor 3 mutation in voided urine is a useful diagnostic marker and significant indicator of tumor recurrence in non-muscle invasive bladder cancer. Cancer Sci 2010;101: 250-8.
    • (2010) Cancer Sci , vol.101 , pp. 250-258
    • Miyake, M.1    Sugano, K.2    Sugino, H.3
  • 55
    • 33747079040 scopus 로고    scopus 로고
    • Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas
    • Hernandez S, Lopez-Knowles E, Lloreta J, et al. Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas. J Clin Oncol 2006;24: 3664-71.
    • (2006) J Clin Oncol , vol.24 , pp. 3664-3671
    • Hernandez, S.1    Lopez-Knowles, E.2    Lloreta, J.3
  • 56
    • 78149483788 scopus 로고    scopus 로고
    • FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy
    • Kompier LC, Lurkin I, van der Aa MN, et al. FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy. PLoS One 2010;5:e13821.
    • (2010) PLoS One , vol.5 , pp. e13821
    • Kompier, L.C.1    Lurkin, I.2    Van Der Aa, M.N.3
  • 57
    • 0035866380 scopus 로고    scopus 로고
    • The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate
    • van Rhijn BW, Lurkin I, Radvanyi F, et al. The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate. Cancer Res 2001;61:1265-8.
    • (2001) Cancer Res , vol.61 , pp. 1265-1268
    • Van Rhijn, B.W.1    Lurkin, I.2    Radvanyi, F.3
  • 58
    • 0038011950 scopus 로고    scopus 로고
    • Molecular grading of urothelial cell carcinoma with fibroblast growth factor receptor 3 and MIB1 is superior to pathologic grade for the prediction of clinical outcome
    • van Rhijn BW, Vis AN, van der Kwast TH, et al. Molecular grading of urothelial cell carcinoma with fibroblast growth factor receptor 3 and MIB1 is superior to pathologic grade for the prediction of clinical outcome. J Clin Oncol 2003;21:1912-21.
    • (2003) J Clin Oncol , vol.21 , pp. 1912-1921
    • Van Rhijn, B.W.1    Vis, A.N.2    Van Der Kwast, T.H.3
  • 59
    • 20344387231 scopus 로고    scopus 로고
    • A molecular signature in superficial bladder carcinoma predicts clinical outcome
    • Dyrskjot L, Zieger K, Kruhoffer M, et al. A molecular signature in superficial bladder carcinoma predicts clinical outcome. Clin Cancer Res 2005;11:4029-36.
    • (2005) Clin Cancer Res , vol.11 , pp. 4029-4036
    • Dyrskjot, L.1    Zieger, K.2    Kruhoffer, M.3
  • 60
    • 1542405934 scopus 로고    scopus 로고
    • FGFR3 and P53 characterize alternative genetic pathways in the pathogenesis of urothelial cell carcinoma
    • van Rhijn BW, van der Kwast TH, Vis AN, et al. FGFR3 and P53 characterize alternative genetic pathways in the pathogenesis of urothelial cell carcinoma. Cancer Res 2004;64:1911-4.
    • (2004) Cancer Res , vol.64 , pp. 1911-1914
    • Van Rhijn, B.W.1    Van Der Kwast, T.H.2    Vis, A.N.3
  • 61
    • 10744222289 scopus 로고    scopus 로고
    • FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder
    • Bakkar AA, Wallerand H, Radvanyi F, et al. FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder. Cancer Res 2003;63:8108-12.
    • (2003) Cancer Res , vol.63 , pp. 8108-8112
    • Bakkar, A.A.1    Wallerand, H.2    Radvanyi, F.3
  • 62
    • 13444279152 scopus 로고    scopus 로고
    • Mutations in TP53, but not FGFR3, in urothelial cell carcinoma of the bladder are influenced by smoking: Contribution of exogenous versus endogenous carcinogens
    • Wallerand H, Bakkar AA, de Medina SG, et al. Mutations in TP53, but not FGFR3, in urothelial cell carcinoma of the bladder are influenced by smoking: contribution of exogenous versus endogenous carcinogens. Carcinogenesis 2005;26:177-84.
    • (2005) Carcinogenesis , vol.26 , pp. 177-184
    • Wallerand, H.1    Bakkar, A.A.2    De Medina, S.G.3
  • 63
    • 84880698009 scopus 로고    scopus 로고
    • Do molecular biomarkers have prognostic value in primary T1G3 bladder cancer treated with Bacillus Calmette-Guerin intravesical therapy
    • Park J, Song C, Shin E, et al. Do molecular biomarkers have prognostic value in primary T1G3 bladder cancer treated with Bacillus Calmette-Guerin intravesical therapy? Urol Oncol 2013; 31:849-56.
    • (2013) Urol Oncol , vol.31 , pp. 849-856
    • Park, J.1    Song, C.2    Shin, E.3
  • 64
    • 0002145419 scopus 로고    scopus 로고
    • New technologies in epidermal growth factor receptortargeted cancer therapy
    • Baselga J. New technologies in epidermal growth factor receptortargeted cancer therapy. Signal 2000;1:12-21.
    • (2000) Signal , vol.1 , pp. 12-21
    • Baselga, J.1
  • 65
    • 0001933248 scopus 로고    scopus 로고
    • The epidermal growth factor receptor (EGFR) - A new target in cancer therapy
    • Wells A. The epidermal growth factor receptor (EGFR) - a new target in cancer therapy. Signal 2000;1:4-11.
    • (2000) Signal , vol.1 , pp. 4-11
    • Wells, A.1
  • 66
    • 0033063774 scopus 로고    scopus 로고
    • The epidermal growth factor receptor and its inhibition in cancer therapy
    • Woodburn JR. The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol Ther 1999;82:241-50.
    • (1999) Pharmacol Ther , vol.82 , pp. 241-250
    • Woodburn, J.R.1
  • 67
    • 84920241849 scopus 로고
    • Epidermal-growth-factor receptors in human bladder cancer: Comparison of invasive and superficial tumours
    • Neal DE, Marsh C, Bennett MK, et al. Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours. Lancet 1985;1:366-8.
    • (1985) Lancet , vol.1 , pp. 366-368
    • Neal, D.E.1    Marsh, C.2    Bennett, M.K.3
  • 69
    • 0025232322 scopus 로고
    • Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma
    • Messing EM. Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma. Cancer Res 1990;50:2530-7.
    • (1990) Cancer Res , vol.50 , pp. 2530-2537
    • Messing, E.M.1
  • 70
    • 0028115726 scopus 로고
    • Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder. A multivariate survival analysis
    • Nguyen PL, Swanson PE, Jaszcz W, et al. Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder. A multivariate survival analysis. Am J Clin Pathol 1994;101:166-76.
    • (1994) Am J Clin Pathol , vol.101 , pp. 166-176
    • Nguyen, P.L.1    Swanson, P.E.2    Jaszcz, W.3
  • 71
    • 0028302276 scopus 로고
    • Expression of epidermal growth factor receptor in bladder cancer as related to established prognostic factors, oncoprotein (c-erbB-2, P53) expression and long-term prognosis
    • Lipponen P, Eskelinen M. Expression of epidermal growth factor receptor in bladder cancer as related to established prognostic factors, oncoprotein (c-erbB-2, P53) expression and long-term prognosis. Br J Cancer 1994;69:1120-5.
    • (1994) Br J Cancer , vol.69 , pp. 1120-1125
    • Lipponen, P.1    Eskelinen, M.2
  • 72
    • 0028939310 scopus 로고
    • Long-term outcome related to epidermal growth factor receptor status in bladder cancer
    • Mellon K, Wright C, Kelly P, et al. Long-term outcome related to epidermal growth factor receptor status in bladder cancer. J Urol 1995;153:919-25.
    • (1995) J Urol , vol.153 , pp. 919-925
    • Mellon, K.1    Wright, C.2    Kelly, P.3
  • 73
    • 0030951820 scopus 로고    scopus 로고
    • Evaluation of epidermal growth factor receptor, transforming growth factor alpha, epidermal growth factor and c-erbB2 in the progression of invasive bladder cancer
    • Ravery V, Grignon D, Angulo J, et al. Evaluation of epidermal growth factor receptor, transforming growth factor alpha, epidermal growth factor and c-erbB2 in the progression of invasive bladder cancer. Urol Res 1997;25:9-17.
    • (1997) Urol Res , vol.25 , pp. 9-17
    • Ravery, V.1    Grignon, D.2    Angulo, J.3
  • 74
    • 0032879598 scopus 로고    scopus 로고
    • Prognostic value of MIB1 score, P53, EGFr, mitotic index and papillary status in primary superficial (Stage pTa/T1) bladder cancer: A prospective comparative study
    • Liukkonen T, Rajala P, Raitanen M, et al. Prognostic value of MIB1 score, P53, EGFr, mitotic index and papillary status in primary superficial (Stage pTa/T1) bladder cancer: a prospective comparative study. Eur Urol 1999;36:393-400.
    • (1999) Eur Urol , vol.36 , pp. 393-400
    • Liukkonen, T.1    Rajala, P.2    Raitanen, M.3
  • 75
    • 1842735518 scopus 로고    scopus 로고
    • Prognostic value of EGF receptor and tumor cell proliferation in bladder cancer: Therapeutic implications
    • Popov Z, Gil-Diez-De-Medina S, Ravery V, et al. Prognostic value of EGF receptor and tumor cell proliferation in bladder cancer: therapeutic implications. Urol Oncol 2004;22:93-101.
    • (2004) Urol Oncol , vol.22 , pp. 93-101
    • Popov, Z.1    Gil-Diez-De-Medina, S.2    Ravery, V.3
  • 76
    • 0036362181 scopus 로고    scopus 로고
    • Why the epidermal growth factor receptor? the rationale for cancer therapy
    • Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 2002;7:2-8.
    • (2002) Oncologist , vol.7 , pp. 2-8
    • Baselga, J.1
  • 77
    • 0038354561 scopus 로고    scopus 로고
    • Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family
    • Bellmunt J, Hussain M, Dinney CP. Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family. Crit Rev Oncol Hematol 2003;46(Suppl):S85-104.
    • (2003) Crit Rev Oncol Hematol , vol.46 , pp. S85-104
    • Bellmunt, J.1    Hussain, M.2    Dinney, C.P.3
  • 78
    • 33745244755 scopus 로고    scopus 로고
    • Schedule dependent efficacy of gefitinib and docetaxel for bladder cancer
    • Kassouf W, Luongo T, Brown G, et al. Schedule dependent efficacy of gefitinib and docetaxel for bladder cancer. J Urol 2006; 176:787-92.
    • (2006) J Urol , vol.176 , pp. 787-792
    • Kassouf, W.1    Luongo, T.2    Brown, G.3
  • 79
    • 36849022660 scopus 로고    scopus 로고
    • A phase II trial of cisplatin, fixed dose-rate gemcitabine and gefitinib for advanced urothelial tract carcinoma: Results of the Cancer and Leukaemia Group B 90102
    • Philips GK, Halabi S, Sanford BL, et al; Cancer and Leukaemia Group B. A phase II trial of cisplatin, fixed dose-rate gemcitabine and gefitinib for advanced urothelial tract carcinoma: results of the Cancer and Leukaemia Group B 90102. BJU Int 2008;101:20-5.
    • (2008) BJU Int , vol.101 , pp. 20-25
    • Philips, G.K.1    Halabi, S.2    Sanford, B.L.3
  • 80
    • 0026321254 scopus 로고
    • Use of immunohistochemically demonstrated c-erb B-2 oncoprotein expression as a prognostic factor in transitional cell carcinoma of the urinary bladder
    • Lipponen P, Eskelinen M, Syrjanen S, et al. Use of immunohistochemically demonstrated c-erb B-2 oncoprotein expression as a prognostic factor in transitional cell carcinoma of the urinary bladder. Eur Urol 1991;20:238-42.
    • (1991) Eur Urol , vol.20 , pp. 238-242
    • Lipponen, P.1    Eskelinen, M.2    Syrjanen, S.3
  • 81
    • 77951471947 scopus 로고    scopus 로고
    • Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: Results in 1005 patients
    • Lae M, Couturier J, Oudard S, et al. Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: results in 1005 patients. Ann Oncol 2010;21:815-9.
    • (2010) Ann Oncol , vol.21 , pp. 815-819
    • Lae, M.1    Couturier, J.2    Oudard, S.3
  • 82
    • 79959556990 scopus 로고    scopus 로고
    • Her2 amplification is significantly more frequent in lymph node metastases from urothelial bladder cancer than in the primary tumours
    • Fleischmann A, Rotzer D, Seiler R, et al. Her2 amplification is significantly more frequent in lymph node metastases from urothelial bladder cancer than in the primary tumours. Eur Urol 2011;60:350-7.
    • (2011) Eur Urol , vol.60 , pp. 350-357
    • Fleischmann, A.1    Rotzer, D.2    Seiler, R.3
  • 83
    • 0026486874 scopus 로고
    • An immunohistologic evaluation of C-erbB-2 gene product in patients with urinary bladder carcinoma
    • Sato K, Moriyama M, Mori S, et al. An immunohistologic evaluation of C-erbB-2 gene product in patients with urinary bladder carcinoma. Cancer 1992;70:2493-8.
    • (1992) Cancer , vol.70 , pp. 2493-2498
    • Sato, K.1    Moriyama, M.2    Mori, S.3
  • 84
    • 77957110450 scopus 로고    scopus 로고
    • Translational research in bladder cancer: From molecular pathogenesis to useful tissue biomarkers
    • Bolenz C, Lotan Y. Translational research in bladder cancer: from molecular pathogenesis to useful tissue biomarkers. Cancer Biol Ther 2010;10:407-15.
    • (2010) Cancer Biol Ther , vol.10 , pp. 407-415
    • Bolenz, C.1    Lotan, Y.2
  • 85
    • 21044446131 scopus 로고    scopus 로고
    • Expression of the epidermal growth factor receptor and Her-2 are predictors of favorable outcome and reduced complete response rates, respectively, in patients with muscle-invading bladder cancers treated by concurrent radiation and cisplatin-based chemotherapy: A report from the Radiation Therapy Oncology Group
    • Chakravarti A, Winter K, Wu CL, et al. Expression of the epidermal growth factor receptor and Her-2 are predictors of favorable outcome and reduced complete response rates, respectively, in patients with muscle-invading bladder cancers treated by concurrent radiation and cisplatin-based chemotherapy: a report from the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 2005;62:309-17.
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 309-317
    • Chakravarti, A.1    Winter, K.2    Wu, C.L.3
  • 86
    • 0034890387 scopus 로고    scopus 로고
    • Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: Prognostic significance and comparative analysis in primary and metastatic tumors
    • Jimenez RE, Hussain M, Bianco FJ Jr, et al. Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors. Clin Cancer Res 2001;7:2440-7.
    • (2001) Clin Cancer Res , vol.7 , pp. 2440-2447
    • Jimenez, R.E.1    Hussain, M.2    Bianco, F.J.3
  • 87
    • 0037058715 scopus 로고    scopus 로고
    • HER2 overexpression in muscle-invasive urothelial carcinoma of the bladder: Prognostic implications
    • Kruger S, Weitsch G, Buttner H, et al. HER2 overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic implications. Int J Cancer 2002;102:514-8.
    • (2002) Int J Cancer , vol.102 , pp. 514-518
    • Kruger, S.1    Weitsch, G.2    Buttner, H.3
  • 88
    • 52649176386 scopus 로고    scopus 로고
    • Prognostic significance of Her2/neu overexpression in patients with muscle invasive urinary bladder cancer treated with radical cystectomy
    • Kolla SB, Seth A, Singh MK, et al. Prognostic significance of Her2/neu overexpression in patients with muscle invasive urinary bladder cancer treated with radical cystectomy. Int Urol Nephrol 2008;40:321-7.
    • (2008) Int Urol Nephrol , vol.40 , pp. 321-327
    • Kolla, S.B.1    Seth, A.2    Singh, M.K.3
  • 89
    • 0036836199 scopus 로고    scopus 로고
    • Overexpression of c-erbB-2 oncoprotein in muscle-invasive bladder carcinoma: Relationship with gene amplification, clinicopathological parameters and prognostic outcome
    • Kruger S, Weitsch G, Buttner H, et al. Overexpression of c-erbB-2 oncoprotein in muscle-invasive bladder carcinoma: relationship with gene amplification, clinicopathological parameters and prognostic outcome. Int J Oncol 2002;21:981-7.
    • (2002) Int J Oncol , vol.21 , pp. 981-987
    • Kruger, S.1    Weitsch, G.2    Buttner, H.3
  • 90
    • 36749029619 scopus 로고    scopus 로고
    • Distinctive expression pattern of ErbB family receptors signifies an aggressive variant of bladder cancer
    • Kassouf W, Black PC, Tuziak T, et al. Distinctive expression pattern of ErbB family receptors signifies an aggressive variant of bladder cancer. J Urol 2008;179:353-8.
    • (2008) J Urol , vol.179 , pp. 353-358
    • Kassouf, W.1    Black, P.C.2    Tuziak, T.3
  • 91
    • 0029655413 scopus 로고    scopus 로고
    • C-erbB-2 in bladder cancer: Molecular biology, correlation with epidermal growth factor receptors and prognostic value
    • Mellon JK, Lunec J, Wright C, et al. C-erbB-2 in bladder cancer: molecular biology, correlation with epidermal growth factor receptors and prognostic value. J Urol 1996;155:321-6.
    • (1996) J Urol , vol.155 , pp. 321-326
    • Mellon, J.K.1    Lunec, J.2    Wright, C.3
  • 92
    • 0034782994 scopus 로고    scopus 로고
    • Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder
    • Chow NH, Chan SH, Tzai TS, et al. Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder. Clin Cancer Res 2001;7: 1957-62.
    • (2001) Clin Cancer Res , vol.7 , pp. 1957-1962
    • Chow, N.H.1    Chan, S.H.2    Tzai, T.S.3
  • 93
    • 37649024111 scopus 로고    scopus 로고
    • Tissue microarray based analysis of prognostic markers in invasive bladder cancer: Much effort to no avail
    • Liedberg F, Anderson H, Chebil G, et al. Tissue microarray based analysis of prognostic markers in invasive bladder cancer: much effort to no avail? Urol Oncol 2008;26:17-24.
    • (2008) Urol Oncol , vol.26 , pp. 17-24
    • Liedberg, F.1    Anderson, H.2    Chebil, G.3
  • 94
    • 0029027518 scopus 로고
    • C-erbB-2 gene amplification: A molecular marker in recurrent bladder tumors
    • Underwood M, Bartlett J, Reeves J, et al. C-erbB-2 gene amplification: a molecular marker in recurrent bladder tumors? Cancer Res 1995;55:2422-30.
    • (1995) Cancer Res , vol.55 , pp. 2422-2430
    • Underwood, M.1    Bartlett, J.2    Reeves, J.3
  • 95
    • 84907432029 scopus 로고    scopus 로고
    • Preliminary results of HER-2/neu screening and treatment with trastuzumab (Herceptin) (T), paclitaxel (P), carboplatin (C) and gemcitabine (G) in patients with advanced urothelial cancer
    • May 18-21. Abstract no. 800
    • Hussain M, Smith DC, Al-Sukhun S, et al. Preliminary results of HER-2/neu screening and treatment with trastuzumab (Herceptin) (T), paclitaxel (P), carboplatin (C) and gemcitabine (G) in patients with advanced urothelial cancer. In: Proceedings of the American Society of Clinical Oncology, 38th Annual Meeting, 2002. May 18-21. Abstract no. 800.
    • Proceedings of the American Society of Clinical Oncology, 38th Annual Meeting, 2002
    • Hussain, M.1    Smith, D.C.2    Al-Sukhun, S.3
  • 96
    • 34250218955 scopus 로고    scopus 로고
    • Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: Results of a multicenter phase II National Cancer Institute trial
    • Hussain MH, MacVicar GR, Petrylak DP, et al; National Cancer Institute. Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: results of a multicenter phase II National Cancer Institute trial. J Clin Oncol 2007;25:2218-24.
    • (2007) J Clin Oncol , vol.25 , pp. 2218-2224
    • Hussain, M.H.1    Macvicar, G.R.2    Petrylak, D.P.3    National Cancer Institute4
  • 97
    • 24044554230 scopus 로고    scopus 로고
    • P53 as a prognostic marker for bladder cancer: A meta-analysis and review
    • Malats N, Bustos A, Nascimento CM, et al. P53 as a prognostic marker for bladder cancer: a meta-analysis and review. Lancet Oncol 2005;6:678-86.
    • (2005) Lancet Oncol , vol.6 , pp. 678-686
    • Malats, N.1    Bustos, A.2    Nascimento, C.M.3
  • 98
    • 0027759847 scopus 로고
    • P53 nuclear protein accumulation correlates with mutations in the P53 gene, tumor grade, and stage in bladder cancer
    • Esrig D, Spruck CH III, Nichols PW, et al. P53 nuclear protein accumulation correlates with mutations in the P53 gene, tumor grade, and stage in bladder cancer. Am J Pathol 1993;143: 1389-97.
    • (1993) Am J Pathol , vol.143 , pp. 1389-1397
    • Esrig, D.1    Spruck Iii., C.H.2    Nichols, P.W.3
  • 99
    • 2342537109 scopus 로고    scopus 로고
    • Clinical evaluation of P53 mutations in urothelial carcinoma by IHC and FASAY
    • Watanabe J, Nishiyama H, Okubo K, et al. Clinical evaluation of P53 mutations in urothelial carcinoma by IHC and FASAY. Urology 2004;63:989-93.
    • (2004) Urology , vol.63 , pp. 989-993
    • Watanabe, J.1    Nishiyama, H.2    Okubo, K.3
  • 100
    • 0034030369 scopus 로고    scopus 로고
    • Reproducibility of P53 immunohistochemistry in bladder tumors. National Cancer Institute, Bladder Tumor Marker Network
    • McShane LM, Aamodt R, Cordon-Cardo C, et al. Reproducibility of P53 immunohistochemistry in bladder tumors. National Cancer Institute, Bladder Tumor Marker Network. Clin Cancer Res 2000; 6:1854-64.
    • (2000) Clin Cancer Res , vol.6 , pp. 1854-1864
    • McShane, L.M.1    Aamodt, R.2    Cordon-Cardo, C.3
  • 101
    • 0028318158 scopus 로고
    • Association of P53 nuclear overexpression and tumor progression in carcinoma in situ of the bladder
    • Sarkis AS, Dalbagni G, Cordon-Cardo C, et al. Association of P53 nuclear overexpression and tumor progression in carcinoma in situ of the bladder. J Urol 1994;152:388-92.
    • (1994) J Urol , vol.152 , pp. 388-392
    • Sarkis, A.S.1    Dalbagni, G.2    Cordon-Cardo, C.3
  • 102
    • 0028051625 scopus 로고
    • Accumulation of nuclear P53 and tumor progression in bladder cancer
    • Esrig D, Elmajian D, Groshen S, et al. Accumulation of nuclear P53 and tumor progression in bladder cancer. N Engl J Med 1994; 331:1259-64.
    • (1994) N Engl J Med , vol.331 , pp. 1259-1264
    • Esrig, D.1    Elmajian, D.2    Groshen, S.3
  • 103
    • 0029063351 scopus 로고
    • Prognostic value of P53 nuclear overexpression in patients with invasive bladder cancer treated with neoadjuvant MVAC
    • Sarkis AS, Bajorin DF, Reuter VE, et al. Prognostic value of P53 nuclear overexpression in patients with invasive bladder cancer treated with neoadjuvant MVAC. J Clin Oncol 1995;13:1384-90.
    • (1995) J Clin Oncol , vol.13 , pp. 1384-1390
    • Sarkis, A.S.1    Bajorin, D.F.2    Reuter, V.E.3
  • 104
    • 0027411102 scopus 로고
    • Nuclear overexpression of P53 protein in transitional cell bladder carcinoma: A marker for disease progression
    • Sarkis AS, Dalbagni G, Cordon-Cardo C, et al. Nuclear overexpression of P53 protein in transitional cell bladder carcinoma: a marker for disease progression. J Natl Cancer Inst 1993; 85:53-9.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 53-59
    • Sarkis, A.S.1    Dalbagni, G.2    Cordon-Cardo, C.3
  • 105
    • 11144357075 scopus 로고    scopus 로고
    • P53 and P21 expression levels predict organ preservation and survival in invasive bladder carcinoma treated with a combined-modality approach
    • Garcia del Muro X, Condom E, Vigues F, et al. P53 and P21 expression levels predict organ preservation and survival in invasive bladder carcinoma treated with a combined-modality approach. Cancer 2004;100:1859-67.
    • (2004) Cancer , vol.100 , pp. 1859-1867
    • Garcia Del Muro, X.1    Condom, E.2    Vigues, F.3
  • 106
    • 1842737599 scopus 로고    scopus 로고
    • Prognostic factors in stage T1 grade 3 bladder cancer survival: The role of G1- S modulators (P53, P21Waf1, P27kip1, Cyclin D1, and Cyclin D3) and proliferation index (ki67-MIB1)
    • Lopez-Beltran A, Luque RJ, Alvarez-Kindelan J, et al. Prognostic factors in stage T1 grade 3 bladder cancer survival: the role of G1- S modulators (P53, P21Waf1, P27kip1, Cyclin D1, and Cyclin D3) and proliferation index (ki67-MIB1). Eur Urol 2004;45:606-12.
    • (2004) Eur Urol , vol.45 , pp. 606-612
    • Lopez-Beltran, A.1    Luque, R.J.2    Alvarez-Kindelan, J.3
  • 107
    • 1842634672 scopus 로고    scopus 로고
    • The prevalence and clinicopathologic correlate of P16INK4a, retinoblastoma and P53 immunoreactivity in locally advanced urinary bladder cancer
    • Tzai TS, Tsai YS, Chow NH. The prevalence and clinicopathologic correlate of P16INK4a, retinoblastoma and P53 immunoreactivity in locally advanced urinary bladder cancer. Urol Oncol 2004;22:112-8.
    • (2004) Urol Oncol , vol.22 , pp. 112-118
    • Tzai, T.S.1    Tsai, Y.S.2    Chow, N.H.3
  • 108
    • 76149145040 scopus 로고    scopus 로고
    • P53 expression in patients with advanced urothelial cancer of the urinary bladder
    • Shariat SF, Bolenz C, Karakiewicz PI, et al. P53 expression in patients with advanced urothelial cancer of the urinary bladder. BJU Int 2010;105:489-95.
    • (2010) BJU Int , vol.105 , pp. 489-495
    • Shariat, S.F.1    Bolenz, C.2    Karakiewicz, P.I.3
  • 109
    • 33846262187 scopus 로고    scopus 로고
    • Prospective evaluation of P53 as a prognostic marker in T1 transitional cell carcinoma of the bladder
    • Dalbagni G, Parekh DJ, Ben-Porat L, et al. Prospective evaluation of P53 as a prognostic marker in T1 transitional cell carcinoma of the bladder. BJU Int 2007;99:281-5.
    • (2007) BJU Int , vol.99 , pp. 281-285
    • Dalbagni, G.1    Parekh, D.J.2    Ben-Porat, L.3
  • 110
    • 46449116543 scopus 로고    scopus 로고
    • TP53 gene mutations as an independent marker for urinary bladder cancer progression
    • Ecke TH, Sachs MD, Lenk SV, et al. TP53 gene mutations as an independent marker for urinary bladder cancer progression. Int J Mol Med 2008;21:655-61.
    • (2008) Int J Mol Med , vol.21 , pp. 655-661
    • Ecke, T.H.1    Sachs, M.D.2    Lenk, S.V.3
  • 111
    • 0004807006 scopus 로고    scopus 로고
    • P53 and the treatment of bladder cancer
    • Esrig D, Elmajian D, Groshen S, et al. P53 and the treatment of bladder cancer. Nature 1997;385:123-4.
    • (1997) Nature , vol.385 , pp. 123-124
    • Esrig, D.1    Elmajian, D.2    Groshen, S.3
  • 112
    • 0033813030 scopus 로고    scopus 로고
    • P53 nuclear accumulation is not associated with decreased disease-free survival in patients with node positive transitional cell carcinoma of the bladder
    • Fleshner N, Kapusta L, Ezer D, et al. P53 nuclear accumulation is not associated with decreased disease-free survival in patients with node positive transitional cell carcinoma of the bladder. J Urol 2000;164:1177-82.
    • (2000) J Urol , vol.164 , pp. 1177-1182
    • Fleshner, N.1    Kapusta, L.2    Ezer, D.3
  • 113
    • 0027450814 scopus 로고
    • Overexpression of P53 nuclear oncoprotein in transitional-cell bladder cancer and its prognostic value
    • Lipponen PK. Overexpression of P53 nuclear oncoprotein in transitional-cell bladder cancer and its prognostic value. Int J Cancer 1993;53:365-70.
    • (1993) Int J Cancer , vol.53 , pp. 365-370
    • Lipponen, P.K.1
  • 114
    • 15644377551 scopus 로고    scopus 로고
    • Biomarker study of primary nonmetastatic versus metastatic invasive bladder cancer. National Cancer Institute Bladder Tumor Marker Network
    • Lianes P, Charytonowicz E, Cordon-Cardo C, et al. Biomarker study of primary nonmetastatic versus metastatic invasive bladder cancer. National Cancer Institute Bladder Tumor Marker Network. Clin Cancer Res 1998;4:1267-71.
    • (1998) Clin Cancer Res , vol.4 , pp. 1267-1271
    • Lianes, P.1    Charytonowicz, E.2    Cordon-Cardo, C.3
  • 115
    • 0033673208 scopus 로고    scopus 로고
    • P53 immunohistochemistry as a prognostic marker in bladder cancer. Playground for urology scientists
    • discussion 700
    • Schmitz-Draüger BJ, Goebell PJ, Ebert T, Fradet Y. P53 immunohistochemistry as a prognostic marker in bladder cancer. Playground for urology scientists? Eur Urol 2000;38:691-9;discussion 700
    • (2000) Eur Urol , vol.38 , pp. 691-699
    • Schmitz-Draüger, B.J.1    Goebell, P.J.2    Ebert, T.3    Fradet, Y.4
  • 116
    • 0035450303 scopus 로고    scopus 로고
    • Correlation of immunohistochemical molecular staging of bladder biopsies and radical cystectomy specimens
    • Tokunaga H, Shariat SF, Green AE, et al. Correlation of immunohistochemical molecular staging of bladder biopsies and radical cystectomy specimens. Int J Radiat Oncol Biol Phys 2001; 51:16-22.
    • (2001) Int J Radiat Oncol Biol Phys , vol.51 , pp. 16-22
    • Tokunaga, H.1    Shariat, S.F.2    Green, A.E.3
  • 117
    • 33744904949 scopus 로고    scopus 로고
    • The predictive value of P53, P27Kip1, and a-catenin for progression in superficial bladder carcinoma
    • Schrier BP, Vriesema JLJ, Witjes JA, et al. The predictive value of P53, P27Kip1, and a-catenin for progression in superficial bladder carcinoma. Eur Urol 2006;50:76-82.
    • (2006) Eur Urol , vol.50 , pp. 76-82
    • Schrier, B.P.1    Vriesema, J.L.J.2    Witjes, J.A.3
  • 118
    • 77953815362 scopus 로고    scopus 로고
    • P53 immunohistochemistry in bladder cancer - A new approach to an old question
    • Goebell PJ, Groshen SG, Schmitz-Drager BJ. P53 immunohistochemistry in bladder cancer - a new approach to an old question. Urol Oncol 2010;28:377-88.
    • (2010) Urol Oncol , vol.28 , pp. 377-388
    • Goebell, P.J.1    Groshen, S.G.2    Schmitz-Drager, B.J.3
  • 119
    • 57449088597 scopus 로고    scopus 로고
    • Molecular biomarkers for urothelial carcinoma of the bladder: Challenges in clinical use
    • Bolenz C, Lotan Y. Molecular biomarkers for urothelial carcinoma of the bladder: challenges in clinical use. Nat Clin Pract Urol 2008;5:676-85.
    • (2008) Nat Clin Pract Urol , vol.5 , pp. 676-685
    • Bolenz, C.1    Lotan, Y.2
  • 120
    • 0034114371 scopus 로고    scopus 로고
    • P53 expression predicts progression and poor survival in T1 bladder tumours
    • Llopis J, Alcaraz A, Ribal MJ, et al. P53 expression predicts progression and poor survival in T1 bladder tumours. Eur Urol 2000;37:644-53.
    • (2000) Eur Urol , vol.37 , pp. 644-653
    • Llopis, J.1    Alcaraz, A.2    Ribal, M.J.3
  • 121
    • 0036487680 scopus 로고    scopus 로고
    • P53 and ki67 expression as prognostic factors for cancer-related survival in stage T1 transitional cell bladder carcinoma
    • discussion 188-9
    • Rodriguez-Alonso A, Pita-Fernandez S, Gonzalez-Carrero J, Nogueira-March JL. P53 and ki67 expression as prognostic factors for cancer-related survival in stage T1 transitional cell bladder carcinoma. Eur Urol 2002;41:182-8;discussion 188-9.
    • (2002) Eur Urol , vol.41 , pp. 182-188
    • Rodriguez-Alonso, A.1    Pita-Fernandez, S.2    Gonzalez-Carrero, J.3    Nogueira-March, J.L.4
  • 122
    • 67349241506 scopus 로고    scopus 로고
    • Predictive value of combined immunohistochemical markers in patients with pT1 urothelial carcinoma at radical cystectomy
    • Shariat SF, Bolenz C, Godoy G, et al. Predictive value of combined immunohistochemical markers in patients with pT1 urothelial carcinoma at radical cystectomy. J Urol 2009;182: 78-84.
    • (2009) J Urol , vol.182 , pp. 78-84
    • Shariat, S.F.1    Bolenz, C.2    Godoy, G.3
  • 123
    • 33947578925 scopus 로고    scopus 로고
    • Cooperative effect of cellcycle regulators expression on bladder cancer development and biologic aggressiveness
    • Shariat SF, Zlotta AR, Ashfaq R, et al. Cooperative effect of cellcycle regulators expression on bladder cancer development and biologic aggressiveness. Mod Pathol 2007;20:445-59.
    • (2007) Mod Pathol , vol.20 , pp. 445-459
    • Shariat, S.F.1    Zlotta, A.R.2    Ashfaq, R.3
  • 124
    • 33846003867 scopus 로고    scopus 로고
    • Predictive value of cell cycle biomarkers in nonmuscle invasive bladder transitional cell carcinoma
    • discussion 487
    • Shariat SF, Ashfaq R, Sagalowsky AI, Lotan Y. Predictive value of cell cycle biomarkers in nonmuscle invasive bladder transitional cell carcinoma. J Urol 2007;177:481-7;discussion 487.
    • (2007) J Urol , vol.177 , pp. 481-487
    • Shariat, S.F.1    Ashfaq, R.2    Sagalowsky, A.I.3    Lotan, Y.4
  • 125
    • 33751208922 scopus 로고    scopus 로고
    • Correlation of cyclin D1 and E1 expression with bladder cancer presence, invasion, progression, and metastasis
    • Shariat SF, Ashfaq R, Sagalowsky AI, Lotan Y. Correlation of cyclin D1 and E1 expression with bladder cancer presence, invasion, progression, and metastasis. Hum Pathol 2006;37: 1568-76.
    • (2006) Hum Pathol , vol.37 , pp. 1568-1576
    • Shariat, S.F.1    Ashfaq, R.2    Sagalowsky, A.I.3    Lotan, Y.4
  • 126
    • 68149179652 scopus 로고    scopus 로고
    • P53 Predictive value for pT1-2 N0 disease at radical cystectomy
    • Shariat SF, Lotan Y, Karakiewicz PI, et al. P53 Predictive value for pT1-2 N0 disease at radical cystectomy. J Urol 2009;182: 907-13.
    • (2009) J Urol , vol.182 , pp. 907-913
    • Shariat, S.F.1    Lotan, Y.2    Karakiewicz, P.I.3
  • 127
    • 2642581915 scopus 로고    scopus 로고
    • P53 mutations as an identification marker for the clonal origin of bladder tumors and its recurrences
    • Dahse R, Gartner D, Werner W, et al. P53 mutations as an identification marker for the clonal origin of bladder tumors and its recurrences. Oncol Rep 2003;10:2033-7.
    • (2003) Oncol Rep , vol.10 , pp. 2033-2037
    • Dahse, R.1    Gartner, D.2    Werner, W.3
  • 128
    • 33748085674 scopus 로고    scopus 로고
    • Neutrophil granulocytes are required for effective Bacillus Calmette-Guerin immunotherapy of bladder cancer and orchestrate local immune responses
    • Suttmann H, Riemensberger J, Bentien G, et al. Neutrophil granulocytes are required for effective Bacillus Calmette-Guerin immunotherapy of bladder cancer and orchestrate local immune responses. Cancer Res 2006;66:8250-7.
    • (2006) Cancer Res , vol.66 , pp. 8250-8257
    • Suttmann, H.1    Riemensberger, J.2    Bentien, G.3
  • 129
    • 0029885357 scopus 로고    scopus 로고
    • Prediction of response to treatment in superficial bladder carcinoma through pattern of interleukin-2 gene expression
    • Kaempfer R, Gerez L, Farbstein H, et al. Prediction of response to treatment in superficial bladder carcinoma through pattern of interleukin-2 gene expression. J Clin Oncol 1996;14:1778-86.
    • (1996) J Clin Oncol , vol.14 , pp. 1778-1786
    • Kaempfer, R.1    Gerez, L.2    Farbstein, H.3
  • 130
    • 0032877579 scopus 로고    scopus 로고
    • Correlation and prognostic significance of P53, P21WAF1/CIP1 and Ki-67 expression in patients with superficial bladder tumors treated with Bacillus Calmette-Guerin intravesical therapy
    • Zlotta AR, Noel JC, Fayt I, et al. Correlation and prognostic significance of P53, P21WAF1/CIP1 and Ki-67 expression in patients with superficial bladder tumors treated with Bacillus Calmette-Guerin intravesical therapy. J Urol 1999;161:792-8.
    • (1999) J Urol , vol.161 , pp. 792-798
    • Zlotta, A.R.1    Noel, J.C.2    Fayt, I.3
  • 131
    • 12144288735 scopus 로고    scopus 로고
    • Pretreatment P53 nuclear overexpression as a prognostic marker in superficial bladder cancer treated with Bacillus Calmette-Guerin (BCG)
    • Saint F, Le Frere Belda M-A, Quintela R, et al. Pretreatment P53 nuclear overexpression as a prognostic marker in superficial bladder cancer treated with Bacillus Calmette-Guerin (BCG). Eur Urol 2004;45:475-82.
    • (2004) Eur Urol , vol.45 , pp. 475-482
    • Saint, F.1    Le Frere Belda, M.-A.2    Quintela, R.3
  • 132
    • 0036184642 scopus 로고    scopus 로고
    • Prognostic value of P53 overexpression in T1G3 bladder tumors treated with Bacillus Calmette-Guerin therapy
    • Peyromaure M, Weibing S, Sebe P, et al. Prognostic value of P53 overexpression in T1G3 bladder tumors treated with Bacillus Calmette-Guerin therapy. Urology 2002;59:409-13.
    • (2002) Urology , vol.59 , pp. 409-413
    • Peyromaure, M.1    Weibing, S.2    Sebe, P.3
  • 133
    • 33845304992 scopus 로고    scopus 로고
    • Prognostic value of P53 for high risk superficial bladder cancer with longterm followup
    • Moonen PM, van Balken-Ory B, Kiemeney LA, et al. Prognostic value of P53 for high risk superficial bladder cancer with longterm followup. J Urol 2007;177:80-3.
    • (2007) J Urol , vol.177 , pp. 80-83
    • Moonen, P.M.1    Van Balken-Ory, B.2    Kiemeney, L.A.3
  • 134
    • 0029768723 scopus 로고    scopus 로고
    • Overexpression of P53 protein in a high-risk population of patients with superficial bladder cancer before and after Bacillus Calmette-Guérin therapy: Correlation to clinical outcome
    • Lacombe L, Dalbagni G, Zhang ZF, et al. Overexpression of P53 protein in a high-risk population of patients with superficial bladder cancer before and after Bacillus Calmette-Guérin therapy: correlation to clinical outcome. J Clin Oncol 1996;14: 2646-52.
    • (1996) J Clin Oncol , vol.14 , pp. 2646-2652
    • Lacombe, L.1    Dalbagni, G.2    Zhang, Z.F.3
  • 135
    • 70349268329 scopus 로고    scopus 로고
    • Protein expression patterns of ezrin are predictors of progression in T1G3 bladder tumours treated with nonmaintenance Bacillus Calmette-Guerin
    • Palou J, Algaba F, Vera I, et al. Protein expression patterns of ezrin are predictors of progression in T1G3 bladder tumours treated with nonmaintenance Bacillus Calmette-Guerin. Eur Urol 2009;56:829-36.
    • (2009) Eur Urol , vol.56 , pp. 829-836
    • Palou, J.1    Algaba, F.2    Vera, I.3
  • 136
    • 33947209498 scopus 로고    scopus 로고
    • Predictive value of P53 and PRB expression in superficial bladder cancer patients treated with BCG and interferon-alpha
    • Esuvaranathan K, Chiong E, Thamboo TP, et al. Predictive value of P53 and PRB expression in superficial bladder cancer patients treated with BCG and interferon-alpha. Cancer 2007;109: 1097-105.
    • (2007) Cancer , vol.109 , pp. 1097-1105
    • Esuvaranathan, K.1    Chiong, E.2    Thamboo, T.P.3
  • 137
    • 0031950890 scopus 로고    scopus 로고
    • Correlation between P53 over expression and response to Bacillus Calmette-Guerin therapy in a high risk select population of patients with T1G3 bladder cancer
    • Lebret T, Becette V, Barbagelatta M, et al. Correlation between P53 over expression and response to Bacillus Calmette-Guerin therapy in a high risk select population of patients with T1G3 bladder cancer. J Urol 1998;159:788-91.
    • (1998) J Urol , vol.159 , pp. 788-791
    • Lebret, T.1    Becette, V.2    Barbagelatta, M.3
  • 138
    • 36849076630 scopus 로고    scopus 로고
    • P53 gene and protein status: The role of P53 alterations in predicting outcome in patients with bladder cancer
    • George B, Datar RH, Wu L, et al. P53 gene and protein status: the role of P53 alterations in predicting outcome in patients with bladder cancer. J Clin Oncol 2007;25:5352-8.
    • (2007) J Clin Oncol , vol.25 , pp. 5352-5358
    • George, B.1    Datar, R.H.2    Wu, L.3
  • 139
    • 0141988849 scopus 로고    scopus 로고
    • Cytokine gene expression in a mouse model: The first instillations with viable Bacillus Calmette-Guerin determine the succeeding Th1 response
    • De Boer EC, Rooijakkers SJ, Schamhart DH, Kurth KH. Cytokine gene expression in a mouse model: the first instillations with viable Bacillus Calmette-Guerin determine the succeeding Th1 response. J Urol 2003;170:2004-8.
    • (2003) J Urol , vol.170 , pp. 2004-2008
    • De Boer, E.C.1    Rooijakkers, S.J.2    Schamhart, D.H.3    Kurth, K.H.4
  • 140
    • 0031890635 scopus 로고    scopus 로고
    • Absence of P53 overexpression and favorable response to cisplatin-based neo-adjuvant chemotherapy in urothelial carcinomas
    • Kakehi Y, Ozdemir E, Habuchi T, et al. Absence of P53 overexpression and favorable response to cisplatin-based neo-adjuvant chemotherapy in urothelial carcinomas. Jpn J Cancer Res 1998;89:214-20.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 214-220
    • Kakehi, Y.1    Ozdemir, E.2    Habuchi, T.3
  • 141
    • 0036419176 scopus 로고    scopus 로고
    • P21 and P53 immunostaining and survival following systemic chemotherapy for urothelial cancer
    • Jankevicius F, Goebell P, Kushima M, et al. P21 and P53 immunostaining and survival following systemic chemotherapy for urothelial cancer. Urol Int 2002;69:174-80.
    • (2002) Urol Int , vol.69 , pp. 174-180
    • Jankevicius, F.1    Goebell, P.2    Kushima, M.3
  • 142
    • 0031012872 scopus 로고    scopus 로고
    • P53 and treatment of bladder cancer
    • Cote RJ, Esrig D, Groshen S, et al. P53 and treatment of bladder cancer. Nature 1997;385:123-5.
    • (1997) Nature , vol.385 , pp. 123-125
    • Cote, R.J.1    Esrig, D.2    Groshen, S.3
  • 143
    • 0030783796 scopus 로고    scopus 로고
    • P53 nuclear immunoreactivity as a predictor of response and outcome following chemotherapy for metastatic bladder cancer
    • Sengelov L, Horn T, Steven K. P53 nuclear immunoreactivity as a predictor of response and outcome following chemotherapy for metastatic bladder cancer. J Cancer Res Clin Oncol 1997;123: 565-70.
    • (1997) J Cancer Res Clin Oncol , vol.123 , pp. 565-570
    • Sengelov, L.1    Horn, T.2    Steven, K.3
  • 144
    • 80052737876 scopus 로고    scopus 로고
    • Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on P53 status
    • Stadler WM, Lerner SP, Groshen S, et al. Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on P53 status. J Clin Oncol 2011;29:3443-9.
    • (2011) J Clin Oncol , vol.29 , pp. 3443-3449
    • Stadler, W.M.1    Lerner, S.P.2    Groshen, S.3
  • 145
    • 0029411679 scopus 로고
    • Immunohistochemical analysis of P53 and proliferating cell nuclear antigen (PCNA) in bladder cancer positive immunostaining and radiosensitivity
    • Ogura K, Habuchi T, Yamada H, et al. Immunohistochemical analysis of P53 and proliferating cell nuclear antigen (PCNA) in bladder cancer positive immunostaining and radiosensitivity. Int J Urol 1995;2:302-8.
    • (1995) Int J Urol , vol.2 , pp. 302-308
    • Ogura, K.1    Habuchi, T.2    Yamada, H.3
  • 146
    • 0031865344 scopus 로고    scopus 로고
    • Prognostic factors in muscleinvasive bladder cancer treated with radiotherapy: An immunohistochemical study
    • Osen I, Fossa SD, Majak B, et al. Prognostic factors in muscleinvasive bladder cancer treated with radiotherapy: an immunohistochemical study. Br J Urol 1998;81:862-9.
    • (1998) Br J Urol , vol.81 , pp. 862-869
    • Osen, I.1    Fossa, S.D.2    Majak, B.3
  • 147
    • 0030813388 scopus 로고    scopus 로고
    • Abnormal BCL-2 and PRB expression are independent correlates of radiation response in muscle-invasive bladder cancer
    • Pollack A, Wu CS, Czerniak B, et al. Abnormal BCL-2 and PRB expression are independent correlates of radiation response in muscle-invasive bladder cancer. Clin Cancer Res 1997;3: 1823-9.
    • (1997) Clin Cancer Res , vol.3 , pp. 1823-1829
    • Pollack, A.1    Wu, C.S.2    Czerniak, B.3
  • 148
    • 0034834191 scopus 로고    scopus 로고
    • P53, P21 and mdm2 expression vs the response to radiotherapy in transitional cell carcinoma of the bladder
    • Rotterud R, Berner A, Holm R, et al. P53, P21 and mdm2 expression vs the response to radiotherapy in transitional cell carcinoma of the bladder. BJU Int 2001;88:202-8.
    • (2001) BJU Int , vol.88 , pp. 202-208
    • Rotterud, R.1    Berner, A.2    Holm, R.3
  • 149
    • 0032521376 scopus 로고    scopus 로고
    • Elevated and absent PRB expression is associated with bladder cancer progression and has cooperative effects with P53
    • Cote RJ, Dunn MD, Chatterjee SJ, et al. Elevated and absent PRB expression is associated with bladder cancer progression and has cooperative effects with P53. Cancer Res 1998;58:1090-4.
    • (1998) Cancer Res , vol.58 , pp. 1090-1094
    • Cote, R.J.1    Dunn, M.D.2    Chatterjee, S.J.3
  • 150
    • 77951572370 scopus 로고    scopus 로고
    • Retinoblastoma protein expression predicts response to Bacillus Calmette-Guerin immunotherapy in patients with T1G3 bladder cancer
    • Cormio L, Tolve I, Annese P, et al. Retinoblastoma protein expression predicts response to Bacillus Calmette-Guerin immunotherapy in patients with T1G3 bladder cancer. Urol Oncol 2010;28:285-9.
    • (2010) Urol Oncol , vol.28 , pp. 285-289
    • Cormio, L.1    Tolve, I.2    Annese, P.3
  • 151
    • 0026700568 scopus 로고
    • Altered expression of the retinoblastoma gene product prognostic indicator in bladder cancer
    • Cordon-Cardo C, Wartinger D, Petrylak D, et al. Altered expression of the retinoblastoma gene product prognostic indicator in bladder cancer. J Natl Cancer Inst 1992;84:1251-6.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1251-1256
    • Cordon-Cardo, C.1    Wartinger, D.2    Petrylak, D.3
  • 152
    • 78449297462 scopus 로고    scopus 로고
    • Expression of PRB, P53, P16 and cyclin D1 and their clinical implications in urothelial carcinoma
    • Lee K, Jung ES, Choi YJ, et al. Expression of PRB, P53, P16 and cyclin D1 and their clinical implications in urothelial carcinoma. J Korean Med Sci 2010; 25:1449-55.
    • (2010) J Korean Med Sci , vol.25 , pp. 1449-1455
    • Lee, K.1    Jung, E.S.2    Choi, Y.J.3
  • 153
    • 0026673062 scopus 로고
    • Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer
    • Logothetis CJ, Xu HJ, Ro JY, et al. Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer. J Natl Cancer Inst 1992;84:1256-61.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1256-1261
    • Logothetis, C.J.1    Xu, H.J.2    Ro, J.Y.3
  • 154
    • 71949095084 scopus 로고    scopus 로고
    • Altered P53 and PRB expression is predictive of response to BCG treatment in T1G3 bladder cancer
    • Cormio L, Tolve I, Annese P, et al. Altered P53 and PRB expression is predictive of response to BCG treatment in T1G3 bladder cancer. Anticancer Res 2009;29:4201-4.
    • (2009) Anticancer Res , vol.29 , pp. 4201-4204
    • Cormio, L.1    Tolve, I.2    Annese, P.3
  • 156
    • 0033991755 scopus 로고    scopus 로고
    • An overview of the cell cycle arrest protein, P21(WAF1)
    • Harada K, Ogden GR. An overview of the cell cycle arrest protein, P21(WAF1). Oral Oncol 2000;36:3-7.
    • (2000) Oral Oncol , vol.36 , pp. 3-7
    • Harada, K.1    Ogden, G.R.2
  • 157
    • 0031661288 scopus 로고    scopus 로고
    • Expression of P21(waf1/cip1) protein in transitional cell bladder tumours and its prognostic value
    • Lipponen P, Aaltomaa S, Eskelinen M, et al. Expression of P21(waf1/cip1) protein in transitional cell bladder tumours and its prognostic value. Eur Urol 1998;34:237-43.
    • (1998) Eur Urol , vol.34 , pp. 237-243
    • Lipponen, P.1    Aaltomaa, S.2    Eskelinen, M.3
  • 158
    • 0037602186 scopus 로고    scopus 로고
    • Association of P53 and P21 expression with clinical outcome in patients with carcinoma in situ of the urinary bladder
    • Shariat SF, Kim J, Raptidis G, et al. Association of P53 and P21 expression with clinical outcome in patients with carcinoma in situ of the urinary bladder. Urology 2003;61:1140-5.
    • (2003) Urology , vol.61 , pp. 1140-1145
    • Shariat, S.F.1    Kim, J.2    Raptidis, G.3
  • 159
    • 0033624177 scopus 로고    scopus 로고
    • Loss of P21Waf1 expression is a strong predictor of reduced survival in primary superficial bladder cancers
    • Migaldi M, Sgambato A, Garagnani L, et al. Loss of P21Waf1 expression is a strong predictor of reduced survival in primary superficial bladder cancers. Clin Cancer Res 2000;6:3131-8.
    • (2000) Clin Cancer Res , vol.6 , pp. 3131-3138
    • Migaldi, M.1    Sgambato, A.2    Garagnani, L.3
  • 160
    • 0033752803 scopus 로고    scopus 로고
    • Evaluation of P21WAF1/CIP1 and cyclin D1 expression in the progression of superficial bladder cancer
    • Liukkonen T, Lipponen P, Raitanen M, et al. Evaluation of P21WAF1/CIP1 and cyclin D1 expression in the progression of superficial bladder cancer. Finbladder Group. Urol Res 2000;28: 285-92.
    • (2000) Finbladder Group. Urol Res , vol.28 , pp. 285-292
    • Liukkonen, T.1    Lipponen, P.2    Raitanen, M.3
  • 161
    • 0032527133 scopus 로고    scopus 로고
    • Effect of P21WAF1/CIP1 expression on tumor progression in bladder cancer
    • Stein JP, Ginsberg DA, Grossfeld GD, et al. Effect of P21WAF1/CIP1 expression on tumor progression in bladder cancer. J Natl Cancer Inst 1998;90:1072-9.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1072-1079
    • Stein, J.P.1    Ginsberg, D.A.2    Grossfeld, G.D.3
  • 162
    • 38049047956 scopus 로고    scopus 로고
    • Multiple biomarkers improve prediction of bladder cancer recurrence and mortality in patients undergoing cystectomy
    • Shariat SF, Karakiewicz PI, Ashfaq R, et al. Multiple biomarkers improve prediction of bladder cancer recurrence and mortality in patients undergoing cystectomy. Cancer 2008;112:315-25.
    • (2008) Cancer , vol.112 , pp. 315-325
    • Shariat, S.F.1    Karakiewicz, P.I.2    Ashfaq, R.3
  • 163
    • 71249096845 scopus 로고    scopus 로고
    • Combination of multiple molecular markers can improve prognostication in patients with locally advanced and lymph node positive bladder cancer
    • Shariat SF, Chade DC, Karakiewicz PI, et al. Combination of multiple molecular markers can improve prognostication in patients with locally advanced and lymph node positive bladder cancer. J Urol 2010;183:68-75.
    • (2010) J Urol , vol.183 , pp. 68-75
    • Shariat, S.F.1    Chade, D.C.2    Karakiewicz, P.I.3
  • 164
    • 0033932176 scopus 로고    scopus 로고
    • Cell cycle regulators in bladder cancer: A multivariate survival study with emphasis on P27Kip1
    • Korkolopoulou P, Christodoulou P, Konstantinidou AE, et al. Cell cycle regulators in bladder cancer: a multivariate survival study with emphasis on P27Kip1. Hum Pathol 2000;31:751-60.
    • (2000) Hum Pathol , vol.31 , pp. 751-760
    • Korkolopoulou, P.1    Christodoulou, P.2    Konstantinidou, A.E.3
  • 165
    • 0033153763 scopus 로고    scopus 로고
    • Loss of P27Kip1 expression correlates with tumor grade and with reduced diseasefree survival in primary superficial bladder cancers
    • Sgambato A, Migaldi M, Faraglia B, et al. Loss of P27Kip1 expression correlates with tumor grade and with reduced diseasefree survival in primary superficial bladder cancers. Cancer Res 1999;59:3245-50.
    • (1999) Cancer Res , vol.59 , pp. 3245-3250
    • Sgambato, A.1    Migaldi, M.2    Faraglia, B.3
  • 166
    • 0035805051 scopus 로고    scopus 로고
    • Decreasing of P27(Kip1) and cyclin e protein levels is associated with progression from superficial into invasive bladder cancer
    • Kamai T, Takagi K, Asami H, et al. Decreasing of P27(Kip1) and cyclin E protein levels is associated with progression from superficial into invasive bladder cancer. Br J Cancer 2001;84: 1242-51.
    • (2001) Br J Cancer , vol.84 , pp. 1242-1251
    • Kamai, T.1    Takagi, K.2    Asami, H.3
  • 167
    • 0034493879 scopus 로고    scopus 로고
    • High-throughput tissue microarray analysis of cyclin e gene amplification and overexpression in urinary bladder cancer
    • Richter J, Wagner U, Kononen J, et al. High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer. Am J Pathol 2000;157: 787-94.
    • (2000) Am J Pathol , vol.157 , pp. 787-794
    • Richter, J.1    Wagner, U.2    Kononen, J.3
  • 168
    • 0032849914 scopus 로고    scopus 로고
    • Loss of cell cycle regulators P27(Kip1) and cyclin e in transitional cell carcinoma of the bladder correlates with tumor grade and patient survival
    • Del Pizzo JJ, Borkowski A, Jacobs SC, Kyprianou N. Loss of cell cycle regulators P27(Kip1) and cyclin E in transitional cell carcinoma of the bladder correlates with tumor grade and patient survival. Am J Pathol 1999;155:1129-36.
    • (1999) Am J Pathol , vol.155 , pp. 1129-1136
    • Del Pizzo, J.J.1    Borkowski, A.2    Jacobs, S.C.3    Kyprianou, N.4
  • 169
    • 0345211630 scopus 로고    scopus 로고
    • Cyclin D1 overexpression lacks prognostic significance in superficial urinary bladder cancer
    • Wagner U, Suess K, Luginbuhl T, et al. Cyclin D1 overexpression lacks prognostic significance in superficial urinary bladder cancer. J Pathol 1999;188:44-50.
    • (1999) J Pathol , vol.188 , pp. 44-50
    • Wagner, U.1    Suess, K.2    Luginbuhl, T.3
  • 170
    • 33646008909 scopus 로고    scopus 로고
    • Cyclin D3 expression in primary Ta/T1 bladder cancer
    • Lopez-Beltran A, Requena MJ, Luque RJ, et al. Cyclin D3 expression in primary Ta/T1 bladder cancer. J Pathol 2006;209: 106-13.
    • (2006) J Pathol , vol.209 , pp. 106-113
    • Lopez-Beltran, A.1    Requena, M.J.2    Luque, R.J.3
  • 171
    • 1842509884 scopus 로고    scopus 로고
    • Combined effects of P53, P21, and PRB expression in the progression of bladder transitional cell carcinoma
    • Chatterjee SJ, Datar R, Youssefzadeh D, et al. Combined effects of P53, P21, and PRB expression in the progression of bladder transitional cell carcinoma. J Clin Oncol 2004;22:1007-13.
    • (2004) J Clin Oncol , vol.22 , pp. 1007-1013
    • Chatterjee, S.J.1    Datar, R.2    Youssefzadeh, D.3
  • 172
    • 0031953814 scopus 로고    scopus 로고
    • P53 and RB expression predict progression in T1 bladder cancer
    • Grossman HB, Liebert M, Antelo M, et al. P53 and RB expression predict progression in T1 bladder cancer. Clin Cancer Res 1998;4: 829-34.
    • (1998) Clin Cancer Res , vol.4 , pp. 829-834
    • Grossman, H.B.1    Liebert, M.2    Antelo, M.3
  • 173
    • 0030893707 scopus 로고    scopus 로고
    • Cooperative effects of P53 and PRB alterations in primary superficial bladder tumors
    • Cordon-Cardo C, Zhang ZF, Dalbagni G, et al. Cooperative effects of P53 and PRB alterations in primary superficial bladder tumors. Cancer Res 1997;57:1217-21.
    • (1997) Cancer Res , vol.57 , pp. 1217-1221
    • Cordon-Cardo, C.1    Zhang, Z.F.2    Dalbagni, G.3
  • 174
    • 0033521887 scopus 로고    scopus 로고
    • Level of retinoblastoma protein expression correlates with P16 (MTS-1/INK4A/CDKN2) status in bladder cancer
    • Benedict WF, Lerner SP, Zhou J, et al. Level of retinoblastoma protein expression correlates with P16 (MTS-1/INK4A/CDKN2) status in bladder cancer. Oncogene 1999;18:1197-203.
    • (1999) Oncogene , vol.18 , pp. 1197-1203
    • Benedict, W.F.1    Lerner, S.P.2    Zhou, J.3
  • 175
    • 34547732470 scopus 로고    scopus 로고
    • Phase II trial of adjuvant gemcitabine plus cisplatin-based chemotherapy in patients with locally advanced bladder cancer
    • Jin JO, Lehmann J, Taxy J, et al. Phase II trial of adjuvant gemcitabine plus cisplatin-based chemotherapy in patients with locally advanced bladder cancer. Clin Genitourin Cancer 2006;5: 150-4.
    • (2006) Clin Genitourin Cancer , vol.5 , pp. 150-154
    • Jin, J.O.1    Lehmann, J.2    Taxy, J.3
  • 176
    • 1842457693 scopus 로고    scopus 로고
    • P53, P21, PRB, and P16 expression predict clinical outcome in cystectomy with bladder cancer
    • Shariat SF, Tokunaga H, Zhou J, et al. P53, P21, PRB, and P16 expression predict clinical outcome in cystectomy with bladder cancer. J Clin Oncol 2004;22:1014-24.
    • (2004) J Clin Oncol , vol.22 , pp. 1014-1024
    • Shariat, S.F.1    Tokunaga, H.2    Zhou, J.3
  • 177
    • 0032877668 scopus 로고    scopus 로고
    • Dysregulation of apoptosis in cancer
    • Reed JC. Dysregulation of apoptosis in cancer. J Clin Oncol 1999; 17:2941-53.
    • (1999) J Clin Oncol , vol.17 , pp. 2941-2953
    • Reed, J.C.1
  • 178
    • 0035900947 scopus 로고    scopus 로고
    • Urine detection of survivin and diagnosis of bladder cancer
    • Smith SD, Wheeler MA, Plescia J, et al. Urine detection of survivin and diagnosis of bladder cancer. JAMA 2001;285: 324-8.
    • (2001) JAMA , vol.285 , pp. 324-328
    • Smith, S.D.1    Wheeler, M.A.2    Plescia, J.3
  • 179
    • 0345868325 scopus 로고    scopus 로고
    • Urine detection of survivin is a sensitive marker for the noninvasive diagnosis of bladder cancer
    • Shariat SF, Casella R, Khoddami SM, et al. Urine detection of survivin is a sensitive marker for the noninvasive diagnosis of bladder cancer. J Urol 2004;171:626-30.
    • (2004) J Urol , vol.171 , pp. 626-630
    • Shariat, S.F.1    Casella, R.2    Khoddami, S.M.3
  • 180
    • 3242752010 scopus 로고    scopus 로고
    • Survivin mRNA copy number in bladder washings predicts tumor recurrence in patients with superficial urothelial cell carcinomas
    • Schultz IJ, Kiemeney LA, Karthaus HF, et al. Survivin mRNA copy number in bladder washings predicts tumor recurrence in patients with superficial urothelial cell carcinomas. Clin Chem 2004;50:1425-8.
    • (2004) Clin Chem , vol.50 , pp. 1425-1428
    • Schultz, I.J.1    Kiemeney, L.A.2    Karthaus, H.F.3
  • 181
    • 33947254466 scopus 로고    scopus 로고
    • Survivin expression is associated with bladder cancer presence, stage, progression, and mortality
    • Shariat SF, Ashfaq R, Karakiewicz PI, et al. Survivin expression is associated with bladder cancer presence, stage, progression, and mortality. Cancer 2007;109:1106-13.
    • (2007) Cancer , vol.109 , pp. 1106-1113
    • Shariat, S.F.1    Ashfaq, R.2    Karakiewicz, P.I.3
  • 182
    • 0041528183 scopus 로고    scopus 로고
    • Survivin mRNA expression is elevated in malignant urothelial cell carcinomas and predicts time to recurrence
    • Schultz IJ, Kiemeney LA, Witjes JA, et al. Survivin mRNA expression is elevated in malignant urothelial cell carcinomas and predicts time to recurrence. Anticancer Res 2003;23:3327-31.
    • (2003) Anticancer Res , vol.23 , pp. 3327-3331
    • Schultz, I.J.1    Kiemeney, L.A.2    Witjes, J.A.3
  • 183
    • 33846469888 scopus 로고    scopus 로고
    • Use of combined apoptosis biomarkers for prediction of bladder cancer recurrence and mortality after radical cystectomy
    • Karam JA, Lotan Y, Karakiewicz PI, et al. Use of combined apoptosis biomarkers for prediction of bladder cancer recurrence and mortality after radical cystectomy. Lancet Oncol 2007; 8:128-36.
    • (2007) Lancet Oncol , vol.8 , pp. 128-136
    • Karam, J.A.1    Lotan, Y.2    Karakiewicz, P.I.3
  • 184
    • 72549108606 scopus 로고    scopus 로고
    • Survivin as a prognostic marker for urothelial carcinoma of the bladder: A multicenter external validation study
    • Shariat SF, Karakiewicz PI, Godoy G, et al. Survivin as a prognostic marker for urothelial carcinoma of the bladder: a multicenter external validation study. Clin Cancer Res 2009;15: 7012-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 7012-7019
    • Shariat, S.F.1    Karakiewicz, P.I.2    Godoy, G.3
  • 185
    • 34648843747 scopus 로고    scopus 로고
    • Survivin expression in patients with non-muscle-invasive urothelial cell carcinoma of the bladder
    • Karam JA, Lotan Y, Ashfaq R, et al. Survivin expression in patients with non-muscle-invasive urothelial cell carcinoma of the bladder. Urology 2007;70:482-6.
    • (2007) Urology , vol.70 , pp. 482-486
    • Karam, J.A.1    Lotan, Y.2    Ashfaq, R.3
  • 186
    • 39349098773 scopus 로고    scopus 로고
    • Survivin: A promising biomarker for detection and prognosis of bladder cancer
    • Margulis V, Lotan Y, Shariat SF. Survivin: a promising biomarker for detection and prognosis of bladder cancer. World J Urol 2008; 26:59-65.
    • (2008) World J Urol , vol.26 , pp. 59-65
    • Margulis, V.1    Lotan, Y.2    Shariat, S.F.3
  • 187
    • 0032413097 scopus 로고    scopus 로고
    • BCL-2 and P53 expressions in invasive bladder cancers
    • Kong G, Shin KY, Oh YH, et al. BCL-2 and P53 expressions in invasive bladder cancers. Acta Oncol 1998;37:715-20.
    • (1998) Acta Oncol , vol.37 , pp. 715-720
    • Kong, G.1    Shin, K.Y.2    Oh, Y.H.3
  • 188
    • 0036875813 scopus 로고    scopus 로고
    • Prognostic significance of P53, BCL-2 and Ki-67 in high risk superficial bladder cancer
    • Stavropoulos NE, Filiadis I, Ioachim E, et al. Prognostic significance of P53, BCL-2 and Ki-67 in high risk superficial bladder cancer. Anticancer Res 2002;22:3759-64.
    • (2002) Anticancer Res , vol.22 , pp. 3759-3764
    • Stavropoulos, N.E.1    Filiadis, I.2    Ioachim, E.3
  • 189
    • 0030043995 scopus 로고    scopus 로고
    • Immunohistochemical analysis of BCL-2 expression in transitional cell carcinoma of the bladder
    • Shiina H, Igawa M, Urakami S, et al. Immunohistochemical analysis of BCL-2 expression in transitional cell carcinoma of the bladder. J Clin Pathol 1996;49:395-9.
    • (1996) J Clin Pathol , vol.49 , pp. 395-399
    • Shiina, H.1    Igawa, M.2    Urakami, S.3
  • 190
    • 0343775631 scopus 로고    scopus 로고
    • Apoptosis, P53, BCL-2, and Ki-67 in invasive bladder carcinoma: Possible predictors for response to radiochemotherapy and successful bladder preservation
    • Rodel C, Grabenbauer GG, Rodel F, et al. Apoptosis, P53, BCL-2, and Ki-67 in invasive bladder carcinoma: possible predictors for response to radiochemotherapy and successful bladder preservation. Int J Radiat Oncol Biol Phys 2000;46:1213-21.
    • (2000) Int J Radiat Oncol Biol Phys , vol.46 , pp. 1213-1221
    • Rodel, C.1    Grabenbauer, G.G.2    Rodel, F.3
  • 191
    • 0034749556 scopus 로고    scopus 로고
    • Prognostic factors in transitional cell cancer of the bladder: An emerging role for BCL-2 and P53
    • Ong F, Moonen LM, Gallee MP, et al. Prognostic factors in transitional cell cancer of the bladder: an emerging role for BCL-2 and P53. Radiother Oncol 2001;61:169-75.
    • (2001) Radiother Oncol , vol.61 , pp. 169-175
    • Ong, F.1    Moonen, L.M.2    Gallee, M.P.3
  • 192
    • 0034627004 scopus 로고    scopus 로고
    • Caspase 3 and P27 as predictors of invasive bladder cancer
    • Burton PB, Anderson CJ, Corbishly CM. Caspase 3 and P27 as predictors of invasive bladder cancer. N Engl J Med 2000;343: 1418-20.
    • (2000) N Engl J Med , vol.343 , pp. 1418-1420
    • Burton, P.B.1    Anderson, C.J.2    Corbishly, C.M.3
  • 193
    • 33646022893 scopus 로고    scopus 로고
    • Soluble Fas-A promising novel urinary marker for the detection of recurrent superficial bladder cancer
    • Svatek RS, Herman MP, Lotan Y, et al. Soluble Fas-A promising novel urinary marker for the detection of recurrent superficial bladder cancer. Cancer 2006;106:1701-7.
    • (2006) Cancer , vol.106 , pp. 1701-1707
    • Svatek, R.S.1    Herman, M.P.2    Lotan, Y.3
  • 194
    • 0036927371 scopus 로고    scopus 로고
    • Immunohistochemical study of pro-apoptotic factors Bax, Fas and CPP32 in urinary bladder cancer: Prognostic implications
    • Giannopoulou I, Nakopoulou L, Zervas A, et al. Immunohistochemical study of pro-apoptotic factors Bax, Fas and CPP32 in urinary bladder cancer: prognostic implications. Urol Res 2002;30:342-5.
    • (2002) Urol Res , vol.30 , pp. 342-345
    • Giannopoulou, I.1    Nakopoulou, L.2    Zervas, A.3
  • 195
    • 26944490408 scopus 로고    scopus 로고
    • Prognostic impact of FAS/CD95/APO-1 in urothelial cancers: Decreased expression of Fas is associated with disease progression
    • Yamana K, Bilim V, Hara N, et al. Prognostic impact of FAS/CD95/APO-1 in urothelial cancers: decreased expression of Fas is associated with disease progression. Br J Cancer 2005;93: 544-51.
    • (2005) Br J Cancer , vol.93 , pp. 544-551
    • Yamana, K.1    Bilim, V.2    Hara, N.3
  • 196
    • 0028884557 scopus 로고
    • Angiogenesis in bladder cancer: Relationship between microvessel density and tumor prognosis
    • Bochner BH, Cote RJ, Weidner N, et al. Angiogenesis in bladder cancer: relationship between microvessel density and tumor prognosis. J Natl Cancer Inst 1995;87:1603-12.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1603-1612
    • Bochner, B.H.1    Cote, R.J.2    Weidner, N.3
  • 197
    • 0030810781 scopus 로고    scopus 로고
    • Relationship of tumor angiogenesis and nuclear P53 accumulation in invasive bladder cancer
    • Bochner BH, Esrig D, Groshen S, et al. Relationship of tumor angiogenesis and nuclear P53 accumulation in invasive bladder cancer. Clin Cancer Res 1997;3:1615-22.
    • (1997) Clin Cancer Res , vol.3 , pp. 1615-1622
    • Bochner, B.H.1    Esrig, D.2    Groshen, S.3
  • 198
    • 59249088847 scopus 로고    scopus 로고
    • Molecular targets and targeted therapies in bladder cancer management
    • Youssef RF, Mitra AP, Bartsch Jr G, et al. Molecular targets and targeted therapies in bladder cancer management. World J Urol 2009; 27:9-20.
    • (2009) World J Urol , vol.27 , pp. 9-20
    • Youssef, R.F.1    Mitra, A.P.2    Bartsch, G.3
  • 199
    • 18744423089 scopus 로고    scopus 로고
    • Thrombospondin-1 expression in bladder cancer: Association with P53 alterations, tumor angiogenesis, and tumor progression
    • Grossfeld GD, Ginsberg DA, Stein JP, et al. Thrombospondin-1 expression in bladder cancer: association with P53 alterations, tumor angiogenesis, and tumor progression. J Natl Cancer Inst 1997;89:219-27.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 219-227
    • Grossfeld, G.D.1    Ginsberg, D.A.2    Stein, J.P.3
  • 200
    • 0034489115 scopus 로고    scopus 로고
    • The prognostic value of angiogenesis factor expression for predicting recurrence and metastasis of bladder cancer after neoadjuvant chemotherapy and radical cystectomy
    • Inoue K, Slaton JW, Karashima T, et al. The prognostic value of angiogenesis factor expression for predicting recurrence and metastasis of bladder cancer after neoadjuvant chemotherapy and radical cystectomy. Clin Cancer Res 2000;6: 4866-73.
    • (2000) Clin Cancer Res , vol.6 , pp. 4866-4873
    • Inoue, K.1    Slaton, J.W.2    Karashima, T.3
  • 201
    • 0036276703 scopus 로고    scopus 로고
    • Angiogenesis in bladder cancer - Prognostic marker and target for future therapy
    • Streeter EH, Harris AL. Angiogenesis in bladder cancer - prognostic marker and target for future therapy. Surg Oncol 2002;11:85-100.
    • (2002) Surg Oncol , vol.11 , pp. 85-100
    • Streeter, E.H.1    Harris, A.L.2
  • 202
    • 77950518406 scopus 로고    scopus 로고
    • Association of angiogenesis related markers with bladder cancer outcomes and other molecular markers
    • Shariat SF, Youssef RF, Gupta A, et al. Association of angiogenesis related markers with bladder cancer outcomes and other molecular markers. J Urol 2010;183:1744-50.
    • (2010) J Urol , vol.183 , pp. 1744-1750
    • Shariat, S.F.1    Youssef, R.F.2    Gupta, A.3
  • 203
    • 84907439093 scopus 로고    scopus 로고
    • Molecular markers for bladder cancer staging and prognosis
    • In: Soloway M, Khoury S, eds., 2nd ed. Paris: ICUD-EAU - Editions 21
    • Shariat SF, Karakiewicz PI. Molecular markers for bladder cancer staging and prognosis. In: Soloway M, Khoury S, eds. Bladder Cancer, 2nd ed. Paris: ICUD-EAU - Editions 21, 2012:217.
    • (2012) Bladder Cancer , pp. 217
    • Shariat, S.F.1    Karakiewicz, P.I.2
  • 204
    • 0029024310 scopus 로고
    • Tumor angiogenesis correlates with lymph node metastases in invasive bladder cancer
    • Jaeger TM, Weidner N, Chew K, et al. Tumor angiogenesis correlates with lymph node metastases in invasive bladder cancer. J Urol 1995; 154: 69-71.
    • (1995) J Urol , vol.154 , pp. 69-71
    • Jaeger, T.M.1    Weidner, N.2    Chew, K.3
  • 205
    • 33749578614 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C expression in bladder transitional cell cancer and its relationship to lymph node metastasis
    • Zu X, Tang Z, Li Y, et al. Vascular endothelial growth factor-C expression in bladder transitional cell cancer and its relationship to lymph node metastasis. BJU Int 2006;98:1090-3.
    • (2006) BJU Int , vol.98 , pp. 1090-1093
    • Zu, X.1    Tang, Z.2    Li, Y.3
  • 206
    • 32944469620 scopus 로고    scopus 로고
    • Lymphangiogenesis and angiogenesis in bladder cancer: Prognostic implications and regulation by vascular endothelial growth factors-A, -C, and -D
    • Miyata Y, Kanda S, Ohba K, et al. Lymphangiogenesis and angiogenesis in bladder cancer: prognostic implications and regulation by vascular endothelial growth factors-A, -C, and -D. Clin Cancer Res 2006;12:800-6.
    • (2006) Clin Cancer Res , vol.12 , pp. 800-806
    • Miyata, Y.1    Kanda, S.2    Ohba, K.3
  • 207
    • 0032854988 scopus 로고    scopus 로고
    • Urinary vascular endothelial growth factor and its correlation with bladder cancer recurrence rates
    • Crew JP, O'Brien T, Bicknell R, et al. Urinary vascular endothelial growth factor and its correlation with bladder cancer recurrence rates. J Urol 1999;161:799-804.
    • (1999) J Urol , vol.161 , pp. 799-804
    • Crew, J.P.1    O'Brien, T.2    Bicknell, R.3
  • 208
    • 0035511776 scopus 로고    scopus 로고
    • Clinical significance of urinary vascular endothelial growth factor in patients with superficial bladder tumors
    • Jeon SH, Lee SJ, Chang SG. Clinical significance of urinary vascular endothelial growth factor in patients with superficial bladder tumors. Oncol Rep 2001;8:1265-7.
    • (2001) Oncol Rep , vol.8 , pp. 1265-1267
    • Jeon, S.H.1    Lee, S.J.2    Chang, S.G.3
  • 209
    • 0033452654 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in primary superficial bladder cancer
    • Chow NH, Liu HS, Chan SH, et al. Expression of vascular endothelial growth factor in primary superficial bladder cancer. Anticancer Res 1999;19:4593-7.
    • (1999) Anticancer Res , vol.19 , pp. 4593-4597
    • Chow, N.H.1    Liu, H.S.2    Chan, S.H.3
  • 210
    • 3242730312 scopus 로고    scopus 로고
    • Prognostic significance of angiogenesis in superficial bladder cancer
    • Stavropoulos NE, Bouropoulos C, Ioachim IE, et al. Prognostic significance of angiogenesis in superficial bladder cancer. Int Urol Nephrol 2004;36:163-7.
    • (2004) Int Urol Nephrol , vol.36 , pp. 163-167
    • Stavropoulos, N.E.1    Bouropoulos, C.2    Ioachim, I.E.3
  • 211
    • 65349189892 scopus 로고    scopus 로고
    • Targeting angiogenesis in bladder cancer
    • Elfiky AA, Rosenberg JE. Targeting angiogenesis in bladder cancer. Curr Oncol Rep 2009;11:244-9.
    • (2009) Curr Oncol Rep , vol.11 , pp. 244-249
    • Elfiky, A.A.1    Rosenberg, J.E.2
  • 212
    • 79952422386 scopus 로고    scopus 로고
    • Predictors of outcome of non-muscleinvasive and muscle-invasive bladder cancer
    • Youssef RF, Lotan Y. Predictors of outcome of non-muscleinvasive and muscle-invasive bladder cancer. Sci World J 2011;11: 369-81.
    • (2011) Sci World J , vol.11 , pp. 369-381
    • Youssef, R.F.1    Lotan, Y.2
  • 213
    • 47949128768 scopus 로고    scopus 로고
    • Positive response to bevacizumab in a patient with metastatic, chemotherapy-refractory urothelial carcinoma
    • Osai WE, Ng CS, Pagliaro LC. Positive response to bevacizumab in a patient with metastatic, chemotherapy-refractory urothelial carcinoma. Anticancer Drugs 2008;19:427-9.
    • (2008) Anticancer Drugs , vol.19 , pp. 427-429
    • Osai, W.E.1    Ng, C.S.2    Pagliaro, L.C.3
  • 214
    • 0026081021 scopus 로고
    • A sensitive enzyme immunoassay for human basic fibroblast growth factor
    • Watanabe H, Hori A, Seno M, et al. A sensitive enzyme immunoassay for human basic fibroblast growth factor. Biochem Biophys Res Commun 1991;175:229-35.
    • (1991) Biochem Biophys Res Commun , vol.175 , pp. 229-235
    • Watanabe, H.1    Hori, A.2    Seno, M.3
  • 215
    • 0032579442 scopus 로고    scopus 로고
    • Expression of basic fibroblast growth factor is associated with resistance to cisplatin in a human bladder cancer cell line
    • Miyake H, Hara I, Gohji K, et al. Expression of basic fibroblast growth factor is associated with resistance to cisplatin in a human bladder cancer cell line. Cancer Lett 1998;123:121-6.
    • (1998) Cancer Lett , vol.123 , pp. 121-126
    • Miyake, H.1    Hara, I.2    Gohji, K.3
  • 216
    • 0028060380 scopus 로고
    • Control of angiogenesis in fibroblasts by P53 regulation of thrombospondin-1
    • Dameron KM, Volpert OV, Tainsky MA, Bouck N. Control of angiogenesis in fibroblasts by P53 regulation of thrombospondin-1. Science 1994;265:1582-4.
    • (1994) Science , vol.265 , pp. 1582-1584
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3    Bouck, N.4
  • 217
    • 0027291618 scopus 로고
    • Comparison of five histopathologic methods to assess cellular proliferation in transitional cell carcinoma of the urinary bladder
    • Cohen MB, Waldman FM, Carroll PR, et al. Comparison of five histopathologic methods to assess cellular proliferation in transitional cell carcinoma of the urinary bladder. Hum Pathol 1993; 24: 772-8.
    • (1993) Hum Pathol , vol.24 , pp. 772-778
    • Cohen, M.B.1    Waldman, F.M.2    Carroll, P.R.3
  • 218
    • 14844354276 scopus 로고    scopus 로고
    • P16 immunoreactivity is an independent predictor of tumor progression in minimally invasive urothelial bladder carcinoma
    • Kruger S, Mahnken A, Kausch I, Feller AC. P16 immunoreactivity is an independent predictor of tumor progression in minimally invasive urothelial bladder carcinoma. Eur Urol 2005;47:463-7.
    • (2005) Eur Urol , vol.47 , pp. 463-467
    • Kruger, S.1    Mahnken, A.2    Kausch, I.3    Feller, A.C.4
  • 219
    • 59049085842 scopus 로고    scopus 로고
    • Multi-institutional validation of the predictive value of Ki-67 labeling index in patients with urinary bladder cancer
    • Margulis V, Lotan Y, Karakiewicz PI, et al. Multi-institutional validation of the predictive value of Ki-67 labeling index in patients with urinary bladder cancer. J Natl Cancer Inst 2009;101: 114-9.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 114-119
    • Margulis, V.1    Lotan, Y.2    Karakiewicz, P.I.3
  • 220
    • 33846206414 scopus 로고    scopus 로고
    • Ki-67 is an independent predictor of bladder cancer outcome in patients treated with radical cystectomy for organ-confined disease
    • Margulis V, Shariat SF, Ashfaq R, et al. Ki-67 is an independent predictor of bladder cancer outcome in patients treated with radical cystectomy for organ-confined disease. Clin Cancer Res 2006;12:7369-73.
    • (2006) Clin Cancer Res , vol.12 , pp. 7369-7373
    • Margulis, V.1    Shariat, S.F.2    Ashfaq, R.3
  • 221
    • 30444455923 scopus 로고    scopus 로고
    • Ki-67 MIB1 labelling index and the prognosis of primary TaT1 urothelial cell carcinoma of the bladder
    • Quintero A, Alvarez-Kindelan J, Luque RJ, et al. Ki-67 MIB1 labelling index and the prognosis of primary TaT1 urothelial cell carcinoma of the bladder. J Clin Pathol 2006;59:83-8.
    • (2006) J Clin Pathol , vol.59 , pp. 83-88
    • Quintero, A.1    Alvarez-Kindelan, J.2    Luque, R.J.3
  • 222
    • 7644221450 scopus 로고    scopus 로고
    • Prognostic value of morphometry in low grade papillary urothelial bladder neoplasms
    • Ramos D, Ruiz A, Morell L, et al. Prognostic value of morphometry in low grade papillary urothelial bladder neoplasms. Anal Quant Cytol Histol 2004;26:285-94.
    • (2004) Anal Quant Cytol Histol , vol.26 , pp. 285-294
    • Ramos, D.1    Ruiz, A.2    Morell, L.3
  • 223
    • 0027141253 scopus 로고
    • Growth fractions in bladder cancer defined by Ki67: Association with cancer grade, category and recurrence rate of superficial lesions
    • Stavropoulos NE, Ioackim-Velogianni E, Hastazeris K, et al. Growth fractions in bladder cancer defined by Ki67: association with cancer grade, category and recurrence rate of superficial lesions. Br J Urol 1993;72:736-9.
    • (1993) Br J Urol , vol.72 , pp. 736-739
    • Stavropoulos, N.E.1    Ioackim-Velogianni, E.2    Hastazeris, K.3
  • 224
    • 0037431547 scopus 로고    scopus 로고
    • Ki-67 index enhances the prognostic accuracy of the urothelial superficial bladder carcinoma risk group classification
    • Santos L, Amaro T, Costa C, et al. Ki-67 index enhances the prognostic accuracy of the urothelial superficial bladder carcinoma risk group classification. Int J Cancer 2003;105: 267-72.
    • (2003) Int J Cancer , vol.105 , pp. 267-272
    • Santos, L.1    Amaro, T.2    Costa, C.3
  • 225
    • 0033385056 scopus 로고    scopus 로고
    • Predictive value of cell cycle markers P53, MDM2, P21, and Ki-67 in superficial bladder tumor recurrence
    • Pfister C, Moore L, Allard P, et al. Predictive value of cell cycle markers P53, MDM2, P21, and Ki-67 in superficial bladder tumor recurrence. Clin Cancer Res 1999;5:4079-84.
    • (1999) Clin Cancer Res , vol.5 , pp. 4079-4084
    • Pfister, C.1    Moore, L.2    Allard, P.3
  • 226
    • 0033839271 scopus 로고    scopus 로고
    • Evaluation of P53 protein overexpression, Ki67 proliferative activity and mitotic index as markers of tumour recurrence in superficial transitional cell carcinoma of the bladder
    • Gontero P, Casetta G, Zitella A, et al. Evaluation of P53 protein overexpression, Ki67 proliferative activity and mitotic index as markers of tumour recurrence in superficial transitional cell carcinoma of the bladder. Eur Urol 2000;38:287-96.
    • (2000) Eur Urol , vol.38 , pp. 287-296
    • Gontero, P.1    Casetta, G.2    Zitella, A.3
  • 227
    • 0034099965 scopus 로고    scopus 로고
    • Prognostic value of MIB1 antibody labeling index to predict response to Bacillus Calmette- Guerin therapy in a high-risk selected population of patients with stage T1 grade G3 bladder cancer
    • Lebret T, Becette V, Hervé J-M, et al. Prognostic value of MIB1 antibody labeling index to predict response to Bacillus Calmette- Guerin therapy in a high-risk selected population of patients with stage T1 grade G3 bladder cancer. Eur Urol 2000;37:654-9.
    • (2000) Eur Urol , vol.37 , pp. 654-659
    • Lebret, T.1    Becette, V.2    Hervé, J.-M.3
  • 228
    • 80052920906 scopus 로고    scopus 로고
    • Expression of cell cycle-associated proteins in non-muscle-invasive bladder cancer: Correlation with intravesical recurrence following transurethral resection
    • Behnsawy HM, Miyake H, Abdalla MA, et al. Expression of cell cycle-associated proteins in non-muscle-invasive bladder cancer: correlation with intravesical recurrence following transurethral resection. Urol Oncol 2011; 29:495-501.
    • (2011) Urol Oncol , vol.29 , pp. 495-501
    • Behnsawy, H.M.1    Miyake, H.2    Abdalla, M.A.3
  • 229
    • 30644462171 scopus 로고    scopus 로고
    • Expression of E-cadherin and alpha-, beta-, gamma-catenins in patients with bladder cancer: Identification of gamma-catenin as a new prognostic marker of neoplastic progression in T1 superficial urothelial tumors
    • Clairotte A, Lascombe I, Fauconnet S, et al. Expression of E-cadherin and alpha-, beta-, gamma-catenins in patients with bladder cancer: identification of gamma-catenin as a new prognostic marker of neoplastic progression in T1 superficial urothelial tumors. Am J Clin Pathol 2006;125:119-26.
    • (2006) Am J Clin Pathol , vol.125 , pp. 119-126
    • Clairotte, A.1    Lascombe, I.2    Fauconnet, S.3
  • 230
    • 44649103239 scopus 로고    scopus 로고
    • Cadherin switching dictates the biology of transitional cell carcinoma of the bladder: Ex vivo and in vitro studies
    • Bryan RT, Atherfold PA, Yeo Y, et al. Cadherin switching dictates the biology of transitional cell carcinoma of the bladder: ex vivo and in vitro studies. J Pathol 2008;215:184-94.
    • (2008) J Pathol , vol.215 , pp. 184-194
    • Bryan, R.T.1    Atherfold, P.A.2    Yeo, Y.3
  • 231
    • 77956933562 scopus 로고    scopus 로고
    • Reciprocal correlation between the expression of cyclooxygenase-2 and E-cadherin in human bladder transitional cell carcinomas
    • Jang TJ, Cha WH, Lee KS. Reciprocal correlation between the expression of cyclooxygenase-2 and E-cadherin in human bladder transitional cell carcinomas. Virchows Arch 2010;457:319-28.
    • (2010) Virchows Arch , vol.457 , pp. 319-328
    • Jang, T.J.1    Cha, W.H.2    Lee, K.S.3
  • 232
    • 33645968678 scopus 로고    scopus 로고
    • Reduced E-cadherin and alpha-catenin expressions have no prognostic role in bladder carcinoma
    • Koksal IT, Ates M, Danisman A, et al. Reduced E-cadherin and alpha-catenin expressions have no prognostic role in bladder carcinoma. Pathol Oncol Res 2006; 12:13-9.
    • (2006) Pathol Oncol Res , vol.12 , pp. 13-19
    • Koksal, I.T.1    Ates, M.2    Danisman, A.3
  • 233
    • 0027301125 scopus 로고
    • Decreased Ecadherin immunoreactivity correlates with poor survival in patients with bladder tumors
    • Bringuier PP, Umbas R, Schaafsma HE, et al. Decreased Ecadherin immunoreactivity correlates with poor survival in patients with bladder tumors. Cancer Res 1993;53:3241-5.
    • (1993) Cancer Res , vol.53 , pp. 3241-3245
    • Bringuier, P.P.1    Umbas, R.2    Schaafsma, H.E.3
  • 234
    • 0345411418 scopus 로고    scopus 로고
    • Altered gammacatenin expression correlates with poor survival in patients with bladder cancer
    • Syrigos KN, Harrington K, Waxman J, et al. Altered gammacatenin expression correlates with poor survival in patients with bladder cancer. J Urol 1998;160:1889-93.
    • (1998) J Urol , vol.160 , pp. 1889-1893
    • Syrigos, K.N.1    Harrington, K.2    Waxman, J.3
  • 235
    • 0035051814 scopus 로고    scopus 로고
    • E-cadherin immunostaining of bladder transitional cell carcinoma, carcinoma in situ and lymph node metastases with long-term followup
    • Byrne RR, Shariat SF, Brown R, et al. E-cadherin immunostaining of bladder transitional cell carcinoma, carcinoma in situ and lymph node metastases with long-term followup. J Urol 2001;165: 1473-9.
    • (2001) J Urol , vol.165 , pp. 1473-1479
    • Byrne, R.R.1    Shariat, S.F.2    Brown, R.3
  • 236
    • 33646201958 scopus 로고    scopus 로고
    • Raf1, Aurora-A/STK15 and E-cadherin biomarkers expression in patients with pTa/pT1 urothelial bladder carcinoma; A retrospective TMA study of 246 patients with long-term follow-up
    • Mhawech-Fauceglia P, Fischer G, Beck A, et al. Raf1, Aurora-A/STK15 and E-cadherin biomarkers expression in patients with pTa/pT1 urothelial bladder carcinoma; a retrospective TMA study of 246 patients with long-term follow-up. Eur J Surg Oncol 2006; 32:439-44.
    • (2006) Eur J Surg Oncol , vol.32 , pp. 439-444
    • Mhawech-Fauceglia, P.1    Fischer, G.2    Beck, A.3
  • 237
    • 33646729863 scopus 로고    scopus 로고
    • N-cadherin as a novel prognostic marker of progression in superficial urothelial tumors
    • Lascombe I, Clairotte A, Fauconnet S, et al. N-cadherin as a novel prognostic marker of progression in superficial urothelial tumors. Clin Cancer Res 2006;12:2780-7.
    • (2006) Clin Cancer Res , vol.12 , pp. 2780-2787
    • Lascombe, I.1    Clairotte, A.2    Fauconnet, S.3
  • 238
    • 34548155914 scopus 로고    scopus 로고
    • The prognostic value of E-cadherin, alpha-, beta- and gamma-catenin in bladder cancer patients who underwent radical cystectomy
    • Kashibuchi K, Tomita K, Schalken JA, et al. The prognostic value of E-cadherin, alpha-, beta- and gamma-catenin in bladder cancer patients who underwent radical cystectomy. Int J Urol 2007;14: 789-94.
    • (2007) Int J Urol , vol.14 , pp. 789-794
    • Kashibuchi, K.1    Tomita, K.2    Schalken, J.A.3
  • 239
    • 33748122878 scopus 로고    scopus 로고
    • The expression of thymidine phosphorylase is a prognostic predictor for the intravesical recurrence of superficial bladder cancer
    • Nonomura N, Nakai Y, Nakayama M, et al. The expression of thymidine phosphorylase is a prognostic predictor for the intravesical recurrence of superficial bladder cancer. Int J Clin Oncol 2006;11:297-302.
    • (2006) Int J Clin Oncol , vol.11 , pp. 297-302
    • Nonomura, N.1    Nakai, Y.2    Nakayama, M.3
  • 240
    • 33748541958 scopus 로고    scopus 로고
    • Thymidine phosphorylase expression as a prognostic marker for predicting recurrence in primary superficial bladder cancer
    • Aoki S, Yamada Y, Nakamura K, et al. Thymidine phosphorylase expression as a prognostic marker for predicting recurrence in primary superficial bladder cancer. Oncol Rep 2006;16: 279-84.
    • (2006) Oncol Rep , vol.16 , pp. 279-284
    • Aoki, S.1    Yamada, Y.2    Nakamura, K.3
  • 241
    • 33947521195 scopus 로고    scopus 로고
    • Aurora-A/STK-15 is a predictive factor for recurrent behaviour in non-invasive bladder carcinoma: A study of 128 cases of non-invasive neoplasms
    • Comperat E, Camparo P, Haus R, et al. Aurora-A/STK-15 is a predictive factor for recurrent behaviour in non-invasive bladder carcinoma: a study of 128 cases of non-invasive neoplasms. Virchows Arch 2007;450:419-24.
    • (2007) Virchows Arch , vol.450 , pp. 419-424
    • Comperat, E.1    Camparo, P.2    Haus, R.3
  • 242
    • 79851488677 scopus 로고    scopus 로고
    • Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms
    • Bufo P, Sanguedolce F, Tortorella S, et al. Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms. Histol Histopathol 2010;25:1371-7.
    • (2010) Histol Histopathol , vol.25 , pp. 1371-1377
    • Bufo, P.1    Sanguedolce, F.2    Tortorella, S.3
  • 243
    • 0035395991 scopus 로고    scopus 로고
    • Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder
    • Shirahama T, Arima J, Akiba S, Sakakura C. Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder. Cancer 2001;92:188-93.
    • (2001) Cancer , vol.92 , pp. 188-193
    • Shirahama, T.1    Arima, J.2    Akiba, S.3    Sakakura, C.4
  • 244
    • 0037366062 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is highly expressed in carcinoma in situ and T1 transitional cell carcinoma of the bladder
    • Shariat SF, Kim JH, Ayala GE, et al. Cyclooxygenase-2 is highly expressed in carcinoma in situ and T1 transitional cell carcinoma of the bladder. J Urol 2003;169:938-42.
    • (2003) J Urol , vol.169 , pp. 938-942
    • Shariat, S.F.1    Kim, J.H.2    Ayala, G.E.3
  • 245
    • 0036844775 scopus 로고    scopus 로고
    • Association of cyclooxygenase-2 expression with prognosis of stage T1 grade 3 bladder cancer
    • Kim SI, Kwon SM, Kim YS, Hong SJ. Association of cyclooxygenase-2 expression with prognosis of stage T1 grade 3 bladder cancer. Urology 2002;60:816-21.
    • (2002) Urology , vol.60 , pp. 816-821
    • Kim, S.I.1    Kwon, S.M.2    Kim, Y.S.3    Hong, S.J.4
  • 246
    • 84897073946 scopus 로고    scopus 로고
    • Blood- and tissue-based biomarkers for prediction of outcomes in urothelial carcinoma of the bladder
    • Xylinas E, Kluth LA, Lotan Y, et al. Blood- and tissue-based biomarkers for prediction of outcomes in urothelial carcinoma of the bladder. Urol Oncol 2014;32:230-42.
    • (2014) Urol Oncol , vol.32 , pp. 230-242
    • Xylinas, E.1    Kluth, L.A.2    Lotan, Y.3
  • 247
    • 84890878317 scopus 로고    scopus 로고
    • Biomarkers in bladder cancer: Translational and clinical implications
    • Cheng L, Davison DD, Adams J, et al. Biomarkers in bladder cancer: translational and clinical implications. Crit Rev Oncol Hematol 2014;89:73-111.
    • (2014) Crit Rev Oncol Hematol , vol.89 , pp. 73-111
    • Cheng, L.1    Davison, D.D.2    Adams, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.