Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes

Phytotherapy Research

Volumn 20, Issue 7, 2006, Pages 561-567

  Mak, Duncan H F ^a   Chiu, P Y ^a   Dong, Tina T X ^a   Tsim, Karl W K ^a   Ko, K M ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Angelica sinensis; Astragalus membranaceus; Erythrocytes; Glutathione; Mitochondrion; Myocardial ischaemia reperfusion injury

Indexed keywords

ANGELICA ROOT; ANGELICA SINENSIS EXTRACT; ASTRAGALUS MEMBRANACEUS EXTRACT; CHINESE DRUG; DANG GUI BUXUE TANG; GLUTATHIONE; UNCLASSIFIED DRUG;

ANGELICA SINENSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASTRAGALUS MEMBRANACEUS; CELL LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; ERYTHROCYTE; EX VIVO STUDY; FEMALE; HEART MITOCHONDRION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY;

ANGELICA SINENSIS; ANIMALS; ANTIOXIDANTS; ASTRAGALUS PLANT; CARDIOTONIC AGENTS; DRUGS, CHINESE HERBAL; ERYTHROCYTES; GLUTATHIONE; MITOCHONDRIA, HEART; MYOCARDIAL REPERFUSION INJURY; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RATS;

EID: 33745987361     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.1904     Document Type: Article

References (25)

1. Ambrosio G, Zweier JL, Flaherty JT. 1991. The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion. J Mol Cell Cardiol 23: 1359-1374.
2. Anderson ME. 1985. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 113: 548-555.
3. Chen SY, Li F. 1993. A Clinical Guide to Chinese Herbs and Formulae. Churchill Livingstone: London, 77.
4. Chiu PY, Tang MH, Mak DH, Poon MKT, Ko KM. 2003. Hepato-protective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins. Free Radic Biol Med 35: 368-380.
5. Ding YX, Quian YY, Xu JZ et al. 1986. Changes in peripheral blood status and microcirculation in haemolytic anaemic animals: Effects of treatment with ginseng, deer antler and 'blood-enriching' injections. Chin Tradit Herbal Drug 17: 44-45.
6. Drabkin DL, Austin JH. 1935. Spectrophotometric studies II. Preparations from washed blood cells, nitric oxide hemoglobin and sulfhemoglobin. J Biol Chem 122: 51-56.
7. Evans WH. 1992. Isolation and characterization of membranes and cell organelles. In Preparative Centrifugation: A Practical Approach, Sanada H (ed.). Oxford University Press: New York, 233-270.
8. Godin DV, Ko KM, Qayumi AK, Jamieson WR. 1989. A method for monitoring the effectiveness of allopurinol pretreatment in the prevention of ischemic/reperfusion injury. J Pharmacol Methods 22: 289-297.
9. Griffith OW. 1980. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106: 207-212.
10. Hess ML, Manson NH. 1984. Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury. J Mol Cell Cardiol 16: 969-985.
11. Li PC, Mak DHF, Poon MKT, Ip SP, Ko KM. 1996. Myocardial protective effect of Sheng Mai San (SMS) and a lignan-enriched extract of Fructus Schisandrae, in vivo and ex vivo. Phytomedicine 3: 217-221.
12. Ma XQ, Shi Q, Duan JA, Dong TT, Tsim KW. 2002. Chemical analysis of Radix Astragali (Huangqi) in China: a comparison with its adulterants and seasonal variations. J Agric Food Chem 50: 4861-4866.
13. McCord JM. 1985. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312: 159-163.
14. Meister A, Anderson ME. 1983. Glutathione. Annu Rev Biochem 52: 711-760.
15. Nie K. 1996. [Drug-pair of radix Astragali and radix Angelicae sinensis on cardiovascular system]. Zhongguo Zhong Xi Yi Jie He Za Zhi 16: 379-381.
16. Olafsdottir K, Reed DJ. 1988. Retention of oxidized glutathione by isolated rat liver mitochondria during hydroperoxide treatment. Biochim Biophys Acta 964: 377-382.
17. Pascoe GA, Olafsdottir K, Reed DJ. 1987. Vitamin E protection against chemical-induced cell injury. I. Maintenance of cellular protein thiols as a cytoprotective mechanism. Arch Biochem Biophys 256: 150-158.
18. Qayumi AK, Godin DV, Jamieson WR, Ko KM, Poostizadeh A. 1993. Correlation of red cell antioxidant status and heart-lung function in swine pretreated with allopurinol (a model of heart-lung transplantation). Transplantation 56: 37-43.
19. Smith CV, Jones DP, Guenthner TM, Lash LH, Lauterburg BH. 1996. Compartmentation of glutathione: implications for the study of toxicity and disease. Toxicol Appl Pharmacol 140: 1-12.
20. Tao JY, Ruan YP, Mei QB et al. 1984. Studies on the anti-asthmatic effect of ligustilide of Dang Gui, Angelica sinensis (Oliv.) Diels. Acta Pharm Sin 19: 561-565.
21. Wang D, Shen W, Tian Y, Sun Z, Jiang C, Yuan S. 1996. Protective effect of active components extracted from radix Astragali on human erythrocyte membrane damages caused by reactive oxygen species]. Zhongguo Zhong. Yao Za Zhi 21: 746-748, 763.
22. Yim TK, Wu WK, Pak WF, Mak DHF, Liang SM, Ko KM. 2000. Myocardial protection against ischaemia-reperfusion injury by a Polygonum multiflorum extract supplemented 'Dang-Gui decoction for enriching blood', a compound formulation, ex vivo. Phytother Res 14: 195-199.
23. Zhao KJ, Dong TT, Tu PF, Song ZH, Lo CK, Tsim KW. 2003a. Molecular genetic and chemical assessment of radix Angelica (Danggui) in China. J Agric Food Chem 51: 2576-2583.
24. Zhao Z, Egashira Y, Sanada H. 2003b. Digestion and absorption of ferulic acid sugar esters in rat gastrointestinal tract. J Agric Food Chem 51: 5534-5539.
25. Zheng HZ, Dong ZH, She J (eds). 1997. Modern Study of Chinese Drugs and Clinical Applications Vol. 2, Xueyuan Press: Beijing, 1822.