Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis

Science Translational Medicine

Volumn 6, Issue 249, 2014, Pages

  Fletcher, Anne L ^a,b,c,d   Elman, Jessica S ^b   Astarita, Jillian ^a,b   Murray, Ryan ^b   Saeidi, Nima ^b   D'Rozario, Joshua ^c   Knoblich, Konstantin ^a   Brown, Flavian D ^a,b   Schildberg, Frank A ^a,b   Nieves, Janice M ^a,b   Heng, Tracy S P ^c   Boyd, Richard L ^c   Turley, Shannon J ^a,b,f   Parekkadan, Biju ^b,e  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e HARVARD STEM CELL INSTITUTE   (United States)

^f GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; CYTOKINE; LIPOPOLYSACCHARIDE; NOS2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL EXPANSION; CELL TRANSPLANTATION; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME METABOLISM; EX VIVO STUDY; FEMALE; FIBROBLASTIC RETICULAR CELL TRANSPLANTATION; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; INFECTION CONTROL; MORTALITY; MOUSE; MOUSE MODEL; NONHUMAN; SEPSIS; SURVIVAL; ANIMAL; BACTEREMIA; BLOOD; CECUM; CELL MOTION; CYTOLOGY; DISEASE MODEL; ENDOTOXEMIA; FIBROBLAST; LIGATION; LYMPH NODE; METABOLISM; PATHOLOGY; PERITONEUM; PUNCTURE; SPLEEN; SURVIVAL ANALYSIS; TRANSPLANTATION;

ANIMALS; BACTEREMIA; CECUM; CELL MOVEMENT; CYTOKINES; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; FEMALE; FIBROBLASTS; LIGATION; LIPOPOLYSACCHARIDES; LYMPH NODES; MICE; NITRIC OXIDE SYNTHASE TYPE II; PERITONEUM; PUNCTURES; SEPSIS; SPLEEN; SURVIVAL ANALYSIS;

EID: 84907383506     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3009377     Document Type: Article

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