Effects of a recombinant gene expression on ColE1-like plasmid segregation in Escherichia coli

BMC Biotechnology

Volumn 11, Issue , 2011, Pages

  Popov, Mladen ^a   Petrov, Stefan ^a   Nacheva, Genoveva ^a   Ivanov, Ivan ^a   Reichl, Udo ^b  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Bulgaria)

^b MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL CELLS; BACTERIAL GROWTH; CELL DIVISIONS; CONTINUOUS CULTIVATION; DAUGHTER CELLS; E. COLI; EXPRESSION IN ESCHERICHIA COLI; FREE CELLS; HETEROGENEOUS POPULATIONS; HOST CELLS; INTERFERON-GAMMA; KINETIC MODELS; PLASMID INSTABILITY; PLASMID SEGREGATION; PLASMID STABILITY; PLASMID-BEARING CELLS; PRODUCT FORMATION; RECOMBINANT DNA; RECOMBINANT GENE EXPRESSIONS; RECOMBINANT PLASMID; RECOMBINANT PROTEIN; REGULATORY ELEMENTS; RIBOSOME BINDING SITES;

BACTERIOLOGY; BINDING SITES; BIOCHEMISTRY; CELL PROLIFERATION; ESCHERICHIA COLI; GENES; GENETIC ENGINEERING; GLUCOSE; GROWTH KINETICS; KINETIC THEORY; MACROMOLECULES; STABILITY;

TRANSCRIPTION;

BACTERIAL PROTEIN; GAMMA INTERFERON; RECOMBINANT DNA; RECOMBINANT PROTEIN;

ARTICLE; BACTERIAL GROWTH; CELL KINETICS; ESCHERICHIA COLI; GENE EXPRESSION; GENE SEQUENCE; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; NONHUMAN; PLASMID; PROMOTER REGION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

DNA, RECOMBINANT; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; INTERFERON-GAMMA; PLASMIDS; RECOMBINANT PROTEINS;

EID: 79952092142     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-11-18     Document Type: Article

References (51)

1. Bentley WE, Kompala DS. Plasmid instability in batch cultures of recombinant bacteria. Chem Eng Educ 1990, 24:168-172.
2. Seo JH, Bailey JE. A segregated model for plasmid content and product synthesis in unstable binary fission recombinant organisms. Biotechnol Bioeng 1985, 27:156-165. 10.1002/bit.260270209, 18553650.
3. Siegel R, Ryu DD. Kinetic study of instability of recombinant plasmid pPLc23trpAl in E. coli using two-stage continuous culture system. Biotechnol Bioeng 1985, 27:28-33. 10.1002/bit.260270105, 18553573.
4. Summers DK, Sherratt DJ. Multimerization of high copy number plasmids causes instability: ColE1 encodes a determinant essential for plasmid monomerization and stability. Cell 1984, 36:1097-1103. 10.1016/0092-8674(84)90060-6, 6323019.
5. Imanaka T, Aiba S. A perspective on the application of genetic engineering stability of recombinant plasmid. Ann NY Acad Sci 1981, 369:1-14. 10.1111/j.1749-6632.1981.tb14172.x, 7020540.
6. Boe L, Gerdes K, Molin S. Effects of genes exerting growth inhibition and plasmid stability on plasmid maintenance. J Bacteriol 1987, 169:4646-4650. 213834, 3308847.
7. Ollis DF. Industrial fermentations with (unstable) recombinant cultures. Phil Trans R Soc London 1982, 297:617-629.
8. Ollis DF, Chang H. Batch fermentation kinetics with (unstable) recombinant cultures. Biotechnol Bioeng 1982, 24:2583-2586. 10.1002/bit.260241120, 18546225.
9. Summers DK. The kinetics of plasmid loss. Trends Biotechnol 1991, 9:273-278. 10.1016/0167-7799(91)90089-Z, 1367567.
10. Ryan W, Parulekar SJ. Recombinant protein synthesis and plasmid instability in continuous cultures of Escherichia coli JM103 harboring a high copy number plasmid. Biotechnol Bioeng 1991, 37:415-429. 10.1002/bit.260370504, 18597388.
11. Boe L, Tolker-Nielsen T. Plasmid stability: comments on the dimer catastrophe hypothesis. Mol Microbiol 1997, 23:247-253. 10.1046/j.1365-2958.1997.2151579.x, 9044259.
12. Herman-Antosiewicz A, Wegrzyn G. Regulation of copy number and stability of phage λ derived pTCλ1 plasmid in the light of the dimer/multimer catastrophe hypothesis. FEMS Microbiol Lett 1999, 176:489-493.
13. Viret JF, Bravo A, Alonso JC. Recombination-dependent concatameric plasmid replicon. Microbiol Rev 1991, 55:675-683. 372842, 1779931.
14. Park SH, Ryu DD. Effect of operating parameters on specific production rate of a cloned-gene product and performance of recombinant fermentation process. Biotechnol Bioeng 1990, 35:287-295. 10.1002/bit.260350310, 18592521.
15. Gupta R, Sharma P, Vyas VV. Effect of growth environment on the stability of a recombinant shuttle plasmid, pCPPS-31, in Escherichia coli. J Biotechnol 1995, 41:29-37. 10.1016/0168-1656(95)00049-V, 7640001.
16. Ryan W, Parulekar SJ. Effects of culture conditions on plasmid stability and production of a plasmid-encoded protein in batch and continuous cultures of Escherichia coli JM103[pUC8]. Ann NY Acad Sci 1990, 589:91-110. 10.1111/j.1749-6632.1990.tb24237.x, 2192668.
17. Bhattacharya SK, Dubey AK. Expression parameters for target gene cloned in Escherichia coli in response to phosphate supply. Biotechnol Lett 1996, 18:1145-1148.
18. Vila P, Corchero JL, Benito A, Villaverde A. Ammonium-mediated reduction of plasmid copy number and recombinant gene expression in Escherichia coli. Biotechnol Prog 1994, 10:648-651. 10.1021/bp00030a010, 7765700.
19. Chew LCK, Tacon WCA, Cole JA. Effect of growth conditions on the rate of loss of the plasmid pAT153 from continuous cultures of Escherichia coli HB101. FEMS Microbiol Lett 1988, 56:101-104.
20. Huang J, Dhulster P, Thomas D, Barbotin JN. Agitation rate effects on plasmid stability in immobilized and free-cell continuous cultures of recombinant E. coli. Enzyme Microbiol Tech 1990, 12:933-939.
21. James AA, Morrison PT, Kolodner R. Genetic recombination of plasmid DNA. Analysis of the effect of recombination-deficient mutants on plasmid recombination. J Mol Biol 1982, 160:411-430. 10.1016/0022-2836(82)90305-9, 6759658.
22. Bentley WE, Mirjalili N, Andersen DC, Davis RH, Kompala DS. Plasmid-encoded protein: the principal factor in the "metabolic burden" associated with recombinant bacteria. Biotechnol Bioeng 1990, 35:668-681. 10.1002/bit.260350704, 18592563.
23. Bhattacharya SK, Dubey AK. Metabolic burden as reflected by maintenance coefficient of recombinant Escherichia coli overexpressing target gene. Biotechnol Lett 1995, 17:1155-1160.
24. Glick BR. Metabolic load and heterologous gene expression. Biotechnol Adv 1995, 13:247-261. 10.1016/0734-9750(95)00004-A, 14537822.
25. Ensley BD. Stability of recombinant plasmids in industrial micro-organisms. Crit Rev Biotechnol 1986, 4:263-277.
26. Stueber D, Bujard H. Transcription from efficient promoters can interfere with plasmid replication and diminish expression of plasmid specified genes. EMBO J 1982, 1:1399-1404. 553223, 6327267.
27. Remaut E, Stanssens P, Fiers W. Plasmid vectors for high-efficiency expression controlled by the pL promoter of coliphage lambda. Gene 1981, 15:81-93. 10.1016/0378-1119(81)90106-2, 6271633.
28. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual 1989, Cold Spring Harbor, Cold Spring Harbor Press.
29. Tsanev RG, Ivanov IG. Immune Interferon: Properties and Clinical Application 2001, CRC Press LLC, USA.
30. Stewart FM, Levin BR. The population biology of bacterial plasmids: a priori conditions for the existence of conjugationally transmitted factors. Genetics 1977, 87:209-228. 1213735, 17248761.
31. Lee SB, Seressiotis A, Bailey JE. A kinetic model for product formation in unstable recombinant populations. Biotechnol Bioeng 1985, 27:1699-1709. 10.1002/bit.260271211, 18553632.
32. Lee C, Kim J, Shin SG, Hwang S. Absolute and relative QPCR quantification of plasmid copy number in Escherichia coli. J Biotechnol 2006, 123:273-280. 10.1016/j.jbiotec.2005.11.014, 16388869.
33. Nacheva G, Todorova K, Boyanova M, Berzal-Herranz A, Karshikov A, Ivanov I. Human interferon gamma: significance of the C-terminal flexible domain for its biological activity. Arch Biochem Biophys 2003, 413:91-98. 10.1016/S0003-9861(03)00113-9, 12706345.
34. Alexiev K, Usheva A, Pavlova M, Ivanov IG. Expression of synthetic human calcitonin genes in plasmid vectors containing tandemly repeated non-overlapping ribosome binding sites. Int J Biochem 1989, 21:987-996. 10.1016/0020-711X(89)90231-0, 2480257.
35. Davidson AM, Dunn A, Day MJ, Randerson PF. A nonlinear technique for the analysis of plasmid instability in micro-organisms. Journal of General Microbiology 1990, 136:59-64.
36. Palaiomylitou MA, Matis KA, Zouboulus AI, Kyriakidis DA. A kinetic model describing cell growth and production of highly active, recombinant ice nucleation protein in Escherichia coli. Biotechnol Bioeng 2002, 78:321-332. 10.1002/bit.10107, 11920448.
37. Altintash MM, Kirdar B, Önsan ZI, Ülgen K. Plasmid stability in a recombinant S. cerevisiae strain secreting a bifunctional fusion protein. J Chem Technol Biotechnol 2001, 76:612-618.
38. Watson JD. Molecular Biology of The Gene 1972, Philadelphia, PA: Saunders, 2.
39. Atkinson B, Mavituna F. Biochemical engineering and biotechnology handbook 1983, New York, Nature Press.
40. Lee SB, Bailey JE. Analysis of growth rate effects on productivity of recombinant Escherichia coli populations using molecular mechanism models. Biotechnol Bioeng 1984, 26:66-73. 10.1002/bit.260260113, 18551588.
41. Bailey JE, Ollis DF. Biochemical Engineering Fundamentals 1986, McGraw-Hill College, 2.
42. Seo JH, Bailey JE. Continuous cultivation of recombinant Escherichia coli: existence of an optimum dilution rate for maximum plasmid and gene product concentration. Biotechnol Bioeng 1986, 28:1590-1594. 10.1002/bit.260281018, 18553877.
43. Cooper NS, Brown ME, Caulcott CA. A mathematical method for analyzing plasmid instability in microorganisms. Journal of General Microbiology 1987, 133:1871-1880.
44. Noak D, Müller G, Roth M. Mathematical modelling of genetic segregation kinetics obtained with chemostat cultures of prokaryotic microorganisms. Zeitschrift für allgemeine Mikrobiologie 1984, 24:459-465.
45. Park SH, Ruy DD, Lee SB. Determination of kinetic parameters related to the plasmid instability: for the recombinant fermentation under repressed condition. Biotechnol Bioeng 1991, 37:404-414. 10.1002/bit.260370503, 18597387.
46. Summers DK, Beton CW, Withers HL. Multicopy plasmid instability: the dimmer catastrophe hypothesis. Mol Microbiol 1993, 8:1031-1038. 10.1111/j.1365-2958.1993.tb01648.x, 8361350.
47. Mosrati R, Nancib N, Boudrant J. Variation and modeling of the probability of plasmid loss as a function of growth rate of plasmid-bearing cells of Escherichia coli during continuous cultures. Biotechnol Bioeng 1993, 41:395-404. 10.1002/bit.260410402, 18609567.
48. Baker TA, Kornberg A. Transcriptional activation of initiation of replication from the E. coli chromosomal origin: an RNA-DNA hybrid near oriC. Cell 1988, 55:113-123. 10.1016/0092-8674(88)90014-1, 2458841.
49. Atlung T. Allele-specific suppression of dnaA(Ts) mutations by rpoB mutations in Escherichia coli. Mol Gen Genet 1984, 197:125-128. 10.1007/BF00327932, 6096668.
50. Flatten I, Morigen, Skarstad K. DnaA protein interacts with RNA polymerase and partially protects it from the effect of rifampicin. Mol Microbiol 2009, 71:1018-1030. 10.1111/j.1365-2958.2008.06585.x, 19170875.
51. Szambowska A, Pierechod M, Wegrzyn G, Glinkowska M. Coupling of transcription and replication machineries in λ DNA replication initiation: evidence for direct interaction of Escherichia coli RNA polymerase and λO protein. Nucleic Acids Res 2011, 39:168-177. 3017604, 20833633.