Mechanisms of plasmid segregation: Have multicopy plasmids been overlooked?

Plasmid

Volumn 75, Issue , 2014, Pages 27-36

  Million Weaver, Samuel ^a   Camps, Manel ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cytoskeleton; DNA binding; Motors; Partition; Replication; Segregation

Indexed keywords

ADAPTOR PROTEIN; MOLECULAR MOTOR; DNA;

ARTICLE; BIOREMEDIATION; CENTROMERE; CYTOPLASM; DAUGHTER CELL; GENE DOSAGE; GENE EXPRESSION; GENE REPLICATION; GENE SEGREGATION; NONHUMAN; PLASMID; PLASMID PARTITIONING; PLASMID SEGREGATION; POLYMERIZATION; PROTEIN SYNTHESIS; RECOMBINANT GENE; BACTERIAL CHROMOSOME; BACTERIAL GENE; BACTERIAL GENETICS; ESCHERICHIA COLI; GENETIC STABILITY; MICROFILAMENT; PAR SYSTEM TYPE I; PAR SYSTEM TYPE II; VERTICAL TRANSMISSION; CHEMICAL STRUCTURE; CHROMOSOME SEGREGATION; DNA REPLICATION; GENE LOCUS; GENETICS; ISOLATION AND PURIFICATION;

CENTROMERE; CHROMOSOME SEGREGATION; DNA; DNA REPLICATION; GENE EXPRESSION; GENETIC LOCI; MODELS, MOLECULAR; PLASMIDS;

EID: 84907372179     PISSN: 0147619X     EISSN: 10959890     Source Type: Journal    
DOI: 10.1016/j.plasmid.2014.07.002     Document Type: Article

References (98)

1. Ah-Seng Y., Lopez F., Pasta F., Lane D., Bouet J.Y. Dual role of DNA in regulating ATP hydrolysis by the SopA partition protein. J. Biol. Chem. 2009, 284(44):30067-30075. Epub 2009/09/11. PubMed PMID: 19740757; PubMed Central PMCID: PMC2781561. 10.1074/jbc.M109.044800.
2. Ah-Seng Y., Rech J., Lane D., Bouet J.Y. Defining the role of ATP hydrolysis in mitotic segregation of bacterial plasmids. PLoS Genet. 2013, 9(12):E1003956. Epub 2013/12/25. PubMed PMID: 24367270; PubMed Central PMCID: PMC3868542. 10.1371/journal.pgen.1003956.
3. Austin S., Ziese M., Sternberg N. A novel role for site-specific recombination in maintenance of bacterial replicons. Cell 1981, 25(3):729-736. Epub 1981/09/01. PubMed PMID: 7026049.
4. Barilla D., Rosenberg M.F., Nobbmann U., Hayes F. Bacterial DNA segregation dynamics mediated by the polymerizing protein ParF. EMBO J. 2005, 24(7):1453-1464. Epub 2005/03/19. PubMed PMID: 15775965; PubMed Central PMCID: PMC1142544. 10.1038/sj.emboj.7600619.
5. Bazaral M., Helinski D.R. Replication of a bacterial plasmid and an episome in Escherichia coli. Biochemistry 1970, 9(2):399-406. Epub 1970/01/20. PubMed PMID: 4904868.
6. Bechert T., Heck S., Fleig U., Diekmann S., Hegemann J.H. All 16 centromere DNAs from Saccharomyces cerevisiae show DNA curvature. Nucleic Acids Res. 1999, 27(6):1444-1449. Epub 1999/02/26. PubMed PMID: 10037804; PubMed Central PMCID: PMC148336.
7. Bernard P., Kezdy K.E., Van Melderen L., Steyaert J., Wyns L., Pato M.L., et al. The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase. J. Mol. Biol. 1993, 234(3):534-541. Epub 1993/12/05. PubMed PMID: 8254658. 10.1006/jmbi.1993.1609.
8. Biek D.P., Strings J. Partition functions of mini-F affect plasmid DNA topology in Escherichia coli. J. Mol. Biol. 1995, 246(3):388-400. Epub 1995/02/24. PubMed PMID: 7877163. 10.1006/jmbi.1994.0094.
9. Bignell C.R., Haines A.S., Khare D., Thomas C.M. Effect of growth rate and incC mutation on symmetric plasmid distribution by the IncP-1 partitioning apparatus. Mol. Microbiol. 1999, 34(2):205-216. Epub 1999/11/17. PubMed PMID: 10564465.
10. Boucher H.W., Talbot G.H., Benjamin D.K., Bradley J., Guidos R.J., Jones R.N., et al. 10 x '20 Progress-development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America. Clin. Infect. Dis. 2013, 56(12):1685-1694. Epub 2013/04/20. PubMed PMID: 23599308; PubMed Central PMCID: PMC3707426. 10.1093/cid/cit152.
11. Bouet J.Y., Nordstrom K., Lane D. Plasmid partition and incompatibility - the focus shifts. Mol. Microbiol. 2007, 65(6):1405-1414. Epub 2007/08/24. PubMed PMID: 17714446. 10.1111/j.1365-2958.2007.05882.x.
12. Bouet J.Y., Ah-Seng Y., Benmeradi N., Lane D. Polymerization of SopA partition ATPase: regulation by DNA binding and SopB. Mol. Microbiol. 2007, 63(2):468-481. Epub 2006/12/15. PubMed PMID: 17166176. 10.1111/j.1365-2958.2006.05537.x.
13. Campbell C.S., Mullins R.D. In vivo visualization of type II plasmid segregation: bacterial actin filaments pushing plasmids. J. Cell Biol. 2007, 179(5):1059-1066. Epub 2007/11/28. PubMed PMID: 18039937; PubMed Central PMCID: PMC2099209. 10.1083/jcb.200708206.
14. Camps M. Modulation of ColE1-like plasmid replication for recombinant gene expression. Recent Patents DNA Gene Sequences 2010, 4(1):58-73. Epub 2010/03/12. PubMed PMID: 20218961; PubMed Central PMCID: PMC2846101.
15. Cascales E., Buchanan S.K., Duche D., Kleanthous C., Lloubes R., Postle K., et al. Colicin biology. Microbiol. Mol. Biol. Rev. MMBR 2007, 71(1):158-229. Epub 2007/03/10. PubMed PMID: 17347522; PubMed Central PMCID: PMC1847374. 10.1128/MMBR.00036-06.
16. Corchero J.L., Villaverde A. Plasmid maintenance in Escherichia coli recombinant cultures is dramatically, steadily, and specifically influenced by features of the encoded proteins. Biotechnol. Bioeng. 1998, 58(6):625-632. Epub 1999/04/01. PubMed PMID: 10099300.
17. Dam M., Gerdes K. Partitioning of plasmid R1. Ten direct repeats flanking the parA promoter constitute a centromere-like partition site parC, that expresses incompatibility. J. Mol. Biol. 1994, 236(5):1289-1298. Epub 1994/03/11. PubMed PMID: 8126720.
18. Diaz Ricci J.C., Hernandez M.E. Plasmid effects on Escherichia coli metabolism. Crit. Rev. Biotechnol. 2000, 20(2):79-108. Epub 2000/07/13. PubMed PMID: 10890453. 10.1080/07388550008984167.
19. Dmowski M., Jagura-Burdzy G. Active stable maintenance functions in low copy-number plasmids of Gram-positive bacteria I. Partition systems. Pol. J. Microbiol. 2013, 62(1):3-16. Epub 2013/07/09. PubMed PMID: 23829072.
20. Ebersbach G., Gerdes K. Bacterial mitosis: partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell. Mol. Microbiol. 2004, 52(2):385-398. Epub 2004/04/07. PubMed PMID: 15066028. 10.1111/j.1365-2958.2004.04002.x.
21. Erdmann N., Petroff T., Funnell B.E. Intracellular localization of P1 ParB protein depends on ParA and parS. Proc. Natl. Acad. Sci. U.S.A. 1999, 96(26):14905-14910. Epub 1999/12/28. PubMed PMID: 10611311; PubMed Central PMCID: PMC24746.
22. Ezaki B., Ogura T., Niki H., Hiraga S. Partitioning of a mini-F plasmid into anucleate cells of the mukB null mutant. J. Bacteriol. 1991, 173(20):6643-6646. Epub 1991/10/01. PubMed PMID: 1917886; PubMed Central PMCID: PMC209005.
23. Firshein W., Kim P. Plasmid replication and partition in Escherichia coli: is the cell membrane the key?. Mol. Microbiol. 1997, 23(1):1-10. Epub 1997/01/01. PubMed PMID: 9004215.
24. Friehs K. Plasmid copy number and plasmid stability. Adv. Biochem. Eng. Biotechnol. 2004, 86:47-82. Epub 2004/04/20. PubMed PMID: 15088763.
25. Garner E.C., Campbell C.S., Weibel D.B., Mullins R.D. Reconstitution of DNA segregation driven by assembly of a prokaryotic actin homolog. Science 2007, 315(5816):1270-1274. Epub 2007/03/03. PubMed PMID: 17332412; PubMed Central PMCID: PMC2851738. 10.1126/science.1138527.
26. Gayathri P., Fujii T., Moller-Jensen J., van den Ent F., Namba K., Lowe J. A bipolar spindle of antiparallel ParM filaments drives bacterial plasmid segregation. Science 2012, 338(6112):1334-1337. Epub 2012/11/01. PubMed PMID: 23112295; PubMed Central PMCID: PMC3694215. 10.1126/science.1229091.
27. Gayathri P., Fujii T., Namba K., Lowe J. Structure of the ParM filament at 8.5A resolution. J. Struct. Biol. 2013, 184(1):33-42. Epub 2013/03/07. PubMed PMID: 23462100; PubMed Central PMCID: PMC3794156. 10.1016/j.jsb.2013.02.010.
28. Gerdes K., Molin S. Partitioning of plasmid R1. Structural and functional analysis of the parA locus. J. Mol. Biol. 1986, 190(3):269-279. Epub 1986/08/05. PubMed PMID: 3023637.
29. Gerdes K., Howard M., Szardenings F. Pushing and pulling in prokaryotic DNA segregation. Cell 2010, 141(6):927-942. Epub 2010/06/17. PubMed PMID: 20550930. 10.1016/j.cell.2010.05.033.
30. Gitai Z. Diversification and specialization of the bacterial cytoskeleton. Curr. Opin. Cell Biol. 2007, 19(1):5-12. Epub 2006/12/21. PubMed PMID: 17178455. 10.1016/j.ceb.2006.12.010.
31. Goh S., Good L. Plasmid selection in Escherichia coli using an endogenous essential gene marker. BMC Biotechnol. 2008, 8:61. Epub 2008/08/13. PubMed PMID: 18694482; PubMed Central PMCID: PMC2527308. 10.1186/1472-6750-8-61.
32. Grabherr R., Bayer K. Impact of targeted vector design on Co/E1 plasmid replication. Trends Biotechnol. 2002, 20(6):257-260. Epub 2002/05/15. PubMed PMID: 12007494.
33. Grabherr R., Nilsson E., Striedner G., Bayer K. Stabilizing plasmid copy number to improve recombinant protein production. Biotechnol. Bioeng. 2002, 77(2):142-147. Epub 2001/12/26. PubMed PMID: 11753920. 10.1002/bit.10104.
34. Grabherr R., Nilsson E., Striedner G., Bayer K. Stabilizing plasmid copy number to improve recombinant protein production. Biotechnol. Bioeng. 2002, 77(2):142-147. Epub 2001/12/26. PubMed PMID: 11753920. 10.1002/bit.10104.
35. Grill S.W., Hyman A.A. Spindle positioning by cortical pulling forces. Dev. Cell. 2005, 8(4):461-465. Epub 2005/04/06. PubMed PMID: 15809029. 10.1016/j.devcel.2005.03.014.
36. Harrison P.W., Lower R.P., Kim N.K., Young J.P. Introducing the bacterial 'chromid': not a chromosome, not a plasmid. Trends Microbiol. 2010, 18(4):141-148. Epub 2010/01/19. PubMed PMID: 20080407. 10.1016/j.tim.2009.12.010.
37. Hatano T., Yamaichi Y., Niki H. Oscillating focus of SopA associated with filamentous structure guides partitioning of F plasmid. Mol. Microbiol. 2007, 64(5):1198-1213. Epub 2007/06/05. PubMed PMID: 17542915; PubMed Central PMCID: PMC1974783. 10.1111/j.1365-2958.2007.05728.x.
38. Hayes C.S., Sauer R.T. Toxin-antitoxin pairs in bacteria: killers or stress regulators?. Cell 2003, 112(1):2-4. Epub 2003/01/16. PubMed PMID: 12526786.
39. Hayes F., Davis M.A., Austin S.J. Fine-structure analysis of the P7 plasmid partition site. J. Bacteriol. 1993, 175(11):3443-3451. Epub 1993/06/01. PubMed PMID: 8501048; PubMed Central PMCID: PMC204743.
40. Heuer H., Smalla K. Plasmids foster diversification and adaptation of bacterial populations in soil. FEMS Microbiol. Rev. 2012, 36(6):1083-1104. Epub 2012/03/08. PubMed PMID: 22393901. 10.1111/j.1574-6976.2012.00337.x.
41. Hiraga S., Jaffe A., Ogura T., Mori H., Takahashi H. F plasmid ccd mechanism in Escherichia coli. J. Bacteriol. 1986, 166(1):100-104. Epub 1986/04/01. PubMed PMID: 3007430; PubMed Central PMCID: PMC214563.
42. Hoischen C., Bolshoy A., Gerdes K., Diekmann S. Centromere parC of plasmid R1 is curved. Nucleic Acids Res. 2004, 32(19):5907-5915. Epub 2004/11/06. PubMed PMID: 15528638; PubMed Central PMCID: PMC528805. 10.1093/nar/gkh920.
43. Hoischen C., Bussiek M., Langowski J., Diekmann S. Escherichia coli low-copy-number plasmid R1 centromere parC forms a U-shaped complex with its binding protein ParR. Nucleic Acids Res. 2008, 36(2):607-615. Epub 2007/12/07. PubMed PMID: 18056157; PubMed Central PMCID: PMC2241845. 10.1093/nar/gkm672.
44. Jensen R.B., Gerdes K. Partitioning of plasmid R1. The ParM protein exhibits ATPase activity and interacts with the centromere-like ParR-parC complex. J. Mol. Biol. 1997, 269(4):505-513. Epub 1997/06/20. PubMed PMID: 9217256. 10.1006/jmbi.1997.1061.
45. Jensen R.B., Gerdes K. Mechanism of DNA segregation in prokaryotes: ParM partitioning protein of plasmid R1 co-localizes with its replicon during the cell cycle. EMBO J. 1999, 18(14):4076-4084. Epub 1999/07/16. PubMed PMID: 10406812; PubMed Central PMCID: PMC1171483.
46. Jensen R.B., Dam M., Gerdes K. Partitioning of plasmid R1. The parA operon is autoregulated by ParR and its transcription is highly stimulated by a downstream activating element. J. Mol. Biol. 1994, 236(5):1299-1309. Epub 1994/03/11. PubMed PMID: 8126721.
47. Jensen R.B., Lurz R., Gerdes K. Mechanism of DNA segregation in prokaryotes: replicon pairing by parC of plasmid R1. Proc. Natl. Acad. Sci. U.S.A. 1998, 95(15):8550-8555. Epub 1998/07/22. PubMed PMID: 9671715; PubMed Central PMCID: PMC21113.
48. Kadoya R., Chattoraj D.K. Insensitivity of chromosome I and the cell cycle to blockage of replication and segregation of Vibrio cholerae chromosome II. mBio 2012, 3(3). Epub 2012/05/10. PubMed PMID: 22570276; PubMed Central PMCID: PMC3350373. 10.1128/mBio.
49. Kroll J., Klinter S., Schneider C., Voss I., Steinbuchel A. Plasmid addiction systems: perspectives and applications in biotechnology. Microb. Biotechnol. 2010, 3(6):634-657. Epub 2011/01/25. PubMed PMID: 21255361. 10.1111/j.1751-7915.2010.00170.x.
50. Kusukawa N., Mori H., Kondo A., Hiraga S. Partitioning of the F plasmid: overproduction of an essential protein for partition inhibits plasmid maintenance. Mol. Gen. Genet. MGG 1987, 208(3):365-372. Epub 1987/07/01. PubMed PMID: 2823057.
51. Lau B.T., Malkus P., Paulsson J. New quantitative methods for measuring plasmid loss rates reveal unexpected stability. Plasmid 2013, 70(3):353-361. Epub 2013/09/18. PubMed PMID: 24042048. 10.1016/j.plasmid.2013.07.007.
52. Leplae R., Lima-Mendez G., Toussaint A. A first global analysis of plasmid encoded proteins in the ACLAME database. FEMS Microbiol. Rev. 2006, 30(6):980-994. Epub 2006/10/27. PubMed PMID: 17064288. 10.1111/j.1574-6976.2006.00044.x.
53. Libante V., Thion L., Lane D. Role of the ATP-binding site of SopA protein in partition of the F plasmid. J. Mol. Biol. 2001, 314(3):387-399. Epub 2002/02/16. PubMed PMID: 11846553. 10.1006/jmbi.2001.5158.
54. Lim G.E., Derman A.I., Pogliano J. Bacterial DNA segregation by dynamic SopA polymers. Proc. Natl. Acad. Sci. U.S.A. 2005, 102(49):17658-17663. Epub 2005/11/25. PubMed PMID: 16306264; PubMed Central PMCID: PMC1308903. 10.1073/pnas.0507222102.
55. Lin D.C., Levin P.A., Grossman A.D. Bipolar localization of a chromosome partition protein in Bacillus subtilis. Proc. Natl. Acad. Sci. U.S.A. 1997, 94(9):4721-4726. Epub 1997/04/29. PubMed PMID: 9114058; PubMed Central PMCID: PMC20791.
56. Livny J., Yamaichi Y., Waldor M.K. Distribution of centromere-like parS sites in bacteria: insights from comparative genomics. J. Bacteriol. 2007, 189(23):8693-8703. Epub 2007/10/02. PubMed PMID: 17905987; PubMed Central PMCID: PMC2168934. 10.1128/JB.01239-07.
57. Mohl D.A., Gober J.W. Cell cycle-dependent polar localization of chromosome partitioning proteins in Caulobacter crescentus. Cell 1997, 88(5):675-684. Epub 1997/03/07. PubMed PMID: 9054507.
58. Moller-Jensen J., Borch J., Dam M., Jensen R.B., Roepstorff P., Gerdes K. Bacterial mitosis: ParM of plasmid R1 moves plasmid DNA by an actin-like insertional polymerization mechanism. Mol. Cell 2003, 12(6):1477-1487. Epub 2003/12/24. PubMed PMID: 14690601.
59. Mukherjee K.J., Rowe D.C., Watkins N.A., Summers D.K. Studies of single-chain antibody expression in quiescent Escherichia coli. Appl. Environ. Microbiol. 2004, 70(5):3005-3012. Epub 2004/05/07. PubMed PMID: 15128562; PubMed Central PMCID: PMC404426.
60. Niki H., Hiraga S. Subcellular distribution of actively partitioning F plasmid during the cell division cycle in E. coli. Cell 1997, 90(5):951-957. Epub 1997/09/23. PubMed PMID: 9298906.
61. Niki H., Hiraga S. Subcellular localization of plasmids containing the oriC region of the Escherichia coli chromosome, with or without the sopABC partitioning system. Mol. Microbiol. 1999, 34(3):498-503. Epub 1999/11/17. PubMed PMID: 10564491.
62. Nordstrom K. Plasmid R1 - replication and its control. Plasmid 2006, 55(1):1-26. Epub 2005/10/04. PubMed PMID: 16199086. 10.1016/j.plasmid.2005.07.002.
63. Nordstrom K., Austin S.J. Mechanisms that contribute to the stable segregation of plasmids. Annu. Rev. Genet. 1989, 23:37-69. Epub 1989/01/01. PubMed PMID: 2694936. 10.1146/annurev.ge.23.120189.000345.
64. Nordstrom K., Gerdes K. Clustering versus random segregation of plasmids lacking a partitioning function: a plasmid paradox?. Plasmid 2003, 50(2):95-101. Epub 2003/08/23. PubMed PMID: 12932735.
65. Ozyamak E., Kollman J.M., Komeili A. Bacterial actins and their diversity. Biochemistry 2013, 52(40):6928-6939. Epub 2013/09/11. PubMed PMID: 24015924. 10.1021/bi4010792.
66. Pillet F., Sanchez A., Lane D., Anton Leberre V., Bouet J.Y. Centromere binding specificity in assembly of the F plasmid partition complex. Nucleic Acids Res. 2011, 39(17):7477-7486. Epub 2011/06/10. PubMed PMID: 21653553; PubMed Central PMCID: PMC3177203. 10.1093/nar/gkr457.
67. Pinto U.M., Pappas K.M., Winans S.C. The ABCs of plasmid replication and segregation. Nat. Rev. Microbiol. 2012, 10(11):755-765. Epub 2012/10/17. PubMed PMID: 23070556. 10.1038/nrmicro2882.
68. Pogliano J., Ho T.Q., Zhong Z., Helinski D.R. Multicopy plasmids are clustered and localized in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 2001, 98(8):4486-4491. Epub 2001/03/29. PubMed PMID: 11274369; PubMed Central PMCID: PMC31861. 10.1073/pnas.081075798.
69. Popov M., Petrov S., Nacheva G., Ivanov I., Reichl U. Effects of a recombinant gene expression on ColE1-like plasmid segregation in Escherichia coli. BMC Biotechnol. 2011, 11:18. Epub 2011/03/03. PubMed PMID: 21362179; PubMed Central PMCID: PMC3061898. 10.1186/1472-6750-11-18.
70. Popp D., Xu W., Narita A., Brzoska A.J., Skurray R.A., Firth N., et al. Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation. J. Biol. Chem. 2010, 285(13):10130-10140. Epub 2010/01/29. PubMed PMID: 20106979; PubMed Central PMCID: PMC2843175. 10.1074/jbc.M109.071613.
71. Possoz C., Junier I., Espeli O. Bacterial chromosome segregation. Front. Biosci. (Landmark Ed). 2012, 17:1020-1034. Epub 2011/12/29. PubMed PMID: 22201788.
72. Reyes-Lamothe R., Nicolas E., Sherratt D.J. Chromosome replication and segregation in bacteria. Annu. Rev. Genet. 2012, 46:121-143. Epub 2012/09/01. PubMed PMID: 22934648. 10.1146/annurev-genet-110711-155421.
73. Reyes-Lamothe R., Tran T., Meas D., Lee L., Li A.M., Sherratt D.J., et al. High-copy bacterial plasmids diffuse in the nucleoid-free space, replicate stochastically and are randomly partitioned at cell division. Nucleic Acids Res. 2014, 42(2):1042-1051. Epub 2013/10/19. PubMed PMID: 24137005; PubMed Central PMCID: PMC3902917. 10.1093/nar/gkt918.
74. Rodionov O., Yarmolinsky M. Plasmid partitioning and the spreading of P1 partition protein ParB. Mol. Microbiol. 2004, 52(4):1215-1223. Epub 2004/05/08. PubMed PMID: 15130136. 10.1111/j.1365-2958.2004.04055.x.
75. Rodionov O., Lobocka M., Yarmolinsky M. Silencing of genes flanking the P1 plasmid centromere. Science 1999, 283(5401):546-549. Epub 1999/01/23. PubMed PMID: 9915704.
76. Rownd R. Replication of a bacterial episome under relaxed control. J. Mol. Biol. 1969, 44(3):387-402. Epub 1969/09/28. PubMed PMID: 5346048.
77. Salje J. Plasmid segregation: how to survive as an extra piece of DNA. Crit. Rev. Biochem. Mol. Biol. 2010, 45(4):296-317. Epub 2010/07/01. PubMed PMID: 20586577. 10.3109/10409238.2010.494657.
78. Salje J., Gayathri P., Lowe J. The ParMRC system: molecular mechanisms of plasmid segregation by actin-like filaments. Nat. Rev. Microbiol. 2010, 8(10):683-692. Epub 2010/09/17. PubMed PMID: 20844556. 10.1038/nrmicro2425.
79. Sawitzke J., Austin S. An analysis of the factory model for chromosome replication and segregation in bacteria. Mol. Microbiol. 2001, 40(4):786-794. Epub 2001/06/13. PubMed PMID: 11401686.
80. Sia E.A., Roberts R.C., Easter C., Helinski D.R., Figurski D.H. Different relative importances of the par operons and the effect of conjugal transfer on the maintenance of intact promiscuous plasmid RK2. J. Bacteriol. 1995, 177(10):2789-2797. Epub 1995/05/01. PubMed PMID: 7751288; PubMed Central PMCID: PMC176950.
81. Silva F., Queiroz J.A., Domingues F.C. Evaluating metabolic stress and plasmid stability in plasmid DNA production by Escherichia coli. Biotechnol. Adv. 2012, 30(3):691-708. Epub 2012/01/17. PubMed PMID: 22244816. 10.1016/j.biotechadv.2011.12.005.
82. Sorensen H.P., Mortensen K.K. Advanced genetic strategies for recombinant protein expression in Escherichia coli. J. Biotechnol. 2005, 115(2):113-128. Epub 2004/12/21. PubMed PMID: 15607230. 10.1016/j.jbiotec.2004.08.004.
83. Stieber D., Gabant P., Szpirer C. The art of selective killing: plasmid toxin/antitoxin systems and their technological applications. BioTechniques 2008, 45(3):344-346. Epub 2008/09/10. PubMed PMID: 18778262. 10.2144/000112955.
84. Summers D.K. The kinetics of plasmid loss. Trends Biotechnol. 1991, 9(8):273-278. Epub 1991/08/01. PubMed PMID: 1367567.
85. Summers D. Timing, self-control and a sense of direction are the secrets of multicopy plasmid stability. Mol. Microbiol. 1998, 29(5):1137-1145. Epub 1998/10/10. PubMed PMID: 9767582.
86. Summers D.K., Sherratt D.J. Multimerization of high copy number plasmids causes instability: CoIE1 encodes a determinant essential for plasmid monomerization and stability. Cell 1984, 36(4):1097-1103. Epub 1984/04/01. PubMed PMID: 6323019.
87. Summers D.K., Beton C.W., Withers H.L. Multicopy plasmid instability: the dimer catastrophe hypothesis. Mol. Microbiol. 1993, 8(6):1031-1038. Epub 1993/06/01. PubMed PMID: 8361350.
88. Thomas C.M. Paradigms of plasmid organization. Mol. Microbiol. 2000, 37(3):485-491. Epub 2000/08/10. PubMed PMID: 10931342.
89. Thomas C.M., Nielsen K.M. Mechanisms of, and barriers to, horizontal gene transfer between bacteria. Nat. Rev. Microbiol. 2005, 3(9):711-721. Epub 2005/09/03. PubMed PMID: 16138099. 10.1038/nrmicro1234.
90. Togna A.P., Shuler M.L., Wilson D.B. Effects of plasmid copy number and runaway plasmid replication on overproduction and excretion of beta-lactamase from Escherichia coli. Biotechnol. Prog. 1993, 9(1):31-39. PubMed PMID: 7763410. 10.1021/bp00019a005.
91. Tomizawa J., Som T. Control of ColE1 plasmid replication: enhancement of binding of RNA I to the primer transcript by the Rom protein. Cell 1984, 38(3):871-878. Epub 1984/10/01. PubMed PMID: 6207935.
92. Van Melderen L., Bernard P., Couturier M. Lon-dependent proteolysis of CcdA is the key control for activation of CcdB in plasmid-free segregant bacteria. Mol. Microbiol. 1994, 11(6):1151-1157. Epub 1994/03/01. PubMed PMID: 8022284.
93. Vecchiarelli A.G., Han Y.W., Tan X., Mizuuchi M., Ghirlando R., Biertumpfel C., et al. ATP control of dynamic P1 ParA-DNA interactions: a key role for the nucleoid in plasmid partition. Mol. Microbiol. 2010, 78(1):78-91. Epub 2010/07/28. PubMed PMID: 20659294; PubMed Central PMCID: PMC2950902. 10.1111/j.1365-2958.2010.07314.x.
94. Vecchiarelli A.G., Hwang L.C., Mizuuchi K. Cell-free study of F plasmid partition provides evidence for cargo transport by a diffusion-ratchet mechanism. Proc. Natl. Acad. Sci. U.S.A. 2013, 110(15):E1390-E1397. Epub 2013/03/13. PubMed PMID: 23479605; PubMed Central PMCID: PMC3625265. 10.1073/pnas.1302745110.
95. Vieira J., Messing J. The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 1982, 19(3):259-268. Epub 1982/10/01. PubMed PMID: 6295879.
96. Watanabe E., Wachi M., Yamasaki M., Nagai K. ATPase activity of SopA, a protein essential for active partitioning of F plasmid. Mol. Gen. Genet. MGG 1992, 234(3):346-352. Epub 1992/09/01. PubMed PMID: 1406581.
97. Weitao T., Dasgupta S., Nordstrom K. Role of the mukB gene in chromosome and plasmid partition in Escherichia coli. Mol. Microbiol. 2000, 38(2):392-400. Epub 2000/11/09. PubMed PMID: 11069664.
98. Yao S., Helinski D.R., Toukdarian A. Localization of the naturally occurring plasmid ColE1 at the cell pole. J. Bacteriol. 2007, 189(5):1946-1953. Epub 2006/12/13. PubMed PMID: 17158664; PubMed Central PMCID: PMC1855736. 10.1128/JB.01451-06.