Afoxolaner against fleas: Immediate efficacy and resultant mortality after short exposure on dogs

Parasite

Volumn 21, Issue , 2014, Pages

  Beugnet, Frédéric ^a   Devos, Christa ^b   Liebenberg, Julian ^b   Halos, Lénaïg ^a   Fourie, Josephus ^b  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b ClinVet International   (South Africa)

Author keywords

Afoxolaner; Ctenocephalides felis; Dogs; Immediate killing; Induced mortality; Short exposure

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; AFOXOLANER; AMINO ACID RECEPTOR BLOCKING AGENT; INSECT PROTEIN; INSECTICIDE; ISOXAZOLE DERIVATIVE; NAPHTHALENE DERIVATIVE;

ANIMAL; ANTAGONISTS AND INHIBITORS; COMPARATIVE STUDY; CONTROLLED STUDY; CTENOCEPHALIDES; DOG; DOG DISEASES; DRUG EFFECTS; FLEA INFESTATIONS; RANDOMIZED CONTROLLED TRIAL; TIME; TREATMENT OUTCOME; VETERINARY;

ANIMALS; CTENOCEPHALIDES; DOG DISEASES; DOGS; EXCITATORY AMINO ACID ANTAGONISTS; FLEA INFESTATIONS; GABA ANTAGONISTS; INSECT PROTEINS; INSECTICIDES; ISOXAZOLES; NAPHTHALENES; TIME FACTORS; TREATMENT OUTCOME;

EID: 84907361303     PISSN: 1252607X     EISSN: 17761042     Source Type: Journal    
DOI: 10.1051/parasite/2014045     Document Type: Article

References (27)

1. Azad A, Radulovic S, Higgins JA, Noden BH, Troyer JM. 1997. Flea-borne rickettsioses: ecologic considerations. Emerging Infectious Diseases, 3, 319-327.
2. Beugnet F, Franc M. 2012. Insecticide and acaricide molecules and/or combinations to prevent pet infestation by ectoparasites. Trends in Parasitology, 28, 267-279.
3. ®) in dogs on adult and immature stages of the cat flea (Ctenocephalides felis). Veterinary Parasitology, 168, 312-317.
4. Brianti E, Gaglio G, Napoli E, Giannetto S, Dantas-Torres F, Bain O, Otranto D. 2012. New insights into the ecology and biology of Acanthocheilonema reconditum (Grassi, 1889) causing canine subcutaneous filariosis. Parasitology, 139, 530-536.
5. Carlotti DN, Costargent F. 1994. Analysis of positive skin tests in 449 dogs with allergic dermatitis. European Journal Companion Animal Practice, 4, 42-59.
6. Dobson P, Tinembart O, Fisch RD, Junquera P. 2000. Efficacy of nitenpyram as a systemic flea adulticide in dogs and cats. Veterinary Record, 147, 709-713.
7. Dryden MW, Blakemore JC. 1989. A review of flea allergy dermatitis in the dog and cat. Companion Animal Practice, 19, 10-17.
8. Dryden MW, Rust MK. 1984. The cat flea: biology, ecology and control. Veterinary Parasitology, 52, 1-19.
9. Dunn AM. 1978. Cestoda, in Veterinary Helminthology, 2nd edn. Heinemann: London.
10. EMEA. 2000. VICH Topic GL9 (GCP). Guideline on Good Clinical Practices.. The European Agency for the Evaluation of Medicinal Products (EMWA/CVMP/VICH/595/98-Final). http://www.ema.europa.eu/docs/en-GB/document- library/Scientific-guideline/2009/10/WC500004343.pdf).
11. Franc M, Bouhsira E. 2009. Evaluation of speed and duration of efficacy of spinosad tablets for treatment and control of Ctenocephalides canis (Siphonaptera: Pulicidae) infestations in dogs. Parasite, 16, 125-128.
12. Hunter JS III, Dumont P, Chester TS, Young DR, Fourie JJ, Larsen DL. 2014. Evaluation of the curative and preventive efficacy of a single oral administration of afoxolaner against cat flea Ctenocephalides felis infestations on dogs. Veterinary Parasitology, 201, 207-211.
13. Just FT, Gilles J, Pradel I, Pfalzer S, Lengauer H, Hellmann K, Pfister K. 2008. Molecular evidence of Bartonella spp. in cat and dog fleas from Germany and France. Zoonoses Public Health, 55, 514-520.
14. Letendre L, Harriman J, Huang R, Kvaternick V, Drag M, Larsen DL. 2014. The intravenous and oral pharmacokinetics of afoxolaner, a novel isoxazoline, used as a monthly chewable antiparasitic for dogs. Veterinary Parasitology, 201, 190-197.
15. Marchiondo AA, Holdsworth PA, Fourie LJ, Rugg D, Kellmann K, Snyder DE, Dryden MW. 2013. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition: guidelines for evaluating the efficacy of parasiticides for the treatment, prevention and control of flea and tick infestations on dogs and cats. Veterinary Parasitology, 194, 84-97.
16. Orloski KA, Lathrop SL. 2003. Plague: a veterinary perspective. Vet. Med. Today: Zoonosis Update. Journal of the American Veterinary Medical Association, 222, 444-448.
17. Otranto D, Dantas-Torres F, Breitschwerdt EB. 2009. Managing canine vector-borne diseases of zoonotic concern: part one. Trends in Parasitology, 25, 157-163.
18. Otranto D, Dantas-Torres F, Breitschwerdt EB. 2009. Managing canine vector-borne diseases of zoonotic concern: part two. Trends in Parasitology, 25, 228-235.
19. Plant JD. 1991. Recognizing the manifestations of flea allergy in cats. Veterinary Medicine, 10, 482-486.
20. Pugh RE. 1987. Effects on the development of Dipylidium caninum and on the host reaction to this parasite in the adult flea (Ctenocephalides felis felis). Parasitology Research, 73, 171-177.
21. Robertson-Plouch C, Baker KA, Hozak RR, Zimmermann AG, Parks SC. 2008. Clinical field study of the safety and efficacy of spinosad chewable tablets for controlling fleas on dogs. Veterinary Therapeutics, 9, 26-36.
22. Rohdich N, Roepke R, Zschiesche E. 2014. A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of bravecto™ (fluralaner) against frontline™ (fipronil) in flea- and tick-infested dogs. Parasites & Vectors, 7, 83.
23. Ross DH, Arther RG, von Simson C, Doyle V, Dryden MW. 2012. Evaluation of the efficacy of topically administered imidacloprid + pyriproxyfen and orally administered spinosad against cat fleas (Ctenocephalides felis): Impact of treated dogs on flea life stages in a simulated home environment. Parasites & Vectors, 5, 192.
24. Rust MK. 2005. Advances in the control of Ctenocephalides felis (cat flea) on cats and dogs. Trends in Parasitology, 21, 232-236.
25. Rust MK, Dryden MW. 1997. The biology, ecology and management of the cat flea. Annual Review Entomology, 42, 451-473.
26. Schenker R, Tinembart O, Hubert-Droz E, Cavaliero T, Yerly B. 2003. Comparative speed of kill between nitenpyram, fipronil, imidacloprid, selamectin and cythioate against adult Ctenocephalides felis (Bouché) on cats and dogs. Veterinary Parasitology, 112, 249-254.
27. Shoop WL, Hartline EJ, Gould BR, Waddell ME, McDowell RG, Kinney JB, Lahm GP, Long JK, Xu M, Wagerle T, Jones GS, Dietrich RF, Cordova D, Schroeder ME, Rhoades DF, Benner EA, Confalone PN. 2014. Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs. Veterinary Parasitology, 201, 179-189.