메뉴 건너뛰기




Volumn 14, Issue 1, 2014, Pages

Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer

Author keywords

Angiopoietins; Biomarker; Ovarian carcinoma; Prognosis; VEGFRs; VEGFs

Indexed keywords

ANGIOPOIETIN 2; GROWTH FACTOR; PACLITAXEL; TUMOR MARKER; VASCULOTROPIN; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR 2; BIOLOGICAL MARKER; CA 125 ANTIGEN;

EID: 84907399835     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-696     Document Type: Article
Times cited : (44)

References (49)
  • 2
    • 84892508265 scopus 로고    scopus 로고
    • Sensitivity and resistance to treatment in the primary management of epithelial ovarian cancer
    • 24071502
    • Colombo PE, Fabbro M, Theillet C, Bibeau F, Rouanet P, Ray-Coquard I. Sensitivity and resistance to treatment in the primary management of epithelial ovarian cancer. Crit Rev Oncol Hematol 2014, 89:207-216. 10.1016/j.critrevonc.2013.08.017, 24071502.
    • (2014) Crit Rev Oncol Hematol , vol.89 , pp. 207-216
    • Colombo, P.E.1    Fabbro, M.2    Theillet, C.3    Bibeau, F.4    Rouanet, P.5    Ray-Coquard, I.6
  • 3
    • 41649102043 scopus 로고    scopus 로고
    • The cancer biomarker problem
    • 18385728
    • Sawyers CL. The cancer biomarker problem. Nature 2008, 452:548-552. 10.1038/nature06913, 18385728.
    • (2008) Nature , vol.452 , pp. 548-552
    • Sawyers, C.L.1
  • 7
    • 63749125392 scopus 로고    scopus 로고
    • VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
    • 19230644
    • Lohela M, Bry M, Tammela T, Alitalo K. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol 2009, 21:154-165. 10.1016/j.ceb.2008.12.012, 19230644.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 154-165
    • Lohela, M.1    Bry, M.2    Tammela, T.3    Alitalo, K.4
  • 8
    • 79960227968 scopus 로고    scopus 로고
    • VEGF and angiopoietin signaling in tumor angiogenesis and metastasis
    • 21481637
    • Saharinen P, Eklund L, Pulkki K, Bono P, Alitalo K. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med 2011, 17:347-362. 10.1016/j.molmed.2011.01.015, 21481637.
    • (2011) Trends Mol Med , vol.17 , pp. 347-362
    • Saharinen, P.1    Eklund, L.2    Pulkki, K.3    Bono, P.4    Alitalo, K.5
  • 9
    • 0028834106 scopus 로고
    • Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation
    • Nagy JA, Masse EM, Herzberg KT, Meyers MS, Yeo KT, Yeo TK, Sioussat TM, Dvorak HF. Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation. Cancer Res 1995, 55:360-368.
    • (1995) Cancer Res , vol.55 , pp. 360-368
    • Nagy, J.A.1    Masse, E.M.2    Herzberg, K.T.3    Meyers, M.S.4    Yeo, K.T.5    Yeo, T.K.6    Sioussat, T.M.7    Dvorak, H.F.8
  • 10
    • 0030026897 scopus 로고    scopus 로고
    • A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
    • 449944, 8617204
    • Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N, Alitalo K. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J 1996, 15:290-298. 449944, 8617204.
    • (1996) EMBO J , vol.15 , pp. 290-298
    • Joukov, V.1    Pajusola, K.2    Kaipainen, A.3    Chilov, D.4    Lahtinen, I.5    Kukk, E.6    Saksela, O.7    Kalkkinen, N.8    Alitalo, K.9
  • 11
    • 0031905861 scopus 로고    scopus 로고
    • Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
    • 18457, 9435229
    • Achen MG, Jeltsch M, Kukk E, Makinen T, Vitali A, Wilks AF, Alitalo K, Stacker SA. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc Natl Acad Sci U S A 1998, 95:548-553. 10.1073/pnas.95.2.548, 18457, 9435229.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 548-553
    • Achen, M.G.1    Jeltsch, M.2    Kukk, E.3    Makinen, T.4    Vitali, A.5    Wilks, A.F.6    Alitalo, K.7    Stacker, S.A.8
  • 15
    • 66349133061 scopus 로고    scopus 로고
    • Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment
    • 19487284
    • Holopainen T, Huang H, Chen C, Kim KE, Zhang L, Zhou F, Han W, Li C, Yu J, Wu J, Koh GY, Alitalo K, He Y. Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer Res 2009, 69:4656-4664. 10.1158/0008-5472.CAN-08-4654, 19487284.
    • (2009) Cancer Res , vol.69 , pp. 4656-4664
    • Holopainen, T.1    Huang, H.2    Chen, C.3    Kim, K.E.4    Zhang, L.5    Zhou, F.6    Han, W.7    Li, C.8    Yu, J.9    Wu, J.10    Koh, G.Y.11    Alitalo, K.12    He, Y.13
  • 16
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • 10498889
    • Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 1999, 18:5356-5362. 10.1038/sj.onc.1203035, 10498889.
    • (1999) Oncogene , vol.18 , pp. 5356-5362
    • Holash, J.1    Wiegand, S.J.2    Yancopoulos, G.D.3
  • 17
    • 0038745370 scopus 로고    scopus 로고
    • Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer
    • Zhang L, Yang N, Park JW, Katsaros D, Fracchioli S, Cao G, O'Brien-Jenkins A, Randall TC, Rubin SC, Coukos G. Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer. Cancer Res 2003, 63:3403-3412.
    • (2003) Cancer Res , vol.63 , pp. 3403-3412
    • Zhang, L.1    Yang, N.2    Park, J.W.3    Katsaros, D.4    Fracchioli, S.5    Cao, G.6    O'Brien-Jenkins, A.7    Randall, T.C.8    Rubin, S.C.9    Coukos, G.10
  • 18
    • 84861661737 scopus 로고    scopus 로고
    • Biomarkers in the development of anti-angiogenic therapies for ovarian cancer
    • 22209539
    • Raja FA, Hook JM, Ledermann JA. Biomarkers in the development of anti-angiogenic therapies for ovarian cancer. Cancer Treat Rev 2012, 38:662-672. 10.1016/j.ctrv.2011.11.009, 22209539.
    • (2012) Cancer Treat Rev , vol.38 , pp. 662-672
    • Raja, F.A.1    Hook, J.M.2    Ledermann, J.A.3
  • 19
    • 85026135671 scopus 로고    scopus 로고
    • Preoperative angiopoietin-2 serum levels: a marker of malignant potential in ovarian neoplasms and poor prognosis in epithelial ovarian cancer
    • Sallinen H, Heikura T, Laidinen S, Kosma VM, Heinonen S, Yla-Herttuala S, Anttila M. Preoperative angiopoietin-2 serum levels: a marker of malignant potential in ovarian neoplasms and poor prognosis in epithelial ovarian cancer. Int J Gynecol Cancer 2010, 20:1498-1505.
    • (2010) Int J Gynecol Cancer , vol.20 , pp. 1498-1505
    • Sallinen, H.1    Heikura, T.2    Laidinen, S.3    Kosma, V.M.4    Heinonen, S.5    Yla-Herttuala, S.6    Anttila, M.7
  • 20
    • 84859880607 scopus 로고    scopus 로고
    • Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma
    • 22374331
    • Llovet JM, Pena CE, Lathia CD, Shan M, Meinhardt G, Bruix J. Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma. Clin Cancer Res 2012, 18:2290-2300. 10.1158/1078-0432.CCR-11-2175, 22374331.
    • (2012) Clin Cancer Res , vol.18 , pp. 2290-2300
    • Llovet, J.M.1    Pena, C.E.2    Lathia, C.D.3    Shan, M.4    Meinhardt, G.5    Bruix, J.6
  • 22
    • 2642573006 scopus 로고    scopus 로고
    • World Health Organization Classification of Tumours. Tumours of the Breast and Female Genital Organs
    • Lyon: IARC Press
    • Tavassoli FA, Devilee P. World Health Organization Classification of Tumours. Tumours of the Breast and Female Genital Organs. 2003, Lyon: IARC Press.
    • (2003)
    • Tavassoli, F.A.1    Devilee, P.2
  • 23
    • 0000335247 scopus 로고
    • Staging announcement
    • Cancer Committee of the International Federation of Gynecology and Obstetrics Staging announcement. Gynecol Oncol 1986, 25:383-385. Cancer Committee of the International Federation of Gynecology and Obstetrics.
    • (1986) Gynecol Oncol , vol.25 , pp. 383-385
  • 29
    • 79251608534 scopus 로고    scopus 로고
    • Serum VEGF levels and tissue activation of VEGFR2/KDR receptors in patients with breast and gynecologic cancer
    • 21208810
    • Koukourakis MI, Limberis V, Tentes I, Kontomanolis E, Kortsaris A, Sivridis E, Giatromanolaki A. Serum VEGF levels and tissue activation of VEGFR2/KDR receptors in patients with breast and gynecologic cancer. Cytokine 2011, 53:370-375. 10.1016/j.cyto.2010.12.007, 21208810.
    • (2011) Cytokine , vol.53 , pp. 370-375
    • Koukourakis, M.I.1    Limberis, V.2    Tentes, I.3    Kontomanolis, E.4    Kortsaris, A.5    Sivridis, E.6    Giatromanolaki, A.7
  • 30
    • 46049083960 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its soluble receptor in benign and malignant ovarian tumors
    • 18037256
    • Artini PG, Ruggiero M, Monteleone P, Carpi A, Cristello F, Cela V, Genazzani AR. Vascular endothelial growth factor and its soluble receptor in benign and malignant ovarian tumors. Biomed Pharmacother 2008, 62:373-377. 10.1016/j.biopha.2007.10.005, 18037256.
    • (2008) Biomed Pharmacother , vol.62 , pp. 373-377
    • Artini, P.G.1    Ruggiero, M.2    Monteleone, P.3    Carpi, A.4    Cristello, F.5    Cela, V.6    Genazzani, A.R.7
  • 31
    • 0032771247 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor in epithelial ovarian neoplasms: correlation with patient survival
    • 10419737
    • Chen CA, Cheng WF, Lee CN, Chen TM, Kung CC, Hsieh FJ, Hsieh CY. Serum vascular endothelial growth factor in epithelial ovarian neoplasms: correlation with patient survival. Gynecol Oncol 1999, 74:235-240. 10.1006/gyno.1999.5418, 10419737.
    • (1999) Gynecol Oncol , vol.74 , pp. 235-240
    • Chen, C.A.1    Cheng, W.F.2    Lee, C.N.3    Chen, T.M.4    Kung, C.C.5    Hsieh, F.J.6    Hsieh, C.Y.7
  • 32
    • 77954243581 scopus 로고    scopus 로고
    • The predictive value of serum VEGF in multiresistant ovarian cancer patients treated with bevacizumab
    • 20471067
    • Smerdel MP, Steffensen KD, Waldstrom M, Brandslund I, Jakobsen A. The predictive value of serum VEGF in multiresistant ovarian cancer patients treated with bevacizumab. Gynecol Oncol 2010, 118:167-171. 10.1016/j.ygyno.2010.03.018, 20471067.
    • (2010) Gynecol Oncol , vol.118 , pp. 167-171
    • Smerdel, M.P.1    Steffensen, K.D.2    Waldstrom, M.3    Brandslund, I.4    Jakobsen, A.5
  • 33
    • 79952184099 scopus 로고    scopus 로고
    • Circulating markers of angiogenesis, inflammation, and coagulation in patients with glioblastoma
    • 20607353
    • Reynes G, Vila V, Martin M, Parada A, Fleitas T, Reganon E, Martinez-Sales V. Circulating markers of angiogenesis, inflammation, and coagulation in patients with glioblastoma. J Neurooncol 2011, 102:35-41. 10.1007/s11060-010-0290-x, 20607353.
    • (2011) J Neurooncol , vol.102 , pp. 35-41
    • Reynes, G.1    Vila, V.2    Martin, M.3    Parada, A.4    Fleitas, T.5    Reganon, E.6    Martinez-Sales, V.7
  • 34
    • 78149359739 scopus 로고    scopus 로고
    • Predictive and prognostic angiogenic markers in a gynecologic oncology group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer
    • 2975758, 20870280
    • Han ES, Burger RA, Darcy KM, Sill MW, Randall LM, Chase D, Parmakhtiar B, Monk BJ, Greer BE, Connelly P, DeGeest K, Fruehauf JP. Predictive and prognostic angiogenic markers in a gynecologic oncology group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer. Gynecol Oncol 2010, 119:484-490. 10.1016/j.ygyno.2010.08.016, 2975758, 20870280.
    • (2010) Gynecol Oncol , vol.119 , pp. 484-490
    • Han, E.S.1    Burger, R.A.2    Darcy, K.M.3    Sill, M.W.4    Randall, L.M.5    Chase, D.6    Parmakhtiar, B.7    Monk, B.J.8    Greer, B.E.9    Connelly, P.10    DeGeest, K.11    Fruehauf, J.P.12
  • 35
    • 54349098298 scopus 로고    scopus 로고
    • Measurement of circulating levels of VEGF-A, -C, and -D and their receptors, VEGFR-1 and -2 in gastric adenocarcinoma
    • 2721446, 18609713
    • Al-Moundhri MS, Al-Shukaili A, Al-Nabhani M, Al-Bahrani B, Burney IA, Rizivi A, Ganguly SS. Measurement of circulating levels of VEGF-A, -C, and -D and their receptors, VEGFR-1 and -2 in gastric adenocarcinoma. World J Gastroenterol 2008, 14:3879-3883. 10.3748/wjg.14.3879, 2721446, 18609713.
    • (2008) World J Gastroenterol , vol.14 , pp. 3879-3883
    • Al-Moundhri, M.S.1    Al-Shukaili, A.2    Al-Nabhani, M.3    Al-Bahrani, B.4    Burney, I.A.5    Rizivi, A.6    Ganguly, S.S.7
  • 37
    • 84873267168 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor (VEGF-C) as a diagnostic and prognostic marker in patients with ovarian cancer
    • 3562180, 23383322
    • Cheng D, Liang B, Li Y. Serum vascular endothelial growth factor (VEGF-C) as a diagnostic and prognostic marker in patients with ovarian cancer. PLoS One 2013, 8:e55309. 10.1371/journal.pone.0055309, 3562180, 23383322.
    • (2013) PLoS One , vol.8 , pp. e55309
    • Cheng, D.1    Liang, B.2    Li, Y.3
  • 38
    • 39049165334 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth
    • 18199548
    • Ebos JM, Lee CR, Bogdanovic E, Alami J, Van SP, Francia G, Xu P, Mutsaers AJ, Dumont DJ, Kerbel RS. Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth. Cancer Res 2008, 68:521-529. 10.1158/0008-5472.CAN-07-3217, 18199548.
    • (2008) Cancer Res , vol.68 , pp. 521-529
    • Ebos, J.M.1    Lee, C.R.2    Bogdanovic, E.3    Alami, J.4    Van, S.P.5    Francia, G.6    Xu, P.7    Mutsaers, A.J.8    Dumont, D.J.9    Kerbel, R.S.10
  • 41
    • 34547779489 scopus 로고    scopus 로고
    • Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins
    • 1939830, 17605814
    • DePrimo SE, Bello CL, Smeraglia J, Baum CM, Spinella D, Rini BI, Michaelson MD, Motzer RJ. Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. J Transl Med 2007, 5:32. 10.1186/1479-5876-5-32, 1939830, 17605814.
    • (2007) J Transl Med , vol.5 , pp. 32
    • DePrimo, S.E.1    Bello, C.L.2    Smeraglia, J.3    Baum, C.M.4    Spinella, D.5    Rini, B.I.6    Michaelson, M.D.7    Motzer, R.J.8
  • 43
    • 84866256300 scopus 로고    scopus 로고
    • Determination of soluble vascular endothelial growth factor receptor 3 (sVEGFR-3) in plasma as pharmacodynamic biomarker
    • Kanefendt F, Lindauer A, Mross K, Fuhr U, Jaehde U. Determination of soluble vascular endothelial growth factor receptor 3 (sVEGFR-3) in plasma as pharmacodynamic biomarker. J Pharm Biomed Anal 2012, 70:485-491.
    • (2012) J Pharm Biomed Anal , vol.70 , pp. 485-491
    • Kanefendt, F.1    Lindauer, A.2    Mross, K.3    Fuhr, U.4    Jaehde, U.5
  • 45
    • 65049090261 scopus 로고    scopus 로고
    • Tumoural expression and circulating level of VEGFR-3 (Flt-4) in metastatic melanoma patients: correlation with clinical parameters and outcome
    • 19157860
    • Mouawad R, Spano JP, Comperat E, Capron F, Khayat D. Tumoural expression and circulating level of VEGFR-3 (Flt-4) in metastatic melanoma patients: correlation with clinical parameters and outcome. Eur J Cancer 2009, 45:1407-1414. 10.1016/j.ejca.2008.12.015, 19157860.
    • (2009) Eur J Cancer , vol.45 , pp. 1407-1414
    • Mouawad, R.1    Spano, J.P.2    Comperat, E.3    Capron, F.4    Khayat, D.5
  • 48
    • 0027405117 scopus 로고
    • Prevalence screening for ovarian cancer in postmenopausal women by CA 125 measurement and ultrasonography
    • 1677033, 8490497
    • Jacobs I, Davies AP, Bridges J, Stabile I, Fay T, Lower A, Grudzinskas JG, Oram D. Prevalence screening for ovarian cancer in postmenopausal women by CA 125 measurement and ultrasonography. BMJ 1993, 306:1030-1034. 10.1136/bmj.306.6884.1030, 1677033, 8490497.
    • (1993) BMJ , vol.306 , pp. 1030-1034
    • Jacobs, I.1    Davies, A.P.2    Bridges, J.3    Stabile, I.4    Fay, T.5    Lower, A.6    Grudzinskas, J.G.7    Oram, D.8
  • 49
    • 84874095390 scopus 로고    scopus 로고
    • Predictive impact of circulating vascular endothelial growth factor in four phase III trials evaluating bevacizumab
    • 23169435
    • Hegde PS, Jubb AM, Chen D, Li NF, Meng YG, Bernaards C, Elliott R, Scherer SJ, Chen DS. Predictive impact of circulating vascular endothelial growth factor in four phase III trials evaluating bevacizumab. Clin Cancer Res 2013, 19:929-937. 10.1158/1078-0432.CCR-12-2535, 23169435.
    • (2013) Clin Cancer Res , vol.19 , pp. 929-937
    • Hegde, P.S.1    Jubb, A.M.2    Chen, D.3    Li, N.F.4    Meng, Y.G.5    Bernaards, C.6    Elliott, R.7    Scherer, S.J.8    Chen, D.S.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.