The prognostic value of E-cadherin, α-, β- and γ-catenin in bladder cancer patients who underwent radical cystectomy

International Journal of Urology

Volumn 14, Issue 9, 2007, Pages 789-794

  Kashibuchi, Keishi ^a   Tomita, Kyoichi ^a,c   Schalken, Jack A ^b   Kume, Haruki ^a   Takeuchi, Takumi ^a   Kitamura, Tadaichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bladder cancer; Catenin; Chemotherapy; E cadherin; Prognosis

Indexed keywords

ALPHA CATENIN; BETA CATENIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; METHOTREXATE; PLAKOGLOBIN; UVOMORULIN; VINBLASTINE;

ADJUVANT THERAPY; ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER GRADING; CANCER PATIENT; CANCER STAGING; CHEMOSENSITIVITY; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYSTECTOMY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

ADULT; AGED; CADHERINS; CARCINOMA, TRANSITIONAL CELL; CATENINS; CYSTECTOMY; FEMALE; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 34548155914     PISSN: 09198172     EISSN: 14422042     Source Type: Journal    
DOI: 10.1111/j.1442-2042.2007.01830.x     Document Type: Article

References (23)

1. Heiken JP, Forman HP, Brown JJ. Neoplasms of the bladder, prostate and testis. Radiol. Clin. North Am. 1994 32:81.
2. Heney NM, Ahmed S, Flanagan MJ et al. Superficial bladder: progression and recurrence. J. Urol. 1983 130:1083 6.
3. Thrasher JB, Crawford ED. Current management of invasive and metastatic transitional cell carcinoma of the bladder. J. Urol. 1993 149:957 72.
4. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991 251:1451 5.
5. Gumbiner BM, McCrea PD. Catenins as mediators of the cytoplasmic functions of cadherin. J. Cell Sci. 1993 17:155 8.
6. Nathke I, Hinck L, Nelson J. Epithelial cell adhesion and development of cell surface polarity possible mechanisms for modulation of cadherin function, organization and distribution. J. Cell Sci. 1993 17:139 45.
7. Peifer M. Cancer, catenins and cuticle pattern: a complex connection. Science 1993 262:1667 8.
8. Ozawa M, Nuruki K, Toyoyama H, Ohi Y. Cloning of an alternative form of plakoglobin (gamma-catenin) lacking the fourth armadillo repeat. J. Biochem. 1995 118:836 40.
9. Lee Y, Wu C, Chen S, Hsu H, Chang Y. The significance of α-, β- and γ-catenin expression in surgically treated non-small cell lung cancers of 3cm or less in size. Thorac. Cardiovasc. Surg. 2002 123:502 7.
10. cas) in bladder tumors. Cancer Res. 1996 56:4154 8.
11. Syrigos K, Harrington K, Waxman J, Krausz T, Pignattelli M. Altered γ-catenin expression correlates with poor survival in patient with bladder cancer. J. Urol. 1998 160:1889 93.
12. Mialhe A, Louis J, Monteleiver S et al. Expression of E-cadherin and α-, β- and γ-catenins in human bladder carcinomas: are they good prognostic factors? Invasion Metastasis 1997 17:124 37.
13. Sobin LH, Wittekind CL, editors. TNM classification of malignant tumors, 6th edition. New York: John Wiley & Sons, 2002.
14. Kashibuchi K, Tomita K, Schalken JA et al. The prognostic value of E-cadherin, α-, β- and γ- catenin in urothelial cancer of the upper urinary tract. Eur. Urol. 2006 49:839 45.
15. Jankowski J, Newham P, Kandemir O, Hirano S, Takeichi M, Pignatelli M. Differential expression of E-cadherin in normal, metaplastic and dysplastic oesophageal mucosa: a putative biomarker. Int. J. Oncol. 1994 4:441 8.
16. Frixen UH, Behrens J, Sachs M et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol. 1991 113:173 85.
17. Vleminckx K, Vacket L, Mareel M, Fiers W, van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991 66:107 19.
18. Nakopoulou L, Gakiopoulou H, Karayiannakis A et al. Abnormal α-catenin expression in invasive breast cancer correlates with poor patient survival. Histopathology 2002 40:536 46.
19. Aaltomaa S, Lipponen P, Ala-Opas M, Eskelinen M, Kosma VM. α-catenin expression has prognostic value in local and locally advanced prostate cancer. Br. J. Urol. 1999 80:477 82.
20. Umbas R, Isaacs BW, Bringuier PP, Xue Y, Deruyne MJ, Schalken JA. Relation between aberrant α-catenin expression and loss of E-cadherin function in prostate cancer. Int. J. Cancer 1997 74:374 3.
21. Nakamura T, Kato Y, Fujii H, Horiuchi T, Chiba Y, Tanaka K. E-cadherin-dependent intercellular adhesion enhances chemoresistance. Int. J. Mol. Med. 2003 12:693 700.
22. Joel WS, Karashima T, Perrotte P et al. Treatment with low-dose interferon-a restores the balance between matrix metalloproteinase-9 and E-cadherin expression in human transitional cell carcinoma of the bladder. Clin. Cancer Res. 2001 7:2840 53.
23. Kadowaki T, Shiozaki H, Inoue M et al. E-cadherin and α-catenin expression in human esophageal cancer. Cancer Res. 1994 54:291 6.