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Volumn 45, Issue 7, 2011, Pages 884-899

Numerical model to characterize the size increase of combination drug and hygroscopic excipient nanoparticle aerosols

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EID: 85012432882     PISSN: 02786826     EISSN: 15217388     Source Type: Journal    
DOI: 10.1080/02786826.2011.566592     Document Type: Article
Times cited : (77)

References (40)
  • 1
    • 0035078971 scopus 로고    scopus 로고
    • Particle Deposition in a Multiple-Path Model of the Human Lung
    • Asgharian, B., Hofmann, W., and Bergmann, R. (2001). Particle Deposition in a Multiple-Path Model of the Human Lung. Aerosol Sci. Technol., 34:332–339.
    • (2001) Aerosol Sci. Technol , vol.34 , pp. 332-339
    • Asgharian, B.1    Hofmann, W.2    Bergmann, R.3
  • 2
    • 33846076698 scopus 로고    scopus 로고
    • Degree of ThroatDeposition Can Explain the Variability in Lung Deposition of Inhaled Drugs
    • Borgstrom, L., Olsson, B., and Thorsson, L. (2006).Degree of ThroatDeposition Can Explain the Variability in Lung Deposition of Inhaled Drugs. J. Aerosol. Med., 19:473–483.
    • (2006) J. Aerosol. Med , vol.19 , pp. 473-483
    • Borgstrom, L.1    Olsson, B.2    Thorsson, L.3
  • 3
    • 0035147895 scopus 로고    scopus 로고
    • Growth and Deposition of Hygroscopic Particulate Matter in the Human Lung
    • Broday, D. M., and Georgopoulous, G. (2001). Growth and Deposition of Hygroscopic Particulate Matter in the Human Lung. Aerosol Sci. Technol., 34:144–159.
    • (2001) Aerosol Sci. Technol , vol.34 , pp. 144-159
    • Broday, D.M.1    Georgopoulous, G.2
  • 4
    • 79954417498 scopus 로고    scopus 로고
    • Stepping into the Trachea with Realistic Physical Models: Uncertainties in Regional Drug Deposition from Powder Inhalers
    • Byron, P. R., Delvadia, R. R., Longest, P. W., and Hindle, M. (2010). Stepping into the Trachea with Realistic Physical Models: Uncertainties in Regional Drug Deposition from Powder Inhalers. Resp. Drug Del. 2010, 1:215–224.
    • (2010) Resp. Drug Del , vol.2010 , Issue.1 , pp. 215-224
    • Byron, P.R.1    Delvadia, R.R.2    Longest, P.W.3    Hindle, M.4
  • 5
    • 0034885367 scopus 로고    scopus 로고
    • Respiratory Deposition Patterns of Salbutamol pMDI with CFC and HFA-134a Formulations in a Human Airway Replica
    • Cheng, Y. S., Fu, C. S., Yazzie, D., and Zhou, Y. (2001). Respiratory Deposition Patterns of Salbutamol pMDI with CFC and HFA-134a Formulations in a Human Airway Replica. J. Aerosol. Med., 14(2):255–266.
    • (2001) J. Aerosol. Med , vol.14 , Issue.2 , pp. 255-266
    • Cheng, Y.S.1    Fu, C.S.2    Yazzie, D.3    Zhou, Y.4
  • 6
    • 0007823303 scopus 로고
    • The Behavior of Sodium Chloride Particles in Moist Air
    • Cinkotai, F. F. (1971). The Behavior of Sodium Chloride Particles in Moist Air. J. Aerosol Sci., 2:325–329.
    • (1971) J. Aerosol Sci , vol.2 , pp. 325-329
    • Cinkotai, F.F.1
  • 8
    • 85010160381 scopus 로고
    • Estimation of the Deposition of Aerosolised Drugs in the Human Respiratory Tract Due to Hygroscopic Growth
    • Ferron, G. A., Oberdorster, G., and Hennenberg, R. (1989). Estimation of the Deposition of Aerosolised Drugs in the Human Respiratory Tract Due to Hygroscopic Growth. J. Aerosol. Med., 2:271.
    • (1989) J. Aerosol. Med , vol.2 , pp. 271
    • Ferron, G.A.1    Oberdorster, G.2    Hennenberg, R.3
  • 9
    • 0031646978 scopus 로고    scopus 로고
    • Estimating the Type of Hygroscopic Behavior Exhibited by Aqueous Droplets
    • Finlay, W. H. (1998). Estimating the Type of Hygroscopic Behavior Exhibited by Aqueous Droplets. J. Aerosol. Med., 11(4):221–229.
    • (1998) J. Aerosol. Med , vol.11 , Issue.4 , pp. 221-229
    • Finlay, W.H.1
  • 11
    • 0000321379 scopus 로고
    • The Effect on Regional Lung Deposition of Coupled Heat and Mass-Transfer between Hygroscopic Droplets and Their Surrounding Phase
    • Finlay, W. H., and Stapleton, K.W. (1995). The Effect on Regional Lung Deposition of Coupled Heat and Mass-Transfer between Hygroscopic Droplets and Their Surrounding Phase. J. Aerosol Sci., 26(4):655–670.
    • (1995) J. Aerosol Sci , vol.26 , Issue.4 , pp. 655-670
    • Finlay, W.H.1    Stapleton, K.W.2
  • 13
    • 0023951406 scopus 로고
    • Morphometry of the Human Pulmonary Acinus
    • Haefeli-Bleuer, B., and Weibel, E. R. (1988). Morphometry of the Human Pulmonary Acinus. Anat. Rec., 220:401–411.
    • (1988) Anat. Rec , vol.220 , pp. 401-411
    • Haefeli-Bleuer, B.1    Weibel, E.R.2
  • 14
    • 77950621926 scopus 로고    scopus 로고
    • In Vitro Characterization of the I-neb Adaptive Aerosol Delivery (AAD) System
    • Hardaker, L. E. A., and Hatley, R. H. M. (2010). In Vitro Characterization of the I-neb Adaptive Aerosol Delivery (AAD) System. Aerosol Med. Pulmonary Drug Del., 23(S1): S11–S20.
    • (2010) Aerosol Med. Pulmonary Drug Del , vol.23 , Issue.S1 , pp. S11-S20
    • Hardaker, L.E.A.1    Hatley, R.H.M.2
  • 15
    • 0007794005 scopus 로고    scopus 로고
    • High Efficiency Fine Particle Generation Using Novel Condensation Technology
    • R. N. Dalby, P. R. Byron, and S. J. Farr, eds., Interpharm Press, Inc., Buffalo Grove, IL
    • Hindle, M., Byron, P. R., Jashnani, R. N., Howell, T. M., and Cox, K. A. (1998).High Efficiency Fine Particle Generation Using Novel Condensation Technology, in Proceedings of Respiratory Drug Delivery VI, R. N. Dalby, P. R. Byron, and S. J. Farr, eds., Interpharm Press, Inc., Buffalo Grove, IL, pp. 97–102.
    • (1998) Proceedings of Respiratory Drug Delivery VI , pp. 97-102
    • Hindle, M.1    Byron, P.R.2    Jashnani, R.N.3    Howell, T.M.4    Cox, K.A.5
  • 16
    • 77955469508 scopus 로고    scopus 로고
    • Evaluation of Enhanced Condensational Growth (ECG) for Controlled Respiratory Drug Delivery in aMouth–Throat and Upper Tracheobronchial Model
    • Hindle, M., and Longest, P.W. (2010). Evaluation of Enhanced Condensational Growth (ECG) for Controlled Respiratory Drug Delivery in aMouth–Throat and Upper Tracheobronchial Model. Pharm Res., 27:1800–1811.
    • (2010) Pharm Res , vol.27 , pp. 1800-1811
    • Hindle, M.1    Longest, P.W.2
  • 18
    • 0032438394 scopus 로고    scopus 로고
    • Improved Airway Targeting with the CFC-Free HFA-Beclomethasone Metered-Dose Inhaler Compared with CFC-Beclomethasone
    • Leach, C. L., Davidson, P. J., and Bouhuys, A. (1998). Improved Airway Targeting with the CFC-Free HFA-Beclomethasone Metered-Dose Inhaler Compared with CFC-Beclomethasone. Eur. Resp. J., 12:1346–1353.
    • (1998) Eur. Resp. J , vol.12 , pp. 1346-1353
    • Leach, C.L.1    Davidson, P.J.2    Bouhuys, A.3
  • 19
    • 67549098260 scopus 로고    scopus 로고
    • Evaluation of the Respimat Soft Mist Inhaler Using a Concurrent CFD and In Vitro Approach
    • Longest, P. W., and Hindle, M. (2009a). Evaluation of the Respimat Soft Mist Inhaler Using a Concurrent CFD and In Vitro Approach. J. Aerosol Med. Pulm. Drug Del., 22(2):99–112.
    • (2009) J. Aerosol Med. Pulm. Drug Del , vol.22 , Issue.2 , pp. 99-112
    • Longest, P.W.1    Hindle, M.2
  • 21
    • 77954309515 scopus 로고    scopus 로고
    • CFD Simulations of Enhanced Condensational Growth (ECG) Applied to Respiratory Drug Delivery with Comparisons to In Vitro Data
    • Longest, P.W., and Hindle, M. (2010). CFD Simulations of Enhanced Condensational Growth (ECG) Applied to Respiratory Drug Delivery with Comparisons to In Vitro Data. J. Aerosol Sci., 41:805–820.
    • (2010) J. Aerosol Sci , vol.41 , pp. 805-820
    • Longest, P.W.1    Hindle, M.2
  • 22
    • 34548582075 scopus 로고    scopus 로고
    • Numerical Simulations of Capillary Aerosol Generation: CFD Model Development and Comparisons with Experimental Data
    • Longest, P. W., Hindle, M., Das Choudhuri, S., and Byron, P. R. (2007). Numerical Simulations of Capillary Aerosol Generation: CFD Model Development and Comparisons with Experimental Data. Aerosol Sci. Technol., 41:952–973.
    • (2007) Aerosol Sci. Technol , vol.41 , pp. 952-973
    • Longest, P.W.1    Hindle, M.2    Das Choudhuri, S.3    Byron, P.R.4
  • 23
    • 67549097448 scopus 로고    scopus 로고
    • Developing a Better Understanding of Spray System Design Using a Combination of CFDModeling and Experiment
    • R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr, and P. M. Young, eds., Davis Healthcare International Publishing, River Grove, IL
    • Longest, P.W., Hindle, M., Das Choudhuri, S., and Byron, P. R. (2008a). Developing a Better Understanding of Spray System Design Using a Combination of CFDModeling and Experiment, in Proceedings of Respiratory Drug Delivery 2008, R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr, and P. M. Young, eds., Davis Healthcare International Publishing, River Grove, IL, pp. 151–163.
    • (2008) Proceedings of Respiratory Drug Delivery 2008 , pp. 151-163
    • Longest, P.W.1    Hindle, M.2    Das Choudhuri, S.3    Byron, P.R.4
  • 24
    • 45049088663 scopus 로고    scopus 로고
    • Comparison of Ambient and Spray Aerosol Deposition in a Standard Induction Port and More Realistic Mouth–Throat Geometry
    • Longest, P. W., Hindle, M., Das Choudhuri, S., and Xi, J. (2008b). Comparison of Ambient and Spray Aerosol Deposition in a Standard Induction Port and More Realistic Mouth–Throat Geometry. J. Aerosol Sci., 39:572–591.
    • (2008) J. Aerosol Sci , vol.39 , pp. 572-591
    • Longest, P.W.1    Hindle, M.2    Das Choudhuri, S.3    Xi, J.4
  • 25
    • 14044273704 scopus 로고    scopus 로고
    • ComputationalModels for SimulatingMulticomponent Aerosol Evaporation in the UpperRespiratory Airways
    • Longest, P.W., and Kleinstreuer, C. (2005). ComputationalModels for SimulatingMulticomponent Aerosol Evaporation in the UpperRespiratory Airways. Aerosol Sci. Technol., 39:124–138.
    • (2005) Aerosol Sci. Technol , vol.39 , pp. 124-138
    • Longest, P.W.1    Kleinstreuer, C.2
  • 26
    • 77954309738 scopus 로고    scopus 로고
    • Characterization of Nanoaerosol Size Change during Enhanced Condensational Growth
    • Longest, P. W., McLeskey, J. T., and Hindle, M. (2010). Characterization of Nanoaerosol Size Change during Enhanced Condensational Growth. Aerosol Sci. Technol., 44:473–483.
    • (2010) Aerosol Sci. Technol , vol.44 , pp. 473-483
    • Longest, P.W.1    McLeskey, J.T.2    Hindle, M.3
  • 27
    • 47249165595 scopus 로고    scopus 로고
    • Condensational Growth May Contribute to the Enhanced Deposition of Cigarette Smoke Particles in the Upper respiratory Tract
    • Longest, P.W., and Xi, J. (2008). Condensational Growth May Contribute to the Enhanced Deposition of Cigarette Smoke Particles in the Upper respiratory Tract. Aerosol Sci. Technol., 42:579–602.
    • (2008) Aerosol Sci. Technol , vol.42 , pp. 579-602
    • Longest, P.W.1    Xi, J.2
  • 29
    • 0036586884 scopus 로고    scopus 로고
    • Evolution of Dry Powder Inhaler Design, Formulation, and Performance
    • Newman, S. P., and Busse, W. W. (2002). Evolution of Dry Powder Inhaler Design, Formulation, and Performance. Resp. Med., 96:293–304.
    • (2002) Resp. Med , vol.96 , pp. 293-304
    • Newman, S.P.1    Busse, W.W.2
  • 30
    • 77950620340 scopus 로고    scopus 로고
    • Mode of Breathing-Tidal or Slow and Deep-through the I-neb Adaptive Delivery (ADD) System Affects Lung Deposition of 99mTc-DTPA
    • Nikander, K., Prince, I., Coughlin, S., Warren, S., and Taylor, G. (2010). Mode of Breathing-Tidal or Slow and Deep-through the I-neb Adaptive Delivery (ADD) System Affects Lung Deposition of 99mTc-DTPA. J. Aerosol.Med., 23(S1):S37–S43.
    • (2010) J. Aerosol.Med , vol.23 , Issue.S1 , pp. S37-S43
    • Nikander, K.1    Prince, I.2    Coughlin, S.3    Warren, S.4    Taylor, G.5
  • 32
    • 25844450169 scopus 로고    scopus 로고
    • Deposition of Corticosteriod Aerosol in the Human Lung by Respimat Soft Mist Inhaler Compared to Deposition by Metered Dose Inhaler or by Turbuhaler Dry Power Inhaler
    • Pitcairn, G., Reader, S., Pavia, D., and Newman, S. (2005). Deposition of Corticosteriod Aerosol in the Human Lung by Respimat Soft Mist Inhaler Compared to Deposition by Metered Dose Inhaler or by Turbuhaler Dry Power Inhaler. J. Aerosol. Med., 18(3):264–272.
    • (2005) J. Aerosol. Med , vol.18 , Issue.3 , pp. 264-272
    • Pitcairn, G.1    Reader, S.2    Pavia, D.3    Newman, S.4
  • 33
    • 0031975760 scopus 로고    scopus 로고
    • Theoretical Analysis ofHygroscopicGrowth Rate of Mainstream and Sidestream Cigarette Smoke Particles in the Human Respiratory Tract
    • Robinson, R., and Yu, C. P. (1998). Theoretical Analysis ofHygroscopicGrowth Rate of Mainstream and Sidestream Cigarette Smoke Particles in the Human Respiratory Tract. Aerosol Sci. Technol., 28:21–32.
    • (1998) Aerosol Sci. Technol , vol.28 , pp. 21-32
    • Robinson, R.1    Yu, C.P.2
  • 34
    • 85010181389 scopus 로고
    • Intercomparison of Experimental Regional Aerosol Deposition Data
    • Stahlhofen, W., Rudolf, G., and James, A. C. (1989). Intercomparison of Experimental Regional Aerosol Deposition Data. J. Aerosol. Med., 2(3):285–308.
    • (1989) J. Aerosol. Med , vol.2 , Issue.3 , pp. 285-308
    • Stahlhofen, W.1    Rudolf, G.2    James, A.C.3
  • 36
    • 70350576692 scopus 로고    scopus 로고
    • Particle Deposition in Human Respiratory System: Deposition of Concentrated Hygroscopic Aerosols
    • Varghese, S. K., and Gangamma, S. (2009). Particle Deposition in Human Respiratory System: Deposition of Concentrated Hygroscopic Aerosols. Inhal. Toxicol., 21(7):619–630.
    • (2009) Inhal. Toxicol , vol.21 , Issue.7 , pp. 619-630
    • Varghese, S.K.1    Gangamma, S.2
  • 37
    • 49649085066 scopus 로고    scopus 로고
    • Effects of the Laryngeal Jet on Nano-and Microparticle Transport and Deposition in an Approximate Model of the Upper Tracheobronchial Airways
    • Xi, J., Longest, P. W., and Martonen, T. B. (2008). Effects of the Laryngeal Jet on Nano-and Microparticle Transport and Deposition in an Approximate Model of the Upper Tracheobronchial Airways. J. Appl. Physiol., 104:1761–1777.
    • (2008) J. Appl. Physiol , vol.104 , pp. 1761-1777
    • Xi, J.1    Longest, P.W.2    Martonen, T.B.3
  • 38
    • 34648816355 scopus 로고    scopus 로고
    • In Vivo–In Vitro Comparison of Deposition in Three Mouth–Throat Models with Qvar and Turbuhaler Inhalers
    • Zhang, Y., Gilbertson, K., and Finlay, W. H. (2007). In Vivo–In Vitro Comparison of Deposition in Three Mouth–Throat Models with Qvar and Turbuhaler Inhalers. J. Aerosol. Med., 20(3):227–235.
    • (2007) J. Aerosol. Med , vol.20 , Issue.3 , pp. 227-235
    • Zhang, Y.1    Gilbertson, K.2    Finlay, W.H.3
  • 39
    • 33745620202 scopus 로고    scopus 로고
    • Isotonic and Hypertonic Saline Droplet Deposition in a Human Upper Airway Model
    • Zhang, Z., Kleinstreuer, C., and Kim, C. S. (2006a). Isotonic and Hypertonic Saline Droplet Deposition in a Human Upper Airway Model. J. Aerosol Med., 19(2):184–198.
    • (2006) J. Aerosol Med , vol.19 , Issue.2 , pp. 184-198
    • Zhang, Z.1    Kleinstreuer, C.2    Kim, C.S.3
  • 40
    • 33745630736 scopus 로고    scopus 로고
    • Water Vapor Transport and Its Effects on the Deposition of Hygroscopic Droplets in a Human Upper Airway Model
    • Zhang, Z., Kleinstreuer, C., and Kim, C. S. (2006b).Water Vapor Transport and Its Effects on the Deposition of Hygroscopic Droplets in a Human Upper Airway Model. Aerosol Sci. Technol., 40:52–67.
    • (2006) Aerosol Sci. Technol , vol.40 , pp. 52-67
    • Zhang, Z.1    Kleinstreuer, C.2    Kim, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.