Protective effect of Danggui (Radix Angelicae Sinensis) on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  Huang, Chih Yang ^a,b   Kuo, Wei Wen ^a   Kuo, Chia Hua ^c   Tsai, Fuu Jen ^a   Liu, Peng Yu ^a   Hsieh, Dennis Jine Yuan ^d,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

^c UNIVERSITY OF TAIPEI   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Angiotensin II; Apoptosis; Cardiomyoblast; Danggui; Radix Angelicae Sinensis; Traditional Chinese Medicine (TCM)

Indexed keywords

ANGELICA SINENSIS EXTRACT; ANGIOTENSIN II; CASPASE 3; CASPASE 9; CYTOCHROME C; HERBACEOUS AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTECTIVE AGENT;

ANGELICA SINENSIS; APOPTOSIS; ARTICLE; CHINESE MEDICINE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME INHIBITION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; IN VITRO STUDY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE POTENTIAL; NICK END LABELING; REPERFUSION INJURY; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; HEART MUSCLE CELL; METABOLISM; MITOCHONDRION; RAT; SIGNAL TRANSDUCTION;

ANGELICA SINENSIS; ANGIOTENSIN II; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE; CELL SURVIVAL; CYTOCHROMES C; DRUGS, CHINESE HERBAL; MITOCHONDRIA; MYOCYTES, CARDIAC; PHOSPHATIDYLINOSITOL 3-KINASES; PROTECTIVE AGENTS; RATS; SIGNAL TRANSDUCTION;

EID: 84907389313     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-358     Document Type: Article

References (39)

1. Tannenbaum GS. Growth hormone secretory dynamics in streptozotocin diabetes: evidence of a role for endogenous circulating somatostatin. Endocrinology 1981, 108:76-82. 10.1210/endo-108-1-76, 6109623.
2. Castellano G, Affuso F, Conza PD, Fazio S. The GH/IGF-1 axis and heart failure. Curr Cardiol Rev 2009, 5:203-215. 10.2174/157340309788970306, 2822143, 20676279.
3. Chang MH, Kuo WW, Chen RJ, Lu MC, Tsai FJ, Kuo WH, Chen LY, Wu WJ, Huang CY, Chu CH. IGF-II/mannose 6-phosphate receptor activation induces metalloproteinase-9 matrix activity and increases plasminogen activator expression in H9c2 cardiomyoblast cells. J Mol Endocrinol 2008, 41:65-74. 10.1677/JME-08-0051, 18495691.
4. Chu CH, Tzang BS, Chen LM, Kuo CH, Cheng YC, Chen LY, Tsai FJ, Tsai CH, Kuo WW, Huang CY. IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Galphaq interaction and protein kinase C-alpha/CaMKII activation in H9c2 cardiomyoblast cells. J Endocrinol 2008, 197:381-390. 10.1677/JOE-07-0619, 18434368.
5. Chu CH, Tzang BS, Chen LM, Liu CJ, Tsai FJ, Tsai CH, Lin JA, Kuo WW, Bau DT, Yao CH, Huang CY. Activation of insulin-like growth factor II receptor induces mitochondrial-dependent apoptosis through G(alpha)q and downstream calcineurin signaling in myocardial cells. Endocrinology 2009, 150:2723-2731. 10.1210/en.2008-0975, 19095737.
6. Hunter JJ, Chien KR. Signaling pathways for cardiac hypertrophy and failure. N Engl J Med 1999, 341:1276-1283. 10.1056/NEJM199910213411706, 10528039.
7. Tappy L, Fujita-Yamaguchi Y, LeBon TR, Boden G. Antibodies to insulin-like growth factor I receptors in diabetes and other disorders. Diabetes 1988, 37:1708-1714. 10.2337/diab.37.12.1708, 2973422.
8. Thrailkill KM. Insulin-like growth factor-I in diabetes mellitus: its physiology, metabolic effects, and potential clinical utility. Diabetes Technol Ther 2000, 2:69-80. 10.1089/152091599316775, 11467325.
9. Lee SD, Chu CH, Huang EJ, Lu MC, Liu JY, Liu CJ, Hsu HH, Lin JA, Kuo WW, Huang CY. Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation. Am J Physiol Endocrinol Metab 2006, 291:E306-E314. 10.1152/ajpendo.00127.2005, 16825605.
10. Lijnen P, Petrov V. Renin-angiotensin system, hypertrophy and gene expression in cardiac myocytes. J Mol Cell Cardiol 1999, 31:949-970. 10.1006/jmcc.1999.0934, 10336836.
11. Sernia C. A critical appraisal of the intrinsic pancreatic angiotensin-generating system. JOP 2001, 2:50-55.
12. Dostal DE, Baker KM. Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart. Mediation by the AT1 receptor. Am J Hypertens 1992, 5:276-280.
13. Timmermans PB, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JA, Smith RD. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 1993, 45:205-251.
14. Wu YC, Hsieh CL. Pharmacological effects of Radix Angelica Sinensis (Danggui) on cerebral infarction. Chin Med 2011, 6:32. 10.1186/1749-8546-6-32, 3174116, 21867503.
15. Wilasrusmee C, Kittur S, Siddiqui J, Bruch D, Wilasrusmee S, Kittur DS. In vitro immunomodulatory effects of ten commonly used herbs on murine lymphocytes. J Altern Complement Med 2002, 8:467-475. 10.1089/107555302760253667, 12230907.
16. Rhyu MR, Kim JH, Kim EY. Radix angelica elicits both nitric oxide-dependent and calcium influx-mediated relaxation in rat aorta. J Cardiovasc Pharmacol 2005, 46:99-104. 10.1097/01.fjc.0000164092.88821.49, 15965361.
17. Chen XP, Li W, Xiao XF, Zhang LL, Liu CX. Phytochemical and pharmacological studies on Radix Angelica Sinensis. Chin J Nat Med 2013, 11:577-587.
18. Yi L, Liang Y, Wu H, Yuan D. The analysis of Radix Angelicae Sinensis (Danggui). J Chromatogr A 2009, 1216:1991-2001. 10.1016/j.chroma.2008.07.033, 18667208.
19. Mak DH, Chiu PY, Dong TT, Tsim KW, Ko KM. Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes. Phytother Res 2006, 20:561-567. 10.1002/ptr.1904, 16619337.
20. Li YD, Ma YH, Zhao JX, Zhao XK. Protection of ultra-filtration extract from Danggui Buxue Decoction on oxidative damage in cardiomyocytes of neonatal rats and its mechanism. Chin J Integr Med 2011, 17:854-859. 10.1007/s11655-011-0897-6, 22057415.
21. Chiu PY, Leung HY, Siu AH, Poon MK, Dong TT, Tsim KW, Ko KM. Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: role of glutathione synthesis and regeneration. Planta Med 2007, 73:134-141. 10.1055/s-2006-957068, 17325989.
22. Meng H, Zhu MZ, Guo J, Sun JY, Pei JM, Huang C. [The study on angiogenesis activity of danggui, chuanxiong and danshen]. Zhong Yao Cai 2006, 29:574-576.
23. Xin YF, Zhou GL, Shen M, Chen YX, Liu SP, Chen GC, Chen H, You ZQ, Xuan YX. Angelica sinensis: a novel adjunct to prevent doxorubicin-induced chronic cardiotoxicity. Basic Clin Pharmacol Toxicol 2007, 101:421-426. 10.1111/j.1742-7843.2007.00144.x, 17971065.
24. Zhang S, He B, Ge J, Li H, Luo X, Zhang H, Li Y, Zhai C, Liu P, Liu X, Fei X. Extraction, chemical analysis of Angelica sinensis polysaccharides and antioxidant activity of the polysaccharides in ischemia-reperfusion rats. Int J Biol Macromol 2010, 47:546-550. 10.1016/j.ijbiomac.2010.07.012, 20691723.
25. Chu CH, Lo JF, Hu WS, Lu RB, Chang MH, Tsai FJ, Tsai CH, Weng YS, Tzang BS, Huang CY. Histone acetylation is essential for ANG-II-induced IGF-IIR gene expression in H9c2 cardiomyoblast cells and pathologically hypertensive rat heart. J Cell Physiol 2012, 227:259-268. 10.1002/jcp.22728, 21412773.
26. Pang JJ, Xu RK, Xu XB, Cao JM, Ni C, Zhu WL, Asotra K, Chen MC, Chen C. Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro. Am J Physiol Heart Circ Physiol 2004, 286:H1063-H1069.
27. Kuo WW, Liu CJ, Chen LM, Wu CH, Chu CH, Liu JY, Lu MC, Lin JA, Lee SD, Huang CY. Cardiomyoblast apoptosis induced by insulin-like growth factor (IGF)-I resistance is IGF-II dependent and synergistically enhanced by angiotensin II. Apoptosis 2006, 11:1075-1089. 10.1007/s10495-006-7028-4, 16699953.
28. Chen QM, Tu VC. Apoptosis and heart failure: mechanisms and therapeutic implications. Am J Cardiovasc Drugs 2002, 2:43-57. 10.2165/00129784-200202010-00006, 14727998.
29. Sharov VG, Todor A, Suzuki G, Morita H, Tanhehco EJ, Sabbah HN. Hypoxia, angiotensin-II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role for p38 MAPK, Fas-L and cyclin D1. Eur J Heart Fail 2003, 5:121-129. 10.1016/S1388-9842(02)00254-4, 12644001.
30. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 1998, 93:215-228. 10.1016/S0092-8674(00)81573-1, 9568714.
31. Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC. Ca2 + -induced apoptosis through calcineurin dephosphorylation of BAD. Science 1999, 284:339-343. 10.1126/science.284.5412.339, 10195903.
32. Choudhary R, Baker KM, Pan J. All-trans retinoic acid prevents angiotensin II- and mechanical stretch-induced reactive oxygen species generation and cardiomyocyte apoptosis. J Cell Physiol 2008, 215:172-181. 10.1002/jcp.21297, 17941088.
33. Liu J, Lin A. Role of JNK activation in apoptosis: a double-edged sword. Cell Res 2005, 15:36-42. 10.1038/sj.cr.7290262, 15686625.
34. Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 1996, 87:619-628. 10.1016/S0092-8674(00)81382-3, 8929531.
35. Onder G, Penninx BW, Balkrishnan R, Fried LP, Chaves PH, Williamson J, Carter C, Di Bari M, Guralnik JM, Pahor M. Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study. Lancet 2002, 359:926-930. 10.1016/S0140-6736(02)08024-8, 11918911.
36. Brink M, Wellen J, Delafontaine P. Angiotensin II causes weight loss and decreases circulating insulin-like growth factor I in rats through a pressor-independent mechanism. J Clin Invest 1996, 97:2509-2516. 10.1172/JCI118698, 507336, 8647943.
37. Isenovic ER, Meng Y, Jamali N, Milivojevic N, Sowers JR. Ang II attenuates IGF-1-stimulated Na+, K(+)-ATPase activity via PI3K/Akt pathway in vascular smooth muscle cells. Int J Mol Med 2004, 13:915-922.
38. Yeste-Velasco M, Folch J, Casadesus G, Smith MA, Pallas M, Camins A. Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry. Neuroscience 2009, 159:1135-1147. 10.1016/j.neuroscience.2009.01.035, 19356694.
39. Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, Xiang J, Lin A. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 2004, 13:329-340. 10.1016/S1097-2765(04)00028-0, 14967141.