Radix Angelica elicits both nitric oxide-dependent and calcium influx-mediated relaxation in rat aorta

Journal of Cardiovascular Pharmacology

Volumn 46, Issue 1, 2005, Pages 99-104

  Rhyu, Mee Ra ^a   Kim, Jung Hyun ^a   Kim, Eun Young ^a  

^a Korea Food Research Institute   (South Korea)

Author keywords

Calcium influx; Endothelium dependent; Endothelium independent; Nitric oxide; Radix Angelica; Vasorelaxation

Indexed keywords

ANGELICA ROOT; ARGININE; ATROPINE; BUTANOL; CALCIUM; CALCIUM CHLORIDE; FERULIC ACID; INDOMETACIN; METHYLENE BLUE; N(G) NITROARGININE; NITRIC OXIDE; NORADRENALIN; POTASSIUM CHANNEL BLOCKING AGENT;

ANGELICA; ANIMAL TISSUE; AORTA; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; CALCIUM TRANSPORT; CHINESE MEDICINE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; VASCULAR RING;

ANGELICA; ANIMALS; AORTA, THORACIC; BUTANOLS; CALCIUM; CALCIUM CHANNEL BLOCKERS; COUMARIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; MALE; NICARDIPINE; NITRIC OXIDE; PLANT EXTRACTS; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION; WATER;

EID: 21444431503     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000164092.88821.49     Document Type: Article

References (32)

1. Chinese Pharmacopoeia Committee. Ministry of Public Health, the People's Republic of China. The Chinese Pharmacopoeia 2000. Beijing: Chemical Industry Publishing House; 2000.
2. Zhy DPQ. Dong Quai. Am J Chin Med. 1987;15:117-125.
3. Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med. 2002;137:805-813.
4. Burke BE, Olson RD, Cusack Randomized BJ. Randomized, controlled trial of phytoestrogen in the prophylactic treatment of menstrual migraine. Biomed Pharmacother. 2002;56:283-288.
5. Mineo S, Takayasu M, Syoichi S. Evaluation of Angelica Radix (Touki) by the inhibitory effect on platelet aggregation. Chem Pharm Bull (Tokyo). 1991;39:2046-2048.
6. Yim TK, Wu WK. Myocardial protection against ischaemia-reperfusion injury by a Polygonum multiflorum extract supplemented 'Dang-Gui decoction for enriching blood', a compound formulation, ex vivo. Phytother Res. 2000;14:195-199.
7. Dong WG, Liu SP, Zhu HH. Abnormal function of platelets and role of angelica sinensis in patients with ulcerative colitis. World J Gastroenterol. 2004;10:606-609.
8. Wang BH, Ouyang JP, Liu YM. Protective effect of Angelica on ECV(304) from injury induced by hyperlipidemic serum in vitro. Sheng Li Xue Bao. 2001;53:240-243.
9. Lei Y, Gao Q, Li YS. Study on effects of astragalus, angelica and their combination on vascular endothelial cell proliferation in vitro. Zhongguo Zhong Xi Yi He He Za Zhi. 2003;23:753-756.
10. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med. 1998;217:369-378.
11. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause. 2002;9:145-150.
12. Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem. 2001;49:2472-2479.
13. Altavilla D, Crisafulli A, Marini H, et al. Cardiovascular effects of the phytoestrogen genistein. Curr Med Chem Cardiovasc Hematol Agents. 2004;2:179-186.
14. Zhang MF. Advances study on antiatherosclerosis of ferulic acid. Chin Trad Herb Drugs. 1990;21:41-43.
15. Suzuki A, Kagawa D, Fujii A, et al. Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats. Am J Hypertens. 2002;15:351-357.
16. Wang B, Ouyang J, Liu Y, et al. Sodium ferulate inhibits atherosclerogenesis in hyperlipidemia rabbits. J Cardiovasc Pharmacol. 2004;43: 549-554.
17. Yamaji Y, Toba Y, Umezato M, et al. General pharmacological studies of γ-oryzanol and its main metabolite, ferulic acid. Pharmacometrics. 1983; 25:947-958.
18. Huang X, Zang Y, Wang Y, et al. Effect of tetramethylpyrazine phosphate and sodium ferulate alone or in combination on hemodynamics in anesthetized dog. Am J Chin Med. 1996;24:169-176.
19. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980; 288:373-376.
20. Brayden JE. Potassium channels in vascular smooth muscle. Clin Exp Pharmacol Physiol. 1996;23:1069-1076.
21. Salom JB, Burguete MC, Perez-Asensio FJ, et al. Acute relaxant effects of 17-b-estradiol through non-genomic mechanisms in rabbit carotid artery. Steroids. 2002;67:339-346.
22. Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol. 1995;268:C799-C822.
23. + channel modulation in arterial smooth muscle. Acta Physiol Scand. 1998;164:549-557.
24. Ko FN, Wu TS, Liou MJ, et al. Vasorelaxation of rat thoracic aorta caused by posthole isolated from Angelica pubescens. Eur J Pharmacol. 1992; 219:29-34.
25. Pang PKT, Shan JJ, Chiu KW Tetramethylpyrazine, a calcium antagonist. Planta Med. 1996;62:431-435.
26. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-2012.
27. Ragazzi E, Chinellato A, Pandolfo L, et al. Endothelial nucleotide-mediated aorta relaxation in aged Watanabe heritable hyperlipidemic rabbits. J Cardiovasc Pharmacol. 1995;26:119-126.
28. Furchgott RF. The role of endothelium in the responses of vascular smooth muscle to drugs. Annu Rev Pharmacol Toxicol. 1984;24:175-179.
29. Fitzpatrick DF, Hirschfield SL, Ricci T, et al. Endothelium-dependent vasorelaxation caused by various plant extracts. J Cardiovasc Pharmacol. 1995;26:90-95.
30. Wazlawik E, Silva MA, Peter RR, et al. Analysis of the role of nitric oxide in the relaxant effect of the crude extract and fractions from Eugenia uniflora in the rat thoracic aorta. J Pharm Pharmacol. 1997;49: 433-437.
31. Andriambeloson E, Kleschyov AL, Muller B, et al. Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Br J Pharmacol. 1997;120:1053-1058.
32. Harada M, Suzuki M, Ozaki Y. Effect of Japanese Angelica root and peony root on uterine contraction in the rabbit in situ. J Pharmacobiodyn. 1984;7:304-311.