Optimal delivery of aerosols to infants during mechanical ventilation

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 27, Issue 5, 2014, Pages 371-385

  Longest, P Worth ^a,b   Azimi, Mandana ^b   Hindle, Michael ^b  

^a Virginia Commonwealth University   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

aerosols; CFD simulations; mechanical ventilation; Monte Carlo modeling; nebulization; neonate; respiratory drug delivery; streamlined wye

Indexed keywords

AEROSOL; AIRWAY CONNECTOR; ARTICLE; ARTIFICIAL VENTILATION; COMPUTATIONAL FLUID DYNAMICS; DRUG DELIVERY SYSTEM; ENDOTRACHEAL TUBE; FLOW RATE; HUMAN; IN VITRO STUDY; INFANT; LUNG MODEL; MEDICAL NEBULIZER; PARTICLE SIZE; STEADY STATE; ADMINISTRATION AND DOSAGE; BIOLOGICAL MODEL; DEVICES; ENDOTRACHEAL INTUBATION; EQUIPMENT DESIGN; EVALUATION STUDY; HYDRODYNAMICS; INHALATION; LUNG; NEWBORN; PHYSIOLOGY; STANDARDS; TIME;

AEROSOL;

AEROSOLS; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; HYDRODYNAMICS; IN VITRO TECHNIQUES; INFANT; INFANT, NEWBORN; INHALATION; INTUBATION, INTRATRACHEAL; LUNG; MODELS, BIOLOGICAL; PARTICLE SIZE; RESPIRATION, ARTIFICIAL; TIME FACTORS;

EID: 84907440720     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2013.1077     Document Type: Article

References (51)

1. Dhand R: Inhalation therapy in invasive and noninvasive mechanical ventilation. Curr Opin Crit Care. 2007;13:27-38.
2. Dhand R: Aerosol delivery during mechanical ventilation: from basic techniques to new devices. J Aerosol Med Pulm Drug Deliv. 2008;21:45-60.
3. Cole CH, Colton T, Shah BL, Abbasi S, MacKinnon BL, Demissie S, and Frantz ID: Early inhaled glucocorticoid therapy to prevent bronchopulmonary dysplasia. N Engl J Med. 1999;340:1005-1010.
4. 1: a selective pulmonary vasodilator in neonatal hypoxemic respiratory failure results of a phase I/II open label clinical. Pediatr Res. 2004;56:579-585.
5. Armangil D, Yurdakok M, Korkmaz A, Yigit S, and Tekinalp G: Inhaled beta-2 agonist salbutamol for the treatment of transient tachypnea of the newborn. J Pediatr. 2011;159: 398-403.
6. Shah V, Ohlsson A, Halliday HL, and Dunn MS: Early administration of inhaled corticosteroids for preventing chronic lung disease in ventilated very low birth weight preterm neonates. Cochrane Database Syst Rev. 2007;(4): CD002057.
7. Berggren E, Liljedahl M, Winbladh B, Andreasson B, Cur-sted T, and Robertson B: Pilot study of nebulized surfactant therapy for neonatal respiratory distress syndrome. Acta Paediatr. 2000;89:460-464.
8. Fink JB: Aerosol delivery to ventilated infant and pediatric patients. Respir Care. 2004;49:653-665.
9. Mazela J, and Polin RA: Aerosol delivery to ventilated newborn infants: historical challenges and new directions. Eur J Pediatr. 2011;170:433-444.
10. Rubin BK, and Fink JB: Aerosol therapy for children. Respir Care Clin N Am. 2001;7:175-213.
11. Dubus JC, Vecellio L, De Monte M, Fink JB, Grimbert D, Montharu J, Valat C, Behan N, and Diot P: Aerosol deposition in neonatal ventilation. Pediatr Res. 2005;58:10-14.
12. Mazela J, Chmura K, Kulza M, Henderson C, Gregory TJ, Moskal A, Sosnowski TR, Florek E, Kramer L, and Keszler M: Aerosolized albuterol sulfate delivery under neonatal ventilatory conditions: in vitro evaluation of a novel ventilator circuit patient interface connector. J Aerosol Med Pulm Drug Deliv. 2013 [Epub ahead of print].
13. Everard ML, Stammers J, Hardy JG, and Milner AD: New aerosol delivery system for neonatal ventilator circuits. Arch Dis Child. 1992;67:826-830.
14. Garner SS, Southgate M, Wiest DB, Brandeburg S, and An-nibale DJ: Albuterol delivery with conventional and synchronous ventilation in a neonatal lung model. Pediatr Crit Care Med. 2002;3:52-56.
15. Fok TF, Al-Essa M, Monkman S, Dolovich M, Girard L, Coates G, and Kirpalani H: Pulmonary deposition of sal-butamol aerosol delivered by metered dose inhaler, jet nebulizer, and ultrasonic nebulizer in mechanically ventilated rabbits. Pediatr Res. 1997;42:721-727.
16. Fok TF, Monkman S, Dolovich M, Gray S, Coates G, Paes B, Rashid F, Newhouse M, and Kirpalani H: Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia. Pediatr Pulmonol. 1996;21:301-309.
17. Sidler-Moix AL, Dolci U, Berger-Gryllaki M, Pannatier A, Cotting J, and Di Paolo ER: Albuterol delivery in an in vitro pediatric ventilator lung model: comparison of jet, ultrasonic, and mesh nebulizers. Pediatr Crit Care Med. 2013;14: E98-E102.
18. Ari A, Atalay OT, Harwood R, Sheard MM, Aljamhan EA, and Fink JB: Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation. Respir Care. 2010;55:845-851.
19. Ahrens RC, Ries RA, Popendorf W, and Wiese JA: The delivery of therapeutic aerosols through endotracheal-tubes. Pediatr Pulmonol. 1986;2:19-26.
20. Heyder J, Gebhart J, Rudolf G, Schiller CF, and Stahlhofen W: Deposition of particles in the human respiratory tract in the size range of 0.005-15 microns. J Aerosol Sci. 1986;17: 811-825.
21. Stahlhofen W, Rudolf G, and James AC: Intercomparison of experimental regional aerosol deposition data. J Aerosol Med. 1989;2:285-308.
22. Kim CS, and Jaques PA: Respiratory dose of inhaled ultra-fine particles in healthy adults. Philos Trans R Soc Lond A Math Phys Eng Sci. 2000;358:2693-2705.
23. Phalen RF, Oldham MJ, Beaucage CB, Crocker TT, and Mortensen JD: Postnatal enlargement of human tracheo-bronchial airways and implications for particle deposition. Anat Rec. 1985;212:368-380.
24. Hofmann W, Martonen TB, and Graham RC: Predicted deposition of nonhygroscopic aerosols in the human lung as a function of subject age. J Aerosol Med. 1989;2: 49-67.
25. Asgharian B, Menache MG, and Miller FJ: Modeling age-related particle deposition in humans. J Aerosol Med. 2004; 17:213-224.
26. Ivri E, and Fink J: Aerosol delivery apparatus and method for pressure-assisted breathing systems. United States Patent. 2007; No. 7, 290, 541 B2. Available at www.google.com.bz/patents/US7290541. Accessed November 4, 2013.
27. Longest PW, Golshahi L, and Hindle M: Improving pharmaceutical aerosol delivery during noninvasive ventilation: effects of streamlined components. Ann Biomed Eng. 2013;41: 1217-1232.
28. Miller DD, Amin MM, Palmer LB, Shah AR, and Smaldone GC: Aerosol delivery and modern mechanical ventilation-in vitro/in vivo evaluation. Am J Respir Crit Care Med. 2003; 168:1205-1209.
29. Turpeinen M, and Nikander K: Nebulization of a suspension of budesonide and a solution of terbutaline into a neonatal ventilator circuit. Respir Care. 2001;46:43-48.
30. Longest PW, Spence BM, Holbrook LT, Mossi KM, Son Y-J, and Hindle M: Production of inhalable submicrometer aerosols from conventional mesh nebulizers for improved respiratory drug delivery. J Aerosol Sci. 2012;51:66-80.
31. Longest PW, Walenga RL, Son Y-J, and Hindle M: High-efficiency generation and delivery of aerosols through nasal cannula during noninvasive ventilation. J Aerosol Med Pulm Drug Deliv. 2013;26:266-279.
32. National Centers for Health Statistics: Length-for-age and weight for age percentiles. 2000. Available at www.cdc.gov/growthcharts. Accessed November 4, 2013.
33. Dunnill MS: Postnatal growth of the lung. Thorax. 1962;17: 329-333.
34. Walsh BK, and DiBlasi RM: Mechanical ventilation of the neonate and pediatric patient. In: BK Walsh, MP Czervinske, and RM DiBlasi, (eds). Perinatal and Pediatric Respiratory Care. Saunders Elsevier, St. Louis, MO; pp. 325-347, 2010.
35. Longest PW, and Hindle M: Evaluation of the Respimat Soft Mist inhaler using a concurrent CFD and in vitro approach. J Aerosol Med Pulm Drug Deliv. 2009;22:99-112.
36. Xi J, Longest PW, and Martonen TB: Effects of the laryngeal jet on nano-and microparticle transport and deposition in an approximate model of the upper tracheobronchial airways. J Appl Physiol. 2008;104:1761-1777.
37. Longest PW, and Vinchurkar S: Validating CFD predictions of respiratory aerosol deposition: effects of upstream transition and turbulence. J Biomech. 2007;40:305-316.
38. Longest PW, Hindle M, Das Choudhuri S, and Xi J: Comparison of ambient and spray aerosol deposition in a standard induction port and more realistic mouth-throat geometry. J Aerosol Sci. 2008;39:572-591.
39. Vinchurkar S, and Longest PW: Evaluation of hexahedral, prismatic and hybrid mesh styles for simulating respiratory aerosol dynamics. Comput Fluids. 2008;37:317-331.
40. Longest PW, and Vinchurkar S: Effects of mesh style and grid convergence on particle deposition in bifurcating airway models with comparisons to experimental data. Med Eng Phys. 2007;29:350-366.
41. Longest PW, Hindle M, Das Choudhuri S, and Byron PR: Numerical simulations of capillary aerosol generation: CFD model development and comparisons with experimental data. Aerosol Sci Technol. 2007;41:952-973.
42. Longest PW, Kleinstreuer C, and Buchanan JR: Efficient computation of micro-particle dynamics including wall effects. Comput Fluids. 2004;33:577-601.
43. Longest PW, and Xi J: Effectiveness of direct Lagrangian tracking models for simulating nanoparticle deposition in the upper airways. Aerosol Sci Technol. 2007;41:380-397.
44. Longest PW, and Hindle M: Numerical model to characterize the size increase of combination drug and hygroscopic excipient nanoparticle aerosols. Aerosol Sci Technol. 2011;45: 884-899.
45. Longest PW, and Hindle M: Condensational growth of combination drug-excipient submicrometer particles: comparison of CFD predictions with experimental results. Pharm Res. 2012;29:707-721.
46. Hindle M, and Longest PW: Condensational growth of combination drug-excipient submicrometer particles for targeted high efficiency pulmonary delivery: evaluation of formulation and delivery device. J Pharm Pharmacol. 2012;64: 1254-1263.
47. Koblinger L, and Hofmann W: Monte Carlo modeling of aerosol deposition in human lungs. Part I: Simulation of particle transport in a stochastic lung structure. J Aerosol Sci. 1990;21:661-674.
48. Koblinger L, and Hofmann W: Analysis of human lung morphometric data for stochastic aerosol deposition calculations. Phys Med Biol. 1985;30:541-556.
49. Asgharian B, Hofmann W, and Bergmann R: Particle deposition in a multiple-path model of the human lung. Aerosol Sci Technol. 2001;34:332-339.
50. Park SS, and Wexler AS: Particle deposition in the pulmonary region of the human lung: a semi-empirical model of single breath transport and deposition. J Aerosol Sci. 2007; 38:228-245.
51. Asgharian B, and Anjilvel S: A Monte Carlo calculation of the deposition efficiency of inhaled particles in lower airways. J Aerosol Sci. 1994;25:711-721.